BLEEDING
Dr. Sally Temraz_March 2, 2015
A. Purpose of the module:
By the conclusion of this TBL module, students will be able to classify the
disorders related to platelets into inherited and acquired, qualitative and
quantitative, with special emphasis on drug and disease induced platelet
disorders. Students should also differentiate disseminated intravascular
coagulation from thrombotic thrombocytopenia purpura (TTP) both clinically
and by laboratory investigations. They should also define the treatment
options for these disorders. Students should also be able to recognize the
pathophysiology and treatment of idiopathic thrombocytopenic purpura (ITP)
as well as heparin induced thrombocytopenia. They should also be able to
differentiate between vonWillebrand disease and Bernard-Soulier disease
with particular emphasis on their clinical features as well as laboratory
findings.
B. Learning objectives :
1. Recognize the role of platelets in hemostasis.
2. Classify platelet disorders into inherited and acquired with a particular
focus on drug induced platelet dysfunction.
3. Differentiate VonWillebrand disease from Bernard-Soulier disease.
[Link] the causes of increased platelet destruction.
[Link] DIC from TTP.
[Link] the pathophysiology of ITP.
[Link] the treatment options and investigations needed for ITP, DIC,
TTP.
C. Advanced Preparation assignment:
-Essential Haematology 6th Edition, A.V. Hoffbrand Chapters 24-25.
-Refer to platelet disorders PowerPoint presentation