23
1. Which of the following would probably not be a characteristic of the Tn3 transposon?
A. i nverted repeat sequences
B. a
ntibiotic resistance gene(s)
C. resolvase gene
D. transposase gene
E. o ri t site
2. Barbara McClintock discovered the first eukaryotic transposable element in
A. f ruit flies.
B. n
ematodes.
C. maize.
D. fungi.
E. p eas.
3. The Ds transposable element of maize cannot transpose on its own because it lacks
A. t ransposase.
B. i nverted repeats.
C. origin of replication.
D. antibiotic resistance.
E. T n10.
4. Hybrid dysgenesis refers to the fact that in Drosophila a cross between a P male and an M
female produce offspring that are
A. d
ead.
B. w
ingless.
C. blind.
D. sterile.
E. h
airless.
5. In order for P element transfer to happen in Drosophila which of the following situations must
occur?
A. a
P crossed with a P female
B. a
P male crossed with an M female
C. an M male crosses with a P female
D. an M male crossed with an M female
E. a
ny male crossed with a P female
6. Which of the following is not true concerning immunoglobulin gene recombination signal
sequences?
A. T
here is a conserved heptamer.
B. T
here is a conserved nonamer.
C. The conserved sequences are separated by a nonconserved sequence of either a 12 bp or a
23 bp sequence.
D. Recombination occurs between a 12 bp signal and a 23 bp signal.
E. R
ecombination only occurs between two heptamers.
7. Which of the following molecules serves as a primer for reverse transcriptase during retroviral
replication?
A. h
ost snRNA
B. v iral RNA
C. host tRNA
D. viral DNA
E. h ost DNA
8. Which of the following is not necessary for retroviral insertion into the host genome?
A. R
NA polymerase II
B. r etroviral pol gene
C. viral protease
D. RNase H
E. r everse transcriptase
9. Which of the following has no reverse transcriptase gene associated with it?
A. H
IV
B. T
y
C. copia
D. L1
E. T
n3
10. Which of the following transposons does not contain LTRs or inverted repeats at its ends?
A. T
y
B. A
lu elements
C. copia
D. Tn3
E. D
s
11. Transposable elements or _________ are DNA fragments that can move from one organism to
another.
________________________________________
12. Bacterial insertion sequences are the simplest of transposons and contain only short inverted
repeat ends and genes for ___________.
________________________________________
13. In ____________transposition both strands of the original DNA move together whereas in
_________ transposition one copy of the DNA moves to a new site while one copy stays in the
genome.
________________________________________
14. __________ receptor genes undergo rearrangement in a manor similar to B-cell immunoglobulin
genes.
________________________________________
15. Somatic hypermutation greatly increases antibody ______.
________________________________________
16. Individuals with SCID, severe combined immunodeficiency disease, have defective ________
genes, which cause loss of B-cell and T-cell function.
________________________________________
17. _______________ is an enzyme that can synthesize DNA from an RNA template.
________________________________________
18. DNA sequences that resemble normal genes but do not function are called________.
________________________________________
19. Insertion of a Group II intron of a particular gene into an intronless version of that same gene is
called_______.
________________________________________
20. Insertion sequences are transposable elements that can inactivate genes.
True False
21. 5′-ACCGTAG—GATGCCA-3′ is an example of an inverted repeat sequence.
True False
22. Antibiotic resistance in bacteria can be transferred using insertion sequences.
True False
23. There are two transposable elements, Ds and Ac, which are necessary for variegation in maize
kernel color.
True False
24. Hybrid dysgenesis may lead to the formation of new species.
True False
25. A Drosophila P female contains the P transposition repressor that prevents hybrid dysgenesis
from occurring.
True False
26. The constant region of an antibody contains the antigen binding domains.
True False
27. Rearrangement of mammalian cell immunoglobulin genes is responsible for the large diversity of
antibodies produced by B-cells.
True False
28. The recombinases RAG-1 and RAG-2 are expressed in both plasma and memory B-cells.
True False
29. HERVs, human endogenous retroviruses make up about 10–20% of the human genome.
True False
30. Non-LTR retrotransposons, such as L1, occupy more of the human genome than exons do.
True False
31. Group II introns are non-LTR retrotransposons that are found only in bacterial cells.
True False
32. The loss of bases or gain of bases is common in immunoglobulin gene rearrangement.
True False
33. Another name for a retrovirus is a retrotransposon.
True False
23 Key
1. Which of the following would probably not be a characteristic of the Tn3 transposon?
A. inverted repeat sequences
B. antibiotic resistance gene(s)
C. resolvase gene
D. transposase gene
E. ori t site
Blooms Level: 1. Remember
Section: 23.01
Weaver - Chapter 23 #1
2. Barbara McClintock discovered the first eukaryotic transposable element in
A. fruit flies.
B. nematodes.
C. maize.
D. fungi.
E. peas.
Blooms Level: 1. Remember
Section: 23.02
Weaver - Chapter 23 #2
3. The Ds transposable element of maize cannot transpose on its own because it lacks
A. transposase.
B. inverted repeats.
C. origin of replication.
D. antibiotic resistance.
E. Tn10.
Blooms Level: 1. Remember
Section: 23.02
Weaver - Chapter 23 #3
4. Hybrid dysgenesis refers to the fact that in Drosophila a cross between a P male and an M
female produce offspring that are
A. dead.
B. wingless.
C. blind.
D. sterile.
E. hairless.
Blooms Level: 2. Understand
Section: 23.02
Weaver - Chapter 23 #4
5. In order for P element transfer to happen in Drosophila which of the following situations must
occur?
A. a P crossed with a P female
B. a P male crossed with an M female
C. an M male crosses with a P female
D. an M male crossed with an M female
E. any male crossed with a P female
Blooms Level: 2. Understand
Section: 23.02
Weaver - Chapter 23 #5
6. Which of the following is not true concerning immunoglobulin gene recombination signal
sequences?
A. There is a conserved heptamer.
B. There is a conserved nonamer.
C. The conserved sequences are separated by a nonconserved sequence of either a 12 bp or
a 23 bp sequence.
D. Recombination occurs between a 12 bp signal and a 23 bp signal.
E. Recombination only occurs between two heptamers.
Blooms Level: 1. Remember
Section: 23.03
Weaver - Chapter 23 #6
7. Which of the following molecules serves as a primer for reverse transcriptase during retroviral
replication?
A. host snRNA
B. viral RNA
C. host tRNA
D. viral DNA
E. host DNA
Blooms Level: 1. Remember
Section: 23.04
Weaver - Chapter 23 #7
8. Which of the following is not necessary for retroviral insertion into the host genome?
A. RNA polymerase II
B. retroviral pol gene
C. viral protease
D. RNase H
E. reverse transcriptase
Blooms Level: 2. Understand
Section: 23.04
Weaver - Chapter 23 #8
9. Which of the following has no reverse transcriptase gene associated with it?
A. HIV
B. Ty
C. copia
D. L1
E. Tn3
Blooms Level: 1. Remember
Section: 23.01
Weaver - Chapter 23 #9
10. Which of the following transposons does not contain LTRs or inverted repeats at its ends?
A. Ty
B. Alu elements
C. copia
D. Tn3
E. Ds
Blooms Level: 1. Remember
Section: 23.04
Weaver - Chapter 23 #10
11. Transposable elements or _________ are DNA fragments that can move from one organism to
another.
transposons
Blooms Level: 1. Remember
Section: 23.01
Weaver - Chapter 23 #11
12. Bacterial insertion sequences are the simplest of transposons and contain only short inverted
repeat ends and genes for ___________.
transposase
Blooms Level: 1. Remember
Section: 23.01
Weaver - Chapter 23 #12
13. In ____________transposition both strands of the original DNA move together whereas in
_________ transposition one copy of the DNA moves to a new site while one copy stays in the
genome.
nonreplicative, replicative
Blooms Level: 2. Understand
Section: 23.01
Weaver - Chapter 23 #13
14. __________ receptor genes undergo rearrangement in a manor similar to B-cell
immunoglobulin genes.
T-cell
Blooms Level: 1. Remember
Section: 23.03
Weaver - Chapter 23 #14
15. Somatic hypermutation greatly increases antibody ______.
diversity
Blooms Level: 1. Remember
Section: 23.03
Weaver - Chapter 23 #15
16. Individuals with SCID, severe combined immunodeficiency disease, have defective ________
genes, which cause loss of B-cell and T-cell function.
Artemis
Blooms Level: 1. Remember
Section: 23.03
Weaver - Chapter 23 #16
17. _______________ is an enzyme that can synthesize DNA from an RNA template.
Reverse transcriptase
Blooms Level: 1. Remember
Section: 23.04
Weaver - Chapter 23 #17
18. DNA sequences that resemble normal genes but do not function are called________.
pseudo-genes
Blooms Level: 1. Remember
Section: 23.04
Weaver - Chapter 23 #18
19. Insertion of a Group II intron of a particular gene into an intronless version of that same gene
is called_______.
retrohoming
Blooms Level: 1. Remember
Section: 23.04
Weaver - Chapter 23 #19
20. Insertion sequences are transposable elements that can inactivate genes.
TRUE
Blooms Level: 2. Understand
Section: 23.01
Weaver - Chapter 23 #20
21. 5′-ACCGTAG—GATGCCA-3′ is an example of an inverted repeat sequence.
FALSE
Blooms Level: 2. Understand
Section: 23.01
Weaver - Chapter 23 #21
22. Antibiotic resistance in bacteria can be transferred using insertion sequences.
FALSE
Blooms Level: 2. Understand
Section: 23.01
Weaver - Chapter 23 #22
23. There are two transposable elements, Ds and Ac, which are necessary for variegation in
maize kernel color.
TRUE
Blooms Level: 1. Remember
Section: 23.02
Weaver - Chapter 23 #23
24. Hybrid dysgenesis may lead to the formation of new species.
TRUE
Blooms Level: 2. Understand
Section: 23.02
Weaver - Chapter 23 #24
25. A Drosophila P female contains the P transposition repressor that prevents hybrid dysgenesis
from occurring.
TRUE
Blooms Level: 2. Understand
Section: 23.02
Weaver - Chapter 23 #25
26. The constant region of an antibody contains the antigen binding domains.
FALSE
Blooms Level: 2. Understand
Section: 23.03
Weaver - Chapter 23 #26
27. Rearrangement of mammalian cell immunoglobulin genes is responsible for the large diversity
of antibodies produced by B-cells.
TRUE
Blooms Level: 2. Understand
Section: 23.03
Weaver - Chapter 23 #27
28. The recombinases RAG-1 and RAG-2 are expressed in both plasma and memory B-cells.
FALSE
Blooms Level: 2. Understand
Section: 23.03
Weaver - Chapter 23 #28
29. HERVs, human endogenous retroviruses make up about 10–20% of the human genome.
FALSE
Blooms Level: 1. Remember
Section: 23.04
Weaver - Chapter 23 #29
30. Non-LTR retrotransposons, such as L1, occupy more of the human genome than exons do.
TRUE
Blooms Level: 1. Remember
Section: 23.04
Weaver - Chapter 23 #30
31. Group II introns are non-LTR retrotransposons that are found only in bacterial cells.
FALSE
Blooms Level: 2. Understand
Section: 23.04
Weaver - Chapter 23 #31
32. The loss of bases or gain of bases is common in immunoglobulin gene rearrangement.
TRUE
Blooms Level: 2. Understand
Section: 23.03
Weaver - Chapter 23 #32
33. Another name for a retrovirus is a retrotransposon.
FALSE
Blooms Level: 2. Understand
Section: 23.04
Weaver - Chapter 23 #33
23 Summary
Category # of Questions
Blooms Level: 1. Remember 18
Blooms Level: 2. Understand 15
Section: 23.01 8
Section: 23.02 7
Section: 23.03 8
Section: 23.04 10
Weaver - Chapter 23 33