Scribd
Upload
3 views2 pages

Moringa Extract Reduces IL-1β in Rats

This study examined the effect of Moringa seeds extract on IL-1β expression in the pancreatic tissue of rats fed a high-fat, high-fructose diet. Rats were divided into four groups - a control fed standard pellets and three test groups fed the high-fat, high-fructose diet. The test groups also received doses of 150mg/kgBW or 200mg/kgBW of Moringa seeds extract. The results showed that both doses of the Moringa extract significantly reduced IL-1β expression in the pancreatic tissue compared to the group fed only the high-fat, high-fructose diet. The study concluded that Moringa oleifera seeds extract can

Uploaded by

bastomy
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
3 views2 pages

Moringa Extract Reduces IL-1β in Rats

This study examined the effect of Moringa seeds extract on IL-1β expression in the pancreatic tissue of rats fed a high-fat, high-fructose diet. Rats were divided into four groups - a control fed standard pellets and three test groups fed the high-fat, high-fructose diet. The test groups also received doses of 150mg/kgBW or 200mg/kgBW of Moringa seeds extract. The results showed that both doses of the Moringa extract significantly reduced IL-1β expression in the pancreatic tissue compared to the group fed only the high-fat, high-fructose diet. The study concluded that Moringa oleifera seeds extract can

Uploaded by

bastomy
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd

ABSTRACT

Adilla Shafryantyo Purnomo, G0015006, 2018. Effect of Moringa Seeds Extract


(Moringa oleifera, Lam.) to IL-1β Expression in Pancreatic Tissue of High-Fat
High-Fructose Fed rats (Rattus norvegicus). Mini Thesis. Medical Faculty, Sebelas
Maret University, Surakarta

Introduction: High intake of fat and sugar has been associated with increase of
metabolism product and inflammation mediators that make damage beta cells of
pancreas. This research aimed to determine the effect of Moringa seeds extract to
IL-1β expression in pancreatic tissue of High-Fat High-Fructose Fed rats (Rattus
norvegicus).

Methods: This was laboratory experimental research using posttest only group
design used twenty-four male Wistar rats which were assigned into 4 groups. KN
(control) were fed with standard pellet, meanwhile K(-), P1, and P2 were fed with
high-fat high-fructose diet while 53 days. Then P1 were given Moringa seeds
extract dose 150mg/KgBW, and P2 were given Moringa seeds extract dose
200mg/KgBW. After 28 days, rats were terminated and make it to be pancreatic
tissue. Expression of IL-1β counted in semiquantitative by IDS, analize with One-
Way ANOVA test, and Tukey HSD as the post hoc.

Result: One-Way ANOVA test showed a significant difference of IL-1β expression


between four group (p < 0.05). Tukey HSD post hoc test showed a significant
difference between KN and K(-) (p < 0.05), K(-) among P1 and P2 showed
significant difference (p < 0.05). But there were not significant difference of IL-1β
expression KN among P1 and P2, also between P1 and P2 there were not significant
difference.

Conclusions: Moringa oleifera seeds extract at dose of 150 mg/kgBW and dose of
200 mg/kgBW significantly reduces IL-1β expression of pancreatic tissue in high-
fat high-fructose fed Wistar rats.

Keyword: Moringa oleifera seeds extract, IL-1β, high fat high fructose diet,
pancreatic tissue

You might also like