The Merck Index,
th
14
Edition
New Edition, New Features
Patricia Heckelman
Kristin Roman
American Chemical Society
233rd National Meeting
Chicago, IL
28 March 2007
Copyright 2007 by Merck & Co., Inc., Whitehouse Station, NJ, USA. All rights reserved.
The Merck Index: Editorial Staff
z
z
z
z
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Maryadele ONeil, Editor
Patricia Heckelman, Senior Associate Editor
Cherie Koch, Associate Editor
Kristin Roman, Assistant Editor
Catherine Kenny, Editorial Assistant
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Chemistrys Constant CompanionTM
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Merck & Co., Inc. Announces
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More than 25,000 copies sold
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What is The Merck Index?
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The Merck Index:
Authoritative and Essential
z Editorial staff researches and analyzes a variety of
sources to identify compounds, data and literature
citations
z Focuses on compounds of significance in research,
commerce and environmental impact
z Structures, physical properties, trademarks and CAS
registry numbers critically evaluated and assigned to
specific chemical entities
z Merck Index Monograph Number used as an international
compound identifier by chemical suppliers and other
reference works
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The Merck Index:
Broad Subject Coverage
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manufacturing
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Its all in The Merck Index
Laboratory
Reagents
10%
Bulk Chemicals
16%
Human Drugs
31%
Agricultural
Compounds
3%
Pesticides
3%
Fragrances
1%
Natural Products Plants
2%
17%
Biological
Food Additives
Compounds
3%
4%
Veterinary Drugs
8%
Pharmaceutic Aids
1%
Diagnostic Aids
1%
Chemistrys Constant CompanionTM
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The Merck Index:
Your Index to Chemical Information
z Collection of monographs covering >18000
compounds with >50000 synonyms
z >15000 Trademarks and manufacturers
z CAS Registry Numbers for >12000 compounds
z >8500 Chemical Structures
Molecular formulae, line formulae, molecular weight,
percentage composition
z Physical Properties
Melting point, boiling point, Log P, density, absorbance
maxima, solubility, flash point, optical rotation
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The Merck Index:
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Controlled Substances, Carcinogens
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Whats New in the Monograph Section
z New content over 500 new monographs
z Extensively revised
More than half of the existing entries updated
Updated with new references and uses
Up-to-date US regulatory information for controlled
substances and carcinogens
More physical properties
Molecular weights recalculated with the latest IUPAC
standards
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Expanded Focus for Researchers
z >100 new monographs covering chemicals of
significance in modern organic synthesis
Polymer additives, solvents, fluorescent stains, reagents
z 25 New Monographs on Named Reagents
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environmentally important compounds
Chemistrys Constant CompanionTM
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Reagents and Commercial Chemicals
z Texanol Isobutyrate
Plasticizer for manufacturing of vinyl flooring, toys, other vinyl
products
z Triflic Acid
Catalyst and solvent; one of the strongest acids known
z Trifluoroethanol
Environmentally friendly alternative to CFCs
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Reagents and Commercial Chemicals
z Selectflor
Electrophilic, versatile fluorinating reagent
z Samarium Iodide
One-electron reducing agent used in organic synthesis
and electron transfer reactions
z Herrmann-Beller Catalyst
Highly efficient palladacycle catalyst; used in carboncarbon bond forming reactions such as the Heck and
Suzuki reactions
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Research Probes and Stains
z Epicocconone
Fluorescent natural product isolated from the fungus
Epicoccum nigrum; biodegradable fluorescent stain for
protein detection
z Maitotoxin
One of the most toxic and largest (mol wt 3422 Da)
natural products known to date; involved in ciguatera fish
poisoning; research tool for ion flux
z PMSF or phenylmethanesulfonyl fluoride
Standard protease inhibitor in biological research
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Human Pharmaceutical Products
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insulin analog
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dipeptidyl peptidase IV (DPP-IV)
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colorectal cancer
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Human Pharmaceutical Products
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phosphatase; antineoplastic
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Abatacept: Orencia (BMS); recombinant chimeric fusion
protein composed of CTLA-4 fused to human IgG; antipsoriatic
z Diagnostic Aid
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Plants and Herbal Medicines
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Herbaceous plant, Andrographis paniculata Nees,
Acanthaceae, used in in treatment of upper respiratory
infections
z Bilberry and Bilberry Extract
Deciduous, dwarf shrub, Vaccinium myrtillus L., Ericaceae;
extract used in eyecare and skin products; used in treatment of
night blindness
z Hoodia
Genus of succulent plants in the family Apocynaceae; used in
African traditional medicine as an appetite suppressant
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The Merck Index:
More than Just the Monographs
z 450 Organic Name Reactions
Unique compilation of reactions
Schema and key references
Excellent teaching tool for organic chemistry
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Organic Name Reactions
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The Merck Index:
Expanded Supplemental Tables
32 Tables/70 Pages of hard-to-find information
z New tables
Vaccines
Acronyms
Physical & mathematical constants
Selected hexoses & pentoses
z Updated Tables
Company register
Manufacturer codes
Glossary
International patent codes
Periodic table
Table of atomic weights
USAN and INN terms for radical and groups
Chemistrys Constant CompanionTM
Copyright 2007 by Merck & Co., Inc., Whitehouse Station, NJ, USA. All rights reserved.
Supplemental Tables
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14th Edition Electronic Products
CD-ROM
Included as companion to the book
Text searchable with structure upgrade available
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Getting Started
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Search Guide: Text Search
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Structure and Properties Searching
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Structure and Properties Searching: Search Results
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Organic Name Reactions
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Copyright 2007 by Merck & Co., Inc., Whitehouse Station, NJ, USA. All rights reserved.
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Highlights for the 14th Edition
z Book/CD reference set is now available
List Price $125 USD; show discount 15%
z Reference set now includes book and CD
z Over 700 new and majorly revised monographs, expanded
supplemental tables, 450 Organic Name Reactions
z CD includes almost 1000 monographs retired from the 12th
& 13th editions
z Includes a free 1-year personal subscription to
CambridgeSoft Internet Edition
z Internet subscriptions and site licenses visit CambridgeSoft
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Chemistrys Constant CompanionTM
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