Name: A.J.

Age: 25 yo

Ingestion of in [Link]
contaminated canned
corned beef

Autolysis of [Link].

Liberation of neurotoxin into

the environment

Liberation of neurotoxin into

the environment

Neurotoxin is absorbed from

the gut and enters the vascular
system

Transport and binding of neurotoxin

to peripheral cholinergic nerve
terminals. (NMJ, Postganglionic
parasympathetic nerve endings, and
peripheral ganglion).

Neurotoxin Heavy chain binds

to nerve terminals

Internalization of neurotoxin
via endocytotic vesicles.

Neurotoxin light chain

translocate to the cytosol
 Neurotoxin light chain
cleaves SNARE proteins
(SNARE-25, Synaptobrevin,
and syntaxin).

Inhibition of release of
acetylcholine into the synapse

Decreased number of available

Ach to bind at the post synaptic
Ach receptors

Low end-plate potential

Minimal to none muscle

depolarization

-Blurring of vision
-Ptosis
-Muscle weakness
-Decreased deep tendon reflex
-Difficulty of breathing may be due
to paralysis of muscles of respiration
including the diaphragm.