NSAID’S Questions:-
1. Name two drugs that can be used for the treatment of PDA
2. Name two NSAIDs which can precipitate the bronchial asthma.
3. Explain why aspirin is avoided in children suffering from fever, though it’s a good
antipyretic?
4. Name a condition where use of NSAIDs may avoid the need of surgery. Name two drugs
preferred for the same?
5. Explain with reasons whether aspirin can be used in a patient of cardiac asthma?
6. What is Reyes syndrome and name a drug that can cause this problem?
7. Name one amino acid used as antidote for paracetmol poisoning. Mention its clinical use?
8. Describe the role of NSAID’s in obstetric practice?
9. List 4 differences between Selective and Non-selective COX inhibitors?
10. What is low dose Aspirin and List 4 uses of low dose aspirin?
11. Beneficial effects and toxicities due to inhibition of PG’s synthesis?
12. List 3differences between Non-narcotic and Narcotic analgesics?
13. Brief out anti-inflammatory anti-platelet actions of NSAID’s?
14. What happens when NSAIDs are administered during pregnancy and Labour?
15. What is ion-trapping what disadvantage is associated with it?
16. What is Acute-salicylate poisoning and mention its treatment?
17. Mention adverse effects of NSAID’s?
18. List the Comorbid conditions aggravated by NSAID’s?
19. Treatment of Acute rheumatic fever?
20. Give one example of Fenamte and Oxicams and mention 2 uses of each?
21. What happens if Ibuprofen and Low dose aspirin are administered together?
22. Mention two uses of Naproxen and why?
23. What are advantages of Ketorolac and mention its uses?
24. Give 2 examples of Preferential COX-2 inhibitors and give 2 uses of each?
25. Give 2 examples of selective COX-2 inhibitors and list advantages and disadvantages of
them?
26. Describe how aspirin differs from other NSAID’s?
27. Give a comparative account of Aspirin, indomethacin and Celecoxib.
28. Describe the clinical uses of aspirin (mention the dose for each use). Mention the
precaution required in using aspirin?
29. Describe with clinical relevance the difference between aspirin and Celecoxib?
30. What is Salicylism? Describe the treatment of this condition?
31. What is aspirin induced asthma and name 2 drugs to avoid this condition?
32. Explain with reasons whether aspirin can be used for all types of arthritis?
33. Comment on analgesic nephropathy. Mention how it can be prevented?
34. Name three PG synthesis inhibitors from different groups and describe their clinical uses?
35. Comment on Fixed dose combinations-
a) Paracetmol + Methionine
b) Dextropropoxyphene or Codine or Pentazocine + Aspirin or Paracetmol
c) Diclofenac (50-75mg) + Misprostol (200μg)
d) NSAID’s + Omeprazole/ Rantidine
e) NSAID’s + Serrtiopeptodase
f) NSAID’s + Chlorzoxazone/Tizanidine.
g) Mefanamic acid + Tranexamic acid / Dicyclomine
MCQ’s:
1) A patient on aspirin will have increase in?
a) Bleeding time b) Clotting time d) Prothrombin time e) Activated partial thromboplastin
time.
2) Which of the following NSAID undergoes enterohepatic circulation?
a) Phenylbuatazone b) Aspirin c) Ibuprofen d) Piroxicam
3) Which of the following statements is NOT TRUE about NSAIDs?
a) Aspirin is an irreversible inhibitor of COX
b) Salicylic acid reduces the vivo syn’s of PG’s.
c) Duration of action of aspirin is primarily related to P.K clearance of the drug from the
body.
d) Antiplatelet effect of LWD aspirin is related to pre-systemic COX inhibition.
4) The chief advantage of Ketorolac over aspirin that is that former-
a) Can be combined more safely with opioid such as codeine.
b) Is available in I.M/I.V.
c) Doesn't prolong bleeding time.
d) Is less likely to cause A/C renal failure in pt’s with pre-existing renal impairment.
5) Rofecoxib as compared to indomethacin is
a) Less likely to cause gastric ulcer & complications.
b) Likely to be more effective in R.A
c) Not likely to produce renal complications.
d) All of the above.
6) A 3 yr old child presented to OPD with the symptoms of influenza. Aspirin is
contraindicated in this patient because of increased risk of-
a) Gastric bleeding b) Thrombocytopenia c) Fanconi syndrome d) Reye’s syndrome.