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Size Reduction Methods in Pharmacy

Size reduction is a process that reduces large solid masses into smaller particles through precipitation or mechanical methods. Precipitation involves dissolving and reprecipitating substances with different solvents, while mechanical processes use grinding equipment. Size reduction provides benefits like improved content uniformity for pharmaceutical mixtures when particle sizes are uniform and small.

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Sushil Kumar Singh
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16 views1 page

Size Reduction Methods in Pharmacy

Size reduction is a process that reduces large solid masses into smaller particles through precipitation or mechanical methods. Precipitation involves dissolving and reprecipitating substances with different solvents, while mechanical processes use grinding equipment. Size reduction provides benefits like improved content uniformity for pharmaceutical mixtures when particle sizes are uniform and small.

Uploaded by

Sushil Kumar Singh
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd

Size Reduction : Size Reduction is a process of reducing large solid unit masses into small unit masses

i.e., coarse particles or fine particles.

Methods of Size Reduction : Size Reduction may be achieved by two methods namely –

1. Precipitation method : In the precipitation method, the substance is dissolved in an


appropriate solvent. Subsequently, it is finely precipitated by the addition of another
solvent, which is miscible with the first, but in the later substance is insoluble. This method is
suitable for the production of raw materials and bulk drugs. Inorganic chemicals, such as
calcium carbonate, magnesium carbonate and yellow mercuric oxide, are prepared by
precipitation method.
2. Mechanical process : In the mechanical process, the substance is subjected to mechanical
forces using grinding equipment (e.g., ball mill, roller mill, hammer mill etc.). In general, dry
grinding or milling is used in the production of tablets and capsules, while wet grinding is
used in the production of suspensions, emulsions and ointments. The method of milling is
applied either in the production of raw materials or as a part of the production cycle in the
manufacture of dosage forms.

Advantages of Size Reduction :

1. Content Uniformity – Mixing of different ingredients can be effective, if the particle size is
uniform and small.

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