Scribd
Upload
7 views1 page

Aminoglycosides and Pharmacokinetics Guide

The document outlines the key concepts and calculations covered in several pharmacokinetics lectures, including: 1) Lectures on aminoglycosides and sepsis covered gram-positive and gram-negative bacteria differences, pharmacokinetics of aminoglycosides, and PK-PD modeling. 2) Other lectures covered applying pharmacokinetics to clinical situations like converting doses between oral and intravenous routes, acetaminophen metabolism with and without ethanol, and the relationship between pharmacokinetics and pharmacodynamics. 3) Additional lectures summarized non-linear pharmacokinetic models, distribution and protein binding, and the pharmacokinetic modeling of insulin.

Uploaded by

Megan Vanhes
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
7 views1 page

Aminoglycosides and Pharmacokinetics Guide

The document outlines the key concepts and calculations covered in several pharmacokinetics lectures, including: 1) Lectures on aminoglycosides and sepsis covered gram-positive and gram-negative bacteria differences, pharmacokinetics of aminoglycosides, and PK-PD modeling. 2) Other lectures covered applying pharmacokinetics to clinical situations like converting doses between oral and intravenous routes, acetaminophen metabolism with and without ethanol, and the relationship between pharmacokinetics and pharmacodynamics. 3) Additional lectures summarized non-linear pharmacokinetic models, distribution and protein binding, and the pharmacokinetic modeling of insulin.

Uploaded by

Megan Vanhes
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd

I.

SIGNIFICANT FIGURES
Enter numerical values only, do not include units.

II. Lecture 15: AMINOGLYCOSIDES & SEPSIS (6 multiple choice questions, 2 calculations)
» Calculations:
Know how to calculate aminoglycoside regimens + how to change this according to TDM
» Concepts:
- Difference between gram negative and positive bacteria (slide 17)
 Positive: has larger peptidoglycan layer
 Negative: contains extra membrane with lipopolysaccharides
 Allows for gram staining
- Basic PK of aminoglycosides + how this relates to prior PK concepts (slide 54)
 Clearance, Vd
 Sepsis + bacterial infections
 MIC, tolerance, resistance – assessing antimicrobial therapy
- PK-PD modeling of aminoglycosides (slide 28)
 PAE – post-antibiotic effect
 AUC above MIC important, as well as Cmax

III. Lecture 14: APPLICATION OF PK TO CLINICAL SITUATIONS (3 calculations)


» Calculations:
- Convert IV dose to Oral
- Convert Oral dose to IV
- Calculate a multiple dose IV dosage regimen

IV. Lecture 13: APAP METABOLISM (1multiple choice)


» Concepts:
- Explain metabolism of APAP in presence and absence of EtOH.
- Toxic metabolite: NAPQI

V. Lecture 12: PK AND PD RELATIONSHIP (2multiple choice, 1 calculation)


» Calculations:
- Calculate the effective duration of a drug + the relationship to alterations in the dose (Teff)
» Concept:
- Review how opioids illustrate the relationship between PK and PD 
 absorption, efficacy, potency, tolerance
 down regulation of receptors
 Tolerance (second to last slide

VI. Lecture 11: DISTRIBUTION AND PROTEIN BINDING (1 graph, 1 calculation)


» Calculations:
- Graph a scatchard plot
- Calculate n and Ka

VII. Lecture 10: NON-LINEAR PK MODELS (2 calculations)


» Calculations:
- Calculate phenytoin dosing rate + adjustments

VIII. INSULIN TBL (2 multiple choice)


» Concepts:
- Explain PK modeling of Afrezza
- Basic PK of Afrezza

You might also like