Cal erat] Bo trey > Wonpuralted Bitak-w-Copose darbraaochier pqs) Bashy, edime | epee ed ntl: 3 > in i i 2 Myventhts 5 al anit @.., FtBacteria — Gram Positive Cocci ‘Strep Preumonia “the alpha knight tournament” Purple Background - G+ ‘knight tournament — = hemolytic, partial hemolysis where the surrounding zone isa green hue Strep Pneumonia Knight ‘Armor ~ Polysaccharide Capsule is major virulence factor Chin is exposed ~ Optochin sensitive, optochin inhibits the growth of strep pneumo Double Lance ~ Lancet shaped diplococci ‘Mud on horses legs - Bile soluble, meaning it does not grow in Bile Rust Colored single lobe an chest — Rust colored sputum and lobar pneumonia Squire mopping up muddy mess MOPS - Meningtides, Ottis ‘Media, Pneumonia, Sinusitis ‘Number 1 sign number one cause of al these diseases. Cracked Shield with the symbol of igA dimer molecule - Protease that cleaves IgA that allows invasion af mucosa reducing host defenses Sickle- Removal of spleen leads to susceptibility of infection by tencapsulated organisms lke in sickle cell anemia. | Crows ~ azithromycin Macrolides 3 Axes- Ceftriaxone ‘Adults in the Mezzanine, Children on the Ground -2 pneumococcal vaccines, adult i 223 valiant polysaccharide vaccine, children is 7 valent but conjugated to a protein. Adults will have a T-Cell independent response creating IgM that does rot last long. Adding the protein adds a more robust antigen response leading toa production of IgG in children. seeesan Strep Viridians No Armor —Not encapsulated Jesters mask protects face including the chin ~ optochin resistant Donkey with bile resistant boots ~ Bile resistant 4, Foul Yellow teeth on donkey — associated with dental carries 5. Deck of cards with plate shield - Synthesizes Dextran’s from glucose which allows strep viridians to adhere to any fibrin from platelets that has been damaged in the heart 6. Strep Sanguineous adheres to fibrin platelet aggregates in damaged heart valves, most commonly occurs in mitral valve.Strep hrescens frowmenia Paopestes - WD ive @ Lonel shaped yfotace/ Code ote Somat riwdeHl outs) i) whe sans “ Solusle yn Bile ( ped “) Canth joe © Gptehin Sensihue a) Polyacchds cpl hyp Le Speufe ee easly _ SuseL Ndisttaw : 7 Ly See _2 Yue tans Seathus —9 _jeltuh xe _____ 3% & co aoe / © poppe elacrts ee ——_—_——— L _— ___feach Lolth vee. nad C- (— feschve Palin\ aS SPafrpertys ix —= = Oy pe a bpp : job = mat vite dene oe SERURREESE L > i ae BD fercbore Berd —O- —Prconifies _ | my : | biog Sapo Soech A Kx “Lomi bos igh [ORF ahr Clow, ORT 5 1 = : Plvel’ ~ E— Bef lamentne— onnth plication Bia owt 2 owppousing, floid d+ Dede ere feree gece hase sh Preset aes pert a ca a anenceo K ee nce all DO Aleskalfoltas_anbni wee So tepte = = = —& Reimar ep Tad i Pfuty graces polly, obstruction — CO Phrexal-Crealiy tpi Poon Cope fe _ Speech b Siete coll Arvemly —9 uke ph ced Spleen T ceMinial finolings b Sudeben Ch bb @ Fevee (Cough (3) Pleserhe an Ope Bed fPevorm ple ming le —O- due Ha Reach @ Lancer sl pet a bs aa home afi cola Py (© Talurited 5 : a optekrs flood Cob) lube ——} tt IS neh poe a dad Iyp ,Bacteria — Gram Positive Bacilli Fe Clostridium botulinum - Robotulism 1 2 10. 4, Purple Hues — Gram Pos Robots made of cans transmitted by improper canning of food allowing it to flourish in the anaerobic ‘environment producing heat stable toxin. “a family are presenting with the same neural symptoms” Lug Nuts ~ Spore formers Gas Mask Obligate Anaerobe Robots struggling to keep body's upright — Flaccid paralysis, descending paralysis. Opposite of Guillen barre syndrome. Multiple people is most likely botulism, not Guillen barre Robots eyelids are droopy ~ early symptoms include ptosis and diplopia, Robots lights are on or off ~ to demonstrate the descending paralysis, toxin is unable to cross BBB so only Peripheral nervous system Power area in the back with the ACh symbol - Cleavage of SNARE protein similar to Tetany toxin, only difference is that botulism attacks motor neurons that release Ach, inhibiting motor neuron release leading to flaccid paralysis. Guy in a suit similar to tetany story cutting wire with scissors ~ Toxin is a protease that cleaves SNARE proteins Robot Baby has no lights on and is limp ~ toxin effects similar to babies and cause flaccid paralysis “Floppy Baby Syndrome” Robot pouring honey all over the baby robot dripping all over the nuts (spores) - Babies lack robust flora of gut that can out compete Clostridium botulinum wil be colonized if they ingest honey. Then they will produce the toxin and have floppy baby syndrome ~ Babies get the toxin by ingestion of spores, adults get the toxin by Ingestion of pre formed antigen from improperly canned foods. eaeTn Saag yg nn ( Nngetdre Cn vine) 7 7 Dnecfyarud prin 5—Ansested, pisfotarcel Fe ae eee se EET 7 Inachinded by Leabig > Sffcd ® = a 3 box ky li 5 kK Feeds crea) 2. SS ra Athelis: verefasla Sal Bobbin spars : il D> Wled fom 364 > Bed > ae = 1 $—ionmunelogic Aype 1S |Phabeare bic il bs 1 "msi Commer Dey, cee aut) 5, Jn bavnany ve SNARE a Pee ten~ Cerro Py Dab cliasme5t6 a. price rrstcction bert —ajnecelnled ym» 4 CP dobet en es Cleat oe if, nef Oper eh pwa enceding frat jven & PER > PNA e ihe Ny 3 foun ath us oe ey Tes ee dae fe a Bese Bode H a> nrintle PrP Jiidtle olive at a ——— if Blepha ce spasin Toomeatts Sunny Clinical Find ing . al oe 2 yor orn ack aw © __ press wre Q_dliplepla x ; is) ys phasis ty. < >: > eapitccong —or X\ f faith =< (5 —tesund foles "Qf Roblin CP) AdecHl \ Bok Dinwm v | i dey suse rem Condarn 17 = -L pow. Boh binan _ | POPPE OYE bee eer E ges SKin pepe’ uv 1 peganed vetted £ Breck —te “pee Gerninet in angebshic eG Cru tensed ardeineBacteria — Gram Positive Bacilli Clostridium tetani— Rhesus Research Revolution 1 2 3 4. ‘Violet Hues ~ Clostridium Genus is Gram Positive Researcher in the midale with gas mask- Obligate anaerobes Walnuts ~ Spore forming Rusty nails and barbed wire, pots of soil Clostridium is found in the dirt and enters the body through a puncture wound Rhesus monkeys that are grinning - Spastic paralysis leading to rgity, ch 1 ‘accompanies with lock jaw. “Monkey in the exaggerated arching back position - reminds us of Opisthosomas Pathogenesis 1. Puncture wound occurs either by nail or barbed wire with tetany spores on it, spores are embedded in the flesh and the organism vegetates and stays at the wound ste. It wil release tetanus toxin that wil cause all the symptoms Monkey operating 2 pulley with scissors on it - Tetanus toxin will travel retrograde through the motor axons tothe spinal cord. Monkey cutting the snare trap - Tetanus toxin will leave snare and inhibit exocytosis ofthe ‘neurotransmitter into the synapse (GABA and glycine) or Renshaw cells G8G labs to represent 2 type of inhibitory neurons, GABA and glycine. If these are inhibited it will result in uncontrolled firing of the motor neurons leading to spastic paralysis, ‘Monkey with wrench and saw - Renshaw cells will sense over activity of nearby motor neurons and when ‘they sense this activity they will attempt to fire and inhibit the motor neuron. So the GABA and Glycine release from these cell is inhibited leading to spasm Researcher with Vaccine in hand ~Toxoid Vaccine, toxin conjugated to protein. Antibody response to the toxin, (evi), also PaRGaR_Clostsickum Tetani == E [eae see cells Tetons SESE eee Eee EEE EGE Eee eee i Fiammiion. See Set _— Ca- widlesptead. py Se/Q— > wound srle 4 foectasle > Recets we Say malt (porclik pnts a pat &. ewnadap > OEM } HAs Cyscum sre a i Poppins Pea P06 NOB Steg ee ascent HH bg | pte Petiin vs i2qsmin——>_exofe n/n ——> VS Ae, do cect af teambizenie ype) Tae — sped — fates pele —t fina Lyle ri/ | ¥ eo Ayer x epctewesntif sf ss 5) « angliside Lccepfis—7 lock Pohibioey anechiasost 2 ASR GT Cmte 2 bot Clinical Lincling :- : oO SPOT Mascxe om & JG) Lack fas w_(_mase fey _Contdachin Cont sachan J 8 6) Rise Saichbinew — Tr] nag yore hef feces —______ & ~ ae .© Opts ofous —_Conttachor 4 eg fenses pauscLes F back | (© Rex 7 whee Pate 313 | i iz (‘or Vo ree bid, osie Se%, oe Dike nese @ Fewmrnat Spore pedir . i , = , ee Sy cf excep fie ooole : L —— 2 2 Apppenee 2Bacteria — Gram Positive Bacilli | rs 2 | Clostridium Id trip to the chocolate factory 1, Walnuts ~ Spore formers 2. Clean sign that reminds employees to wash hands, that is directly over the chocolate machine to show that it Clindamycin and poorly washed hands can cause it - Nosocomial diarthea, spores easily transferred from patient to patient, antibiotics will wipe out normal flora making patients immunocompromised and able to be colonized then create the toxin. Clindamycin is one of the main antibiotics that will use this. 3. Workstation A and workstation 8 - 2 exotoxins that are produced by C Diff. 4. Ais for Apple and is for exotoxin A ~ Binds to the brush border of the intestine and causes inflammation, cell death and watery diarrhea. A for Apple 5. Employee picking up the apple and brushing chocolate on them — brushing is for targeting the brush border, the proximity to the chocolate canal will emind you that exotoxin A causes diarrhea. Brush Border Toxin ‘causing watery diarrhea, 6. Bis for black licorice and is for exotoxin B ~ B is for Black Licorice ~ disrupts cytoskeleton integrity by depolymerizing actin leading to enteracyte death and necrosis, Yellowish grey exudate that forms a pseudo ‘membrane that covers the colonic mucosa. This is why itis called a pseudomembranous colitis. 7. Black Licorice —looks like actin 8. Little kid chewing them apart ~ Depolymerization of actin filaments 9. Worker packing the licorice in sheets of yellowish plastic ~ Pseudo membrane formation kid walking in the flowing chocolate ~ Assay to detect TOXIN in stool that will be detected downstream 11, Gas mask — Obligate anaerabe 12. Violet - Gram Positive 13. Van with the mouth look alike - Oral Vancomycin txt 14, Train—txt Metronidazole PIALlostiiolium oli Disease-- —_— © Peudomembanesy cxbins ® Nosocomial, oliats hea \ Fanyniston, . > Colomees Lasse. datobue (co/e1 ] Fecal — otal loufe gato) Rackesian rif —— —beararitted ands ; tt ml See F —Pa thes enesis > wa sty. invades 9 reshma? rer tesa _— _ Antibiotts —_» Sapptcn netinaD + Dae HEE ei Heian fe L C APfigle gaat ( 2 Glucesqfale ——9 RRP Phere Ch fists ‘ofoxnh —> hyp masrn Actin @lLar eahskelepl t It oR Lact L 1 be’ CO ob sewspert prep Sata Clinical — FhadlinSS TR Pacudoveeen ee Petossfushle ) OP | 4 _sheobs(h ey Cs bavaten > > Wisccindes - etfs hit el eo _fevet | Abe Jonna! pain SO ip tele seep Pert pulfisel WIC aurepnco ers Swe srl “Pesech™ | 1 =F A Tons in Stolk > preudorembsquows Colrbs oltshngut ted Prarn _fasrsientclfyretssn ole fp ati intake : { rersyy. exotoxin delechur Gere _ free roby n — tr 1 HRP a eee eee a yr PER fee Sa em EEE EEE Ee : 7 Gneakt Sasi hull and speufrcity 0 — } 4 I Ey Pe eae ee Se C-cifP eile - ve = = \ oven rf Psy ave Col onged ~ | bs) PasnA Becloa rd ol seas 4Bacteria — Gram Positive Bacilli ium perfringes ~ Private Ringen’s Motorcycle Accident Motorcycle accidents and deep penetrating military combat wounds ~ Classic Presentations, Large amounts of flesh are exposed to dirt and dust Walnuts and knocked over dirt - Forms spores that are found in soil Gas leaking out or the motorcycle - Causes Gas Gangrene after it enters the wound, clostridial myonecrosis, gas produced under tissue and has a cracking sound on palpation a flag - Alpha toxin that effects lipid bilayer and lyses RBC’s. Myonecrosis involves alpha tox lecithiinase (phospholipase) Clothespins are arranged opposite of each other ~ showing the lipid bilayer and how itis damaged Red tomatoes on the ground — Lecithinase can cause red cell hemolysis. Red sign “double fine zone” - Double zone of hemolysis Gas Mask - Obligate anaerobe Slow sign - Slow onset diarthea due to spores needing to reproduce in the gut then create the toxin 10. Woman holding a pencil —1* line txt is IV Penicillin GVo ighum — Pesfeinged Clostichome _Peafg Q Ga Gangioxe of Monectosis Ee ae a0. cso buss fascias ——— & 9d peg Cras resus —> Flesh Cahong ye eh 1 TY vas Cfeshitagas 1 Sie Feat eee Rs *, : {Bow_onission Lig a Soil eae 7 Cae NAVAB A | | | | { | eel! O-rreivteqcl—heeidend Oar __womds i g & Cophe Above —— - PPP OP PRD AIS Poicgene (Gwin powmatred Specially muscle fuse) a ADohg doxin———> | hii Alpha toxin —> tr was a) er Seer i: t BL Level S75 ) Degradehive En2yw J cana a EE LLPRA RRA APCbinicalB Liveling ef : EE Pain, dema, Celubrhs, Jang sere ee fet Hasnclyis —9 Testnleca—__ eee > faxb Gretn Blady Vepinel obschaste jh eloried sifis Doosle Lemelyss tn Rood Baa ee Dgecs; jLadt ya Sf Yo bt (ales [| Psccsp: a5 — pole ey oy Feed [Poisoning on 0 t fa pect eve) > Sop P— 5 Cardammate fj P i ah Fre ante Grew _onove 4opiely i Poe Ashealed free we j zs Wormap Phin jn exten ref S 7rboTne | a Sane a) _ Entesedoxrn Ls: Aeteuy She Ouse > fovrn piedued rng Heal D —ptfotined fonin CHI nvend — fnclng : oe Paetsch oy (Lose jew v4 hss Ver? iGBacteria — "Neisseria meningitides "A shocking Death on Campus" 1 23 > B avdea Takes Place ina College dorm - Easily spread in areas witha lot of people, military recruits, college dorms via ressiraton droplets Red Hue ~ Gram Neg IMAC =Reminds us ofthe common features Inspection ofa bottle of MALT liquor -Only rmeningitides ferments maltose Long Catton Swab - Nasopharyngeal swab suggests that itis found in nasal cavities first and transmitted via respiratory secretions. ‘Syringes on the floor We have vaccines for ACD polysaccharide capsules but not 8 Covered up syringes - Capsule isthe major virulence factor, type 8 strain isnot included inthe vaccine Sickle and Hammer Flag Sickle cell disease are more susceptible to Neisseria meningitides because itis ‘encapsulated Burning Envelopes ~N. Meningitides Invades hhemotogenously leading to a massive Immune response generated but LOS (lipocligiosaccharides) proteins, these are Neisseria's version of LPS, it grows ‘so much ofit that it outgrows the surface area of the bacteria and begins blabbing off. These blebs of LOS. ‘envelope that lead to a massive inflammatory response, "LOS envelopes caught fire 10. Pathogenesis, a, Burning Envelopes - Inflammatory response b. leaky sprinklers - Leakage of interstitial fluid by capillaries) hypovolemia . Dark Spots on Carpet - Characteristic petechial rash leading to thrombocytopenia leading to DIC d. Red spot on boxers also mean petechial rash . Water sprinkler on and shock coming from ‘electrical outlet - Capillary leakage can lead to shock f. Waterhouse in the background - Vasoconstriction will go to max to attempt to maintain blood pressure and adrenals ‘can infarct and will contribute to shock (Waterhouse fritter syndrome) 11, 15% mortality rate 12, Axes on Firefighter - Treatment - 3rd generation cephalosporin (ceftriaxone) 13, Police with rifle - Close contacts will need rifampinissesia _ (Men amyts( pening Paepest Antiynic : org Ant ephaseryhe vo eye “hens af pn tgexnsily OF jeetysnechavelen Cops te me ae es it (Sexe Ay Hs Co ames commen Jigs Tote —Pe nlycchauide _ pute i O_Giam — Nesahve LE) Emdoboyin —> Outer meins—» LOS LGp-Oxidess— =5 Cy cbtense © ——— plsogh neelin gi ine pusply Iy. © Irbibited $4 forse hoex-rachkard Katty Nets Bleed peg Cy Glued “in chece/gh Ajab Carbon ou Shad 5 __&e"C * Qnach i Qh shy dyes Ze & = Patho genen' & p-—--—AL Bareemnclialeh—> Nessphapserl erat—o Betomt Ge : dsansit lets ORT Casw'et sym Phomreh'——> fo} och zB iat, inetd jody [ ponin§o— Recta Fain yh Aissernined /_phaeep root Ady (ti wen 5 Used — Sf A shel /detmifor'y = i lose Qua shea A ghsone Casts > © ca as wikis Reccwis amy ~S oe area fog Be ioaas Meninsiht —> pafhanh eller fen A months 9 Sdughecceey Pf’ om Nazca betwen Ig ate viet — Bank dnd —-(r- Rena Uitalenct — Pactss: = * C_Piyecan Coppelo —> Los—s Rua Psp by pmue® frevet, shock SS @y198 pate — leaves _o.A_—> helps allechiy ay SS aw branes + UTR isBinds facts HC gnhibite cab) —> fedducen operation mac. peedecter _ ee inst polyscectaaite (Qe bs) Inte gediny CC) y _ Eeatigumar—>_ fe D Moc bored Hawmeflohininese —> Inhrhid Ch Ch — — a Jrrceeased _Ineselonce J obseayt Chica) Findings y £ Meaning Bs Meniningoceccem 4 : a = ke Fos wakes beuiy— Fridle sichStx 4, Hecdache, Snelson Sifj_meck A oiske spinel Fluid SS ba) ; Dey Adienal posffiaing, forts eas 7 Q ; ~* hocks wvielesprenel py nas Ra aserabery bpten r9 en WL La oom agrat—Co Late Bleeder spina Go Guam megehve Cocet Ser ie Snet 4_Spnal flew bode — fst econ 9 — gp _ve diplececei pat G _feterin phe 4 poate je ed di nero he tae ® aber lube —> Cpe Aas la > P pol yescaet Te a > Snead SOO CO, erwitmahBacteria — Neisseria gonorrhea - "The Violinists last Clap” 11 12. ‘Mac ~ Reminds us of all the common features of the Neisseria species Flirting with someone at the bar - Sexually transmitted infection Gonzo’s - Gonorrhea 2 red pillows on chairs - with Gram Neg diplococci Seats with the high back white chairs - Facultative intracellular and invade PMN's White spots on chairs — look like nuclei, trying to look like PMIN's Giass falling off the table and breaking - Not encapsulated NOT ENCAPSULATED Effects genitalia first —in male’s causes urethritis and prostatitis and orchicitis. Female infection a. Chandelier (uterus w/ fallopian tubes and ovaries) candle wax is falling - Pelvic inflammatory Disease - purulent white discharge Fitz Hugh Curtis Band - PID spreading to peritoneum - Fitz Hugh Curtiss syndrome - Violin string like adhesions in liver from spread into peritoneum. . Statue fell with cracks on one knee - May cause polyarthritis in the knee and is asymmetric Mother holding a baby shielding the baby’s eyes - Can be passed on to baby during delivery and. ‘cause a conjunctivitis w/ in 5 days of birth. Statue w/ three axes, and three axe emblem on wall - Ceftriaxone is treatment but will need treatment for chlamydia, macrolide Zpack Shell shape napkins — reminder to treat for chlamydia due to coinfection. LPBAE - ave aw(Semerey ‘ Messe aso Gomushnere ee & a DB Sepwall Psonsmrigion ee eR EH EEL & 0 Abymplrwmnhe 1m women ond S4mphoache in pen OF & a faned Defcon Crmnedn Sout J ofan CF c Ansiectaf. mu ps agree fr = Uitte fates ; te titer pon 4 __@ + zs : © (eos Dubie phe oet he rn pee eee en a OO ndes nwemfprene jee teins eo ( La A jrsctean - 7 oa b = oe = 7 > eo eee hb ~ 5 ——fnadhindn Pynphoshe pane, elusin) _s Csb. i pefeanch nel tie + ~ Lane! fo cbisurern ade anf chon ~ CDintad Cina inBi. Men —» UY/ thsrbs —> Asai Pleviknd cbsdlarce TBR Baal aay nd Magna disilane _ Ppscen oe _> Pd, Slpphs Seat aC Fae Fea TRLnebo dal Pasoab eye L L \ ee _Aageget Newew tyewen + Hones or poatii a Weare __ Phowpgi ds = Poe a cnet men > pe >» _Findlinss_95 im eee in be thik discharge eneg Md oyne o— boron —S 48 Le Z geal Cut hte Tatrely { 7 in ove e eo FG tm ve ipnSeneamLe eet sao im bb © __aiphesa_tm C 2 [os — onetned fli zs e— bg cle _Speitn Utethis) Cesuie sSEEEEES spit) [ered L Gee phe Pies Contain Prrhedin er 4 ___ fen => reread ac a 7 Tae maeG sketchymicro veestetcnmeracom Chiamydia Trachomatis, Pneumonia, philapsittaci: the pirates of Calam Island TL, White island - Gram Indeterminate - does not gram stain 2 stuck onan island - Obligate intracellular bacteria» 2. Stuck on an island - Cannot create its own ATP which i why itis intracellular 4, "No mermaid sign” - Lack of muramic acd in the cell wal 5. Pearls outside of the cell - Elementary bodies - 1st stage of lite cyle outside ofthe cell. Ths the INFECTIOUS form Elementary enters the eukaryotic cell and are taken up by phagosomes. Elementary Enters 6, Pearl inside the clam - Reticulate body - 2nd stage andis active and multiply, aka the DIVIDING form. Reticular Replicate to form Inclusion Bodies seen under ‘microscope in cells when infected. Reticulate Replicates 7. Peatle spread everywhere inclusion bodies seen when under a microscope 8. Treasure chest of gems - Visualized using Giemsa stain 9, Gnats around treasure chest - Diagnose with NAAT tet. Aka PCR. 10, Monkeys and pirate slapping the knee - Reiter's syndrome: reactive arthritis, cross react af antibodies fighting chlamydia hits knee or sacroiliac joint. "can't see, cant pee, cant climb a tre’ 11, Symptoms of trachomatous ~3 types |. AC: Blindness - Pirate's blind - Trachoma: leading cause ‘of blindness in world |i, Hand shield sun from eye “Transmission: hand to eye contact, posibly from forites 2. Mermaid at head of ship-D ST 1. Scene takes place in water and leak inthe ship- Most ‘common Bacteria STin US, watery sicharge, Ghon has a mucopurulent discharge ih Flying the Jolley roper uterus lag - Can turn into PIO lo symptoms, ectopic pregnancies as well il Mermaid shielding babies eyes wearing clamshell bra = Baby can gt infection if mother has it curing delivery ving it natal gonjunetivts 2nd preumens. Gaby will resent w/in 1-2 weeks witha possble cough (Staccato cough) or conjunctivitis. Gonorrhea will present 2-4 days bu-atey |. Mermaid w/ bamacte around inguina region Lymphogranuioma Venerum = infection of inguinal nodes, Presents 95a tender lymphadenopathy wit gaining lymph nodes 12. Clam Shel ra on adult mermaid Chlamyia ‘Pneumonia: Walking pneumonia, more common inthe elderly [Link]- Chlamydia Pita: Transmitted by Bids, causes fneumonia and transmitted by bird droppings 14 Treatment a. Crows - Macroides -anthromycin [Link] whee! Tetracytine - €. Confection of Chlamnyla and gonorrhes treat with cephtriaxane svaRRaRChlamydid_Teachomnahit —thmentary fed} —> J—> Fox» 1 ves L O©Q_ Obligate DovJsacepla tl’ 3 . ineEne &- fnciusion” hecly at pe : — ; tb Gente Kael andes bon > Ute thichis : => _takeey | plon- = nde chen med presley te epee Dluteny ¢_ Aerd x ahin Side whent — eliechatae NS, PUSH NS spec hd Vy women m 7 UD woren Ge Vaginal Aischae asecgey p> —» CSpyna its p Ina f preesien 7 peng ty 4 PID» Dadeeh ( yt ec hpic Pp 3) Bish fo 9afeckd omothew pave hnh's———— Picross, u yo eres oy Rene tive Asters > uverhs the ther S7r 9¢ PAPPPOPP PPP KP PPPPPVARAIP PFI D ; JIIIDIG r,s BeHCh tome Conjtre fivils —» fiw CI-C3 .. y Gensblg Cam phos ser fonig Ve ne bum — > tenia by f ep? Phaade —Chlam' de, Prerronorn' - A pe? Preumonrs —> Die caused Myeapleme Prcurrmoe Cheong als PSM Byiats B® Pop 5 Ne sese 0-9 Prunmenit - Cranes ASS 1) le Lives Hleaed NS: oe vd - Hepedomegaly - fesicaselhs Heasing (oes Lives ilypensl enuplall . uf edits 4 (pb _Diasnasls s+ -Bacteria — Gram Positive Bacilli Bacillus Anthracis and Bacillus cereus ~ King Anthra’s Axe Vikings standing around red hot flames and black in the middle ~ Black Eschar with erythematous ring. . Viking ships lined up in the background - Large {gram pos rods in chains Leather armor ~ encapsulated, this one is made of a protein 4. D Belt Buckles - Capsulated with Poly -D glutamate 5. Air Bellow - Obligate Aerobe 6. walnuts ~ Bacillus anthracis is a spore forming bacteria allowing them to survive in very poor environments 7. Viking Camp Test - EF Toxin increases cAMP intercellulaily this will cause fluid to go extracellular space leading to edema inhibiting host defenses and preventing phagocytosis 8. MAP with Lethal Factor Viking Burning it - LF (lethal Factor), exotoxin that acts as a protease and cleaves MAP Kinase, this isa signal transduction protein that is responsible for cell ‘growth. This factor will lead to necrosis and black eschar ‘9. Sheep pulmonary anthrax, wool sorters disease. Spores can get into woo! and hide of animals and persist there. People will inhale the spores when the animal is handled. 10, Axe that is dripping blood - represent pulmonary anthrax that can move to mediastinal lymph nodes progressing to hemorrhagic mediastianitis Viking ship with a mast supposed to look like a chest xray— widened mediastinum Flower and Bicycle wheel on the ship ~ txt is fluoroquinolone or doxycycline Bacillus cereus Aerobic and spore forming 3. Viking reheating rice and vomiting - ‘Associated with food poisoning ~ reheated fried rice— Bacillus _ a _ Disease: SEE SEE eee eee eee Ct Anthsax > Aninals - 2 Culancew * is Hn Palrnond sy aaah ms : GAT 1& = epee bee eee hte Gta te ‘i ——_ iy Found 9m Choy _— Wo ea ZAebein —= pe L only hacles: ortmbet _sahich 1s oven $F n Got _____________ rence = a E —_— Thaurna Pe Stin—s Spots on Mayme pe cia — Peet Lveka, Baad wool) — >» Ca ia poem jfintheaxAnthise —foxrh Seager eee = beenu factor Catal! oe Sabswnif 9 Medive —_(émeg matic Mefieely) Saba’ fb —» Binding t Protective ff iy 2019 1» Leurnan Camp Dayecls EE LL <2 Mndibs against fd, pagatecn— a frum AiSease cee en — ~ Chenuss pp APR hi ke 4 __ Chini = OO fypicae _Lesis “GL eet Echo i Lesuar _Calleel stalin ad fustaley » Banc ajnata—aeleath Ves —> black Eschav " Aiseage—> fu Cmonary “Aatigert on— cry _| SF tas apt Saphei— Avy, Coush 4 Sub=Skinal peso @ ey ae mow hea i__aue nih's ¢ Bl ovel iy pleural ef isin char fake and Ysag Prswmentd Absent mediastrel widening ete —_n__chest X-RAY 6f— Varmi + tet -P i Broly Arave Cab Dies, | ab Dingess @ pe Bat ath “sme nk— Cage Chouined Gea tue filed. Age Menahemolyhct Comets fy] 7 Appeasance.Bacteria — Gram Positive Bacilli | Corynebacterium Diphtheria - Corazon de la Corrida 1. Purple Hues - Gram Pos, non-spore forming 2. Guy playing Morocco’s that are blue and red ~ Bacteria is club shaped and y or v shaped, Metachromatic granules that stain with aniline dyes, Metachromatic granules will stain red and the rest of the cell will stain blue. 3. Zig Zag shape in the morocco - V or y shape the bacteria will form 4, 2 subunits A and B, Ais active and B is binding 1. Man playing an accordion wearing a bow tie - Toxin causes Ribosylation of elongation factor 2, this will inhibit ribosome function inhibiting protein synthesis leading to cell death 2. Kids in the stand eating grey cotton candy wrapped with a plastic wrap - This will ead to pseudomembranous exudate that will be found in the oral pharynx 5. Bull extending its neck with droplets coming out of the mouth and nose - Found in throat and tonsils because the infection is transmitted by respiratory droplets, Can cause airway obstruction and lymphopathy, this will cause bulls neck (thickening of the neck) Cape in the shape of a heart - Can lead to myocarditis like arrhythmias and heart block. Lethal effect of diphtheria Man eating the sausage links - Will damage the myelin of nerve fibers, the sausage man eating the myelin having a neuropathy. Television and kid laughing - Lab diagnosis -plate on Tellurite and Loeflers media (tele like television and loughlers will be the kid laughing like enjoying a show) 9. Bulls tongue sticking out and licking the matador - Eleks test — in-vitro assay that has antitoxin on i 10. Why it’s in another language - Immigrants most lkely to get this 11. Syringes in the bull - DTaP vaccine is used, given with tetanus and pertussis. Toxoid Vaccine BSECoryne bacterium Dighth ety Jd. aps Perens PPE ee I O Gm a i BU} shaped fesmahon IIIIS = Otani i tb pains los elo 4 Stony onretacle Stains dest 4 Cell blue hued tans las —Easmminin — o_Arsboine Déeplets Sue) —— @ Lv causing skin lessens pe ye bagi ma —— D_lrvasive n> Ev bish, —e— Calne ge ~~ TeRTA [ cre — a pa beckaplire j—_+ aisle Pol pephide ete phage 7 a6: ic : Be passe (fonet ace “ \ a Lyseceme - A Aomenin \ & domain Poy il, J Cleaver Njechnanil Pind [one TP pry fh AD and ] Es | Ince patel Ben ini [ phere Th Racleend nope | heuphe feline _tpanafested fe Tn se Co Pechn onhibtvon ae— Fy teste Pops DL Local 92plammabin 1m tha oat —> Grad ah fi baivess —_ ya sh patina y= fae Py Anhtedy ——> _Wearhestin bin Lily Sched > erboal patie shodeediasd for» Dae ction (_Ponteadet mal) Zz bo T ale Inflommodin jnplanaahien_ nist = Donnan, oat O_O ticks dhesert _[eucdomemboanre onsils ancl ed feet 4 Gove font, fvsty Ball i meck__olue f _ceavrenl ymphadinep pathy re ol Mem bine Ear kersion—pab— Cage poe ee ~ Backed 5 Arey Obs kuch O__ pyensdits — fresnel 4 Nerve weakness + paralysis ap pe - ——flagutgiintio tta-exgh ness __ PoripherI— Mewes > Hifechs —omnclr Fonte maAay ataneoy atiphtorin:- Uleesahns _ Skin lesrons Coveted 4 geey oe eabtone,Bacteria — Gram Positive Bacilli C7 Listeria monocytogenes ~ Santa's List 1. B—Hemolytic Lightbulb - Hemolytic 2. Purple ornaments tumbling down the Christmas tree - Motile and facultative intracellular, tumbling motility extracellular Purple oblong shaped ornaments ~ Gram Positive Bacilli Rocket toys notice that one is still inside Santa’s bag - Rapidly palymerizes actin along the cell wall allowing it to move quickly in the cell. Rocket “Actin Racket” Intracellular movement Cat - Catalase Positive Icicles ~ Listeria survives and multiplies in near freezing temperatures Milk and cheese left out for Santa - Can contaminate food ites even if they are refrigerated, like milk, cheese Pregnant — Pregnant women are more likely to get listeria than anyone else. May lead to termination or disease in the newborn 9. Meningitis helmet - Newborns can get meningitis from the mom, can also get in in adults over 60 10. Guitar with amp ~txt is AmpicilinPee ~ OD Meningitis ond Sepsr Tn fleur bob ny 4 ‘g/9.4 494. Frat /Pee5n ent evoomen_and _Inroim camplerniied Ad cs = I @ i I io 2 Febuk Gatto ontesrhs = y es hos. os eS : f= bsam eve OC_V/Y Osgowerhey Gastereeylenhs —> * * {- faa prradomiegt eh Cold enbepkewaf it cL > f- Path enedy:. a th i ——4y7 Pregnant Waren ond Ionmunvco pe) sed I OG a T Add? —_ O— Menges —_Pammiyn Acie — ess — Placenta __ot clus delivery i Gs fs nant Gel Waren Lewe Vodlacey = [er t~-wrechected —Sovomarnity ghPathosenes’s ——> cepend om lm iene —>onedateh Ly —“tntetnclsa—F Ly pytetneln(lisketig) and — E= S Cadlhesn, hn El Pana da Enfess Cell—= Listesiolyin 2 Eva cles —phasisems aoe oe _Cotl-rmedinteel Ionmun thy Soypat tae dur_\ Showrh __jaacsale Coll J Z (6) perm — Recess ymcoabee pcb Propatsrom b bacteng—Phweugh membre ont human coll pp otter cao lemiged DO Phegnard wines Compsomised ; L ; ft Udo tt Abethov/ fser=ehse Lake igs Meningitis / _ L (U-4we) sisf west hs Diseased? baba ae f $ Gasheentos hs Aiorthos Ditle Vomitus, pbdeminnD oeBacteria — Gram Indeterminate Gardnerella vaginalis - The fish garden - Bacterial Vaginosis, 1 Zz 3 Purple and red graffiti - Gram Variable Rod Venus fly trap eating all of the fish - Normal vaginal flora is lactic bacili, an overgrowth of anaerobic flora will get rid of normal flora Dog sniffing the white grey discharge from the vulva like Venus fly trap- Thin grayish white malodorous odorous from the vagina pH 4.5 and up sign ~ pH is when infection occurs Dog sniffing - Positive Whiff Test w/ 10% KOH prep Inspector inspecting the missing fish stain - Microscopic exam shows blue clue cells with dark blue spots, diffuse coating of bacteria Metra train - Treatment - metronidazoleChatdnere sa Vaginal/s _ Piserse, Backed Vagimosis ( Sexeally Ackve E © Geam Vaniable z Yrsall Su G Stswche tall apie tye Ceol w ot feses puspile cole Aut Pf fhinnex / a meee eee “a | Cauer patcgenes jo Mgetiehion wey fa | y | —Vi t a a Fr CD Mebilancay————— —— — ~ oO wnigeeplsms —howyms — 0 flembuly GE) Deeaphmy “Utealfim O—Nor—-frana ferred axa lly E terete cilLUs. Anegrcbey ——> VAQ Yes)tay Findings GQ) Mak= edoutew), whit |] Cleicd Van cl _olise habe @. Fishy _oclet ‘} olachayy © Iflommmashron “pbserck ined! ara Called vaginosis ret vaginshs gv V & Inching ©) elem Cobra Cab Dragngi5 : O Cha_ Cl Ss Say Vain t epricatot Ce _eove tod with ha chen 5 —paheet 5 vaginal clischa rye dseafel with of leon—> Pager fies cncll $$ UUpiererrenianin iy fee ee aN 1 G6 da GS oC PbveBacteria — Gram Negative Bacilli Milk Container - Ferments lactose - Grow pink on MacConkey’s Agar Capsule - Encapsulated - Facultative Anaerobic, Oxidase negative, 1K Cake - Main Virulence Factor - Capsular K antigen and Flagellar H Antigens ‘Green Coasters - Metalic green sheen on EMB Agar (Cat- Catalase Positive #1 UTI Bladder Drink with long fimbriae bow off girls head - Fimbriae that wil lead to UTIs #2 cause of UTIs Red Strawberry Milkshake - Ecol leading cause of gram neg sepsis by LPS endotoxin in outer cell membrane Meningitis Helmet - Causes neonatal meningitis ony if have the K antigen EHEC. Severe Hemorrhagic Colitis caused by 0157 H7 Burger - Most Commonly caused by eating undercooked meat. 'b. Red Stool and bloody Ketchup Causes bloody diarrhea, red stool symbol © Sorbitol Free Coke - Only [Link] that does not ferment sorbitol 4. Gorilla tay, Blown up ballaon - Toxin: inhibits ribosome 3t the GOs position, Shiga like Toxin ean eause hemolytic Uuretic syndrome. Shiga like toxin damages endothelial cells of capillaries inthe glomerulus. Damaged endothelial lining causes platelets to adhere decreasing platelet count causing thrombocytopenia and these platelet clumps will hemolysis RBCS. Little tone fever but mucosal inflammation or invasion "[Link] Burger only $1.57" - 0157:H7 Antigen is associated with outbreaks. ETEC travelers’ Diarrhea Water Truck Transmitted via water sources. It’sin Spanish - Recent travel to Mexico where they drank the water, called Montezuma's revenge. “ol Agua” - Heat labile toxin produces cAMP “San Gabrie Stable produces cGMP Brown Stoo! with water above it - Watery Diarrhea . Treatment 8. TMPAMXer fluoroquinolones seasé: Cols — = : oTL TD amest..Gmmer_ Cats, <5 5 Bam _Negahve 5 Belay Lbheodeprzveles Arejehecs ae Reriadall Meinyhe Be i (i Shean ve ed (blo np bac Heobice tare e,) cuived) [i West —Pikerclent — reap techie Bos Hey jn Col and Feces ne (Wi Fetonsench Lac tse C Disbrguiirel gern Shayella _ aud Sabmone/fa) US page inlelalelelaad 445 bis ainle ba: —— Pathogens [ S . Lol Lomponents Coathsihasfng disease Gassing 7 Jan = G ppt . apple = Poareter 2 Ha, Se Eads toxin (8) Exiohovin STS Peed Foualbsex_ (4) wes 44_diasth ve oe Losin Coll Spetifte —> dort attack Coley cell. a tk cue Lobe UD: lay meld Aden ae Gye a heir — LF ond Cholera —Posin—9 C0 49' 22 — Add; CS hmvlafs— i : por aieayeter Pe Pestera>—Piree exelay — “comb h—>_ CAMP alependvit fin pet 5 Tn rae Bh gre. Dhephreylatin >P Pansperke 1 ol ee BF Pampok Pepe cece gS cape TRS ema pint eg — 4a | gk watery diwhoes Cebelern ine mse chen tiiy) e Cycler Steed “ 7 ins (WO Het sable (GP) > BR Guengln _,—elo_mot eau fn flaminaher Ot jnvasfon 7 5. snucesaf’. ud psee “Ee @ Bloody dig tihoe:. - aia Non- Te Peeducrns Gastain E-Cob, (EHEC) —> Enero invasive (we toxin Pel. }laye sctohine —> Bleed "ae vad recone Satta Argschon 4 _Iflamen vateg {Wei pli) Cell in __Stol * ; aad Shae ee ae = Se Lyin ea : * ? , Bins [fee 7 ok paaducmny £ coi» pleedy digtshes _ Ss Xp RNA Shiga doxin —> Aemoves Adewnt fom Lane Siberia | . : ae Stops we tein Syrtass 7 sensi fe haw) yy = cytepathre «f Vere Qrohkey) Gils!bis a at ( [ 4 -Q oie HT“ Stam J Cobi> Unelecested fred F 7 he (alticed Contact fe Aaya conta thea oa oe >} fhe Stain) ———_— tee gi) —— ee q Heme ye Veen Span 4 2 CIT: HT —> Shiga Prin —> _ flood 4 . 0 A a — a i: r X | Som Ble tichey eee -_ veel) \ 4 E Goebel 1g I~ q © ete — an See [- FiCea a open L. areal fyoseisal fe 8 (ep aati i fect-eets—olisfreted- = — i — pl Atle oy a Talal oP cele j Ty — eoith- “Tapa Spain PiD@i(Adbeyor peoleins — hind fp Accsplets_an Uvney teach Epi te bts Inf 9 onl e sofort lat Cal) ’ P Fim bia Pdi Mise called Polyne phithise assecinled pil i giri —> Pink Colores fH MCCEN | & lad Lach fer ao —_ ny hee 1 EN a a eS — selene Sn pes eee —— ~ cychoteXin “(ps eS Sapss of co ia Cepia Ah Meningihs— pe 5 an 1 fe Cee aban ——w sine) Fach — ca Ps ee tober chitin —> shat ade SS ad Cam ERECT 3 lroly > Coarpig_im phdeen F fv, ONT HI—» fled » + HUG (Heomelphe Utena = Sytletas. poll German Sant _clisesse Caused £4 0/644 Qutside- Lutennal Tract TO earareeapeMe ASE Cat ant Bisprescel lus i histh ——> Memingihs ¢ Sepsis Esually cl Looenurily_Asyaried UTI (3) NesocemiaD > Comden yn =i ? wren and women USE 4 a = ae Pas ynact 4 inlet int Jusnagy Catnelers | |______wem CD captor 15 * Se ita " = eda do = eet Peeqoy 4 wo | ae eee, RE z aha Nerdy a aps : Se cars Fevexy Pant Part Coytevertebel Rgle ferole dt aliycugig, otgram-negative rods, Jood agar plate and on r or MacConkey’s agar. e, forms pink colonies, of containing rown initially « g! edium, such as EMB ag scherichia coli, which ferments lactos whereas lactose-negative organisms are colorless. On EMB agar, E, coli colonies have a characteristic green sheen. Some of the important features that help distinguish E. coli from other lactose-fermenting gram-negative rods are as follows: (1) it produces indole from tryptophan, (2) it decarboxylates (3) it uses acetate as its only source of carbon, and (4) it 0157:H7 does not ferment sorbitol, tant criterion that distinguishes it enterotoxigenic lysine, is motile. Escherichia coliBacteria — Gram Negative Bacilli sketchymicro ‘nee caso “Saimonelia he amon daner 11 Gram Negative - Non lactose Fermenter, white on ‘MacConkey’s 2. TallFlopping around - Motil Indole Negative dve to lack coftryptophanase 3. Plates back Mas postive All motile enteric colonies stain blackonhektaen agar 4 Glass dome over salmon - Capsulated - Poste for trate tblzatin tums indicator bive due to alkane pH 5. Lemon Acid lable need high des to cause an infection patients on proton pump inhbaitor more suscepitle to Infection 5 Bled Cages w/ MO rvadesthroveh colon through the macrophages to get into the cole, Facultative itracellar 7%. Saimonels (et) ‘3 Chicken: Caused by eating undercooked Chickens 1B Candle Causes nfiammatory Darthes, Gastroentertis Turkey Baster- Contains ype secretion system that detects eukarytic ells that wil increase infetivcy {8 Salmonela Typhi typhoid Fever always fom 3 HUMAN source 13. Chef Apron -Harboredin the Gall ladder, Typhoid Mary 1b. Red spots on apron to remind us that patents get con thee stomach due toinfetion “Bones on the head of salmon and sickle- cause of ‘osteomyelitis in adults with sickle cel Bird droppings - Can cause "pea soup” diarrhea & Flower on table - Treated with fluoroquinolone, or a ‘cephalosporin (ceftriaxone) Syringe sticking leg of seagull - Live, Attenuated Vaccine 9, Treatment many resistances {&. Gastroenteritis Antibiaties not warranted, Do natuse antidiarcheal Sal. Septicemia Aggressive Chloramphenicol, amp, Amox, or TMP/SMO for 10 days « Flouroguinalones ~Cipro/levo 4. CEFTRIAKONE FOR INVASIVE AND BLOODY Salmonella Typhi (right) ‘Three Phases 1. After sufficient bacteria have multiplied in the intestines there is a manifestation of lethargy dull frontal headache, ‘CONSTIPATION, rise in body temp. binds to Phase 2: Development of a bacteremia, patients have fever nd are severely il wth a Dull Expressionless look, rose spots develop mainly on the trunk Phase 3: Second Bacteremia occurs from reinfection of biliary tract, pus in stools and bleeding in peyers patches, NNeum Necrosis s9d0848ANR Ns ee Shuonella Dy a lin 1sease. «- Emletorotihs (iy Fphod Ff ve (9 i Weeme with omedaspalte Pech such 9g as Osten hh rs Peopeiai es = amelie ae = Cham ave Beds Don't foamed Cae-fose i Cy tit rclyc fro i fcaauttre . i cs « | cena Lay b- 7 eats Gwe Ai patie _& z iets 2 i & Divison Yhap ferrs oly sae eS em yep AT syinested ef a | oe Ama i o : ent Sept - - Fa ment M hon “meal ry ports him thsangh ie Pace fevacta fants gies poy matron + aig bbleg q1b Lait Heid 4f— ‘oashccle ft IN Uy Enferte Fevers eases Cif SpmPams—> pith ply “4 Peyees patches edi mn Corer —9ypbes hr — > Fe bess fa plage lono=7 cs 9 Spread fp phage ae Livete sl eo a bladdes > Spheernis —. Lndolores caued Entec Fe curt a hho Ind: leyhine > few a Pans dferst “evasion ” (ie Sephcam 4 faeces panausuuuenes sua Z -e- Jnsculss_gsaph Sapte fon eee Dur alias ~ cs = Qislesmylih gt Prsyrnernt -- On 207 zpeckal Asgue pe Sngateb ancl nse _vnest_ Proyrnt silk ms een SGT! Braet 6 ye — _o Cauties g be fi ¢ yond “Hamers _ ae (andercetsd) Cdinieel findiv3s. sd WHUICT Gyhte emitting —> sabdeninel aint lig sshes si or non breody niet 6 ebselop Sews sone oe — Bade se aya Shee, > Peer ati aBacteria — Gram Negative Bacilli ‘Shigella: She Gorilla's Circus 1 aveeea Red Stool with flames surrounding it - Gram Negative enteric causes gastroenteritis, (inflammatory) leading to watery diarrhea and then finally bloody diarrhea Green Tutu - Green colonies on hektoin agar INDOLE POSITIVE, differentiate salmonella from Shigella: Salmonella will grow black Chained to the weight- Immotile, non-lactose, non H2S, LPS{endotoxin) leads to inflammation, type Ill secretion Gorilla walking over the acid - Acid Stable - needs far fewer organisms to cause infection ‘Cannon shooting a gorilla and landing on a pad w/ an M - Shigella induces M Cells in peyers patches to phagocytose them and they escape from the phagolysasome to prior to destruction. ‘And then will use the host cells actin cytoskeleton to create a tail it can use to propel itself from. ‘one cell to the other. Facultative intracellular Damages tissue and releases cytokines that will inflame the tissue causing bloody diarrhea Shigella Dysentaria a. Kid using a whip on the blood cells - Leads to hemolytic uremic syndrome in younger children most commonly under 10 years of age. Progerminal diarrhea following with acute renal failure (glomerular damage). Form shistocytes b. 60s hourglass - Shiga Toxin will bind to the 60s unit of ribosomes and inhibit translation, Turkey baster - Uses a type 3 secretion system to release micro enzymes. ‘Treatment with Macrolides and Fluoroquinolones aeSMG ELLA —Diseae E nfe [Link] Non — Locfose “Jesmsntos cbshin ¥ i DP Mrmam able. Ono $2 Jom ca fees i(abior e cle syof produce ty | 1 @e Pied Iie 3 oS ried ve Lnw PScasomrssieny pallea occu in E Noe PAVgenic bac esp eC OSTIHT Shige dex ecucrol SY 5 Shigshxn pice duce 4 by fy fart shigaten> paedued Ce, inreal : ry a Iueubalen pests Shain 79319999) ob fevse# Plebowvinap Gap t Diasthen (fret watery Daler Bleed ancl muccus) tiiHtt} & ves ty ce ~y ¥ sha 4 shige \ I v hi “ti ¢ Somel | Yoon elses a “age 4 2 chyt \ A saitelBacteria — Gram Negative Bacilli Vibrio Cholera - Colonel Cholera's Base Camp Mustache - COMMA SHAPED Gram Negative Curved rod Enteric Tract Bacilli BASE in BASE cAMP ~ Prefers to grow in alkaline media Blue Ring - Oxidase Positive - Grows on TCBS agar Lemon - Grows in alkaline environments, ACID LABILE - Dies with acid ice Patties - Causes Profuse watery diarrhea "Rice Water" stool Outhouse dumping directly into the river - Cholera is transmitted fecal oral due to poor sanitation that gets into food and is not an invasive infection River walls are mucosal wall and the water is the intestinal lumen - Found in the intestines and is found in the intestinal mucosae Raft that is attached to the shore - Attaches to the mucosa by fimbriae that attach to ganglioside receptors in the intestinal wall. Then releases cholera toxin - Main Virulence Factor AB type toxin a, BASE cAMP map - Upregulates production of Gas cAMP by binding to and increasing activating adenylate cyclase b. GS grenade - Then it will activate the GS pathway. Activates GS, upregulates cAMP, Produces watery diarrhea through an efflux if Cl and H2O 10. Treatment ‘Drinking some water - Oral rehydration therapy with electrolytes 11. Vibrio Vulnificus and paraliticus Oysters - Can contaminate seafood, especialy oysters. b. Vibrio V. causes Acute Gastroenteri Vibrio P. Causes fulminating septicemia leading to death. Marked edema and necrosis seaesanVidw'o Cholera INARKN i | lala als Digtckea ma bat vec chalets ep sy wade — B saman_Coscnt Sp j Spel Pet Sezn'lebtine Maralihon + ned aracdeyunde rede S ¢, Ee eS ol—3 E-Tst R Brom pe Coes Seselyee| “7 oF aes =v t Alun $82 — ales pie we Dyecpsotetn ” In: = ft Kiush Rorles tPordestine —F py athplicabn 4 “hua See tedin 2 Leeed Chole fxn celled Cholecagen & A Siw as e — — Inetled tm egal Perteomes (5 relerea) I | | ee Lb ne pps seglahor g 6 Bina Ganges Becht pater a ented rete He fe ‘omy lancer SL Acenglat Cyetse } campih—> cpap chaperone Binasa— ph pesleb 4p. jo Daupests fr ontmb. —9 Coss QD vor ancl fd Prom coll — conten eFplix enka ge Cr Necbepef | — le by haa hor + Elec behyle Pnbste y 9 le; th | > YY PP PP eT HII IIS S a Clinies| © Poof Wales — chascheq—> No RBC [oBe tr shoo! _@ Rice wets S fool Ge Abdeaned Pa» & lew 4 fosid > keel 2 Casdiae poulase & Les 4 Hees oe K 5 Meiosis tlgpok Cond —: Compy| bac for. Disease,- Erteéctolh's —» Spee i aly > ¢ hibten Poopeshes > ms © Cand @ -vwe G@ Comma] ibeped Q)ancse—aetophOie gee bet in tf 0, Sanu — thoan af mephoaye DoF G Grew ied? at od 7 Pa thegenesif.. FRemboniasior ws /- tab oil. aoufe Poa trrophsdy : Poud bye Meaty Uapasteniiacd Pathe - Lonterrante droite final feces Poppe bith chauleg—y childien Humgn— Hainan favs asion ZL fbvnal— urement Leael in Ca ue 9 cligecltg 4,, tnp: auth — i Biv. vel bra teleg _ foul LSet Afadles Levert Shido Parn Hhreds dintche4 mae ber eE POPP PPPPLEP IARI LI VIALS SD J fetymes with fy bacte ajDich beches _[kains hacks J lib Ren chor ra Pea poschne Shoah Jejn— S04 Piles’s ay peti [cave ps this ae ! p 7 Sepetone pete ¢ Jb _pscending free — ‘ 4 Grorllean bare ——— Gyicbsont (ae ras n0SIS ——— ComplBacteria — Gram Negative Bacilli Helicobacter Pylori: The helicopter Pilot 10, 11, 12. Red Helicopter -Curved Gram Negative rod Mustache that is comma shaped - Helical slender curved rod Shape found in pylorus of the stomach Not a rare infection. Helicopters are motile - Motile by way of flagella Ammonia bottle - Urease positive - MAJOR VIRULENCE FACTOR - allows to reduce the acidity of the stomach and allows Helicobacter to survive there. Can be tested with Urea breath test, radioactive urea that is broken down and exhaled as CO2 and NH by urease positive organisms. Blue ring - Oxidase Positive ~ all curved rods are oxidase positive Bullet holes in helicopter, Gas pump w/duodenum - Causes 95% of all duodenal ulcers Crab - Mechanism of Chronic infection causes increased acid infection. At risk of developing gastric adenocarcinoma Tissues that are thrown in garbage - Patient can develop lymphoma of mucous associated lymphoid tissue. Treatment a. Gas Pump with duodenum and H+ Bomb - Proton Pump Inhibitor b. Amoxicillin - ammo ©. Crow w/ Keep Clear - Macrolide - Clarithromycin Transmission a. Fecal Oral or Oral seaeeau__Hebitobat feb» —Diger ee —@ Gaduns =n a fe phe ykets Gastse Caicirieg —__ — —_@) MALT ils : wb —pee spas ab _ fb jes a ler u = 7 Sa = } | ) calfecl MALT yrphons Blee dog $y yfo J (B-Cell fone & favs 06 ty}T—— | tt ta pf eo Lisnally tn Stomach uM fa I | pio feacde iru’ Can oceus ebewhere fn IT. Cas Dieg nosis, a G gam Sarninp } Guedes oy beapsy Sperone, pom _G! Shomgch (__Ulea hyeath lotBacteria — Gram Negative Bacilli Pseudomonas - The suters of peude Mona 1 10. un 2 3 aa 15, 16. wv, 19, Red theme - Gram Negative rod Bathtub - Thrives in aquatic environments, hot tub flicults Blue Ring - Oxidase Positive Cat - Catalase Positive - Chronic Granulomatous Disease heightened risk Blue Green on tub - Produces a blue green pigment when plated may even turn wounds bie. It's from Pyocyanin and pyoverdin Grapes being eaten - Fruity grape like odor Air bellow Bilowing the flames - Obligate Aerobe ‘Nurse pouring chlorine to remind us ofthe dysfunctional channel of CF patients - Most comman Gram Neg Nosocomial Pneumonia, respiratory failure in CF patients, Chlorine channels in CF ‘Nurse Coughing Causes pneumonia ‘Mortar and pestle w/ Fish bones - Osteomyelitis inthe lV drug users and Diabetics. Glass Capsule - Encapsulated ‘Maid on fre - Burn patients are especially susceptibe. ‘Chamber Pot - Indwelling catheter infections from UTIs, chamber pot, nosocomial UT's Prurtic folliculitis (Hot tub folicultis) Dalmatian Dog - Can lead to ecthyma gangrenosom (black spots onthe Dalmatian) ‘ear trumpet mai listening - Otitis Externa ( swimmers ear) 1 suter in green - Exotoxin A -Ribosolation of elongation factor 2, leads to inhibition of protein synthesis and cell death Piper suiter and Suiter with a Sai and flower - Treatment -Piperaclin (pencil) , aminoglycosides and Fluoroquinolone 39d0858Led oenenas Diseases :. eee eee i} — on 2 ae RTL Ceyshe hs c *ealibs) im Batr Patient —_ and otis — eG meet or cbabe he patient Precouanly of _ Buskbald _ ) ec, : pace val Pophil a > Ken thamoned Pe ee —e i € Pp. Poeudsonerde i aera ia feeaee = i Ale Rioraasis x es ; : gamantatray ~~ eC os ~ -ve_ @ ob), ss SS e @ Dow? ferret Can sow 1h nd —> Saree ReciprenfS Resta? asmpfecant eapeavelly Pflesexgisinrese yf pace Tluve yn heya —> Inf Gqugd 1” hopry si ae (Sigee aly) - ae Ce ntPR Asus est i ts yocpinm —pyoverctin- C4 fuoseseriny ——— f & / 5 cen vio po in wound oo ot Yelle 5 blot : L Flea? uxdet oy only Syphon 4 P Acca arreng che fiseuclorns Mass ye ~ Pathe enes!S o Found jn Soil and HO a Found On _ sein ond onersf qreas _ URT 4} hospital pacers 7 ae - Abitity fo pion waters C ~S © plaids Susgical efytripnt nto aL Cause) InFehes p> hapitined partorb with ae L - G@)_entenve buss an al - _@ Cgshe. Disses : - ; ato 6 Fese with oratmal Cleatsn ce srmpparies ime - o Fon aiiin o— Comptes : i Gl Q Prclese iting Co tedess a x & lew Mexthephid Court Cisefity- - Venbilates ajseciafed Nesoc. gmal) Prcumer's ! ms =) SO, vitalence Faete 7 Qe rhe Shock - Enceteorn => Cavser Sepsist ph _@ Exotorin —> Exeter A> ppp Adssyahior ~& é EEL —> _fotein syrthevs b La fissee oe Mec wsrs - —_ (3) Elastrs + Protease > Hislelowe t facilitate Racknal c myanion fy Bfecel _¢ freeity 0 ei &a a amucesaf Celt & Pyotjanin ——> Jame, adoy fy 4cFType i _ Sectch J medicded 4 Bavspod pomp 7 te hacterad Cell wet membsane VATRAAA ' oa t i bon fot) flo analy baat — © e e Cc Seated ge ce ec — & € 7 e & Got OUT €é_ (CF Pato) & Ss —_— ee id— anfechor Expect Baro) ls G__venhle be Preunrenie Cent s © ftom thee sit) / Raclens s Zottess blood —9 Cawes pepe — > Spheads s & Ey fetncb Ohh ae ttle bk falindiilg Q_ flhulihs es ; Gh Paved issund Theos Sole 2 jy ee6s Corlect (exe wer Cobresl? Qik chro pikechos Whe Caused by (im ¢F pata) L Z Auskhollerig | Ste pope pho a09-95 & Chev enic Jon (ab DUTEIIIIIII2. y FELECTH, CEEEEELBacteria — Gram Negative Rods V Chocalaté Cavered Haemophilus Influenza - "Phyllis's Chocolate Covered Cherries" 10. 1. 12. 13. 14. 15, 3 Red Hues - Gram Neg ‘Shape of the candy machine and candy on top of the machine - Coccobatillary Shape Chocolate sign - Grown in chocolate agar 10 cent sign - Needs Factor 10 “Hemodin” 5 cent sign - Grown on chocolate agar needs factor 5 (NAD, nicotinamide) and factor 10 (Hemodiin) “hemoTEN" Child Coughing and aerosol spray - Infection primarily moved by aerosol transmission leading to droplets going to respiratory track calling pneumonia CChild sticking out the red tongue screaming - Disease Epiglottitis - symptoms Drooling, inflamed epiglotts, strider, drooling Cherries - "cherry red epiglottis" Child plugging his ears - Otitis Media Meningitis helmet and Bee fiying around - Meningitides - only caused by type B capsular form. Sickles attached to belts - Sepsis and Septic arthritis in patients without a spleen, hemophilic infections, especially sickle cell disease Syringe and Capsule with the Bee flying around it - Vaccine for only the type B capsule is conjugated with diphtheria toxoid and haemophilus type B capsule Dipped for 2.18 - Vaccinate between 6 weeks - 18 months (bound to diphtheria) Dip=Diphtheria ‘Three Axes -Treatment Ceftriaxone Rifle - Treatment for close contacts is rifampin aesae