Hormonal Changes in Adolescent Growth
Hormonal Changes in Adolescent Growth
Section- SE 142
Reg no. -10804540
Roll no. – 45
ACKNOWLEDGEMENT
It is not until you undertake the project like this one that you realize how massive the effort it
really is, or how much you must rely upon the Selfless efforts and goodwill of others. There are
many who helped us with this project, and we want to thank them all from the core of our
Hearts.
We owe special words of thanks to our Teachers Mrs. Kamal preet kaur for her vision,
thoughtful counseling and encouragement at every step of the project. We are also thankful to
the teachers of the Department for giving us the best of knowledge and guidance throughout the
project.
And last but not the least, we find no words to acknowledge the financial assistance & moral
support rendered by our parents in making the effort a success. All this has become reality
because of their blessings and above all by the grace of god.
Contents:
General Introduction to Adoloscent
characterstics of adolescent period
Adolescent growth and development
Growth
a) Linear growth
b) Growth velocity
Stages of growth
a) Prenatal
b) Postnatal
1) Infancy
2) Childhood
3) Adolescence
Hormonal basis of adolescence
a) Physiological changes
b) Maturity
1) Skeleton
2) Dental
3) Shape age
Senescence
Ageing
Theories of ageing
Development
Normal physical growth and development
Changes in Weight and Body Composition
Normal physchosocial and cognitive development
Factors affecting growth and development
Introduction to Adolescent: Adoloscent derived from the Latin word ‘adolescere’ means
‘to grow’ or ‘to mature’. Adolescence (ages 11 to 21), the transition between childhood and
adulthood, is one of the most dynamic periods of human development. Adolescence is
characterized by dramatic physical, cognitive, social, and emotional changes. These changes
along with adolescents growing independence, search for identity, concern with appearance,
need for peer acceptance, and active lifestyle, can significantly affect their physical activity
behaviors.
Adolescence period runs between childhood and adulthood and is also called the
period of teenage. The child experiences a number of changes in this transitional period.
Puberty: Process by which a person attains sexual maturity and the ability to reproduce.
GENERAL CHARACTERISTICS OF ADOLESCENCE PERIOD:
• Combination of opposites- behaves like a child in many ways and on the other hand he likes to
be treated as an adult.
Growth = Growth is a dominant biological activity during the first two decades or so of human
life, including, of course nine months of prenatal life. While growing the individual also matures.
Growth is an increase in the size of the body as a whole or the size attained by specific parts of
the body. It can be measured in terms of centimeters and kilograms or metabolic balance i. e.
retention of hydrogen and calcium in the body. It is a fundamental characteristic of all living
organisms. Growth is a form of motion.
Growth means the increase in the size of the various parts and organs
of the body by multiplication of cells and intercellular components during the period
commencing from fertilization to physical maturity. Changes in size are outcomes of three
underlying cellular processes: (a) an increase in cell number or hyperplasia; (b) an increase in
cell size or hypertrophy; (c) an increase intercellular substances or accretion. Hyperplasia,
hypertrophy and accretion all occur during growth, but the predominance of one or another
process varies with age and the tissue involved. The increase in number is a function of cell
division (mitosis), which involves the replication of DNA and the subsequent migration of the
replicated chromosomes into functional and identical cells. The increase in cell size involves an
increase in functional units within the cell, particularly protein and substrates, as is especially
evident in the muscular hypertrophy that occurs with regular resistance exercise.
Linear or Distance growth: It is overall growth at some point of time. Gradually, with
time, there occurs increase in height and weight of a child which can be revealed by measuring at
some point of time.
STAGES OF GROWTH: The stages or phases of growth have been classified in different
manners by different researchers.
1)Prenatal Period: The prenatal period comprises, on the average, about 10 lunar months
(there are 28 days in a lunar month), 9 calendar months, or 40 weeks. A fertilized egg of a
multicellular animal is transformed into an embryo by cell division, growth and differentiation.
This growth into the embryo is called prenatal growth. In the prenatal period (before birth) the
embryo is formed with rudiments of all organs and systems. Prenatal growth has three distinct
stages: the fertilized ovum (egg), or zygote (first 2 weeks); the embryo (from 2 to 8 weeks) and
the foetus (from 2 to 10 lunar months). The human ovum at conception is about 0.1 mm in
diameter. During the first part of this period (ovum), it is like a homogeneous mass. During the
embryonic stage, though the rate of growth is slow, yet during this time the differentiation
process in the mass to form various regions which later on give rise to different parts, like head,
arm, leg and others starts. By the eighth week the embryo becomes child-like in appearance.
During foetus stage the rate of growth in length as well as weight is considerably high.
2)Postnatal Period: Postnatal growth is commonly divided into the following age periods.
a)Infancy: Infancy comprises the first year of life. This is a period of rapid growth in most
bodily systems and dimensions and rapid development of the neuromuscular system. After birth,
he growth is oriented towards functional state of life. Growth is mainly by addition of more cells
or increase in the protoplasm. It can be said that anabolic processes exceed catabolic processes
and there is increase in size, shape and weight. This characterizes the infant stage. Immediately
after birth the rate of growth increases. In case weight the peak velocity is reached at two months
after birth. The cells become larger in size. The cervical and lumber curvatures of the spinal
column appear as the baby begins to straighten the head and tries to sit up and to stand. During
infancy growth is very rapid. More than 50 percent of birth length and 200 percent of birth
weight take place during the first year of life.
b)Childhood: Childhood ordinarily spans from the end of infancy (the first birthday) to the start
of adolescence. The infant attains childhood before reaching adolescence. It is often divided into
early childhood and middle childhood. The early childhood is the period of eruption of milk
teeth. The middle childhood (7 to 10 years) is the period of eruption of permanent teeth, though
not all erupt. The late childhood starts from the prepubertal period and continues up to the time
of puberty. Childhood is period of relatively steady progress in growth and maturation and rapid
progress in neuromuscular or motor development.
c)Adolescence: After childhood comes adolescence period. The adolescence period extends
from the time of puberty upto around 20 years. In this period of life, the hormonal influences
play a leading role in order to attain sexual maturity. During this period there is a marked
acceleration of growth which is known as adolescence growth spurt. The adolescence spurt is a
constant phenomenon and occurs in all children, though it varies in intensity and duration from
one child to another. In boys it takes place, on the average from age 12 to 15. In girls the spurt
begins about two years earlier than in boys. Differentiation in primary and secondary sexual
characteristics marks the adolescence period. There are changes in the reproductive organs, in
body size and shape, in the relative proportions of muscle, fat and bone and in a variety of
physiological functions.
At adolescence sex differences in physical increase greatly, due chiefly to the
differential action of hormones, gonadal and other. Men become considerably larger, acquire
broader shoulders, a deeper larynx; women enlarge their pelvic diameter and deposit fat in
various strategic places, including the breast.
2)Maturity: In the adolescent period of life, the hormonal influences play a leading role in
order to attain sexual maturity. The endocrine glands under the direction of pituitary hormones
prepare the body for adulthood. An important sign of maturity is reproductive maturity. During
adolescence reproductive maturity begins but not completed. The active reproductive period
extends upto 40 or 45 years of age in the human beings. The cessation of growth of height is also
regarded as a sign of maturity.
There have been found biological criteria for maturity. There are three such criteria.
a. Skeletal Maturity
b. Dental Maturity
c. The shape age.
a. The Skeletal Maturity: Bones show gradual development in its histologic structure.
There appears first a main ossification center and gradually, with time, there appear many
subsidiary centers that fuse with the main ossification centre. Such centres are easily diagnosed
in X-rays because ossification centres, because of its high calcium content, make it opaque. The
bone-age is calculated by the number of ossification centres as well as stage of its development.
The X-rays of hand bones is matched with the atlas specifying the changes with increasing age
and found out to which of the sample in the atlas the radiograph matches. In recent times, there
can be found developmental age of each bone. Hence each bone is matched separately and given
a score. The total scores thus gained is matched with therange of score of the standard group.
b. Dental Maturity :
It is calculated on the basis of stages of calcification as seen in the jaw X-rays in just the same
way the skeletal maturity assessment through radiograph.
c. Shape Age: Shape age is difficult to derive and is a research problem. Mere calculating
height or weight or 1Q do not give any indication of age. In shape age, a combination of body
measurements are taken into account, all of which change with ages but independent of final size
and shape. It should not concern us here because, as already stated, it is a research problem.
Individuals are characterized by several maturational characteristic.
Senescence : The term senescence is used when talking about the changes which occur during
the period of obvious functional decline in the later year of life-span. Some people use the term
ageing for the same processes and period. Others use it in a much general way, with ageing
meaning simply growing older, and ageing changes being any changes related to age, regardless
of when in the life span they occur. Thus, the onset of puberty might be described as an ageing
change, but not as a senescent change.
After the active phase in the span of life, there is a declining process
resulting in old age or senescence. During this period many molecular and cellular changes
occur. There are also organismic changes. These changes are measurable and can be explained,
but these do not exhibit any specific pattern or well-defined sequence. It seems that a multi-
causal mechanism is involved in this process. In some individuals the changes are fast; in others
slow. Individuals are characterised by several senescent characteristics such as graying of hair,
loss of strength, reduction in sensory capabilities, poor homeostatic mechanisms, reduced
resistance of body against the diseases, cardiovascular irregularity and several other criteria. Like
maturity characteristics, the senescent characteristics also appear at different chronological ages.
A person at 35 years of age may suffer from graying of his or her hair, loss of homeostatic
mechanisms and a cardiovascular irregularity. In such cases, chronological age of the person is
low, but his or her biological age is much advanced. For late maturers, however, biological age is
generally lower than chronological age.
AGEING: Ageing is a process involving many changes in the body. There are molecular,
cellular and organismic changes. These changes are measurable and can be explained. After the
active phase in the span of life, there is a declining process resulting in old age or senescence. It
seems that a multi-causal mechanism is involved in this process. Some of the changes are –
1. Decline in metabolic efficiency.
2. Decrease in the power of replacing worn out old cells repairing the damaged tissues, organs
and organ systems. A few organs responsible for vital functions may become functionally
inefficient.
Manifestation of these changes, as the individual grows older is known as ageing. Thus, ageing
may be defined as the deterioration in the structure and function of body cells, tissues and organs
of the individual.
Theories of ageing : Several theories have been put forward to explain the process of ageing.
1. Ageing is due to interaction of the genetic material and the environment, a product nature and
nurture combination.
2. Ageing is caused by accumulation of some harmful products of metabolism in the cells and in
intercellular spaces. In other words the internal environment of cells undergoes adverse changes
resulting in ageing.
3. Ageing is due to intrinsic property of the genetic material ( gene = DNA ) i. e. the programme
is already there in the body and it is undergone as predetermined activity.
4. Wear and tear theory suggests that the tissues of the body become wornout because of
continuous and constant usage and are not replenished that fast.
5. Very high rate of metabolic activity during life advances old age, and slow rate enhances the
lifespan.
Because of ageing the tissues do not renew and as a result cells show senile
involution. The memory declines. Aged persons need more time to learn and to react. Systolic
blood pressure increases. The speed of conduction in motor nerves shows a decline. The range of
accommodation of the eye lens declines. Peripherial resistance and circulation time in the
cardiovascular system show an increase. There is reduction of density of long bones and
vertebrae, and therefore, height and sitting height show decrease. Vital capacity and muscle tone
declines. Arm span circumference of forearm ad that of calf diminishes.
Visible changes due to ageing are morphological and physiological. A
dry skin shriveled and stooping body with wrinkled skin is often quite visible in old persons.
With age the heart’s efficiency to pump blood diminishes. Brain and kidneys receive smaller
quantities of blood. The quantity of blood passing through the lungs is reduced consequently
affecting intake of oxygen. With age the number of taste buds in the tongue and the number of
kidney tubules (nephrons) get reduced. Bone marrow does not produce as many new cells as they
were producing when the body was young. Cells do not retain water and therefore dry skin, less
volume of blood and less urine is formed. Muscles become weak and bones get brittle.
All these changes are mainly due to physical and physiological changes within
the cells and intercellular spaces in the tissues. Cellular changes include chromosomal
abnormalities and mutations in the genetic material. Inactivation of certain enzymes, productions
of defective proteins are all due to increased defects of the DNA structure. Some cells of the
brain accumulate worn out cell organelles or pigments. In other words, cells in different parts of
the body lose their efficiency. The intercellular proteins especially collagens undergo a marked
change in their constitution. These proteins which are permeable, flexible and easily soluble in
young persons, become less permeable, rigid and insoluble as age advances. These property
changes affect gaseous exchanges and expulsion of nitrogenous wastes.
The beginning of biological growth and development during adolescence is signified by the
onset of puberty, which is often defined as the physical transformation of a child into an adult. A
myriad of biological changes occur during puberty including sexual maturation, increases in
height and weight, completion of skeletal growth accompanied by a marked increase in skeletal
mass, and changes in body composition. The succession of these events during puberty is
consistent among adolescents, however, there may be a great deal of deviation in the age of
onset, duration, and tempo of these events between and within individuals. For this reason,
adolescents of the same chronological age can vary greatly in physical appearance. This has
direct relevance for the nutrition requirements of adolescents. A 13-year-old male who has nearly
completed the linear growth spurt associated with puberty and has experienced significant
muscular development will have remarkably different energy and nutrient needs than those of a
13-year-old male who has not yet experienced puberty. Consequently, sexual maturation should
be used to assess the extent of biological growth and development and the individual nutritional
needs of adolescents in place of chronological age.
Sexual Maturation Rating (SMR), also known as Tanner Staging, is
based upon a scale of secondary sexual characteristics that permits health professionals to gauge
the degree of pubertal maturation that has occurred among adolescents, regardless of
chronological age. SMR is based on the appearance of pubic hair, the development of breasts,
and the occurrence of menarche among females; and on the degree of testicular and penile
development and the appearance of pubic hair among males. SMR stage 1 corresponds with
prepubertal growth and development, while stages 2-5 indicate the progression of puberty. By
SMR stage 5, sexual maturation has been completed. Sexual maturation correlates remarkably
well with linear growth, changes in weight and body composition, and hormonal changes.
Figure 1 depicts the occurrence of the linear growth spurt and the onset of menarche relative to
the occurrence of secondary sexual characteristics among females during puberty. The first signs
of puberty among females are the development of breast buds and sparse pubic hair, which
occurs between ages 8-13 on average (SMR stage 2). The onset of menstruation occurs 2-4 years
after the initial appearance of breast buds and pubic hair, usually during SMR stage 4. The
average age of menarche is 12.4 years for females in the United States, but the age at which it
occurs is highly variable; menarche can occur as early as 9 or 10 years of age or as late as 17
years of age. The onset of menstruation may be delayed in females who restrict their caloric
intake and body weight or who are competitive athletes.
There appear to be ethnic and racial differences in the initiation of sexual maturation among US
females. Research indicates that African American girls may enter puberty earlier than their
white peers. Among females in a large study, 48% of African American girls had reached SMR
stage 2 by age 8, compared to 15% of their white peers.2 Among African American girls in that
study, the average age of initial breast development was 8.8 years, while it was 9.9 years for
white females. Pubic hair growth began at age 8.7 years in African American females, occurring
almost 2 years earlier than their white peers. Menarche, however, occurred at approximately the
same time in both groups– 12.2 years for African American and 12.8 for white females. The
findings of that study suggest that, on average, puberty may begin earlier and last longer among
African American females than among white females.
The linear growth spurt begins most commonly during SMR
stage 2 in females, between 9.5 and 14.5 years of age. Peak velocity of linear growth takes place
at the end of SMR stage 2 and during SMR stage 3, approximately 6 to 12 months prior to
menarche. It is estimated that 15 to 25% of final adult height is gained during the growth spurt of
puberty.3 The average increase in height is estimated at 8.24 in (20.5 cm), with a range of 2-10
in (5-25 cm) seen in most females. During the peak of the linear growth spurt, females gain
roughly 3.5 in (8 - 9 cm) per year. The linear growth spurt lasts 24 to 26 months, ceasing by 16.5
years of age in most females. Some adolescent females experience small increments of growth
past age 19 years, however. Linear growth may be delayed or slowed among females who
severely restrict their caloric intake.
Adolescent males gain an average of 20 lb (9 kg) per year during puberty. Overall,
male teens gain 15-65 lb (7-30 kg) during puberty, with a mean gain of 52.2 lb (23.7 kg). Body
fat levels decrease among males during adolescence, dropping to an average of 12% body fat by
the end of puberty. Body composition changes more significantly among females during puberty.
The average lean body mass of teen females falls from 80%-74% while average body fat levels
increase from 16%-27% by the end of adolescence. Females experience a 120% increase in body
fat during puberty. On average, teen females acquire approximately 2.5 lb (1.14 kg) of body fat
mass each year during puberty. While the accretion of body fat mass is a normal, physiologically
essential process, adolescent females often view it with negativity. Weight dissatisfaction is
widespread among teenage females, leading to an increased risk of health-compromising
behaviors such as excessive caloric restriction, frequent dieting, use of diet pills or laxatives,
severe body image distortions and eating disorders.
Cognitive Development:
The early stage of adolescence is a time of great cognitive development. At the beginning of
adolescence, cognitive abilities are dominated by concrete thinking, egocentrism, and impulsive
behavior. The ability to engage in abstract reasoning is not highly developed in most young
teens, limiting their capacity to comprehend nutrition and health relationships. Young
adolescents also lack the skills necessary to problem solve in an effort to overcome barriers to
behavior change and the ability to appreciate how current behaviors can affect future health
status. Middle adolescence is characterized by growth in emotional autonomy and increasing
detachment from family. The bulk of physical growth and development is completed during this
stage, however body image concerns may continue to be a source of trepidation, especially
among males who are late to mature and females who have experienced great changes in body
composition and size. Conflicts over personal choice, including food choices, become
increasingly common during this stage of adolescence. Peer groups become more important than
family and their influence with regard to making food choices peaks. Coinciding with the
increased importance of peer acceptance, the initiation of health compromising behaviors such as
smoking, alcohol consumption, using street drugs, and engaging in sexual activities often occurs
during middle adolescence. Teens may consider themselves invincible and often still display
impulsive behaviors.
Abstract reasoning skills begin to emerge among most teens during middle
adolescence, however,these skills may not be highly developed. Adolescents will often regress to
concrete thinking skills when faced with overwhelming emotions or stressful situations. Teens
start to comprehend the relationship between existing health behaviors and future health status
but their desire to fit in with peers may make it difficult for adolescents to make health related
choices based upon knowledge rather than peer pressure.
The late stage of adolescence is characterized by the development of a
strong personal identity. Biological growth and development has concluded among most teens
and body image issues are less common. Older adolescents are able to manage increasingly
sophisticated social situations, are able to suppress impulsive behaviors, and are less affected by
peer pressure. Economic and emotional dependence upon family is markedly decreased and
conflict over personal issues, such as food choices, also decreases. Relationships with a single
individual become more influential than those with a group of peers as a stronger sense of
personal identity emerges.
The expansion of abstract reasoning skills continues to occur during late
adolescence, which assists teens in developing an ability to comprehend how current health
behaviors affect long-term health status. This is an especially important skill for adolescent
females who plan to have children or who become pregnant during late adolescence. Older teens
are now capable of learning problem solving skills that can assist them in overcoming barriers to
behavior change.
1)Genetic control: The height, weight or body-build of a child or an adult always represents the
resultant of both the genetical and environmental forces, together with their interaction. It is a
long way from the possession of certain genes to the acquisition of a height of 2m. gene depends
for its expression firstly on the internal environment created by all the other genes, and secondly
on the external environment. The control of body size is certainly a complicated affair involving
many genes, yet a disturbance in a single gene or group of genes may produce a widespread and
drastic effect, as in the condition of achondroplasia, which is inherited as a simple dominant. On
the other hand, the effects may be quite restricted and specific. The genetic control of dental
maturation and eruption appears to be separate from that of skeletal maturation, and there is even
evidence that the genes controlling the growth of different segments of the limbs are independent
of each other. It is now believed that dental development and the sequence of ossification are
primarily genetically controlled; the timing of ossification is partly influenced by genetic factors
and partly by environmental ones. Maturation as a whole is even more affected by environment,
but genetic influences are still detectable. It seems that the genetic materials operate throughout
entire period of growth. Heredity influenced the rate of growth of early maturers or late maturers.
Parent – offspring correlation in regard to height from birth to maturity for each are and sex has
been reported. Chromosomal abnormalities suggest genetical control on growth. Genetic factors
probably play the leading part in the difference between male and female patterns of growth.
5)Cultural: The physical growth of human beings is definitely affected by cultural factors.
Culture differs from ethnic group to ethnic group. The body growth differences correlate with
varied cultural groups. The physical growth of the body follows some adaptations in different
geographical areas of distribution of the groups.
6)Socio economic: Socioeconomic influence on human growth is also a well known factor.
Children from different socioeconomic levels differ in average body size at all ages that have
been investigated. The upper groups being always more advanced along the course to maturity.
The cause of this socio - economic differential are
probably multiple. Nutrition is almost certainly one, and with it all the habits of regular meals,
sleep, exercise and general organization that distinguish, from the point of view, a good home
from a bad one. Growth differences are more closely related to the home conditions than to the
strictly economic status of the families and home conditions reflect the intelligence and
personality of the parents.
Size of family exerts an indirect influence on the rate of growth. In a large
family with limited income the children do not get proper nutrition. As a result the growth is
affected. The number of children in the family exerts an effect on the children’s rate of growth.
Children in large families have been shown to be usually smaller and lighter than children in
small families. Possibly this is because in large families children tend to get less individual care
and attention.