→

MULTI SYSTEM DISORDER

320013 t ORGANS

AUTO -

Ab t

Type 2 HR Type 3 HR

RISK FACTORS

→ A
> > o
e,
→
reproductive age group
7 Pre reproductive g postmenopausal age groups
→ DIE female hormones

→
HLA DQ
.

→
Uv RAYS

→
DRUGS [ SULFONAMIDES ]

→
INFECTIONS ( septicemia C
Neutrophil Extracellular traps ])

→ f- ]
COMPLEMENT PROTEIN DEFICIENCY C
, /Cz/C4

CRITERIA FOR DIAGNOSIS

M
→
Malar Rash

D →
Discoid Rash

s → serositis

O
→
oral ulcers

→
A Arthritis

→
p photosensitivity

B →
Blood cells destruction by Auto Db

R →
Renal Involvement

→
A ANA C Anti Nuclear Ab ]

I Immunological leading
→
defects to other Ab

N
→
Neurological manifestations [ Epilepsy a psychosis ]

→
I 4 Out of II → SLE

→
Oral cavity involvement → Painless ulcers

→ →
Joints involvements Non erosive Arthritis

→ Butterfly Rash
→
Skin involvement BUTTER FLY RASH

[ Tin intensity on ox rays exposure ]

→
pulmonary involvement →
neuritis C more common )

SHRINKING LUNG SYNDROME

I dit weakness of
diaphragm ]
 →
KIDNEY INVOLVEMENT

Diffuse
→
Type II Glomerulonephritis I proliferative Glomerulonephritis

glomerulonephritis
→
sub of
me type
postman

→ LOOP LESIONS
WIRE -

Seen

mugham
Depositions mom
[Link]
[Link]
Blood human Mms www.
vessels

→
CARDIAC INVOLVEMENT

pericarditis [ ]

ENDOCARDITIS
→ common

→
Endocarditis → more LIBMAN SACK [ LSE → SHE ]
→
. Lower OF Mitral Endocardium
surface
valve [ ] involved more

→
SPLEEN INVOLVEMENT

→
ONION SKIN APPEARANCE in Blood vessels seen

→ reactions
die to immune complexes onionskin
appearance

AUTO ANTIBODIES
Libman sack
Endocarditis
I ANTI NUCLEAR ANTIBODIES →
most Sensitive Test For D ,

}
2 ANTI SMITH ANTIBODIES
most Specific Test For DX
3 DS ANTIBODIES
ANTI DNA
-

→
4 ANTI
-

120 ANTIBODY QIW Neonatal lupus

→
high risk For congenital Heart Block

→
alw subacute cutaneous
lupus

5 ANTI -
°
ANTIBODY
→
alw Psychosis
6 ANTI Glycoprotein Ab
132
-

→ seen C Reproductive ]
in q age group
→
presents I Recurrent Abortion

→
induces thrombotic state
pro

predisposed to
-

DVT E Deep vein thrombosis ]

I thrombosis ]
Hut Hepatic vein

stroke

→
aka ANTI PHOSPHOLIPID ANTIBODIES I APLA ]

responsible For APLA SYNDROME

-

IO

20 may alw SLE

-

APLA

→
causes Tapti [ in vitro I

→ reacts I CARDIOLIPIN Antigen

responsible for False Positive VDRL

-

DRVVT [ DILUTE RUSSEL VIPER VENOM TEST ]

→
→
detects auto Ab more specifically
 .

LE
→
CELL Seen in SLE
→
Neutrophil I Macrophage I
damaged cell in it

→
present in vitro

LE CELL

TREATMENT
→
STEROIDS

→
DRUGS RESPONSIBLE :

S
→
SULFONAMIDES ( DAPSONE ]

→
It HYDRALAZINE

→
I ISONIAZID E

→
p PROCDINAMIDE

→
HIO drug intake tht

→
involved
NO Kidney I Brain

→
ANTI HISTONE ANTIBODIES tht

→ HLA
alw DR 4

TILA DRG

→
Offending
→
TREATMENT Withdrawal of
drug