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Simple Syrup Preparation in Pharmacy

This document summarizes the preparation of a simple syrup by dissolving 850g of sucrose in purified water to make 1000mL of solution. It then provides computations to determine the amount of sucrose needed to make 30mL of simple syrup. The rest of the document asks and answers questions about syrups. It discusses other preparation methods for syrups, consequences of concentrations that are too high or low, storage requirements, uses of syrups, and examples of 5 commercial syrup products with their generic and brand names and uses.

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156 views5 pages

Simple Syrup Preparation in Pharmacy

This document summarizes the preparation of a simple syrup by dissolving 850g of sucrose in purified water to make 1000mL of solution. It then provides computations to determine the amount of sucrose needed to make 30mL of simple syrup. The rest of the document asks and answers questions about syrups. It discusses other preparation methods for syrups, consequences of concentrations that are too high or low, storage requirements, uses of syrups, and examples of 5 commercial syrup products with their generic and brand names and uses.

Uploaded by

J'mhaeGamboa
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd

Gamboa, Jhorelyn Mhae Abad October 29,2020

BS Pharmacy 2A C-PPDF1

Laboratory Exercise No. 9

PREPARATION OF SIMPLE SYRUP

OBJECTIVE: To prepare simple syrup by simple solution.

MATERIALS: laboratory set of apparatus, 60 ml amber bottle

PROCEDURE: Prepare 30-ml.

Sucrose 850 g

Purified water, q.s.

To make 1000 ml

COMPUTATION:
850 g 0 25,000
= = =25.5 g
1000 mL 30 mL 1000
QUESTIONS:

1. What are syrups?

Syrups are a viscous concentrated solution of a sugar, such as sucrose, in


water or other aqueous liquid; combined with other ingredients, such a
solution is used as a flavored vehicle for medications.

2. State other methods for the preparation of syrup and give the advantages and
disadvantages on each method.

Other methods for the preparation of syrup are:

1. Agitation without Heat

Advantages:

a. The product has maximum stability.

b. Through placing all ingredients in a vessel larger than the volume of the
syrup than agitation of the mixture.

c. Medication dissolved in the minimum solvent than incorporated into the


syrup

Disadvantages:

a. Time consuming

2. Solution with heat

Advantages:

a. Desired to prepare the syrup as quickly as possible.

b. Can be used for thermostable medications and non-volatile materials.

Disadvantages:

a. When the syrup is greatly overheated, it becomes amber colored as the


sucrose caramelize, sugar inversion may happen.

b. Decomposition by heat, syrup cannot be sterilized by autoclaving.

3. Addition of a medicated liquid

Advantages:

Disadvantages:

4. Percolation

Advantages:
a. Preparation of extractive of the drug and then the preparation of the
syrup.

Disadvantages:

a. Elixirs are clear, sweetened hydroalcoholic solutions intended for oral


use and are usually flavored to enhance their palatability. 10-12%
alcohol self-preserving.

3. Consequences of too concentrated syrups and too diluted syrup.

If the syrup id too much concentrated, a pellicle or crystals will form upon its
surface and it will be a thick liquid, while if it the syrup if too dilute, it will
ferment and be a thin liquid.

4. What is the official storage of syrup?


The official storage of syrups is in a bottle that will protect them against heat
and sunlight. They should be stored in a cool dry place, and once it is opened,
it must be refrigerated only until one (1) month (for simple syrups), and about
six (6) months for rich simple syrups.

5. Uses (3) of syrups.


1. Vehicle for medicine
2. Sweetener
3. Preserving

6. Site (5) commercial products (syrup) available in the market. State the generic and
brand names and its corresponding uses.

1. Generic name: Paracetamol


Brand name: Tempra
Use: Relieves pain and reduces fever
2. Generic name: Ambroxol
Brand name: Ambrolex
Use: Makes the mucus less thick and sticky and easier to cough

3. Generic name: Cefaclor


Brand name: Celor
Use: Treats certain infections caused by bacteria, such
as pneumonia and other lower respiratory tract
infections, and infections of the skin, ears, throat,
tonsils, and urinary tract

4. Generic name: Cefixime


Brand name: Cefivir
Use: Treat certain kinds of bacterial infections

5. Generic name: Cefalexin


Brand name: Zelexin
Use: Used to treat bacterial infections, such as
pneumonia and other chest infections, skin
infections and urinary tract infections
References:

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Common questions

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Commercial syrups often include preservatives and stabilizers to enhance shelf life and stability, unlike home-prepared simple syrups, which rely on sugar concentration and refrigeration. Commercial formulations are also standardized for consistency, whereas home preparations may vary .

Syrups should be stored in bottles that protect against heat and sunlight, kept in a cool, dry place. Simple syrups should be refrigerated for up to one month after opening, while rich simple syrups can last about six months .

The solution with heat method is advantageous for quickly preparing syrups, especially with thermostable medications. However, it risks overheating, leading to sucrose caramelization, sugar inversion, and potential decomposition by heat, thus compromising syrup stability and safety .

Syrups are viscous, concentrated solutions of sugar in water or other liquids, which makes them effective as a flavored vehicle for medications. This viscosity aids in masking the taste of bitter medications and providing a soothing texture for oral consumption .

Too concentrated syrups may form a pellicle or crystals on the surface and become a thick liquid, while too diluted syrups may ferment, resulting in a thin liquid .

Percolation offers the advantage of preparing a drug extract before syrup preparation, enhancing the incorporation of medicinal properties. However, a disadvantage is that the use of percolation requires additional steps and careful execution to avoid contamination and degradation of extracts .

The agitation without heat method has several advantages, including maximum stability of the syrup, the ability to place all ingredients in a vessel larger than the syrup volume for optimal agitation, and the dissolution of medication in minimal solvent before incorporating into the syrup . The disadvantage of this method is that it is time-consuming .

Improper storage of syrups, such as exposure to heat and sunlight, can lead to degradation, affecting their effectiveness and safety. Mitigation involves storing syrups in appropriate bottles in a cool, dry place, and refrigerating once opened .

Preparation methods like agitation without heat maintain maximum stability and avoid degrading active ingredients, making syrups more effective as medicine vehicles. Solution with heat may risk ingredient degradation if excessive heat is applied, affecting its use for sensitive medications. Percolation ensures better extraction, enhancing medicinal use but requires precision .

Caramelization during syrup preparation with heat alters the syrup's color and flavor, turning it amber and potentially creating by-products that affect taste and safety. This can also lead to sugar inversion, where the breakdown of sucrose affects sweetening properties and stability .

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