Ageing Process and Physiological Changes
Ageing Process and Physiological Changes
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Abstract
Ageing is a natural process. Everyone must undergo this phase of life at his or her own
time and pace. In the broader sense, ageing reflects all the changes taking place over the
course of life. These changes start from birth—one grows, develops and attains maturity.
To the young, ageing is exciting. Middle age is the time when people notice the age-related
changes like greying of hair, wrinkled skin and a fair amount of physical decline. Even the
healthiest, aesthetically fit cannot escape these changes. Slow and steady physical impair-
ment and functional disability are noticed resulting in increased dependency in the period
of old age. According to World Health Organization, ageing is a course of biological
reality which starts at conception and ends with death. It has its own dynamics, much
beyond human control. However, this process of ageing is also subject to the constructions
by which each society makes sense of old age. In most of the developed countries, the age
of 60 is considered equivalent to retirement age and it is said to be the beginning of old
age. In this chapter, you understand the details of ageing processes and associated phys-
iological changes.
1. Introduction
The term ‘Elderly’ is applied to those individuals belonging to age 60 years and above, who
represent the fastest growing segment of populations throughout the world. The percentage of
elderly in developing countries tends to be small, although numbers are often large. In the year
1990, there were more than 280 million people belonging to the age 60 years or over in
developing regions of the world, and 58% of the world’s elderly were living in less-developed
regions [1].
© 2018 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative
Commons Attribution License ([Link] which permits unrestricted use,
distribution, and reproduction in any medium, provided the original work is properly cited.
4 Gerontology
Figure 1. Speed of population ageing in developed countries. Source: U.S. Census Bureau [3]; Kinsella & Gist [4].
Figure 2. Speed of population ageing in developing countries. Source: U.S. Census Bureau [3]; Kinsella & Gist [4].
Ageing Process and Physiological Changes 5
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It is expected that by the year 2020, 70% of the world’s elderly population will be in developing
countries, with the absolute number exceeding 470 million which is double the number of the
developed world [5]. The main factor responsible for this changing pattern of population
ageing includes a rapid decline in both fertility and premature mortality [6]. Decline in fertility
is particularly apparent in some developing countries like China, Cuba and Uruguay, although
the fertility level in other developing countries such as Kenya, Zaire and Bangladesh remains
high [7].
Ageing is associated with many neurological disorders, as the capacity of the brain to transmit
signals and communicate reduces. Loss of brain function is the biggest fear among elderly
which includes loss of the very persona from dementia (usually Alzheimer’s disease). Multiple
other neurodegenerative conditions like Parkinson’s disease or the sudden devastation of a
stroke are also increasingly common with age [8].
Alzheimer’s and Parkinson’s diseases are the progressive neurodegenerative diseases associ-
ated with ageing [9]. Alzheimer’s is characterised by progressive cognitive deterioration along
with a change in behaviour and a decline in activities of daily living. Alzheimer’s is the most
common type of pre-senile and senile dementia. This disease causes nerve cell death and tissue
loss throughout the brain, affecting nearly all its functions. The cortex in the brain shrivels up
and this damages the areas involved in thinking, planning and remembering. The shrinkage in
a nerve cell is especially severe in the hippocampus (an area of the cortex that plays a key role
in the formation of new memories) as well as the ventricles (fluid-filled spaces within the
brain) also grow larger. Alzheimer’s disease causes an overall misbalance among the elderly
by causing memory loss, changes in personality and behaviour-like depression, apathy, social
withdrawal, mood swings, distrust in others, irritability and aggressiveness [10, 11].
Nearly, 33 million Indians have neurological disorders, and these occur twice as often in rural
areas [12]. According to the World Health Organisation (WHO) [13], nearly 5% of men and 6%
of women aged 60 years or above are affected with Alzheimer’s-type dementia worldwide. In
India, the total prevalence of dementia per 1000 elderly is 33.6%, of which vascular dementia
constitutes approximately 39% and Alzheimer’s disease constitutes approximately 54% [14].
Stroke is another common cause of mortality worldwide [13]. However, in India, the preva-
lence rate of stroke among elderly is reported to be very low compared to Western countries
[15–17].
2.2. Cognition
A mild decline in the overall accuracy is observed with the beginning of the 60s that progresses
slowly, but sustained attention is good in healthy older adults. Cognitive function declines and
6 Gerontology
impairments are frequently observed among the elderly. Normally, these changes occur as
outcomes of distal or proximal life events, where distal events are early life experiences such
as cultural, physical and social conditions that influence functioning and cognitive develop-
ment [17].
Cognition decline results from proximal factors (multiple serial cognitive processes) including
processing speed, size of working memory, inhibition of extraneous environmental stimuli and
sensory losses. This is a threat to the quality of life of those affected individuals and their
caregivers [18].
Impaired cognition among elderly is associated with an increased risk of injuries to self or others,
the decline in functional activities of daily living and an increased risk of mortality [19–21]. Mild
cognitive impairment is increasingly being recognised as a transitional state between normal
ageing and dementia [22, 23].
According to various studies [24–26], the effect of normal ageing on memory may result from the
subtly changing environment within the brain. The brain’s volume peaks at the early 20s and it
declines gradually for rest of the life. In the 40s, the cortex starts to shrink and people start noticing
the subtle changes in their ability to remember or to do more than one task at a time. Other key
areas like neurons shrink or undergo atrophy and a large reduction in the extensiveness of
connections among neurons (dendritic loss) is also noticed. During normal ageing, blood flow in
the brain decreases and gets less efficient at recruiting different areas into operations. The whole
group of changes taking place in the brain with ageing decreases the efficiency of cell-to-cell
communication, which declines the ability to retrieve and learn [27]. It also affects the intelligence,
especially fluid intelligence (problem-solving with a novel material requiring complex relations)
declines rapidly after adolescence. Perceptual motor skills (timed tasks) decline with age [28].
2.4.1. Vision
Ageing includes a decline in accommodation (presbyopia), glare tolerance, adaptation, low-
contrast activity, attentional visual fields and colour discrimination. Changes occur in central
processing and in the components of the eye. These numerous changes affect reading,
balancing and driving [29].
2.4.2. Hearing
Ageing causes conductive and sensory hearing losses (presbycusis); the loss is primarily high
tones, making consonants in speech difficult to discriminate [30].
salivary glands get affected, and the volume and quality of saliva diminish. All changes
combine to make eating less interesting [32]. Studies show that the physiological decline in
the density of the taste acuity and papillae results in a decline of gustatory function [33]. In
fact, studies done on taste dysfunction show that ageing-associated changes in the density of
taste acuity may affect taste function differently in different regions of the tongue [34]. Taste
perception declines during the normal ageing process. A study done on the healthy elderly
shows that after about 70 years of age, taste threshold begins to increase resulting in dysgeusia
[34]. Chewing problems associated with loss of teeth and use of dentures also interfere with
taste sensation and cause reduction in saliva production [32].
2.4.4. Smell
As we get older, our olfactory function declines [35]. Hyposmia (reduced ability to smell and to
detect odours) is also observed with normal ageing [36]. The sense of smell reduces with an
increase in age, and this affects the ability to discriminate between smells. A decreased sense of
smell can lead to significant impairment of the quality of life, including taste disturbance and
loss of pleasure from eating with resulting changes in weight and digestion [36].
It has been reported that more than 75% of people over the age of 80 years have evidence of
major olfactory impairment. Many long-term studies show the evidence of a decline in olfac-
tion considerably after the seventh decade [37]. Another study found that 62.5% of 80–97-year-
olds had olfactory impairments [38]. However, it is widely accepted that taste disorders are far
less prevalent than olfactory losses with age [38]. Ageing also causes atrophy of olfactory bulb
neurons. Central processing is altered, resulting in a decreased perception and less interest in
food [39].
2.4.5. Touch
As we age, our sense of touch often declines due to skin changes and reduced blood circulation
to touch receptors or to the brain and spinal cord. Minor dietary deficiencies such as the
deficiency of thiamine may also be a cause of changes [40]. The sense of touch also includes
awareness of vibrations and pain. The skin, muscles, tendons, joints and internal organs have
receptors that detect touch, temperature or pain [41].
A decline in the sense of touch affects simple motor skills, hand grip strength and balance.
Studies have shown that muscle spindle (sensory receptors within the muscle that primarily
detects changes in the length of this muscle) and mechanoreceptor (a sense organ or a cell that
responds to mechanical stimuli such as touch or sound) functions decline with ageing, further
interfering with balance [42].
Normal ageing is characterised by a decrease in bone and muscle mass and an increase in
adiposity [43, 44]. A decline in muscle mass and a reduction in muscle strength lead to risk of
8 Gerontology
fractures, frailty, reduction in the quality of life and loss of independence [45]. These changes in
musculoskeletal system reflect the ageing process as well as consequences of a reduced physical
activity. The muscle wasting in frail older persons is termed ‘sarcopaenia’. This disorder leads to
a higher incidence of falls and fractures and a functional decline. Functional sarcopaenia or age-
related musculoskeletal changes affect 7% of elderly above the age of 70 years, and the rate of
deterioration increases with time, affecting over 20% of the elderly by the age of 80 [46]. Strength
declines at 1.5% per year, and this accelerates to as much as 3% per year after 60 years of age [47].
These rates were considered high in sedentary individuals and twice as high in men as compared
with those in women [48]. However, studies show that on an average, men have larger amounts
of muscle mass and a shorter survival than women. This makes sarcopaenia potentially a greater
public health concern among women than among men [48].
Skeletal muscle strength (force-generating capacity) also gets reduced with ageing [45, 46]
depending upon genetic, dietary and, environmental factors as well as lifestyle choices. This
reduction in muscle strength causes problems in physical mobility and activity of daily living.
The total amount of muscle fibres is decreased due to a depressed productive capacity of cells
to produce protein. There is a decrease in the size of muscle cells, fibres and tissues along with
the total loss of muscle power, muscle bulk and muscle strength of all major muscle groups like
deltoids, biceps, triceps, hamstrings, gastrocnemius (calf muscle), and so on. Wear and tear or
wasting of the protective cartilage of joints occurs. The cartilage normally acts as a shock
absorber and a gliding agent that prevents the friction injuries of the bone. There are stiffening
and fibrosis of connective tissue elements that reduce the range of motion and affect the
movements by making them less efficient. As part of the normal cell division process, telomere
shortening occurs. DNA is more exposed to chemicals, toxins and waste products produced in
the body. This whole process increases the vulnerability of cells.
With ageing, toxins and chemicals build up within the body and tissues. As a whole, this
damages the integrity of muscle cells. Physical activity also decreases with age, due to a change
in lifestyle. Somehow, the physiological changes of the muscles are aggravated by age-related
neurological changes [49]. Most of the muscular activities become less efficient and less
responsive with ageing as a result of a decrease in the nervous activity and nerve conduction.
A study was done by Williams et al. [50], who evaluated the muscle samples from both elderly
and young adults and suggested that limb muscles are 25–35% shorter and less responsive in
elderly healthy individuals when compared to young adults. In addition, the overall fat
content of muscles was also higher in elderly population, suggesting transformation in the
normal remodelling with age. Age-related musculoskeletal changes are much more prominent
in fast-twitch muscle fibres as compared to slow-twitch muscle fibres. With ageing, the total
water content of the tissue decreases and loss of hydration also adds to the inelasticity and
stiffness. Alterations in the basal metabolic rate and slowing metabolism (as part of the
physiological ageing process) result in muscle changes. This leads to the replacement of pro-
teins with fatty tissue (that makes muscle less efficient).
Hormonal disorders can affect the metabolism of bones as well as muscles. Research suggests
that menopause in women marks the aggravation in the deterioration of musculoskeletal
changes due to lack of oestrogen that is required for the remodelling of bones and soft tissues.
Certain systemic conditions like vascular disorders or metabolic disorders, in the case of
Ageing Process and Physiological Changes 9
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diabetes, affect the remodelling of tissues as the rate or volume of nutritional delivery for the
regeneration of cells is compromised. It is very important to control the pathological processes to
optimise healing and repairing the potential of the musculoskeletal system. Essential vitamins
like vitamin D and vitamin C play major roles in the functional growth of muscles and bones.
Lack of certain minerals like calcium, phosphorus and chromium can be the result of age-related
digestive issues. As such, it results in imbalance in the production of certain hormones like
calcitonin and parathyroid that regulate the serum concentration of vitamins and minerals (due
to tumours that are highly prevalent in elderly) or it causes a decreased absorption from the gut.
Age-related deterioration of muscular strength and balance control mechanisms has been
associated with a reduced performance on functional tasks [51–53]. Comparing the isometric
strength levels of the same muscle group, the loss of strength begins sooner among women
than among men. It is reported that women are weaker than men in the absolute strength of
various muscle groups in all stages of life. Various studies state that women have a longer life
span, so the prevalence of disability among women is also more compared with men and it is
marked with advancing age [54–56].
The human body is made up of fat, lean tissue (muscles and organs), bones and water. After
the age of 40, people start losing their lean tissue. Body organs like liver, kidneys and other
organs start losing some of their cells. This decline in muscle mass is associated with weakness,
disability and morbidity [57, 58].
The tendency to become shorter occurs among the different gender groups and in all races.
Height loss is associated with ageing changes in the bones, muscles and joints. Studies show
that people typically lose almost one-half inch (about 1 cm) every 10 years after age 40 [59].
Height loss is even more rapid after age 70. These changes can be prevented by following a
healthy diet, staying physically active and preventing and treating bone loss [60, 61].
Changes in the total body weight vary for men and woman, as men often gain weight until
about age 55 and then begin to lose weight later in life. This may be related to a drop in the
male sex hormone testosterone. Women usually gain weight until age 67–69 and then begin to
lose weight. Weight loss later in life occurs partly because fat replaces lean muscle tissue and
fat weighs less than muscle [60]. Studies have also shown that older people may have almost
one-third more fat compared to when they were younger. Fat tissue builds up towards the
centre of the body, including around the internal organs [60, 62, 63].
Today, as standards of living continue to rise, weight gain is posing a growing threat to the health of
inhabitants from countries all over the world. Obesity is a chronic disease, prevalent in both
developed and developing countries, and it is affecting all age groups. Indeed, it is now so common
10 Gerontology
that it is replacing the more traditional public health concerns, such as infectious diseases and
undernutrition, as the most common and significant contributors of ill health [64–67] (Figure 3).
As per World Health Organisation (WHO), globally, approximately 2.3 billion elderly people
are overweight and more than 700 million elderly people are obese [68]. Most elderly belong-
ing to the middle and high socio-economic groups are prone to obesity and complications
related to obesity, due to sedentary lifestyles and a reduced physical mobility [69]. Obesity is
considered as one of the major risk factors which causes the onset and increases the severity of
non-communicable diseases (NCDs). It is a worldwide health problem, affecting elderly from
both developed and developing countries. In elderly, obesity contributes to the early onset of
chronic morbidities and functional impairments which lead to premature mortality [70].
The population in developed countries have proportionally a greater number of older adults living
to older ages, and the prevalence of obesity is rising progressively, even among this age group [71].
The prevalence of obesity among elderly belonging to United States ranges from 42.5% in
women to 38.1% in men, belonging to the age group 60–79 years. The prevalence differs for
the elderly belonging to the age group 80 years and above, that is, 19.5% for females and 9.6%
for males [72–74].
Comparatively, the prevalence of obesity in Europe is slightly lower but it is still a significant
health issue. The prevalence of obesity among elderly in the United Kingdom is 22% among
women and 12% among men aged 75 years or older [70, 75–77]. These statistics bode ill as the
proportion of world’s elderly population is growing rapidly (Figure 4).
In Australia, the percentage of weight gain has been so high that instead of losing weight with
an increase in life, men and women aged 60–70 weigh more on average than they did when
they were 20 years younger (Figure 5). Australian studies show that the prevalence of obesity
Figure 3. Prevalence of obesity among elderly aged 60 years and above, by sex: The United States, 2013. Source: [68].
Ageing Process and Physiological Changes 11
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Figure 4. Trends in weight by age cohort, 1980–2000 (Australia). Source: Bennett et al. [81].
Figure 5. Worldwide prevalence of obesity among elderly women and men with BMI of ≥30 kg/m2. Source: OECD [79].
Analysis of health survey data.
12 Gerontology
among elderly has increased in the age group of 60–69 years at about 24% for males and 30%
for females, whereas it is less common among the elderly belonging to age group 80 years and
above [78, 80]. Studies show that the percentage of Australian elderly reporting increased
abdominal fat is markedly increasing over the years. Based on waist circumference, more than
30% of elderly males and 44% of elderly females in Australia are currently at a substantially
increased risk of NCDs [78, 80, 81].
Studies from the Netherlands show that obesity was present in 18% of men and 20% of women
belonging to the age group of 60 years and above [82]. Also, the increase in waist circumfer-
ence ranged from 40% among males to 56% among females [82, 83].
In France, studies show that the prevalence of obesity among elderly was relatively stable
during early years (1980–1991), 6.4–6.5% in males and 6.3–7.0% among females [83], but
studies from recent years [84, 85] have highlighted a sharp increase in obese elderly,
19.5% for both males and females; this prevalence rate decreased gradually after 70 years
of age, that is, from 19.5 to 13.2% [86]. The Scottish Health Survey shows that in 10 years
(2003–2013), the prevalence of obesity has increased as the body mass index (BMI) con-
tinues to rise in people 60–70 years of age, especially among females [87]. In this same
period, there was an increased curve shown for the waist circumference (5–10 cm) in both
the sexes between 50 and 70 years of age. This inappropriate increase in waist circumfer-
ence and a slight increase in BMI in the Scottish Health Survey may indicate a substantial
gain in visceral fat mass and loss of lean tissue that predisposes to ill health in the obese
elderly [88, 89].
In Spain, 35% of subjects aged 65 years or older suffered from obesity (30.6% of males and
38.3% of females) and 61.6% had an increased waist circumference (50.9% of males and 69.7%
of females) [88].
Over the past years, obesity among elderly was considered as a problem only in high-income
countries, but the trend is changing now; excess weight, as well as obesity, is dramatically
increasing in low-income and middle-income countries as well, particularly in urban settings
[90]. Various studies show a significant change in the mean body weight, physical activity and
diet along with progressive economic development in developing countries. Possibilities are
high that obesity and its co-morbidities will continue to affect an increasing number of
populations in these regions. Lifestyle and environmental factors are acting in a synergistic
manner to fuel the obesity epidemic. As per WHO estimates, there is a decline in undernour-
ished population across the world, whereas the overnourished population has increased to 1.2
billion [90]. A WHO report shows that more than 1 billion elderly are overweight and 300
million are obese. The problem of obesity is increasing in the developing world with more than
115 million people suffering from obesity-related problems [90]. The obesity rate has increased
threefold or more since 1980 in the Middle East, the Pacific Islands and India [91, 92]. However,
the prevalence of obesity is not as high in all developing countries, like China and some
African nations [93].
Ageing Process and Physiological Changes 13
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As per the WHO report, the prevalence of overweight and obese elderly in China was 19.0 and
2.9%, respectively. However, the prevalence has increased over the past years; in the latest
study, the prevalence of overweight and obesity among elderly was 21.0 and 7.4% [94, 95].
There was a slight increase in the prevalence of overweight and obesity among women than
among men in China.
According to WHO estimates, among all Gulf regions, Kuwait ranked number one with the
highest prevalence of overweight and obesity (78.8%) among elderly (60 years and above) [92].
Worldwide, Kuwait is ranked 11th, that is, the highest in obesity among the Arab countries
and the Middle East [93, 96]. Studies from Sri Lanka show a prevalence rate of 25.2% for
overweight and 9.2% for obesity. The prevalence of central obesity among elderly was highest
at 26.2% [97, 98]. The prevalence of overweight and obesity in Brazil was 41.8% for females and
23.4% for males. According to the prevalence studies of obesity among elderly in Nigeria [99],
overweight among elderly ranged from 20.3 to 35.1% and obesity ranged from 8.1 to 22.2%.
WHO reported that the prevalence of obesity in Sub-Saharan African countries ranged
between 3.3 and 18.0% and that obesity has become a leading risk factor for diabetes mellitus
and cardiovascular diseases in the urban areas of Africa [93, 99]. The situation can get worse
within a decade if the present trend continues and overweight could emerge as the single most
important public health problem in adults. Overweight or obesity may not be a specific disease
but it is certainly considered as a major contributory factor leading to various degenerative
diseases in adult life. Prevention and control of this problem must, therefore, claim priority
attention [100].
As per a study done in Delhi on urban elderly, nearly 14% of men and more than 50% of
women belonging to what may be a higher-income group (HIG) were overweight (BMI >25)
and obese (BMI >30) [101]. The prevalence of abdominal obesity among the elderly group was
also reported as high. Assuming that the HIG in India number is around 100 million (half the
number of the middle class), it may be computed that there are roughly 40–50 million over-
weight subjects belonging to the HIG in the country today. Visweswara et al. [102] studied
females of Hyderabad (60 years and above) belonging to the high socio-economic status and
reported the prevalence rate of obesity as 36.3%. Gopinath et al. [103] studied urban elderly in
Delhi and reported the rate of prevalence of obesity as 33.4%. A study done in the Union
Territory of Chandigarh showed an increase in BMI (>25) resulting in the high prevalence rate
of overweight (33.14%) and obesity (7.54%) among elderly [104, 105].
The relationship between energy intake and energy expenditure is an important determinant
of body fat mass. Obesity occurs when the consumption of calories is more than the calorie
expenditure. The possible causes of obesity are depicted in Figure 6. Various studies indicate
that how much we eat does not decline with advancing age; therefore, it is likely that a
decrease in energy expenditure particularly in the beginning of old age (50–65 years) contrib-
utes to the increase in body fat as we age [62, 106]. At the age of 65 years and above, hormonal
14 Gerontology
changes cause an accumulation of fat. Ageing is associated with a decline in the secretion of
growth hormone, serum testosterone, resistance to leptin and a reduced responsiveness to
thyroid hormone [107]. Studies show that resistance to leptin could cause a decrease in the
ability to regulate appetite downward [74]. Several other genetic, environmental and social
factors contribute to obesity among elderly.
Science does show a link between obesity and heredity [109]. Various studies indicate that obesity
is related to the inherited genes and there is a link between obesity and heredity [110–113].
According to a study, visceral fat is more influenced by the genotype than subcutaneous fat [114].
Like genetics, environment also has a major role to play in obesity. The food we consume,
physical activity and lifestyle behaviour are all influenced by the environment. For example,
the adoption of modern diet over traditional diet, the trend towards ‘eating out’ rather than
Ageing Process and Physiological Changes 15
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preparing food in the home, the development of high-rise buildings that often lack sidewalks
and a deficit of readily accessible recreation areas are some of the common environmental
factors associated with obesity.
Poverty and low education level also appeared as a reason for obesity among elderly. Studies
state that the lack of nutritional knowledge, purchase of low-cost fat and organ meat are also
associated with overweight and obesity. Poor hygienic conditions also appeared as a major
reason [114].
Other health issues and illnesses that are associated with obesity and weight gain are
hyperthyroidism, polycystic ovary syndrome, Cushing’s syndrome and depression [2].
Obese elderly are more likely to report symptoms of depression, such as hopelessness,
sadness or worthlessness [115]. Sleep plays a major role. Lack of sleep contributes to obesity
[106]. Certain drugs, such as antidepressants and steroids, may stimulate appetite or cause
water retention or reduce the metabolic rate [82], causing an increase in weight. Health
issues like arthritis and joint pain decrease mobility and activity intolerance, contributing to
obesity [116]. Joint pain decreases mobility, and activity intolerance may lead to weight gain
because of a decreased activity. Older adults are more likely than younger adults to experi-
ence functional limitations associated with chronic illnesses that may begin a stress-pain-
depression cycle that can result in lifestyle patterns leading to obesity [117]. Finally, the
complex relationship between lifestyle pattern and functional ability merits attention as a
contributor to obesity [93].
7. Conclusion
Conflict of interest
Author details
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![fractures, frailty, reduction in the quality of life and loss of independence [45]. These changes in
musculoskeletal system r](/p?url=https%3A%2F%2Fscreenshots.scribd.com%2FScribd%2F252_100_85%2F365%2F492291853%2F7.jpeg&__src=https%3A%2F%2Fwww.scribd.com%2Fdocument%2F492291853%2FAgeing-Process-and-Physiological-Changes&__type=image)


![Figure 4. Trends in weight by age cohort, 1980–2000 (Australia). Source: Bennett et al. [81].
Figure 5. Worldwide prevalence](/p?url=https%3A%2F%2Fscreenshots.scribd.com%2FScribd%2F252_100_85%2F365%2F492291853%2F10.jpeg&__src=https%3A%2F%2Fwww.scribd.com%2Fdocument%2F492291853%2FAgeing-Process-and-Physiological-Changes&__type=image)