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Advanced Bioinorganic Chemistry Syllabus

This document provides the syllabus for Chemistry 502, an advanced course on bioorganic and inorganic chemistry offered in the winter of 2011, which will cover topics at the interface of biology and chemistry including metal ion homeostasis and nucleic acids. The course will be taught by two professors and evaluated through a midterm, paper critique, and final exam. Students will write a short critique paper on a current topic by analyzing a research article from a relevant journal published between 2008-2011.

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Radu Suciu
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56 views2 pages

Advanced Bioinorganic Chemistry Syllabus

This document provides the syllabus for Chemistry 502, an advanced course on bioorganic and inorganic chemistry offered in the winter of 2011, which will cover topics at the interface of biology and chemistry including metal ion homeostasis and nucleic acids. The course will be taught by two professors and evaluated through a midterm, paper critique, and final exam. Students will write a short critique paper on a current topic by analyzing a research article from a relevant journal published between 2008-2011.

Uploaded by

Radu Suciu
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd

Chemistry 502 - SYLLABUS

Advanced Bio Organic & Inorganic Chemistry


Winter 2011

Tue and Thu, 10:05-11:25 am, Room: Otto Mass 217


Prerequisites: Organic Chemistry 302, or permission from instructor.

Instructors:
Dr. D. Scott Bohle (Jan 4th – Feb 17th)
Office: Otto Maass 233A; Tel. 514-398-7409; Email: [Link]@[Link]
Dr. Masad J. Damha (March 1st – April 7th )
Office: Otto Maass 413A; Tel. 514-398-7552; Email: [Link]@[Link]

Evaluation:
Midterm (Feb 17; OM 217; 10-11:30am) 35%
Critique (Due April 7 – at noon) 25%
Final Exam (date TBA) 35%

There is no required textbook for this course however we recommend Biochemistry by Voet and
Voet. Whenever possible, relevant material will be handed in class.

The following relevant Textbooks are available on Reserve at the Schulich [Link]. Library:
(a) Hermann Dugas, In Bioorganic chemistry: a chemical approach to enzyme action; (b) Donald
Voet and Judith G. Voet, In Biochemistry; (c) Robert A. Copeland, In Enzymes: A Practical
Introduction to Structure, Mechanism, and Data Analysis.

TOPICS
I. Introduction: problems at the interface of biology and chemistry.
II. Distilled principles of biochemistry and cell biology.
III. Metal ion Homeostasis, bioinorganic redox chemistry & the electron transport chain.
IV. Phosphate chemistry.
V. Nucleosides, nucleic acids, amino acids and peptides.

Critique: Select a topic of current interest in Bioorganic & Bioinorganic Chemistry. To do


this, check out a "hot" article published in one of the following journals and write a short
CRITIQUE (not a review) of it: Science, Nature, Proceedings of the National Academy of
Sciences, Biochemistry, Angewandte Chemie International Edition, Journal of the American
Chemical Society, ACS Chemical Biology, Inorganic Chemistry, Nucleic Acids Research,
Chemistry & Biology, ChemBioChem, Organic Letters, Journal of Biological Chemistry, and
Journal of Medicinal Chemistry (the article must have been published within 2008-2011).
Topics will be approved on a first-come basis, and no duplicate topics will be allowed, so make
your choice early to avoid disappointment, and have a back-up in mind. Avoid picking up an
article which you have presented or written on in the past.
The essay must not exceed 8 pages in length including references; format: 1.5 line
spacing, font size 12, 1-in margins. There will be deductions for essays exceeding this page limit
or not following the required format. You must also include copies of the 2 or 3 most significant
references that you used in preparing the report (these are to be collated to your essay and should
not exceed an additional 20 pages; please don't photocopy an entire book!).
On the front page, start the essay with the Title of the article and Your Name, followed
by an Abstract (1 paragraph) summarizing your essay (not the article). This is followed by a
brief Summary of the article (ca. 1-2 pages). The remaining pages should provide a detailed
Critique of the article (strengths, weaknesses, mistakes, technical problems, etc), and finally a
short Conclusion of your essay (1 paragraph). Insert many figures in text to help the reader. No
more than one page of References (typically 0.5 page) should be included in the 8 pages of your
essay. The essay is due on Tue April 7 at NOON (bring to Departmental Office, Room 322,
Otto Maass).

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