ADLN-PERPUSTAKAAN UNIVERSITAS AIRLANGGA
ABSTRACT
Drug Utilization Study of Albumin
in Patients with Chronic Kidney Disease
(Study at Internal Department
Dr. Soetomo Teaching Hospital Surabaya)
Syarifah Nurul Maulidah
Background: Chronic Kidney Disease (CKD) is defined as the
presence of kidney damage or decreased glomerular filtration rate
(GFR) for 3 months or more. CKD is one of the disease that has high
prevalence and it tends to lead to further complications. HT with the
most common complication (90,9%), followed by diabetes mellitus
(63,6%). In the CKD condition will occur disturbances trigger fluid
retention. The retention of an impact on the increase in extracellular
fluid volume which causes increased blood pressure and edema. This
can lead to hypoalbuminemia in patients with CKD. To encourage
fluid retention in the circulation may be given intravenous albumin.
Objectives: To evaluate albumin therapy received by CKD patients
at Internal Department Dr. Soetomo General Hospital Surabaya in
order to assess drug utilization by knowing of drug therapy profiles.
Subjects and Methods: It was a prospective study conducted from
March 16th to July 15th 2015 at Internal Department Dr. Soetomo
General Hospital Surabaya. Inclusion criteria is CKD patient who
received albumin therapy with albumin pre and albumin post. As for
the analysis, the descriptive approach is employed to illustrate the
data.
Results: In this study, total samples obtained were 11 patients. Type
of albumin used is albumin 20% 100 mL. The average increase in
the levels of albumin in patients with chronic kidney disease who
received albumin fluid is equal to 0,31±0,02 g/dL. In addition, there
are also cases where patients requiring albumin treatment were not
received albumin therapy and adverse drug reaction.
Conclution: The results of the study showed that albumin is one of
hipoalbuminemia therapy to patients with chronic kidney disease.
Keyword: albumin, chronic kidney disease, drug utilization study.
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SKRIPSI STUDI PENGGUNAAN..... SYARIFAH NURUL M.