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Material Safety Data Sheet

5-Fluorouracil MSDS

Section 1: Chemical Product and Company Identification

Product Name: 5-Fluorouracil Contact Information:

Catalog Codes: SLF2023 [Link], Inc.
14025 Smith Rd.
CAS#: 51-21-8 Houston, Texas 77396
RTECS: YR0350000 US Sales: 1-800-901-7247
International Sales: 1-281-441-4400
TSCA: TSCA 8(b) inventory: 5-Fluorouracil
Order Online: [Link]
CI#: Not available.
CHEMTREC (24HR Emergency Telephone), call:
Synonym: 5-Fluoro-2,4(1H,3H)-pyrimidinedione 1-800-424-9300
Chemical Formula: C4H3FN2O2 International CHEMTREC, call: 1-703-527-3887
For non-emergency assistance, call: 1-281-441-4400

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight

{5-}Fluorouracil 51-21-8 100

Toxicological Data on Ingredients: 5-Fluorouracil: ORAL (LD50): Acute: 230 mg/kg [Rat]. 115 mg/kg [Mouse].

Section 3: Hazards Identification

Potential Acute Health Effects:

Very hazardous in case of skin contact (irritant), of ingestion. Hazardous in case of inhalation. Slightly hazardous in case of
skin contact (permeator), of eye contact (irritant). Severe over-exposure can result in death.
Potential Chronic Health Effects:
CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not
available. DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to blood. Repeated or prolonged exposure
to the substance can produce target organs damage. Repeated exposure to an highly toxic material may produce general
deterioration of health by an accumulation in one or many human organs.

Section 4: First Aid Measures

Eye Contact: Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be
used.

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Skin Contact:
After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with running
water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin. Cold water may be used.
Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash contaminated clothing before
reusing.
Serious Skin Contact:
Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medical
attention.
Inhalation: Allow the victim to rest in a well ventilated area. Seek immediate medical attention.
Serious Inhalation:
Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If
breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medical
attention.
Ingestion:
Do not induce vomiting. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that
the toxic material was ingested; the absence of such signs, however, is not conclusive. Loosen tight clothing such as a collar,
tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention.
Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: May be combustible at high temperature.

Auto-Ignition Temperature: Not available.
Flash Points: Not available.
Flammable Limits: Not available.
Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated
compounds.
Fire Hazards in Presence of Various Substances: Not available.
Explosion Hazards in Presence of Various Substances:
Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product in
presence of static discharge: Not available.
Fire Fighting Media and Instructions:
SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Fire Hazards: Not available.
Special Remarks on Explosion Hazards: Not available.

Section 6: Accidental Release Measures

Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container.
Large Spill: Use a shovel to put the material into a convenient waste disposal container.

Section 7: Handling and Storage

Precautions:
Keep locked up Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the
residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. Avoid contact with

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skin Wear suitable protective clothing In case of insufficient ventilation, wear suitable respiratory equipment If ingested, seek
medical advice immediately and show the container or the label.
Storage:
Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly closed. Keep in a
cool, well-ventilated place. Highly toxic or infectious materials should be stored in a separate locked safety storage cabinet or
room.

Section 8: Exposure Controls/Personal Protection

Engineering Controls:
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
below the exposure limit.
Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of a Large Spill:
Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid
inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
product.
Exposure Limits: Not available.

Section 9: Physical and Chemical Properties

Physical state and appearance: Solid. (Solid crystalline powder.)

Odor: Odorless.
Taste: Not available.
Molecular Weight: 130.08 g/mole
Color: White.
pH (1% soln/water): Not available.
Boiling Point: Not available.
Melting Point: Decomposes. (282C or 539.6F)
Critical Temperature: Not available.
Specific Gravity: Not available.
Vapor Pressure: Not applicable.
Vapor Density: Not available.
Volatility: Not available.
Odor Threshold: Not available.
Water/Oil Dist. Coeff.: Not available.
Ionicity (in Water): Not available.
Dispersion Properties: See solubility in water, methanol.
Solubility:
Partially soluble in cold water, methanol. Insoluble in diethyl ether.

Section 10: Stability and Reactivity Data

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Stability: The product is stable.
Instability Temperature: Not available.
Conditions of Instability: Not available.
Incompatibility with various substances: Not available.
Corrosivity: Not available.
Special Remarks on Reactivity: Not available.
Special Remarks on Corrosivity: Not available.
Polymerization: No.

Section 11: Toxicological Information

Routes of Entry: Absorbed through skin. Inhalation. Ingestion.

Toxicity to Animals: Acute oral toxicity (LD50): 115 mg/kg [Mouse].
Chronic Effects on Humans: The substance is toxic to blood.
Other Toxic Effects on Humans:
Very hazardous in case of skin contact (irritant), of ingestion. Hazardous in case of inhalation. Slightly hazardous in case of
skin contact (permeator).
Special Remarks on Toxicity to Animals: Not available.
Special Remarks on Chronic Effects on Humans: Not available.
Special Remarks on other Toxic Effects on Humans: Not available.

Section 12: Ecological Information

Ecotoxicity: Not available.

BOD5 and COD: Not available.
Products of Biodegradation:
Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.
Toxicity of the Products of Biodegradation: The products of degradation are as toxic as the original product.
Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

Waste Disposal:

Section 14: Transport Information

DOT Classification:
Identification:
Special Provisions for Transport: Not available.

Section 15: Other Regulatory Information

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Federal and State Regulations:
California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer,
birth defects or other reproductive harm, which would require a warning under the statute: 5-Fluorouracil California prop. 65:
This product contains the following ingredients for which the State of California has found to cause birth defects which would
require a warning under the statute: 5-Fluorouracil Pennsylvania RTK: 5-Fluorouracil Massachusetts RTK: 5-Fluorouracil
TSCA 8(b) inventory: 5-Fluorouracil SARA 302/304/311/312 extremely hazardous substances: 5-Fluorouracil SARA 313 toxic
chemical notification and release reporting: 5-Fluorouracil CERCLA: Hazardous substances.: 5-Fluorouracil
Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
Other Classifications:
WHMIS (Canada):
CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC). CLASS D-2B: Material causing other toxic effects
(TOXIC).
DSCL (EEC):
R38- Irritating to skin. R48/22- Harmful: danger of serious damage to health by prolonged exposure if swallowed.
HMIS (U.S.A.):
Health Hazard: 2
Fire Hazard: 1
Reactivity: 0
Personal Protection: E
National Fire Protection Association (U.S.A.):
Health: 2
Flammability: 1
Reactivity: 0
Specific hazard:
Protective Equipment:
Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator
when ventilation is inadequate. Safety glasses.

Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.
Created: 10/09/2005 05:34 PM
Last Updated: 05/21/2013 12:00 PM

The information above is believed to be accurate and represents the best information currently available to us. However, we
make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume
no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for
their particular purposes. In no event shall [Link] be liable for any claims, losses, or damages of any third party or for
lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if [Link]
has been advised of the possibility of such damages.

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