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Comprehensive Guide to Drug Biotransformation and Pharmacology

The document discusses various topics related to pharmacology including: 1. Defining biotransformation and types of biotransformation reactions 2. Describing phase 1 and phase 2 biotransformation reactions 3. Discussing routes of drug administration, volume of distribution, plasma half-life and their clinical significance 4. Explaining concepts like antagonism, idiosyncrasy, therapeutic index, potency, and tachyphylaxis 5. Interpreting dose response curves to determine drug potency and margin of safety 6. Explaining first order and zero order elimination 7. Describing receptor mechanisms of action and examples of enzyme inducers and inhibitors 8. Defining pharmacogen

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25 views3 pages

Comprehensive Guide to Drug Biotransformation and Pharmacology

The document discusses various topics related to pharmacology including: 1. Defining biotransformation and types of biotransformation reactions 2. Describing phase 1 and phase 2 biotransformation reactions 3. Discussing routes of drug administration, volume of distribution, plasma half-life and their clinical significance 4. Explaining concepts like antagonism, idiosyncrasy, therapeutic index, potency, and tachyphylaxis 5. Interpreting dose response curves to determine drug potency and margin of safety 6. Explaining first order and zero order elimination 7. Describing receptor mechanisms of action and examples of enzyme inducers and inhibitors 8. Defining pharmacogen

Uploaded by

yusma
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd

GENERAL PHARMA

1. Define biotransformation. Define toxic biotransformation of drug with


example and name type II biotransformation reactions.
2. Name all biotransformation reactions. Describe phase 1 and phase 2
reactions with examples
3. Define routes of drug administration with their merits and demerits
4. Define volume of distribution of drug
5. Define plasma half-life and describe its clinical [Link] of plasma
half-life in designing dosage regimens
6. Define and classify antagonism/ antagonist with examples
7. Explain idiosyncrasy, pharmocogentics, therapeutic index, potency and
tachyphylaxis.
8. Dose response curve of four drugs on isolated ileum of guinea pig are
shown hereWhich curve represents the most potent drug? Define potency.
Considering curve A and C tobe the same drug, what can you comment?
How the margin of safety is depicted in dose response curve? Which curve
shows the narrowest margin of safety? Name 3 drugs with narrow
therapeutic index. Define a partial agonist. Which curve represents a partial
agonist
9. Explain first order and zero order elimination with examples.
[Link] receptor and drug mechanism of action with examples.
[Link] are enzyme inducers and inhibitors? Explain their clinical significance.
What is enzyme induction? Examples and describe how it effect the
pharmacokinetics of drug
[Link] phrmacogenetics. Give 3 examples how genetic variations can
influence drug response. Write fast and slow acetylator status
[Link] reversal phenomenon. First dose effect with examples
[Link] tolerance and tachyphylaxis. Give difference b/w the two
[Link] clinical sig of tolerance and tachyphylaxis with examples
[Link] b/w
ligand and second messenger
clearance and excretion
[Link] mechanism of transmembrane signaling. Give examples
[Link] any 4 second messengers. What is the sig of second messenger
signaling?
[Link]. Slow and fast acetylators with examples
[Link] reversal reflex
[Link] dose effect

ANS
1. Explain cholinesterase inhibiting drugs and explain organo phosphorus
poisoning and its management
2. Describe effects of pilocarpine on eye
3. Describe pharmacological effects of pilocarpine
4. Adverse effects and contraindication of atropine
5. Describe therapeutic use and adverse effects of sympathomimetic agents.
Write down 8 therapeutic uses of sympathomimetic drugs
6. Enumerate beta blockers and its adverse effects
7. Describe adverse effects and contraindications of antimuscuranic drugs.
Classify antimuscuranic drugs according to its clinical uses and write its
contraindication. Write down therapeutic classification of anti-muscarinic
drugs
8. Classify alpha receptor blockers and its therapeutic uses and write the
rationale of its use in blood pressure.3 clinical uses and 3 major A/E of
alpha blockers. A/E of alpha adrenergic blockers
9. Classify beta receptor blockers and its adverse effects
[Link] the effects of epinephrine and nor epinephrine on BP and heart. Also
mention the receptors producing the effect. Explain epinephrine reversal
phenomenon of dale. Enlist cardiovascular effects of epinephrine
[Link] cholinesterase inhibiting drugs.
12. Classify anticholinerguic drugs therapeutically. Write down 4
pharmacological uses of aticholinergic drugs. Name drugs used in angle
glaucouma
[Link] is prazosin? What is the rationale of its use in BP?
[Link] down pharmacological effects of adrenaline
[Link] of action of beta blockers in hypertension and angina pectoris
[Link] the use of drugs in these situation
[Link] in anaphylactic shock
[Link] in hypovolemic shock
[Link] in congestive cardiac failure
[Link] in acute congestive glaucoma
21.

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