UNIVERSITY OF NOVI SAD
FACULTY OF MEDICINE
Study program: Integrated Academic Studies in Pharmacy
Course title: Analytical Chemistry II
Teacher: Radomir V. Malbaša, Vesna B. Tepavčević, Nataša P. Milošević
Course status: Compulsory
ECTS Credits: 6
Condition: General chemistry
Course aim
Acquiringtheoretical and practical knowledge ofclassical quantitative chemical analysis, with emphasis on pharmaceuticals and other
preparations relevant to the pharmaceutical profession.
Expected outcome of the course:
Students learn how to apply analytical methods and sample preparation methods in quantitative chemical analysis.
Laboratory practice in the identification of various compounds, in model and real systems. Sample preparation and application of
gravimetric and volumetric analyzes.
Course description
Theoretical education
1. Quantitative analysis. Methods. Comparison of analytical methods. Classification of analytes regarding the contents of
components. Sample distribution regarding the size of samples. General course of analysis. Classical methods of quantitative
analysis.
2. Gravimetry. Types of gravimetric analyses. Gravimetric precipitation methods. Gravimetric evaporation methods.
Stoichiometric calculations in gravimetry.
3. Volumetric analysis. Basics on the volumetric analysis. Conditions for applying the chemical reaction in volumetric analysis.
Equivalence point and the end-point of titration. Determination of the equivalence point. Standard solutions: primary,
secondary, and commercial standard solutions. Techniques of the volumetric analyses. Classification of the volumetric methods.
Indicators. Classification of indicators. Calculations in volumetry.
4. Acid-base titration. Application of acid-base titrations. Acidimetry. Alkalimetry. Titration curves. Potentiometric titration.
Stoichiometric calculations.
5. Precipitation titration. Conditions of applying the precipitation reaction in volumetry. Classification of precipitation titrations.
Argentometry (classification, application, indicators). Stoichiometric calculations.
6. Complexometric titrations. Definition. Role. Titrations with inorganic complexing agents. Examples. Chelatometry.
Stoichiometric calculations.
7. Oxidation-reduction titrations (redox titrations). Types of redox methods. Primary standards. Indicators: redox, specific,
inorganic. Equivalent point potentials. Titration curve: symmetrical and non-symmetrical. Permanganometry. Iodimetry (direct
and indirect). Stoichiometric calculations.
8. Acid-base titrations in non-aqueous medium. Properties and classification of organic solvents according to their acid-base
characteristics. Leveling and differentiating effects of solvents. Determination of acids and bases in non-aqueous mediums.
9. Data processing of the results of quantitative analysis. Criteria associated with the quality of analytical results. Accuracy and
precision. Evaluation of accuracy and precision. Errors in experimental measurements. Statistical methods of evaluation.
Practical education:
Laboratory practiceisfollowing the above-mentioned lectures:
Gravimetry
Determination of dry matter content and water content in pharmaceutical preparations.
Determination of ash residues in pharmaceutical preparations.
Determination of iron by using a gravimetric method of precipitation.
Volumetry
Chelatometry – Determination of zinc, calcium and magnesium, and determination of water hardness.
Argentometry – Determination of chlorides according to Mohr and Volhardt, determination of iodides according to Fajans.
Acid-base titrations – Preparation and standardization of hydrochloric acid solution and sodium-hydroxide solution, determination
of sodium-hydroxide, phosphorous acid and acetic acid, determination of temporary water hardness.
Redox titrations – Permanganometry: preparation and standardization of potassium permanganate solution and determination of
iron according to Zimmerman-Reinhart. Indirect iodimetric titrations –preparation and standardization of sodium-thiosulfate
solution, determination of copper.
Literature
Compulsory
1. Harvey D. Modern Analytical Chemistry. Boston: McGgaw-Hill; 2000. (selected chapters)
Additional
1. Scoog DA, West DM, Holler FJ, Crouch SR. Fundamentals of Analytical Chemistry. Belmont: Brooks/Cole; 2004. (selected
chapters)
Number of active classes Theory: 30 Practice: 60
Teaching methods
Lectures, laboratory exercises, consultations.
Student activity assessment (maximally 100 points)
Pre-exam activities points Final exam points
Lectures 5 Written
Practices 15 Oral 30
Colloquium 2 ×25 ..........
Essay