E-BOOK
SARM'S
SELECTIVE ANDROGEN RECEPTOR MODULATORS
G
U
I
D
E
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CHEERS,
B Y B I O T E C H
the ULTIMATE
GUIDE to
SARM'S
1-5............... what are sarms?
6-9............... prohormone vs sarms
9-11............ study cases
11-13.......... references
14-15.......... Andarine
16-17.......... Ostarine
18-20.......... ligandrol
21-24.......... testolone
25-28.......... myostine
29-32.......... Cardarine
33-36......... Ibutamoren
37-40.......... Stenabolic
WHAT
are
SARM'S ?
Selective Androgen Receptor
Modulators (SARMs)
Selective Androgen Receptor Modulators (SARMs) are a
class of therapeutic compounds that have similar
properties to anabolic agents, but with reduced androgenic
properties. This property allows SARMs the advantage of
androgen-receptor specificity, tissue selectivity, and the
lack of steroid-related side effects. Some potential side
effects of anabolic steroid use include acne, liver damage,
breast tissue development, and shrinking of the testicle in
males, and deepening of the voice, growth of hair on the
face, stomach, upper back, and abnormal menstrual cycles
in females. SARMs have the ability to differentiate
between anabolic and androgenic activities, and this
provides the potential for therapeutic opportunities in a
variety of medical conditions including muscle-wasting
diseases, osteoporosis, cancer, and hypogonadism.
1
What is the current status of SARMs on
the WADA Prohibited List?
SARMs have been prohibited by the World Anti-Doping
Agency (WADA) since 2008. SARMs have the potential to
be misused for performance enhancement in sport due to
their anabolic properties as well as ability to stimulate
androgen receptors in muscle and bone. They are
currently prohibited at-all-times in the category of “other
anabolic agents” under section S1.2 of the WADA
Prohibited List. Some examples of SARMs are Ostarine
and Andarine.
Is there a list of clinically-approved
SARMs?
The first non-steroidal SARMs were introduced in 1998
and since then there has been a growing list of drug
candidates in this new class of therapeutics. Many SARM
drug candidates have been subject to pre-clinical and
clinical trials by global pharmaceutical companies.
However, full clinical approval for human consumption as
prescription drugs has not yet been accomplished for any
of the substances. Published scientific literature, reviews
on recent developments and clinical trials of SARM drug
candidates are available.
2
What are the number of Adverse
Analytical Findings for SARMs?
SARMs were added to the WADA Prohibited List in 2008.
The first Adverse Analytical Finding (AAF) with a SARM
drug candidate was reported in 2010. Since then, there has
been a steady increase in the number of AAFs reported
globally. As per the WADA Anti-Doping Testing Figures
report, over 30 AAFs have been reported for SARMs
between 2012 and 2014.
What is the detection strategy for
SARMs?
Due to the recent increase in the number of SARMs-
related AAFs in doping control samples, anti-doping
agencies have taken a proactive approach to tackle SARMs
abuse in sport. Potential SARM drug candidates are
investigated even though clinical trials for these drugs are
not yet complete. This allows anti-doping agencies to
integrate testing strategies for SARMs, in an efficient and
timely manner, to routine testing procedures.
Demonstration and effectivity of this strategy was in 2010,
when an AAF was reported with the non-approved and
officially discontinued SARM drug candidate, Andarine. As
a more recent example of preventive doping research,
metabolites of LG121071, a potential SARM drug candidate,
were generated in vitro and a detection method was
established for urine samples based on liquid-
chromatography-tandem mass spectrometry. This assay
serves as a detection method in sport drug testing.
3
Can SARMs be found in dietary
supplements?
SARMs are not legal ingredients for dietary supplements.
However, there have been instances of products
containing SARMs being sold illegally as dietary
supplements. These products could pose significant health
risks to athletes. Since SARMs are prohibited at-all-times
on the WADA Prohibited List, consumption of these
dietary supplements could also lead to an Anti-Doping
Rule Violation (ADRV) in sport. Athletes should be aware
that SARMs ingredients could be listed on dietary
supplement product labels under various names, and
should be cautious when consuming such products. As an
example, in 2014, the U.S. Food and Drug Administration
(FDA) issued a warning letter to a dietary supplement
company as one of their products contained an
unapproved SARM ingredient, Ostarine. According to the
letter, a dietary supplement cannot include a substance
that is being investigated as a new drug candidate; in this
case, Ostarine.
What Are the Side Effects of
SARMs?
The evidence here is largely anecdotal. On online forums,
users report strength gains, but they also frequently seek
advice about issues such as high blood pressure, skin
rashes and impotence. Problems with eye-sight appear to
be particularly common; andarine is reported to give
users’ vision a green or yellow tinge.
4
Most of the available information online comes from
sellers and YouTubers, so there's a tendency for advice to
skew positive. Dr Ian Boardley, a senior lecturer in sports
psychology at Birmingham University, says: “If someone is
using them themselves, it’s in their interest to believe they
can use them safely. I think that’s happening with SARMs.”
Even if users conduct significant amounts of research into
their chosen substances, the conclusions they draw are not
necessarily accurate. “One of the things we often see is the
distortion and selective use of information to support their
behaviour,” he explains. “It’s quite a dangerous process.”
Where Did SARMs Come
From?
SARMs were created by accident. In the early Nineties, a
scientist named Professor James T Dalton was working on
pioneering treatments for prostate cancer when he
identified the molecule andarine – the first SARM. It was
of little use in treating prostate cancer, but it had a
remarkable effect on muscle growth. “It was the opposite
of what we were looking for at the time,” he told Men's
Health. “But we turned almost all of our attention to this.
We knew we really had something unique.”Several years
later, Dalton went on to create a more refined version,
known as ostarine. In clinical trials, elderly men given a 12-
week course of the drug increased lean muscle mass
and reduced fat, while gaining more than a 15%
improvement in stair climb power. But a subsequent trial
in cancer patients failed to produce the desired results and
the drug's development halted. Dalton has since tried to
curb the companies operating a black market for his
discoveries. “We reached out with cease and desist letters
to a couple of them, we reached out to the FDA to try
shutting them down," he says. "But it’s rampant and there’s
really little that can be done to control it.”
5
Pro
HORMONES
vs
SARM'S
Sometimes gaining lean muscle mass can be difficult. Even
with a strict diet and exercise regimen, there are variables
you can’t always avoid. So to help combat the struggle
there are products like pro hormones and SARMs. But
what are these compounds and how can they effect you?
Pro Hormones
Prohormones are precursors to specific hormones. When
consumed, the prohormone are converted into hormones
by some of the enzymes found in the body. This will
increase the levels of anabolic hormones in the body. Thus
stimulating muscle growth within a shorter period. For a
more in-depth overview of prohormones you can check
out our guide
6
Benefits
The benefits for pro hormones will vary depending on
you and the pro hormone you take. The different
compounds work better for different goals, such as bulking
or cutting. The more common benefits you may see
throughout compounds include:
1. Increased Muscle Mass†
2. Decreased Fat Mass†
3. Increased Endurance†
4. Decreased Recovery Time†
5. Increased Strength.†
Side Effects
Like how the benefits vary, so will the side effects. Some
pro hormones convert to estrogen and thus have a
different set of side effects to look out for. But, all pro
hormones will have androgenic effects to some level, so
these side effects will carry over.
Some of these side effects include:
1. AcneHair Loss
2. High Blood Pressure
3. Low LibidoLethargy
4. Water Retention
5. Gynecomastia (for estrogenic pro
hormones)
7
SARMs
SARMs (or Selective Androgen Receptor Modulators) are
similar to anabolic steroids. This is due to their more
direct way of signalling and stimulating androgen
receptors. Unlike with pro hormones which go through a
two step conversion to become a target hormone.
However, it has been noted the potency of SARMs are not
as strong as in a pro hormone.
Benefit
Also unlike with pro hormones, there is not a lot of
research to back up the potential benefits or side effects
with SARMs. There are different types of SARMs, as well,
so the benefits will vary per compound. The claimed
benefits include:
Increased Lean Muscle Mass
†
Decreased Body Fat†
Increased Strength†
Decreased Recovery Time†
Some of the more common compounds include:
MK-677
LGD-4033
(Ligandrol)
MK-2866 (Ostarine)
GSX-007 (Andarine)
GW-50156 (Cardaine)
8
Side Effects
Again because of the lack of research the potential of side
effects is indefinite. Though there are side effects that have
been anecdotally attributed to sarm use. Some of these
side effects include
Testicular Atrophy
Acne/Cysts
OilyHair And Skin
Increased Blood
Pressure
Lowered Sperm Count
SARMs do not appear to convert to estrogen or DHT. So
there should not be a concern of gynecomastia or other
estrogenic side effects.
Study cases
Case Study #1 – The Personal Trainer
A 37-year-old personal trainer, Allan initially dismissed
SARMs as a fitness fad. “There are a lot of supplements
that come out on the market that say they do this and that,
but the majority of the time they do absolutely nothing,”
he says. That changed when he started seeing YouTubers
he respected recommending them: “I was sitting up
thinking, alright, I’m interested now.” Allan had
never taken steroidsbut, having reached his mid-thirties,
was intrigued to discover a supplement that could help
him maintain his athletic performance. He placed an order
for ostarine, which he’d seen described as one of the
mildest SARMs, and started out on what he believed was a
small [Link] problems started almost immediately.
9
Allan took his first dose at lunchtime, then left the
house to run some errands before going to the gym.
Within hours, he was overcome by a strange sensation:
anxious, shaky, a general sense of unease. Allan hoped
the feelings would fade; instead, they got worse. “After a
few days this anxiety was constant,” he says. “After just
over two weeks, that's when I was like, this isn’t for me.”
Before giving up on SARMs, he went online to seek
advice about his symptoms. He recalls being told: “Man
up, you’ll get through it, you’ll be growing in no time.”
Instead, Allan decided to follow his instincts: “I’d rather
have my mental health intact than have slightly bigger
muscles.”
Case Study #2 – The Sports Coach
Andy, a tennis coach in his late thirties, first noticed
SARMs being advertised online around two years ago. He
recalls seeing them marketed as a “steroid alternative that
would give you similar effects”. Andy had been going to
the gym for two decades, working out three or four times a
week. “I’m always looking at supplements, but I was never
going down the steroids route,” he says. “For me, the
health risks were always that bit too high.”Andy began
doing further research. He joined Facebook groups,
watched YouTube videos, and read scientific papers. “I
wanted to make sure, if I was going to do it, it was as safe as
it could be,” he says. Around a year after he first heard of
SARMs, he ordered ostarine online. Soon enough, he
began noticing changes in the mirror. He looked leaner
and more muscular. The only downside was some
headaches. Andy went on to try another SARM named
LGD-4033, which increased his bench curl by nearly a
quarter. But after two SARMs cycles, he decided that was
enough; he still had lingering concerns about the long-
term health implications. “Once there’s more research
maybe I would take them longer,” he says.
10
Case Study #3 – The Gym-Goer
Aaron, a 33-year-old from Stoke-on-Trent, used to use
steroids but stopped after suffering severe acne. Two years
ago, he saw a YouTube video recommending SARMs,
“basically saying they’ve got dead-low risks and all the
benefits of anabolic steroids”. His first course of ostarine
seemed to work. “I put on quite a bit of muscle, I was really
lean, I looked really, really good in a very short time
period,” he says. The effects were less dramatic than when
he’d taken steroids, but SARMs seemed much safer and
the side effects less severe. Aaron placed another order and
went on to run three more cycles.
Halfway through his fourth cycle, Aaron noticed an
alarming development: his testicles had shrunk. “I just
woke up one day and they were gone,” he says. He stopped
taking SARMs and began taking hormones in an attempt
to kickstart his body’s natural testosterone production. It
didn’t work. “I was doing everything I could and they just
wouldn’t come back,” he says. “So, I made the decision to
turn to anabolics.” Aaron believes he was sold oral steroids
under the guise of SARMs, which caused his body’s natural
testosterone production to shut down. He’s now resigned
to permanently cycling steroids: “I’m ready to do what I’m
doing now for the rest of my life.”
References
Ostrowski J, Kuhns JE, Lupisella JA, Manfredi MC, Beehler
BC, Krystek SR, Bi Y, Sun C, Seethala R, Golla R, Sleph PG,
Fura A, An Y, Kish KF, Sack JS, Mookhtiar KA, Grover GJ,
Hamann LG (January 2007).
11
Ostrowski J, Kuhns JE, Lupisella JA, Manfredi MC, Beehler
BC, Krystek SR, Bi Y, Sun C, Seethala R, Golla R, Sleph PG,
Fura A, An Y, Kish KF, Sack JS, Mookhtiar KA, Grover GJ,
Hamann LG (January 2007). "Pharmacological and x-ray
structural characterization of a novel selective androgen
receptor modulator: potent hyperanabolic stimulation of
skeletal muscle with hypostimulation of prostate in
rats". Endocrinology. 148 (1): 4–12. doi:10.1210/en.2006-
0843. PMID 17008401.
Manfredi MC, Bi Y, Nirschl AA, Sutton JC, Seethala R,
Golla R, Beehler BC, Sleph PG, Grover GJ, Ostrowski J,
Hamann LG (August 2007). "Synthesis and SAR of
tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-
dioxide analogues as highly potent selective androgen
receptor modulators". Bioorganic & Medicinal Chemistry
Letters. 17(16): 4487–
90. doi:10.1016/[Link].2007.06.007. PMID 17574413.
Zhang X, Li X, Allan GF, Sbriscia T, Linton O, Lundeen
SG, Sui Z (August 2007). "Design, synthesis, and in vivo
SAR of a novel series of pyrazolines as potent selective
androgen receptor modulators". Journal of Medicinal
Chemistry. 50 (16): 3857–
69. doi:10.1021/jm0613976. PMID 17636947.
Long YO, Higuchi RI, Caferro TR, Lau TL, Wu M,
Cummings ML, Martinborough EA, Marschke KB, Chang
WY, López FJ, Karanewsky DS, Zhi L (May 2008).
"Selective androgen receptor modulators based on a series
of 7H-[1,4]oxazino[3,2-g]quinolin-7-ones with improved in
vivo activity". Bioorganic & Medicinal Chemistry
Letters. 18 (9): 2967–
71. doi:10.1016/[Link].2008.03.062. PMID 18400499.
12
Ke HZ, Wang XN, O'Malley J, Lefker B, Thompson DD
(2005). "Selective androgen receptor modulators--
prospects for emerging therapy in
osteoporosis?" (PDF). Journal of Musculoskeletal &
Neuronal Interactions. 5 (4): 355. PMID 16340136.
M.S. Steiner; et al. (June 2010). "Effect of GTx-024, a
selective androgen receptor modulator (SARM), on stair
climb and quality of life (QOL) in patients with cancer
cachexia". J Clin Oncol. 28 (1534).
Piu F, Gardell LR, Son T, Schlienger N, Lund BW, Schiffer
HH, Vanover KE, Davis RE, Olsson R, Bradley SR (March
2008). "Pharmacological characterization of AC-262536, a
novel selective androgen receptor modulator". The Journal
of Steroid Biochemistry and Molecular Biology. 109 (1–2):
129–37. doi:10.1016/[Link].2007.11.001. PMID 18164613.^
Vajda EG, López FJ, Rix P, Hill R, Chen Y, Lee KJ, O'Brien
Z, Chang WY, Meglasson MD, Lee YH (February 2009).
"Pharmacokinetics and pharmacodynamics of LGD-3303
[9-chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-3H-
pyrrolo-[3,2-f]quinolin-7(6H)-one], an orally available
nonsteroidal-selective androgen receptor modulator". The
Journal of Pharmacology and Experimental
Therapeutics. 328 (2): 663–70.
13
READ
before
ANDARINE
you BUY
(S-4)
Andarine is an investigational drug that has not yet been
approved by the US Food and Drug Administration (FDA).
It is part of a class of drugs called selective androgen
receptor modulators (SARMs). Some supplement
companies have included andarine in products
for bodybuilding. The FDA
considers supplements containing andarine to be illegal.
People use andarine to improve athletic performance and
for conditions such as involuntary weight loss in people
who are very ill (cachexia or wasting
syndrome), osteoporosis, and prostate health, but there is
no good scientific evidence to support these uses. Using
andarine can also be unsafe.
How does it work?Andarine attaches to proteins in the
body known as androgen receptors. When andarine binds
to these receptors, it tells the muscles and bones in the
body to grow. Unlike some other chemicals that bind to
androgen receptors, such as steroids, andarine doesn't
seem to cause as many side effects in other parts of the
body.
14
users
Age-related muscle loss (sarcopenia).
Athletic performance.
Enlarged prostate (benign prostatic
hyperplasia or BPH).
Involuntary weight loss in people who are very ill
(cachexia or wasting syndrome).
[Link] [Link] conditions.
More evidence is needed to rate andarine for these uses.
side effects
When taken by mouth: Andarine is POSSIBLY
UNSAFE. Liver damage, heart attack, and stroke have been
reported in some people taking drugs like
andarine. Special Precautions &
Warnings:Pregnancy and breast-feeding: There isn't
enough reliable information to know if andarine is safe to
use when pregnant or breast-feeding. Stay on the safe side
and avoid use.
dosing
The appropriate dose of andarine depends on several
factors such as the user's age, health, and several other
conditions. At this time there is not enough scientific
information to determine an appropriate range of doses
for andarine. Keep in mind that natural products are not
always necessarily safe and dosages can be important. Be
sure to follow relevant directions on product labels and
consult your pharmacist or physician or
other healthcare professional before using.
15
READ
before
OSTARINE
you BUY
(MK-2866)
Ostarine is an investigational drug that has not yet been
approved by the US Food and Drug Administration (FDA).
It is part of a class of drugs called selective androgen
receptor modulators (SARMs). Some supplement
companies have included ostarine in products
for bodybuilding. The FDA
considers supplements containing ostarine to be illegal.
How does it work? Ostarine attaches to proteins in the
body known as androgen receptors. When ostarine binds
to these receptors, it tells the muscles in the body to
grow. Unlike some other chemicals that bind to
androgen receptors, such as steroids, ostarine doesn't
seem to cause as many side effects in other parts of the
body
users
Ostarine is used by mouth to improve athletic
performance and for involuntary weight loss in people
who are very ill, also known as cachexia or wasting
syndrome. But there is very little good scientific research
to support these uses.
.
Involuntary weight loss in people who are very ill
(cachexia or wasting syndrome).
Early research shows that taking ostarine can increase
lean body mass by a small amount in cancer patients
who seem to be losing [Link]-related muscle loss
(sarcopenia).
16
Early research shows that taking ostarine can increase
lean body mass by a small amount in elderly adults.A
group of inherited disorders that cause muscle
weakness and muscle loss (muscular dystrophy).
Breast [Link] of bladder control (urinary
incontinence).Other conditions.
More evidence is needed to rate ostarine for these uses.
side effect
When taken by mouth: Ostarine is POSSIBLY
UNSAFE when taken by mouth. Liverdamage has been
reported in some people taking ostarine. Other common
side effects of ostarine include stomach
pain, constipation, diarrhea, headache, nausea, fever, heart
attack, and stroke. Special Precautions &
Warnings:Pregnancy and breast-feeding: There isn't
enough reliable information to know if ostarine is safe to
use when pregnant or breast-feeding. Stay on the safe side
and avoid use.
Liver problems: Ostarine might cause liver problems in
some people. People with a history of liver problems
should avoid ostarine.
dosing
The appropriate dose of ostarine depends on several
factors such as the user's age, health, and several other
conditions. At this time there is not enough scientific
information to determine an appropriate range of doses
for ostarine. Keep in mind that natural products are not
always necessarily safe and dosages can be important. Be
sure to follow relevant directions on product labels and
consult your pharmacist or physician or
other healthcare professional before using.
17
READ
before
LIGANDROL
you BUY
(LGD-4033)
Who doesn’t want a perfect set of abs and that shredded
body with veins popping out? SARMS are the new way of
attaining those body goals for most of us. LGD 4033 is one
such SARM that can help you to get [Link] is one of the
newest additions to the SARM realm. It is still under
research to discover its full potencies and side-effects. But
before you try out this compound, make sure you know
everything about it. We will be reviewing it to understand
its benefits, dosage, PCT, and if it is safe enough for you to
use. Read on!
LGD 4033, also known as Ligandrol is a Selective
Androgen Receptor Modulator (SARM). It was developed
by a San Diego based company, Ligand Pharmaceuticals. It
is currently under research at Viking Therapeutics. It
connects to the androgen receptors in the muscles and
bones inside your body selectively. It is known to benefit
in curing muscle wasting and bone diseases. It can also
help in building lean muscle mass and inhibiting muscle
[Link] are also considered a safer option than steroids.
It is believed that they don’t affect other organs in the
body, unlike steroids. Also known as Anabolicum, it has
become the preferred performance enhancer of many
fitness enthusiasts and bodybuilders. SARMs only became
popular because there were concerns regarding the effects
of steroids. They are known for minimal side effects that
can be reversed with regular PCT.
18
users
Increased Strength:With great muscles, there is an
inflow of strength in your body. You get more energy
to work out effectively. You can lift heavier weights in
the gym without any strain in your body. Ligandrol
also helps in increasing the strength which is crucial for
the workouts. You experience considerable strength
gain with this SARM. But do not forget to take a
protein-rich diet that will help you replenish the lost
energy.
Maintain Muscle Mass:Once you gain the desired
muscle mass, it is important to maintain it as well. LGD
4033 can help you sustain this mass as well during a
caloric deficit. This deficit is formed when your calorie
intake is less than what you are burning. This is done
because you need to lower your calorie intake in the
cutting phase. After you gain the mass, it’s time to get
that shredded look. Ligandrol ensures that you only
experience the burning of fat during this phase. It
prevents muscle loss and maintains them.
Enhanced Recovery:After those long hours in the gym
and training hard, your muscles can undergo serious
wear and tear. The muscle fibers tear during this and
rebuild themselves. This rebuilding makes them much
stronger and thus adding to your body strength. LGD
4033 ensures the speedy recovery of those muscles.
With this, you can get back to training in no time. As
the recovery is faster, you can save yourself from all
the serious injuries during the workout session.
side effects
LGD4033 is still a research chemical. Therefore, it should
be used in moderation. SARMs have very few side effects
if they are used in proper amounts. The most common
side effects are nausea, headaches, water retention, and
fatigue. It can also lead to testosterone suppression which
is one of the major side effects.
19
Testosterone is crucial for males to gain muscle
strength. Increase your water intake if you feel such
symptoms, it can help you get some temporary relief.
These side effects are very rare and most people don’t
even experience them. If you stop the use immediately
and go for PCT, the side effects go away. PCT stands
for Post Cycle Therapy that you can take after the SARM
cycle. These are a bunch of supplements that help you
fight the side effects. A couple of weeks rest after the PCT
will help you recover fine. You can easily order these
therapy supplements [Link] people don’t know
about PCT and therefore don’t use it. If you don’t use PCT
supplements, your body takes a longer time to recover.
During this time you lose all your gains and all your hard
work goes to [Link] you think your symptoms are getting
out of hand, go for it. You can start with the mild PCT or
anti-estrogen to relieve the symptoms. Then, there is the
Red PCT which is made from all-natural seed extracts. Go
for the one that suits you the best.
dosing
Ligandrol is strong enough SARM in itself and most
people don’t feel the need to stack it with some other
compound. It gives you the desired results without getting
[Link] still, in case you feel the need, you can stack it
up witH SARMS like Ostarine MK 2866, Testolone, and
RAD 140. They have to be combined with Ligandrol in
recommended amounts for better results. For rapid
muscle gains, you can stack up 5 mg of LGD4033 with 10
mg of RAD 140 for 8- 10 weeks to get increased strength
and gains. This is one of the popular stack combinations
out there. You need to use PCT for 4 weeks after this. For
cutting, it is recommended to stack up 20 mg of Ostarine
MK 2866 with 5 mg of LGD 4033 per day for 8 weeks. It
maintains muscle mass during the caloric deficit. You will
get extra strength in your cut muscles. To gain strength
and muscle mass, you can stack up 10 mg of YK 11 with 10
mg of LGD 4033 for 8 weeks. This not only builds strength
but also minimizes side effects.
20
READ
before
TESTOLONE
you BUY
(RAD-140)
If you’ve been involved in the fitness community recently,
you may have noticed that a lot of guys are using SARMs
to drastically speed up muscle growth and fat [Link] fact,
many athletes have been commenting on their usage
lately, and have noted just how effective they can be at
helping users build muscle and shred [Link] what is
RAD140? How does it work? Are there any side effects that
you should be concerned about? Well, in this article we
will present you with the facts about this fascinating new
SARM, just how it works, and what the research has to say.
users
RAD-140, like other SARMs, are known for their ability to
enhance muscle gain, strength, and speed along the
process of fat loss. They do this by targeting certain
receptors in your [Link] receptors are known
as androgen receptors. When something binds to them, it
tells your body to build muscle. This is why SARMs are so
effective at helping users pack on pounds of lean muscle
mass, in record [Link] key though, is that they only
target the “good” androgen receptors, and they ignore the
“bad.” When you take a steroid like Testosterone
Enanthate or Trenbolone Acetate, they target all of your
androgen [Link] is why steroids are known for
giving such great results in the gym, but it’s also why
they’re known for causing a plethora of side effects, such
as:
21
Gynecomastia
Rapid Mood
Swings
Terrible Acne
Liver Toxicity
Thankfully with SARMs, you will experience very few of
these side effects. Let’s explore just how effective RAD 140
really is though, with some proven results.
In a previous post on Testolone, Jon Anthony of Masculine
Development explained that he gained 21 pounds of
muscle, and lose 12 pounds of fat, in just 60 days on RAD-
[Link] fact, these are the types of gains that most users can
only experience on steroids, but thankfully, SARMs such
as RAD 140 have almost none of the same side [Link]
RAD140 cycle consisted of taking 30mg/day, first thing in
the morning, for 60 days total – and as you can see by the
results images above, the progress was quite [Link] of
these results are not only from taking 30mg of RAD 140,
but likely also from following a good workout routine, and
adhering to a very healthy diet – SARMs without a proper
workout routine and diet won’t give you those results,
though – hard work is always [Link] users think
they’ll get the same results if they just take RAD-140, and
while it’s true you may experience some good results, to
get the most out of your SARMs cycle you want to
combine it with a great diet, and rigorous workout routine
Side Effects
In his report Jon said that he did not experience any side
effects on RAD-140. This doesn’t mean that there aren’t
any side effects that you should be aware of,
[Link] on a SARMs cycle, always be sure to avoid
drinking alcohol. SARMs are processed by your liver, so
drinking alcohol can add an excessive amount of stress on
your liver while on cycle.
22
Gynecomastia
Back Acne
Testosterone
Suppression
It’s important to note that these side effects will mostly
appear in very high dosages, such as taking more than 30
milligrams of RAD 140 per day. Most science suggests that
dosages under this amount are relatively [Link] fact,
according to studies, SARMs such as Testolone are very
well tolerated, and users generally experience very few
side effects while taking [Link] study conducted by
the Department of Chemistry at the University of Illinois,
found that RAD 140 actually had some favorable effects on
blood lipids, and was well tolerated:“Clinical chemistry
indicated the expected lowering of lipids (LDL, HDL,
triglycerides).28 Despite the rather dramatic increases in
body weight over such a short time, there was no elevation
of liver enzyme transaminase levels in any animal at any
dose >2 fold over its baseline value.29,30 Given the well-
established relationship between oral androgen use and
liver stress indicators, we were quite pleased that at a dose
10-fold greater than the fully effective dose we saw
minimal liver enzyme elevations.31”This means that users
can expect to take SARMs, and gain many of the benefits
of steroids, with almost none of the side effects. So, if
you’re intrigued, then read on.
dosing
Generally speaking, the maximum recommended daily
dosage for taking RAD140 is 30 milligrams. Anything
more than this hasn’t been tested in clinical research.
10mg/day (Beginners)
20mg/day (Intermediate)
30mg/day (Advanced)
23
Depending on your experience with selective androgen
receptor modulators, you may want to adjust your dosage
accordingly. It’s recommended to take your dose first
thing in the morning on an empty stomach, so that it
immediately goes to work on your muscle [Link]
addition to this, taking a post cycle therapy is highly
recommended.
In conclusion, RAD 140 is a popular SARM which
thousands of users across the world have taken to boost
muscle growth, shred fat, and increase strength in the
[Link] you do decide to get on a cycle of RAD 140, always
be sure to check with your doctor first – remember that
this is not medical advice, just opinion and reporting on
the [Link] your cycle, be sure to run a post cycle
therapy, to get yo levels back up to normal – you can
consider talking with your doctor if you’d like, as well, to
make a [Link] summary, Testolone is the most powerful
SARM currently available on the market, but more
research should be done to determine the long-term
effects.
24
READ
before
MYOSTINE
you BUY
(YK-11)
In conclusion, RAD 140 is a popular SARM which
thousands of users across the world have taken to boost
muscle growth, shred fat, and increase strength in the
[Link] you do decide to get on a cycle of RAD 140, always
be sure to check with your doctor first – remember that
this is not medical advice, just opinion and reporting on
the [Link] your cycle, be sure to run a post cycle
therapy, to get your testosterone levels back up to normal
– you can consider talking with your doctor if you’d like,
as well, to make a [Link] summary, Testolone is the most
powerful SARM currently available on the market, but
more research should be done to determine the long-term
effects.
YK11 belongs to a class of research chemicals known
as SARMS, which were initially developed to help treat
muscle wasting in cancer [Link] androgen
receptor modulators, or SARMs for short, have potent
muscle building effects, and are generally well tolerated in
studies. [R]While they were initially created to help cancer
patients combat muscle wasting, bodybuilders quickly
caught on, and realized that healthy individuals who took
SARMs could experience steroid-like effects.
25
users
Similar to other SARMs such as Ostarine, YK11 works by
binding to androgen receptors in the body, signalling
skeletal muscles to [Link] makes YK11 unique
however, is the fact that it is not only a SARM, but also a
myostatin inhibitor, which gives it an added anabolic
[Link] body normally produces something called
myostatin, which limits how much muscle you can grow
naturally—YK11 inhibits the production of myostatin,
unlocking your genetic [Link] does this by binding to
androgen receptors and inducing the muscle cells to
produce more follistatin, which inhibits myostatin
production. [R]To put it in layman’s terms, YK11 removes
the “muscle growth limit” that your body places on itself—
so that users can experience rapid gains.
While there are minimal YK11 studies regarding the effects
on humans, we do know that this SARM has an extremely
anabolic effect on animals.
In fact, mice that have low levels of myostatin, which is
what YK11 inhibits, have on average twice as much muscle
mass as rats who don’t.
Here are some reported benefits of YK11 usage:
Rapid Muscle Growth
Increased Sex Drive
Enhanced Strength
Muscle Hardening
The biggest benefit of YK11 is the rapid muscle growth, as
users often report gaining 10-15 pounds or more from one
12 week cycle of YK11.
26
Side Effects
Because there are no studies regarding the safety of YK11
use in humans, most of the side effects reported are from
body building cycle logs.
Some users report zero side effects in the short run, and
some report many side effects—so the short term negative
effects of YK11 will vary.
Here are some potential side effects of YK11 use:
Testosterone
Suppression
Mild Liver Toxicity
Joint And Tendon Pain
Increased Aggression
The most obvious side effect of YK11 use is testosterone
suppression, but this is common with all SARMs, from
Ostarine to Ligandrol (LGD-4033).
Side effects of YK 11 can be mitigated by taking
supplements on cycle for tendon pain and liver support,
and by doing a proper PCT, as well.
dosing
Because there have been no human trials with YK11
treatment, there is no medically established dose of YK11
for human use to date.
However, the general consensus amongst body builders is
that 10 mg is a good dosage for muscle growth and
performance enhancement.
Here are the YK 11 dosage guidelines:
27
Beginner Dose: 10 mg per day
Intermediate Dose: 15 mg per
day
Advanced Dose: 20 mg per day
While some users have reported taking dosages as high as
30 mg per day, most agree that taking between 10 mg and
15 mg to start is [Link] are often dosed in mg/ml, so
to take a dosage of 10 mg per day would be equivalent to
taking one full dropper of the YK11 from Proven Peptides.
28
READ
before
CARDARINE
you BUY
(GW-501516)
Cardarine, otherwise known as its research name
GW501516, is a research chemical that has garnered the
eye of many athletes around the [Link] it’s often
lumped in with SARMs, Cardarine isn’t technically a
SARM—it’s a PPARδ receptor agonist, developed to
improve cardiovascular health in those suffering from
diseases.
Recently however, many bodybuilders and athletes have
been using Cardarine to shred fat and enhance endurance
—does it work, though?
In this article, we’ll cover the results, dosage, cycle
guidelines, and take a look at what the clinical research has
to say about Cardarine so far.
users
Cardarine is often placed in the group of SARMs, although
this isn’t entirely accurate—while Cardarine may be
similar to SARMs, it is not a [Link], sometimes
known by its research chemical name GW-501516, is a
peroxisome proliferator-activated receptor delta agonist
that was initially developed to help treat metabolic and
cardiovascular diseases.
29
Recreational users soon discovered that Cardarine could
also be used to drastically increase endurance and
accelerate fat loss, [Link] fact, according to most cycle
logs and anecdotal evidence, Cardarine can be used as a
powerful cutting agent, to lose fat rapidly, and to seriously
improve endurance levels.
Shortly after ingestion, Cardarine works by binding to the
PPAR Delta receptor, and signals the liver to draw energy
from fatty acids. [R]Typically, your body draws energy
from blood sugars (glucose), however by switching the
preferred source to fatty acids, fat loss is [Link]
fact, it isn’t uncommon for people using Cardarine for
bodybuilding to report losing over 10-15 pounds from one
8-12 week [Link] however, Ligand
Pharmaceuticals, the same company that
created Ligandrol, abandoned Cardarine research in 2007,
so there isn’t very much clinical data regarding this drug’s
fat loss effects.
While Cardarine hasn’t technically been approved for
human usage, many of bodybuilders report losing large
amounts of fat on Cardarine [Link] fact, it isn’t
uncommon for users to report losing 10-15 pounds of fat
from a 12 week cycle of Cardarine, even at a relatively low
dose such as 10 mg.
Here are some benefits
Accelerated Fat Loss
Enhanced Endurance
Great Cutting Agent
Improved Blood
Lipids
The most impressive benefit of Cardarine, is its ability to
increase endurance in users. In fact, one study found that
lab rats that took Cardarine increased endurance by over
200% more than placebo.
30
Side Effects
According to the Australian Department of Health, as well
as clinical research, there are no known side effects of
taking Cardarine.
While there are no known short term side effects of GW-
501516 use in humans, more research should be done on
the long term [Link] common question people have
relates to a study which found that Cardarine caused
cancer growth to develop in organs of lab rats.
It has been noted, however, that the rats in this study were
given Cardarine for roughly 2/3 of their life straight (with
no breaks).With this in mind, the evidence that Cardarine
could cause cancer in humans is shaky at best—no
bodybuilder is going to dose Cardarine daily for two thirds
of his life (roughly 50 years straight).
dosing
Clinical trials conducted on humans used Cardarine
dosages ranging from 2.5 mg to 10 mg per day, although
some people have used up to 20 mg.
Here are the Cardarine dosage guidelines
Beginner: 5 mg per day
Intermediate: 10 mg per day
Advanced: 20 mg per day
For example, an intermediate dosage of Cardarine would
be 10 mg per day, or one full dropper of the Cardarine
(GW-501516) from Proven [Link] effects of
Cardarine are dose-dependent, meaning that if you take a
higher dosage of GW-501516, you will experience more fat
loss, endurance, and energy, as well as potentially more
side effects.
31
Bulking & Cutting Stacks
Some users take multiple SARMs at once, which allows
them to experience even more muscle growth, fat loss, and
enhanced athletic [Link] (GW501516) is
generally best suited for a cutting stack, as it allows users to
burn fat rapidly, and enhances endurance
Sample Bulking Stack Sample Cutting Stack
Cardarine – 10 mg per day Cardarine – 20 mg per day
Ligandrol – 20 mg per day Ostarine – 25 mg per day
Andarine – 50 mg per day
YK11 – 10 mg per day
Sample Cardarine Bulking & Cutting StacksWhile
Cardarine is generally considered a good SARM for
cutting, it can also be used to do a lean bulk, as it prevents
fat gain even when in a minor caloric surplus, according to
many cycle logs and user reports.
32
READ
before
IBUTAMOREN
you BUY
(MK-677)
Ibutamoren, otherwise known as MK 677, is a research
chemical that increases human growth hormone (HGH) in
the [Link] it was initially developed to treat growth
hormone deficiency, many bodybuilders have started
using MK 677 to build muscle and recover [Link] 677
shows tremendous promise to help users build muscle,
recover faster, increase bone density, improve sleep
quality, and [Link] this article we will cover the clinical
research regarding Ibutamoren, exploring potential
dosages, benefits, cycle results, and more.
Ibutamoren, often referred to by its research name MK-
677, is often grouped together with SARMs, although
technically it isn’t a [Link], MK 677 is a ghrelin
receptor agonist, and a growth hormone secretagogue,
which means that it increases HGH in users.
Initially, Ibutamoren was developed as a potential
treatment for children and elderly people suffering from
growth hormone deficiencies.
That being said, bodybuilders quickly discovered that if a
healthy person takes MK 677, they will experience rapid
muscle growth and recovery.
33
users
While more clinical research should be done on the
benefits and long term side effects of MK 677, there’s a lot
of anecdotal evidence out [Link] people use MK 677
for bodybuilding, even though it isn’t technically approved
for human use (yet)—and they report a number of effects.
Here are some benefits of MK 677 (Ibutamoren)
Increased Growth Hormone
Improved Sleep Quality
Faster Recovery Post-Workout
Enhanced Muscle Growth
Increased Bone Density
Better Immune System
Function
Because Ibutamoren (MK677) increases human growth
hormone (HGH) in users, they can expect all the benefits
that come from having more of [Link] includes more
muscle growth, better sleep quality, faster healing and
recovery after the gym, and of course, higher growth
hormone levels.
Because MK-677 increases growth hormone in users who
take it, users can expect to rapidly build muscle, far faster
than you could [Link] of the MK 677 results
reported on Reddit involve users gaining very large
amounts of muscle, and radically transforming their
physiques.
In fact, many bodybuilding cycle logs report gaining over
10-15 pounds of muscle from one 12 week cycle of
Ibutamoren (MK-677).Users in particular who have a hard
time sleeping or eating enough to bulk up will benefit a lot
from MK 677, as it’s a phenomenal bulking compound.
34
Side Effects
Many studies have shown that even long-term usage of
MK-677 is generally well tolerated, without any seriously
concerning side effects
That being said, more research should be done on the
long-term side effects of MK-677, and it still may have
some shorter term side effects, too.
Here are some potential MK 677 side effects
Increased Appetite
Fatigue & Lethargy
Tingly Fingers
Higher Fear
Sensitivity
Intense Dreams
Ibutamoren is also known for causing increased water
retention, which is a common side effect of increased
HGH levels—this makes it more suited towards bulking
than cutting.
dosing
Even a small dose of MK 677 has a very positive effect on
growth hormone levels, overall muscle growth, REM sleep
quality, and much [Link], the most common MK-
677 dose is 25 mg per day. That being said, the more you
take, up to a point, the more benefits you will likely get.
Here are the anecdotal MK 677 dosage guidelines
Beginner: 10 mg per day
Intermediate: 25 mg per
day
Advanced: 50 mg per day
35
Studies have shown that taking 10 mg vs 50 mg per day of
MK 677 doesn’t have a significant difference on growth
hormone, but it does have a significant increase on IGF-1.
This means that, if your primary concern is growth
hormone increase, a moderate dosage of 10-25 mg per day
of MK 677 would be just [Link] SARMs and research
chemicals are dosed in mg/ml, so taking 25 mg of MK 677
is equal to one full dropper of MK-677
Bulking & Cutting Stacks
MK677 is a phenomenal bulking SARM and is often
stacked with other SARMs, such as RAD 140 or Ligandrol,
to bulk up faster.
Sample Bulking Stack Sample Bulking Stack
MK 677 – 50 mg per day MK 677 – 25 mg per day
RAD 140 – 15 mg per day Ostarine – 25 mg per day
YK11 – 10 mg per day Andarine – 50 mg per day
Because MK-677 increases growth hormone, it’s primarily
best for a bulking stack, however it can also be used to
retain lean muscle mass while [Link] may choose to
combine this research drug with a SARMs such as Ostarine
or Cardarine for cutting, and Ligandrol or RAD 140 for
bulking.
36
READ
before
STENABOLIC
you BUY
(SR-9009)
While many people group Stenabolic, or SR9009, into the
SARMs category, it’s actually not a SARM—it’s a PPAR
Delta receptor [Link], it is often grouped with
SARMs, because they’re both research chemicals that have
profound effects that body builders find [Link] a
compound like SR 9009, many recreational users report
rapid weight loss, decreased cholesterol, and enhanced
endurance [Link] this article, we will cover the known
side effects, dosages, cycles, and more, so that the readers
of this site can get accurate facts and information.
Despite many misguided people grouping SR9009
together with SARMs, Stenabolic is not a SARM—rather, it
is a PPARδ receptor [Link] (SR9009) was
initially developed by professor Thomas Burris at the
Scripps Research Institute, as potential treatment for
people suffering from cardiovascular and metabolic
diseases.
It didn’t take long for body builders to realize that healthy
individuals could take SR9009 to drastically enhance
endurance, [Link] while Stenabolic is currently not
approved for human use, this hasn’t stopped many
endurance runners from taking it recreationally.
37
users
Similar to Cardarine (GW-501516), Stenabolic works by
binding to the PPAR Delta receptor, which signals the
body to increase mitochondria [Link] if you recall
anything from your biology class, it’s probably that
mitochondria is the powerhouse of the cell. This is one of
the reasons why SR9009 is known for increasing overall
energy and endurance.
By increasing the amount of mitochondria in the skeletal
muscles, Stenabolic enables users to attain
supraphysiological endurance [Link] fact, one study
found that lab mice treated with SR9009 could run for
much farther distances, and for much longer periods of
time.
To date, there have been no human trials conducted with
Stenabolic, so many of these benefits haven’t yet been
observed in human [Link] being said, many users
report drastic increases in endurance and energy levels,
both for cardiovascular and muscular workouts.
Here are some benefits of Stenabolic (SR9009)
Rapid Fat Loss
Improved Cholesterol
Enhanced
Inflammation
Higher Energy Levels
In addition to these benefits, Stenabolic also doesn’t
suppress natural testosterone levels, like SARMs such
as RAD 140 or Ligandrol do.
What kind of results can you expect from an SR9009
cycle? Well, the truth is that the results will vary depending
on the dosage and cycle [Link] being said, many
users who use SR9009 for weight loss report losing 10-15
pounds from just one 8-12 week cycle of Stenabolic.
38
Most cycle logs and user reports suggest that you can
expect to lose 10-15 pounds and drastically increase your
endurance from one [Link], remember that SR9009
has not been approved by the FDA for human use, either
—so many of these results are anecdotal from body
builders.
side effects
Because SR9009 has never been tested in human trials, the
long term side effects aren’t known very well—more
research should be done on [Link] do, however, have
many reports from body building forums and user cycle
logs, explaining the short term side effects they
experienced.
Here are some user reported side effects of
Stenabolic
Difficulty
Sleeping
Moderate Nausea
Mild Headaches
Most users who log their Stenabolic experience online
claim to experience no side effects, however this hasn’t
been proven or disproven in studies.
dosing
Because no human trials have been conducted with SR-
9009 to date, it’s difficult to ascertain a good dosage for
bodybuilding and [Link] being said, the general
consensus amongst body builders is that 10-40 mg is
usually the best dosage to get good results with minimal
side effects.
39
Here are the best SR9009 dosages
Beginner: 10 mg per day
Intermediate: 20 mg per day
Advanced: 40 mg per day
The effects of Stenabolic are dose dependent, meaning
that the more you take, the more benefits and also side
effects you will likely [Link] intermediate cycle,
for example, which is 20 mg per day, would be the
equivalent of one full dropper of the SR9009
Bulking & Cutting Stacks
Some users choose to take multiple SARMs at once, to
enhance the effects they experience, build more muscle,
and lose more fat.
Sample Bulking Cycle Sample Cutting Cycle
SR9009 – 10 mg per day SR9009 – 20 mg per day
Ligandrol – 20 mg per day Ostarine – 25 mg per day
YK11 – 10 mg per day Andarine – 50 mg per day
Because Stenabolic is naturally best for weight loss, most
users choose to combine it with SARMs that are good for
cutting, such as [Link] being said, it can also be
used on a bulking cycle, to prevent too much fat from
being gained while building muscle, even in a caloric
surplus.
40
where to buy
SARM'S ?
BIOTECH-LONDON
BIOTECH-LONDON
+44 7478303506
[Link]
INFO@[Link]
