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ER, PR, HER-2 Status in Breast Cancer

ER, PR, and HER-2 status can predict breast cancer prognosis. This study examined the relationship between ER, PR, and HER-2 status and the degree of malignancy in breast cancer patients. The majority of subjects were ages 41-50. ER, PR, and HER-2 status was most commonly negative. The highest degree of malignancy was grade 3. Chi-square tests found a relationship between ER, PR status and degree of malignancy, but not for HER-2 status.

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4 views1 page

ER, PR, HER-2 Status in Breast Cancer

ER, PR, and HER-2 status can predict breast cancer prognosis. This study examined the relationship between ER, PR, and HER-2 status and the degree of malignancy in breast cancer patients. The majority of subjects were ages 41-50. ER, PR, and HER-2 status was most commonly negative. The highest degree of malignancy was grade 3. Chi-square tests found a relationship between ER, PR status and degree of malignancy, but not for HER-2 status.

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tiffanyalmnd
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ABSTRACT

RELATIONSHIP ESTROGEN RECEPTOR (ER) STATUS,


PROGESTERON RECEPTOR (PR) STATUS, AND HUMAN EPIDERMAL
GROWTH FACTOR RECEPTOR2 (HER2) WITH MALIGNANCY
DEGREES OF BREAST CANCER IN ABDOEL MOELOEK HOSPITAL
BANDAR LAMPUNG

By

RIA JANITA RIDUAN

Breast cancer is one of the highest malignancy and have a fairly high mortality in
women. The level of malignancy of breast cancer can be judged by the degree of
malignancy of breast cancer. In addition to the estrogen receptor, progesterone
receptor and HER2 that is expressed in breast cancer can also predict cancer
prognosis significantly.
This study aims to determine the relationship of estrogen receptor status,
progesterone receptor, and HER2 with the degree of malignancy of breast
cancer. Subjects used is breast cancer patients who have known the degree of
malignancy, the status of ER, PR and HER2 in 20142015 in hospitals Abdoel
Moeloek Bandar Lampung earned by 54 people.
The results showed that the age of majority is obtained at the age of 4150 years
as many as 25 respondents (46.3%), status of ER, PR and HER2 is the most
negative as many as 32 respondents (59.3%) in the ER and PR status, a total of 33
respondents (61.1%) in HER2, while the highest degree that is grade 3 as many
as 41 respondents (75.9%). Results of the analysis of ChiSquare test was
obtained p<0.05 except for the HER2. So it can be concluded that there is a
relationship between receptor status of ER, PR with the degree of malignancy of
breast cancer.

Keyword: breast cancer, histological grade, estrogen receptor, progesterone


receptor, HER2

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