Generic name: metronidazole Brand name: Flagyl CLASSIFICATION: Anti-infectives, Anti-protozoals ACTION: Disrupts DNA and protein synthesis

s in susceptible organisms Bactericidal, or amebicidal action INDICATION / USES: Amebicide in the management of amebic dysentery COMMON ADVERSE EFFECTS: CNS: seizures, dizziness, headache GI: abdominal pain, anorexia, nausea, diarrhea, dry mouth, furry tongue, glossitis, unpleasant taste, vomiting Hematologic: leukopenia Skin: rashes, urticaria CONTRA-INDICATIONS: hypersensitivity NURSING CONSIDERATIONS: Administer with food or milk to minimize GI irritation. Tablets may be crushed for patients with difficulty swallowing. Instruct patient to take medication exactly as directed evenly spaced times between dose, even if feeling better. Do not skip doses or double up on missed doses. If a dose is missed, take as soon as remembered if not almost time for next dose. May cause dizziness or light-headedness. Caution patient or other activities requiring alertness until response to medication is known. Inform patient that medication may cause an unpleasant metallic taste. Inform patient that medication may cause urine to turn dark. Advise patient to consult health care professional if no improvement in a few days or if signs and symptoms of superinfection (black furry overgrowth on tongue; loose or foul-smelling stools develop).

Celcoxx - Detailed Prescribing InformationNonsteroidal AntiInflammatory Drugs (NSAIDs) Contraindication Patients with known hypersensitivity to celecoxib and those who have demonstrated allergic-type reactions to sulfonamide. Patients who have experienced asthma, urticaria, or allergic-type reactions after taking acetyl salicylic acid (ASA) or other NSAIDs including other COX-2 specific inhibitors. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients..Patients who have previously had a myocardial infarction (MI) or stroke and in the peri-operative period undergoing cardiac or major vascular surgery. Indications. For the relief of the signs and symptoms of osteoarthritis andrheumatoid arthritis in adults. Management of acute pain in adults especially in postoperative pain. Reduce the number of adenomatous colorectal polyps in familial adenomatous polyposis (FAP), as an adjunct to usual care (eg, endoscopic surveillance surgery). Treatment of dysmenorrheal The following adverse drug reactions have been reported during therapy of celecoxib:Most Common: Gastrointestinal: Abdominal pain, diarrhea, dyspepsia, flatulence, [Link] and Peripheral Nervous System: Dizziness, [Link]: Pharyngitis, rhinitis, sinusitis, upper respiratory tract [Link]: Back pain, insomnia, rash. Mechanism of Action: Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic and antipyretic activities. The mechanism of action of celecoxib is believed to be due to inhibition of prostaglandin synthesis, primarily via inhibition of cyclooxygenase-2 (COX-2), and at therapeutic concentrations in humans, celecoxib does not inhibit the cyclooxygenase-1 (COX-1) isoenzyme. Cardiovascular Thrombotic Events: Chronic use of celecoxib may cause an increased risk of serious adverse cardiovascular thrombotic events, MI and stroke which can be [Link] NSAIDs, both COX-2 selective and nonselective, may have a similar risk. Patients with known cardiovascular disease or risk factors for cardiovascular disease may be at greater risk. To minimize the potential risk for an adverse cardiovascular event in patients treated with celecoxib, the lowest effective dose should be used for the shortest duration possible.