Bio Sci 97 GENETICS Fall Qtr, 2015

School of Biological Sciences, University of California, Irvine Version: 23 September

Section D MWF 10:00-10:50 PSLH 100 (Course Code 05360)

Section A MWF 11:00-11:50 PSLH 100 (Course Code 05330)
Section B MWF 3:00 - 3:50 BS3 1200 (Course Code 05340)

Instructor information
Dr. Bardwell (bardwell@[Link]), Dr. Cinquin ([Link]@[Link]), Dr Warrior
(rwarrior@[Link])

Provisional lecture schedule; please check website for updates

Lect Day Date Subject Reading Assignments
1 F 25 Sept Overview, DNA structure and replication 1 & 7.1-7.2
2 M 28 Sept DNA replication, PCR, sequencing 7.3, 7.4, 7.5 Mastering Genetics
"Introduction or 1"
assignment due
3 W 30 Sept Gene Expression: Transcription of 8.1, 8.3, 8.4
mRNA
4 F 2 Oct Translation of mRNA 9
5 M 5 Oct Chromosome Structure 11 Mastering Genetics
"Assignment 2" due
6 W 7 Oct Mendel 2.1, 2,2

7 F 9 Oct Mendel II and Chi Square 2.3 2.6 Mastering Genetics

Last Day to Drop "Assignment 3" due
8 M 12 Oct Mitosis/Meiosis 3
9 W 14 Oct Gene interactions and Sex determination 4 Mastering Genetics
"Assignment 4" due
F 16 Oct EXAM 1 24% of your grade
10 M 19 Oct Linked genes and mapping I 5.1 to 5.4
11 W 21 Oct Linked genes and mapping II
12 F 23 Oct Linked genes and mapping III Mastering Genetics
"Gene mapping"
assignment due
13 M 26 Oct Bacteria I 6
14 W 28 Oct Bacteria II Mastering Genetics
"Bacterial genetics"
assignment due
15 F 30 Oct Cloning from DNA libraries 16.1, 16.2
16 M 2 Nov Recombinant DNA I 17 Mastering Genetics
"Cloning from DNA
libraries"
assignment due
17 W 4 Nov Recombinant DNA II
18 F 6 Nov Review
M 9 Nov EXAM 2 24% of your grade
W 11 Nov Veterans Day No Class

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 19 F 13 Nov From Gene to Protein to Disease Chapter 10
pp. 761-2 (Case Study)
Extra Reading #1
20 M 16 Nov Mutagenesis & Repair part I Ch. 12.1-12.5
Issue: DNA typing in forensics Skim 12.6-12.8
Read case study on 415-16

21 W 18 Nov Mutagenesis & Repair part II Skim Chapter 13

Issue: Genetically Modified Food etc. Extra Reading #2
22 F 20 Nov Advanced Pedigree Analysis I Extra Reading #3

23 M 23 Nov Chromosome Structure & Disease Reread: Experimental Insight 5.1 (p. 168)
Issue: Genetic Testing Case Study (p. 379) Pp. 71-73 (cell cycle) Pp.
247-8 (telomeres)
Extra Reading #3
24 W 25 Nov Cancer I

F 27 Nov Thanksgiving Break No Class

25 M 30 Nov Cancer II

26 W 2 Dec Population Genetics I Chapter 22 (but not 22.8)

Issue: Eugenics Extra Reading #4

27 W 4 Dec Population Genetics II

Last Day of Class
28 F 9 Dec Complex Traits Chapter 21
Issue: Designer Babies Extra Reading #5
Dec 7, 11 Cumulative Final Exam 42% of your grade
(`6% Warrior, 6% Cinquin, 30% Bardwell)
Section D (10 AM class) Final: Monday, 7 December, 10:30 AM - 12:30 PM, PSLH 100
Section B (3 PM class) Final: Monday, 7 December, 4:00 PM - 6:00 PM, BS3 1200
Section A (11 AM class) Final: Friday, 11 December, 8:00 AM - 10:00 AM, PSLH 100

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Bio 97 GENETICS: Fall 2015

Texts
Required: ICLICKER RESPONSE SYSTEM ISBN:978-0-7167-7939-1. Available from UCI
bookstore. Both iClicker1 and iClicker2 are OK.
Required: Genetic Analysis: Integrated Analysis Custom Version for UCI (Contains content
from Sanders & Klug). Book ISBN: 9781323142806
Required: Modified Mastering Genetics access code Custom Version for UCI (Contains custom
eBook to resemble the physical book and includes Learning Catalytics) Code ISBN:
9781323156179 This is an online site that has additional exercises, examples and videos etc.

The UCI custom edition has a DNA replication complex on the cover and has a blue-violet
background. ISBN: 9781323142806.

The text book comes bundled with access to an ebook and the online site Mastering
Genetics that has additional exercises, examples and videos etc. You also get a rebate for
an iClicker that you will need for class. The price at the campus bookstore for the whole
bundle is $111.50. There will be a SPECIAL access code card for Mastering at the
bookstore. REGULAR MASTERING GENETICS CARDS WILL NOT WORK FOR THE
BIO 97 COURSE!! Students will need to purchase the package at the bookstore or
purchase direct access from Pearson through
[Link]. About 10 copies of the text will be on reserve at
the Science Library.
Lectures
Lectures will be given as Power Point or PDF presentations.
Every effort will be made to post lectures to the class website before the scheduled class,
but this may not always be possible because we are constantly striving to improve and
update our lectures.
Some material covered in class will not be present in the text, and this material may be
covered on the exams.
Important announcements may be made in class, and may not be repeated via an email
broadcast.
10% of your grade will be participation points. These will be awarded for responding to
clicker questions during lecture (3%), for responding to online quizzes (2%), for
completing assignments on Mastering Genetics (3%) and for providing instructor
evaluations (2% - 0.5% for each instructor, 0.5% for your TA). Please see FAQ below for
additional information.

Mastering Genetics
We will assign homework exercises from Mastering Genetics. Correct answers to at least
75% of the questions in an individual assignment will earn you full credit for that
assignment.
Completing 75% of the Mastering Genetics assignments will earn you full credit. DONT
panic if you miss an assignment.
To do Mastering Genetics Exercises You must enter the course code that corresponds
to your Bio 97 lecture (A, B, or D):
SECTION A - Course ID: warrior82031

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 SECTION B - Course ID: warrior02344
SECTION D - Course ID: warrior28121

Discussion sections
The discussion sections are optional; but we STRONGLY encourage you to attend.
The discussions will incorporate active learning exercises that many students find helpful.
You must attend the discussion section that you are formally enrolled in.
The TAs for Bio97 A, B & D are:
Head TA: Grant Rutledge grutledg@[Link]
Admin TA: Yilun Jimmy Zhu yilunz@[Link]
Kerrigan Blake kerrigab@[Link]
Alison Mills ammills@[Link]
Thomas Caldwell tcaldwel@[Link]
Wendy Ullmer wullmer@[Link]
Casey Cruz cruzc3@[Link]
Mia Maltz mmaltz@[Link]
Kyria Roessler kroessle@[Link]

Useful Apps

Gene Tutor A very useful app that covers the same topics that we do. Includes study
materials and problems. Designed for the Molecular and Mendelian Genetics course at Barnard
College/Columbia University in New York. Free from Apple App Store. Android version
available.

Molecules allows you to download and visualize, and manipulate 3D structures of biological
molecules. Start with DNA, tRNA, ATP, Insulin. Free from Apple App Store.

Talking Glossary of Genetic Terms National Human Genome Research Institute. Free from
Apple App Store.

Gene Screen Four animations introducing the concepts of genetics and inheritance,
population genetics, recessive genetic diseases*, and genetic screening. Free from Apple App
Store.

Enrollment changes
All enrollment questions will be handled by Bio Sci Student Affairs (1st floor Bio Sci 3, 949-824-
5318). No add/drop cards will be signed by professors. Bio Sci does not allow drops after the
second week in lecture courses. Students are responsible for all materials from the start of the
term. Failure to take any exams or quizzes, even those given before you have added the
course, will result in a zero score for each quiz or exam.

Tutoring

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The Learning and Academic Resources Center (LARC), and by Bio Sci Peer Tutoring provide
tutoring and supplementary instruction. Check the Study Tips and tutoring tab on the Bio97 web
page for links and details.

Office hours
Office hours for each instructor will be posted on the class web site and/or announced in class.

Examinations
Examinations are based on lecture, reading and discussion section material.
Your grade will be based on your exams and in class participation (midterm 1: 24%,
midterm 2: 24%, Final: 42%, participation: 10%).
The final exam will be cumulative, but will be weighted towards Prof. Bardwells material.
Answers to the exam will be posted on the class website in a timely manner after the
exam is over.

Examination Procedure
You must take the exam in the section you are enrolled in.
Assigned seating will be in force for all exams. Failure to sit in your assigned seat
could jeopardize your grade.
There will be no make-up exams given.

Grading Policy:
Course grades will be based on a standard curve developed for each section.
A window to submit concerns regarding the multiple choice questions will occur after the
key is posted.
There will be no extra credit assignments given, and nobody will be given 1 extra point
to raise them to the next higher grade, so please do not ask.

Messageboard
We will be using Piazza to answer questions regarding course material and
administrative issues that affect the whole class.
Please do not email the instructors or Head TA with questions that could be posted to the
Piazza.
The instructors and TAs will monitor Piazza and correct errors.
Individual inquiries regarding administrative issues may be directed to the Head TA if
necessary.

E-mail
You will get announcements through an e-mail listserve for the course.
Make sure that your directory is not full and that you are getting the messages (at least
one will have been sent by the first day of class).
Do not use this listserve to reply to us.
If you must contact your instructors/TAs by email, PLEASE USE THE FOLLOWING
FORMAT:
Dear Dr. (or Professor) Warrior/Cinquin/Bardwell OR Mr./Ms. (your own TA):
(A short email written in complete sentences without abbreviations.)
Signed with your full name, section, and student ID#.
Emails not following this format will not be answered.

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Questions? Please read the course and clicker FAQ sheets before asking your instructors or
your TAs; many common questions are answered there. Questions that are not personal in
nature but might apply to multiple students should be posted to the Piazza. For personal
questions about clickers, exams, or grading should be directed to the Administrative TA, Michael
Chiang mchiang3@[Link], or use the confidential messaging option in Piazza. Questions
about Discussion sections should be directed to your Discussion leaders. Questions about
enrollment should be directed to Bio Sci Student Affairs. Questions about lecture material are
best addressed in class, in discussion section, before or after class, in office hours, or through
the Piazza. We cannot answer questions by email as this is very inefficient and is not likely to
help you as much as a conversation anyway. Please also take advantage of your Discussion
leaders and their office hours!

Study Habits. To do well in this course, you should: 1) attend all lectures, 2) keep up with your
reading and assignmentsyou will not do well if you try to catch-up right before an exam, 3)
ask questions in class, outside of class, in discussions, in office hours, 4) participate actively in
lecture and discussion. Learning the vocabulary of genetics is essential to do well in the
coursekeeping a list of new words and their meanings may be helpful. Recopying your notes
after each lecture may help you identify areas that are confusing BEFORE you start studying for
the exam. Outlining the material may help you to see the big picture. Trying to write your own
exam questions after each lecture may help you identify the key concepts. The assigned
problems will give you practice manipulating the conceptsthese problems are assigned for
your benefit only, and the answers are not collected or graded. Forming a study group or taking
advantage of LARC or the free BioSci tutoring may also help some students. Note: no one
may drop the course after the second week, and the course will not be given again until
next summer or fall. Begin learning the material immediately and continue with regular
study in order to meet the demands of this difficult course. Failing the course will delay
for one year those continuing in Bio Sci.

Academic conduct and dishonesty: We recognize that the vast majority of students are
responsible, honest, and proud of their accomplishments. In the interest of supporting the rights
of these students to a fair examination and the course grade that they deserve, the following
policies will apply during exams:

1) The items permitted during the exam are: student ID, pencil, pen, eraser. Depending
on the exam, a basic, non-programmable calculator may also be allowed (buy yourself
one now if you bring a programmable calculator to exam you will not be allowed to
use it). No notes of any sort may be brought into the exam.
2) Sharing of materials, including calculators, is not permitted. Come to examinations
equipped to do the examinations on your own. During the examinations, keep your
eyes on your own paper and shield it from the eyes of others. No communication
between students should occur during examinations.
3) No questions will be answered during the exam. If questions are found to be unclear,
they will be deleted after the exam or multiple answers will be accepted.
4) During examinations, phones and pagers must be turned OFF and should not be visible
at any time during the exam. A ringing phone/pager will be considered grounds for an
F on the exam.
5) Take the seat assigned to you on a seating chart posted before each examination.
Seating may be spot-checked during the examination, and you will fail the exam if you
are seated elsewhere.

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You will be required to sign a statement at the beginning of each exam affirming that you
understand these rules and will abide by them. Academic dishonesty in any form will not be
tolerated and will result in a failing grade as per School policy. Any such incident will be
reported to the Associate Dean and is subject to additional disciplinary action according to the
terms and protections of applicable Academic Senate policies.

We are aware that clickers also provide opportunities for cheating. Please note that bringing
someone elses clicker to class and clicking in for them when they are not present at
lecture is academic dishonesty. If we observe you using more than one clicker in class,
we will confiscate the clickers and report the incident to the Associated Dean of Students
to become a permanent part of your academic record. Incidents of cheating can also
prevent you from receiving academic honors at graduation. At the minimum, all students
participating in this form of dishonesty will lose all clicker points for the course. If you notice that
clickers are being used inappropriately in class, please let your TA or the instructors know.

LETS HAVE FUN THIS QUARTER, GENETICS IS COOL!!