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DNA Replication Modeling Activity Guide

The document provides instructions for building a model of DNA, including materials needed and steps to follow. Students will cut out basic DNA subunits, color code them, and glue them together in the proper order to form nucleotides and a DNA ladder. They will then separate the ladder and add new nucleotides to demonstrate replication, resulting in two complete DNA models taped together. The document concludes with questions about DNA components and replication.

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Jeanine Nadua
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245 views4 pages

DNA Replication Modeling Activity Guide

The document provides instructions for building a model of DNA, including materials needed and steps to follow. Students will cut out basic DNA subunits, color code them, and glue them together in the proper order to form nucleotides and a DNA ladder. They will then separate the ladder and add new nucleotides to demonstrate replication, resulting in two complete DNA models taped together. The document concludes with questions about DNA components and replication.

Uploaded by

Jeanine Nadua
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd

Materials

 Cut Outs of basic subunits of DNA


 Colors or markers
 Scissors
 Tape or glue
 Paper & pencil

Procedure:

1. Cut out all of the units needed to make the nucleotides from the handout provided.
2. Color code the Nitrogenous bases, phosphorus, and deoxyribose sugar as follows —
Adenine = red, Guanine = green, Thymine = yellow, Cytosine = blue, Phosphate = brown, and Deoxyribose = purple.
3. Using the small squares and stars as guides, line up the bases, phosphates and sugars.
4. Now glue the appropriate parts together forming nucleotides.
5. Construct DNA model using the following sequence to form a row from top to bottom – cytosine (topmost), thymine, guanine, and adenine (bottommost).
6. Let this arrangement represent the left half of your DNA molecule.
7. Complete the right side of the ladder by adding the complementary bases. You will have to turn them upside down in order to make them fit.
8. Your finished model should look like a ladder.
9. To show replication, separate the left side from the right side, leaving a space of about 6-8 inches.
10. Use the remaining nucleotides to complete the molecule using the left side as the base.
11. Build a second DNA model by adding new nucleotides to the right half of the original piece of the molecule.
12. Tape the nucleotides together to form 2 complete DNA ladders.
Questions:

1. Of the 4 bases, which other base does adenine most closely resemble?

2. List the 4 different nucleotides.

3. Which 2 molecules of a nucleotide form the sides of a DNA ladder?

4. If 30% of a DNA molecule is Adenine, what percent is Cytosine?

5. What does the term replication mean?

6. What is another name for adenine and three phosphate molecules attached to it?

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