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Glycolysis Pathway: Energetics & Significance

This document provides an overview of the topics to be covered in a biochemistry theory course. It outlines 5 units that will examine biomolecules, bioenergetics, carbohydrate metabolism, lipid metabolism, amino acid metabolism, nucleic acid metabolism, enzymes, and genetic information transfer. Several key metabolic pathways such as glycolysis, the citric acid cycle, beta-oxidation of fatty acids, and the urea cycle are mentioned. Important enzyme kinetics concepts and different types of enzyme regulation are also listed. The course appears to provide foundational knowledge in biochemistry and metabolism.

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Deepak
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52 views2 pages

Glycolysis Pathway: Energetics & Significance

This document provides an overview of the topics to be covered in a biochemistry theory course. It outlines 5 units that will examine biomolecules, bioenergetics, carbohydrate metabolism, lipid metabolism, amino acid metabolism, nucleic acid metabolism, enzymes, and genetic information transfer. Several key metabolic pathways such as glycolysis, the citric acid cycle, beta-oxidation of fatty acids, and the urea cycle are mentioned. Important enzyme kinetics concepts and different types of enzyme regulation are also listed. The course appears to provide foundational knowledge in biochemistry and metabolism.

Uploaded by

Deepak
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd

BP203 T.

BIOCHEMISTRY (Theory)

These topics was completed

Unit I
Biomolecules
Introduction, classification, chemical nature and biological role of carbohydrate, lipids, nucleic
acids, amino acids and proteins.
Bioenergetics
Concept of free energy, endergonic and exergonic reaction, Relationship between free energy,
enthalpy and entropy; Redox potential. Energy rich compounds; classification; biological
significances of ATP and cyclic AMP

Unit II
Carbohydrate metabolism
Glycolysis- Pathway, energetics and significance. Citric acid cycle- Pathway, energetics and
significance. HMP shunt and its significance; Glucose-6-Phosphate dehydrogenase (G6PD)
deficiency. Glycogen metabolism Pathways and glycogen storage diseases (GSD)
Gluconeogenesis Pathway and its significance.
Hormonal regulation of blood glucose level and Diabetes mellitus.
Biological oxidation
Electron transport chain (ETC) and its mechanism, Oxidative phosphorylation & its
mechanism and substrate level phosphorylation, Inhibitors ETC and oxidative
phosphorylation/Uncouplers.

Unit III
Lipid metabolism
β-Oxidation of saturated fatty acid (Palmitic acid). Formation and utilization of ketone bodies;
ketoacidosis.
BP203 T. BIOCHEMISTRY (Theory)

These topics are pending

Unit III
Lipid metabolism
De novo synthesis of fatty acids (Palmitic acid). Biological significance of cholesterol and
conversion of cholesterol into bile acids, steroid hormone and vitamin D. Disorders of lipid
metabolism: Hypercholesterolemia, atherosclerosis, fatty liver and obesity.
• Amino acid metabolism
General reactions of amino acid metabolism: Transamination, deamination &
decarboxylation, urea cycle and its disorders. Catabolism of phenylalanine and tyrosine and their
metabolic disorders (Phenyketonuria, Albinism, alkeptonuria, tyrosinemia). Synthesis and
significance of biological substances; 5-HT, melatonin, dopamine, noradrenaline, adrenaline.
Catabolism of heme; hyperbilirubinemia and jaundice.

Unit IV
• Nucleic acid metabolism and genetic information transfer
Biosynthesis of purine and pyrimidine nucleotides. Catabolism of purine nucleotides and
Hyperuricemia and Gout disease. Organization of mammalian genome. Structure of DNA and
RNA and their functions DNA replication (semi conservative model) Transcription or RNA
synthesis. Genetic code, Translation or Protein synthesis and inhibitors.

Unit V
• Enzymes
Introduction, properties, nomenclature and IUB classification of enzymes. Enzyme kinetics
(Michaelis plot, Line Weaver Burke plot) Enzyme inhibitors with examples. Regulation of
enzymes: enzyme induction and repression, allosteric enzymes regulation. Therapeutic and
diagnostic applications of enzymes and isoenzymes. Coenzymes –Structure and biochemical
functions

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