Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii.
[1] Infections with
toxoplasmosis usually cause no symptoms in adult humans.[2] Occasionally there may be a few
weeks or months of mild flu-like illness such as muscle aches and tender lymph nodes.[3] In a
small number of people, eye problems may develop. In those with a weak immune system,
severe symptoms such as seizures and poor coordination may occur. If infected
during pregnancy, a condition known as congenital toxoplasmosis may affect the child. [3]
Toxoplasmosis is usually spread by eating poorly cooked food that contains cysts, exposure to
infected cat feces, and from a mother to a child during pregnancy if the mother becomes
infected. Rarely the disease may be spread by blood transfusion. It is not otherwise spread
between people.[1] The parasite is only known to reproduce sexually in the cat family. However, it
can infect most types of warm-blooded animals, including humans.[4] Diagnosis is typically by
testing blood for antibodies or by testing amniotic fluid for the parasite's DNA.[5]
Prevention is by properly preparing and cooking food. It is also recommended that pregnant
women not clean cat litter boxes.[6] Treatment of otherwise healthy people is usually not needed.
During pregnancy spiramycin orpyrimethamine/sulfadiazine and folinic acid may be used for
treatment.[7]
Up to half of the world's population is infected by toxoplasmosis but have no symptoms.[8] In the
United States about 23% are affected[9] and in some areas of the world this is up to 95%.[1] About
200,000 cases of congenital toxoplasmosis occur a year.[10] Charles Nicolle and Louis
Manceaux first described the organism in 1908. In 1941 transmission during pregnancy from a
mother to a child was confirmed.[11]