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Fast Disintegrating Tablets for Asthma Treatment

This document discusses the need and objectives of developing fast disintegrating tablets of Montelukast sodium to improve treatment for asthma patients. Fast disintegrating tablets dissolve rapidly in the mouth, providing a more convenient dosage form compared to normal tablets. The objectives of this study are to 1) evaluate drug-excipient interactions using FTIR, 2) formulate and evaluate fast dissolving tablets using natural and synthetic superdisintegrants, 3) determine the physicochemical properties of the formulations, 4) study in-vitro drug dissolution, 5) examine drug release kinetics, and 6) conduct short-term stability testing of the best formulation.

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Sunil Chaudhary
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8 views2 pages

Fast Disintegrating Tablets for Asthma Treatment

This document discusses the need and objectives of developing fast disintegrating tablets of Montelukast sodium to improve treatment for asthma patients. Fast disintegrating tablets dissolve rapidly in the mouth, providing a more convenient dosage form compared to normal tablets. The objectives of this study are to 1) evaluate drug-excipient interactions using FTIR, 2) formulate and evaluate fast dissolving tablets using natural and synthetic superdisintegrants, 3) determine the physicochemical properties of the formulations, 4) study in-vitro drug dissolution, 5) examine drug release kinetics, and 6) conduct short-term stability testing of the best formulation.

Uploaded by

Sunil Chaudhary
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd

CHAPTER-2

AIM AND OBJECTIVE

NEED OF WORK AND STUDY


NEED FOR THE STUDY:
To hurdle these problems, a new dosage form known as fast disintegrating tablets, has been

developed which rapidly disintegrate and dissolve in saliva. These are also termed as mouth

dissolving tablets, montelukast sodium tablets, orally disintegrating tablets, quick

disintegrating tablets, fast dissolving tablets, rapid dissolving tablets, porous tablets, quick

melt tablets and rapid melt tablets.1 According to United States Food and Drug

Administration (USFDA), fast disintegrating tablets are those solid dosage forms containing

medicinal substances or active ingredient which dissolves or disintegrates within a matter of

seconds when placed upon the tongue. Fast disintegrating tablets have greater advantage over

normal tablet dosage form, one of which is, it provides rapid disintegration and absorption

and rapid onset of action. In this formulation the amount of drug going to the first pass

metabolism is reduced by increasing the absorption of drug, in the oral cavity leading to

greater bioavailability.10

OBEJECTIVE OF THE STUDY:

The objectives of the present work are to formulate immediate release tablets to improve the

quality of treatment for the patients suffering from asthma.

 To evaluate the drug-excipient interaction by FTIR.

 To formulate and evaluate fast dissolving tablets of Montelukast sodium using

combination of natural and synthetic superdisintegrants.

 To evaluate the physiochemical parameters of the formulated product.

 To determine In-vitro dissolution studies.

 To study drug release kinetics.

Department of Pharmaceutics, Mallige college of pharmacy, Bangalore Page 8


CHAPTER-2
AIM AND OBJECTIVE

 To Carry out sort term stability study of best formulation

Department of Pharmaceutics, Mallige college of pharmacy, Bangalore Page 9

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