Urinary Incontinence
In the field of geriatrics, the terms used are often not useful clinical.
Currently, most discharge summaries list urinary incontinence were poorly as urinary incontinence is
not a diagnosis
An alternative discharge summary if chest pain and haematemesis is presented the way urinary
incontinence is usually presented.
Ageing bladder
- Decline in
Detrusor contraction
Capacity
Flow rates
Sensory function
- Increase
Post-micturition volume
Urethral resistance
Uninhibited contraction
Nocturia
- Other
Prostatic hypertrophy – In males
Vaginal mucosa atrophy – In females
Reduction in acetylcholinesterase nerves
Less compliant bladder
As one gets older
- Less warning of a full bladder
- Prostatic symptoms
- Increase frequency
- Nocturia
- Less agile
- But patients tend to get wiser
Standard causes of urinary incontinence
- Urge
Detrusor instability
Overactive bladder (OAB) – Idiopathic
Detrusor hyperreflexia
Upper motor neurology
Stroke
Dementia
Multiple sclerosis (MS)
High cord
Detrusor hyperactivity with hypo-contractility
- Stress When patients cough, it can result in leakage
Sphincter deficiency
Post-operative
Trauma (obstetric)
Ageing
Radiation
Neurology low spinal cord
Neuropathy
Radiation
- Retention
Obstruction
Detrusor hyperactivity with hypo-contractility
Dyssynergy
Neurological
Lower cord
Continence is controlled by the autonomic nervous system (ANS)
For urinary incontinence in the elderly, consider
- Acute/Reversible vs persistent
- Medical history/comorbidities
- Drugs
- Environment
- Social
Acute/reversible causes – DIAPPERS
- D: Delirium
- I: Infection
- A: Atrophic vaginitis
- P: Pharmaceuticals
- P: Psychological
- E: Excess fluid and out
- R: Restricted mobilty/dexterity
- S: Stool impaction
Takes a history
- DIAPPERS
- Urgency symptoms
- Stress
- Neurological symptoms
Examination
- Per rectal
- Per vaginal
AXR can be used as part of work-up as well
Geriatric assessment includes
- Pre-morbid function
- Cognitive
- Drugs
- Other
Social
Sensory
Vision
Hearing
Dentition
Comorbidities affect continence
- Impaired
Physical
Cognitive
Sensory/motor deficits
Communication
- Raised abdominal pressures
Chronic lung disease
- Increased nocturia
Diabetes mellitus (DM)
Heart failure
Hypercalcaemia
Venous insufficiency
Urinary incontinence red flags
- Sudden onset
- Neurological symptoms
- Pain
- Haematuria
Physical examination
- Central nervous system
Sensory/motor
- Rectal
Anal ring power
Prostate – in males
- Genito urinary
Lesions
Prolapse
- Functional ability
Balance
Dexterity
Activities of daily living (ADLs)
Investigations
- Urinalysis
- Bladder diaries (if patient is relatively well)
Time
Volume
Incontinence
Urgency
Triggers
- Imaging
- Urodynamics
- Pre- and post-void volumes
Urodynamics are usually done by surgical teams to help differentiate the need for surgical vs medical
management
Treatments are dependent on the cause
- Generic/non-medical
Weigh loss
Bladder retraining
Pelvic floor muscle exercises (Kegel exercises)
If cognitive impaired
Regular voiding
Double voiding
Voiding another time after patient thinks they are initially finished
Psychology
- Specialised treatments
Bladder botox
Useful for hyperactive bladders
Sacral nerve remodulation – I.e., “Pacemaker” for the bladder
Surgery
Usually for stress incontinence
Drugs used for detrusor instability
- β3-agonist: Mirabegron
- M3 blocker: Anticholinergic agents
Drugs used for OAB – Effectiveness of anticholinergics
- Oxybutynin
- Propantheline
- Tolterodine
- Trospium
- Propiverine
- Solifenacin
- Improvements in
Leakages in 24h: ~1
Number of voids/24h: ~1
Volume of voids: 40-60ml
- Conclusion
“For many of the outcomes studied, the observed difference between anticholinergics
and placebo may be of questionable clinical significance”
- M1:
Brain
Salivary glands
- M2:
Smooth muscle
80% of detrusor
Heart
Midbrain
- M3:
Smooth muscle
20% of detrusor
Salivary glands
Some brain tissues
Ocular lens
- M4:
Forebrain
- M5:
Substantia nigra
Eyes
Anticholinergic agents are antimuscarinic and hence anti-parasympathetic. Hence, sympathetic
effects predominate
- As such, side effects include
Constipation
Xerostomia
Blurred vision
Tachycardia
Urinary retention
Anticholinergics and the brain
- Mild cognitive impairment (MCI)
Memory
Language
Visuospatial
Reaction time
Attention
- Dementia
Oppose the cholinesterase inhibitors
Increased risk of delirium
- Delirium
Increased
Hosptial stay
Functional decline
Morbidity and mortality
Nursing home placements
Many drugs have anti-cholinergic effects including
- Oxybutinin
- Nifedepine
- Amytryptilline
- Atropine
- Diltiazem
- Benztropine
- Isosorbide dinitrate
- Dihenhydramine
Ageing has important effects on drugs
- Changes in ageing
Renal and hepatic ageing
Fat/water and albumin
Receptors and transport less efficient
Drug history – Simplify
- Do the drugs match the diagnosis?
Are they appropriate?
- Are there side effects and are they worth it?
- Can the drugs be stopped?
Non-medical issues affecting continence
- Who they live with
- Privacy
- Anxiety
Fear of being incontinent
Incontinence requires a multidiscplinary approach
- Occupational therapists (OT)
- Physiotherapists
- Pharmacist
- Speech pathologist
- Nurse specialist
- Social worker
- Dietician
- Dentist
- Optician
- Auditory specialisit
Environment – Indoor
- Toilet modification
Rails
Raised seats
- Personal
Mobility
Velcro/aids
Commodes/bottle
Pads/catheter
- Staff/centre involvement
Prompt/ timed and double voids
Good signage and pictures
As a doctor it is important to understand the causes and exacerbations of urinary incontinence in
order to be able to properly manage it.
First line advice – to all patients
- Drink less
Stop drinking after 6pm
Including alcohol
- Avoid caffeine
- Stop smoking
- Additional
Pelvic floor exercises
Lose weight
Bladder retraining Can be done for all patients
Prompt/double voiding
Case 1
80 year old female
Gives a 3 year history of urinary urgency
Now has a 1 year history of urge incontinence, small frequency volumes, urgency and nocturia but
no pain.
Diagnosis? – Overactive bladder
Case 2
79 year old male
Presented to the hospital ED with following symptoms
- Not passing urine for 24 hours
- Abdomen really bloated and suprapubic pain and tenderness
Further history
- 2 years of decreased urinary flow, dribbling and nocturia
Diagnosis? – BPH
Case 3
49 year old male
Presented to ED with the following symptoms
- 3 days of incontinence and poor flow
- 3 days “off legs” now unable to walk overnight and can’t feel legs
Further History
- 1 year of cough, smoker, weight loss
Diagnosis – Cord Compression
Case 4
60 year female presented to their GP clinic with the following symptoms for 3 years
- Worsening incontinence
- No warning to incontinence
- Occurs with standing or coughing
- Has had 8 children via normal vaginal birth
- May have a prolapse
Diagnosis? – Weak pelvic floor