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Actidione (Cycloheximide) MSDS Guide

This document provides a material safety data sheet for cycloheximide, also known as actidione. It lists cycloheximide as being very hazardous if it contacts skin or is ingested or inhaled. Cycloheximide is 100% of the composition and is toxic to animals in low doses. Exposure can damage the nervous system, liver, blood, kidneys, gastrointestinal tract and skin. It is a reproductive toxin and developmental toxin for females. Personal protective equipment including gloves, goggles and a dust respirator are recommended when handling it due to the toxic risks.

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Dasari Venkatesh
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19 views6 pages

Actidione (Cycloheximide) MSDS Guide

This document provides a material safety data sheet for cycloheximide, also known as actidione. It lists cycloheximide as being very hazardous if it contacts skin or is ingested or inhaled. Cycloheximide is 100% of the composition and is toxic to animals in low doses. Exposure can damage the nervous system, liver, blood, kidneys, gastrointestinal tract and skin. It is a reproductive toxin and developmental toxin for females. Personal protective equipment including gloves, goggles and a dust respirator are recommended when handling it due to the toxic risks.

Uploaded by

Dasari Venkatesh
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

He a lt h 3

1 1
Fire
3 0
Re a c t iv it y 0
P e rs o n a l E
P ro t e c t io n

Material Safety Data Sheet


Actidione (Cycloheximide) MSDS
Section 1: Chemical Product and Company Identification

Product Name: Actidione (Cycloheximide) Contact Information:


Catalog Codes: 20039 Finar Limited
184-186/P, Chacharwadi Vasna,
CAS#: 66-81-9 Sarkhej-Bavla Highway,
Ta.: Sanand, Dist.: Ahmedabad,
RTECS: MA4375000
Email: info@[Link]
TSCA: TSCA 8(b) inventory: No products were found. Web: [Link]
CI#: Not available.
Synonym: Actidione; 4-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-
hydroxyethyl]-2,6-piperidinedione
Chemical Name: Cycloheximide
Chemical Formula: C15-H23-N-O4

Section 2: Composition and Information on Ingredients


Composition:

Name CAS # % by Weight


Actidione 66-81-9 100

Toxicological Data on Ingredients: Actidione: ORAL (LD50): Acute: 2 mg/kg [Rat]. 133 mg/kg [Mouse]. 65 mg/kg
[Guinea pig].

Section 3: Hazards Identification

Potential Acute Health Effects:


Very hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Severe over-exposure can
result in death. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized
by itching, scaling, reddening, or, occasionally, blistering.
Potential Chronic Health Effects:
CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Development toxin [POSSIBLE]. The substance
is toxic to the nervous system, liver. The substance may be toxic to blood, kidneys, gastrointestinal tract, skin. Repeated or
prolonged exposure to the substance can produce target organs damage. Repeated exposure to a highly toxic material may
produce general deterioration of health by an accumulation in one or many human organs.

Section 4: First Aid Measures

p. 1
Eye Contact:
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
minutes. Cold water may be used. WARM water MUST be used. Get medical attention immediately.
Skin Contact:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing
and shoes. Cover the irritated skin with an emollient. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get
medical attention immediately.
Serious Skin Contact:
Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medical
attention.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical
attention.
Serious Inhalation:
Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If
breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medical
attention.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention immediately.
Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: May be combustible at high temperature.


Auto-Ignition Temperature: Not available.
Flash Points: Not available.
Flammable Limits: Not available.
Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
Fire Hazards in Presence of Various Substances: Not available.
Explosion Hazards in Presence of Various Substances:
Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in
presence of static discharge: Not available.
Fire Fighting Media and Instructions:
SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Fire Hazards: Not available.
Special Remarks on Explosion Hazards: Not available.

Section 6: Accidental Release Measures

Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container.
Large Spill:
Poisonous solid. Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray to
reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition sources. Call for
assistance on disposal.

p. 2
Section 7: Handling and Storage

Precautions:
Keep locked up.. Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate
the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. In case of
insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the
container or the label. Avoid contact with skin and eyes.
Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area.

Section 8: Exposure Controls/Personal Protection

Engineering Controls:
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
below the exposure limit.
Personal Protection:
Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of a Large Spill:
Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid
inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
product.
Exposure Limits: Not available.

Section 9: Physical and Chemical Properties

Physical state and appearance: Solid. (Crystalline solid.)


Odor: Not available.
Taste: Not available.
Molecular Weight: 281.34 g/mole
Color: Colorless.
pH (1% soln/water): Not available.
Boiling Point: Decomposes.
Melting Point: 120°C (248°F)
Critical Temperature: Not available.
Specific Gravity: Not available.
Vapor Pressure: Not applicable.
Vapor Density: Not available.
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: Not available.
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water, methanol, diethyl ether, acetone.
Solubility:

p. 3
Soluble in methanol, diethyl ether, acetone. Very slightly soluble in cold water.

Section 10: Stability and Reactivity Data

Stability: The product is stable.


Instability Temperature: Not available.
Conditions of Instability: Not available.
Incompatibility with various substances: Not available.
Corrosivity: Not available.
Special Remarks on Reactivity: Not available.
Special Remarks on Corrosivity: Not available.
Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Absorbed through skin. Eye contact. Inhalation. Ingestion.


Toxicity to Animals: Acute oral toxicity (LD50): 2 mg/kg [Rat].
Chronic Effects on Humans:
DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Development toxin [POSSIBLE]. Causes
damage to the following organs: the nervous system, liver. May cause damage to the following organs: blood, kidneys,
gastrointestinal tract, skin.
Other Toxic Effects on Humans: Very hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans: Embryotoxic and/or foetotoxic in animal.
Special Remarks on other Toxic Effects on Humans: Not available.

Section 12: Ecological Information

Ecotoxicity: Not available.


BOD5 and COD: Not available.
Products of Biodegradation:
Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The products of degradation are as toxic as the original product.
Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal:

Section 14: Transport Information

DOT Classification: CLASS 6.1: Poisonous material.

p. 4
Identification: : Toxic solid, organic, n.o.s. (Cycloheximide) UNNA: 2811 PG: I
Special Provisions for Transport: Not available.

Section 15: Other Regulatory Information

Federal and State Regulations:


California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer,
birth defects or other reproductive harm, which would require a warning under the statute: Cycloheximide California prop. 65:
This product contains the following ingredients for which the State of California has found to cause birth defects which would
require a warning under the statute: Cycloheximide Pennsylvania RTK: Cycloheximide Florida: Cycloheximide Michigan critical
material: Cycloheximide Massachusetts RTK: Cycloheximide New Jersey: Cycloheximide SARA 302/304/311/312 extremely
hazardous substances: Cycloheximide CERCLA: Hazardous substances.: Cycloheximide: 1 lbs. (0.4536 kg)
Other Regulations:
OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the
European Inventory of Existing Commercial Chemical Substances.
Other Classifications:
WHMIS (Canada):
CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC). CLASS D-2A: Material causing other toxic
effects (VERY TOXIC).
DSCL (EEC):
R28- Very toxic if swallowed. R38- Irritating to skin. R40- Possible risks of irreversible effects. R41- Risk of serious damage to
eyes. R62- Possible risk of impaired fertility. R63- Possible risk of harm to the unborn child.
HMIS (U.S.A.):
Health Hazard: 3
Fire Hazard: 1
Reactivity: 0
Personal Protection: E
National Fire Protection Association (U.S.A.):
Health: 3
Flammability: 1
Reactivity: 0
Specific hazard:
Protective Equipment:
Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator
when ventilation is inadequate. Splash goggles.

Section 16: Other Information

References: Not available.


Other Special Considerations: Not available.
Created: 10/06/2010
Last Updated: 24/11/2012

The information above is believed to be accurate and represents the best information currently available to us. However, we
make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume

p. 5
no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for
their particular purposes. In no event shall Finar Limited be liable for any claims, losses, or damages of any third
party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Finar
Limited has been advised of the possibility of such damages.

p. 6

Common questions

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The ecological impact of Cycloheximide is not fully detailed in terms of ecotoxicity, BOD5, or COD values; however, it is noted that the degradation products may be as toxic as the original compound, particularly in long-term scenarios . This suggests a potential for environmental persistence and toxicity, warranting careful management of waste disposal and environmental release.

When handling Cycloheximide, recommended PPE includes splash goggles, a lab coat, and a dust respirator, with certification for respirator equivalency being necessary . This equipment prevents inhalation and skin contact with the hazardous compound, reducing the risk of irritation, systemic toxicity, and contamination. For large spills, full protective suits and self-contained breathing apparatus are advised to further ensure safety .

Cycloheximide is listed under California Proposition 65 as a chemical known to cause cancer, birth defects, or other reproductive harm, necessitating a warning for usage or exposure . Federally, Cycloheximide is recognized under the OSHA Hazard Communication Standard as hazardous, and it is subject to regulation under various state and federal programs, including California's Prop 65, Pennsylvania RTK, Michigan critical material, and New Jersey SARA 302/304/311/312. It also has a CERCLA designation due to its hazardous nature .

In experimental animal studies, Cycloheximide has shown acute oral toxicity with LD50 values of 2 mg/kg in rats, indicating its high toxicity . Chronic effects in humans may involve developmental toxicity affecting the reproductive system, with possible damage to the nervous system, liver, and other organs upon prolonged exposure . These findings underscore the potential health risks Cycloheximide poses to humans, necessitating stringent control and caution in environments where exposure might occur.

Cycloheximide is classified as a Class 6.1 poisonous material under DOT regulations, with a UNNA code of 2811 and Packing Group I, reflecting its high toxicity level . The special transportation provisions underline the need for safeguarding against accidental release and ensuring the safety of personnel and the environment during transport.

Cycloheximide is very hazardous in case of skin contact, acting as an irritant, and can cause severe health effects such as itching, scaling, and reddening, potentially leading to blistering . If skin contact occurs, it is critical to immediately flush the skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. An emollient should be used to cover the irritated area, and medical attention must be sought immediately .

Cycloheximide should be handled with strict precautions: it must be kept locked up, away from heat and sources of ignition. Empty containers should be evaporated under a fume hood to prevent fire risks. The handling process should not involve ingestion or breathing of dust, and appropriate respiratory equipment is necessary if ventilation is insufficient. The chemical should be stored in tightly closed containers in cool and well-ventilated areas to avoid any accidental exposure or degradation of safety measures .

Cycloheximide is generally stable under normal conditions of use and storage . There aren't specific conditions of instability detailed, implying that typical handling and storage precautions (such as avoiding exposure to heat and ignition sources) suffice to maintain stability. Unknown factors could potentially include reactions with incompatible substances, though specific incompatibilities are not listed .

Cycloheximide is considered possibly combustible at high temperatures, although its auto-ignition temperature and explosive limits are not available . In case of a fire, dry chemical powder can be used for small fires, while water spray, fog, or foam are recommended for larger fires. Water jets should be avoided. Firefighting efforts should focus on reducing vapors with water spray and removing any ignition sources .

Cycloheximide's solubility profile, being soluble in methanol, diethyl ether, and acetone but very slightly soluble in cold water, dictates its handling and use in laboratory environments . Such solubility properties imply that organic solvents may be needed for dissolving and manipulating this compound, which also necessitates stringent solvent handling procedures and adequate ventilation to manage odorous and potentially harmful solvent vapors.

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