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Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

Chapter 23: Respiratory System

I. Functions of the Respiratory System
A. List and describe the five major functions of the respiratory system:
1. ______________________________________________________________
______________________________________________________________
______________________________________________________________
______________________________________________________________
______________________________________________________________
2. ______________________________________________________________
______________________________________________________________
3. ______________________________________________________________
______________________________________________________________
4. ______________________________________________________________
______________________________________________________________
5. ______________________________________________________________
______________________________________________________________
______________________________________________________________
II. Anatomy and Histology of the Respiratory System
A. Nose
1. Consists of ____________________ and the ____________________
2. External Nose
a. The largest part is composed of ______________________________
b. What bones make the bridge of the nose? _______________________ &
extensions of the ____________________ and ____________________
4. Nasal Cavity
a. Extends from the ____________________ to the ___________________
1. What are the nares? _______________________________________
2. What are the choanae? _____________________________________
b. What is the vestibule? _________________________________________

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Community College of Southern Nevada

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Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

c. What forms the floor of the nasal cavity and separates it from the oral
cavity? ____________________
d. The nasal septum is composed of:
1. Anterior part is ____________________
2. Posterior part consists of:
a. ____________________ bone
b. Perpendicular ______________________________
e. What are the conchae? ________________________________________
1. Where are they located in the nasal cavity? ____________________
f. What is a meatus? ___________________________________________
g. The paranasal sinuses open into ______________________________
h. The nasolacrimal duct opens into ______________________________
i.

Functionally the nasal cavity:

1. Passageway _____________________________________________
2. Cleans ________________________________________
3. Humidifies and ______________________________
4. Sensory organ for ____________________ located _______________
5. Resonating ________________________________________

B. Pharynx
1. Common opening for both ____________________ & __________________
2. Inferiorly connected to:
a. Respiratory system at the ______________________________
b. Digestive system at the ______________________________
3. Nasopharynx
a. Superior part of the pharynx and extends from ____________________ to
______________________________
b. What is the uvula attached to? ______________________________
c. Functionally the soft palate prevents ______________________________
d. Mucus containing trapped particles from the nasal cavity moves through
the nasopharynx and is ____________________

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Created by Martin E. Hicks,

Community College of Southern Nevada

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Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

e. The auditory tubes from _________________ open into the nasopharynx

a. They function to ___________________________________________
f. Where is the pharyngeal tonsil or adenoid located? __________________
4. Oropharynx
a. Extends from ____________________ to the ____________________
b. The opening to the oral cavity is called the ____________________
c. What two sets of tonsils are located near the opening to the oral cavity?
1. ______________________________
2. ______________________________
5. Laryngopharynx
a. Extends from the ____________________ to the ___________________
b. Passes posterior to the ______________________________
C. Larynx
1. Consists of an outer casing of ____________________ that are connected to
one another by ____________________ & ____________________
2. What is the largest unpaired cartilage? ______________________________
3. What cartilage forms the base of the larynx? __________________________
4. Which cartilage projects as a free flap toward the tongue? _______________
a. This cartilage is composed of ______________________________
b. During swallowing it covers _____________________________________
5. The paired cartilages:
a. Where are the arytenoid cartilages? ______________________________
b. Where are the corniculate cartilages? _____________________________
c. Where are the cuneiform cartilages? _____________________________
___________________________________________________________
6. Two pairs of ligaments extend from ______________________________ to
____________________________________________________________
a. The superior pair is called ___________________________________
1. Functionally when they come together _________________________
________________________________________________________
b. The inferior pair is called _______________________________________
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Chapter 23: Respiratory System

c. What is the glottis? ___________________________________________

d. What is laryngitis? ____________________________________________
7. Functionally the larynx:
a. Maintain an open _____________________________________________
b. Prevent ____________________________________________________
c. Primary source of ____________________________________________
1. Higher pitched tones are produced when _______________________
2. Progressively lower tones ___________________________________
3. Why do males have lower-pitched voices? ______________________
4. Movement of the cartilages is controlled by ______________________
5. Movement of arytenoid cartilages:
a. Lateral rotation _________________________________________
b. Medial rotation _________________________________________
c. Anterior/posterior movement ______________________________
D. Trachea
1. Describe the structure of the trachea: _______________________________
______________________________________________________________
2. Functionally the C-shaped cartilage ____________________ the trachea and
__________________________________________________ for air
3. The posterior wall of the trachea is ____________________ but contains:
a. Elastic ______________________________
b. Bundles of ________________________ called ____________________
4. What does the smooth muscle do during coughing? ____________________
5. Describe the structure of the mucous membrane: ______________________
______________________________________________________________
a. What functional role do the cilia play? _____________________________
6. At the level of the fifth thoracic vertebrae the trachea divides into __________
______________________________________________________________
7. What is the carina? ______________________________________________
E. Tracheobronchial Tree
1. What does the term tracheobronchial tree refer to? _____________________
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Chapter 23: Respiratory System

______________________________________________________________
2. Conducting Zone
a. Extends from the ____________________ to ____________________
b. How many generations of branching are present? ___________________
c. Functionally the conducting zone is a ___________________________ &
contains epithelial tissue that helps _______________________________
d. The trachea divides into the __________ & ________________________
1. Compared to the left primary bronchus, the right primary bronchus is:
a. ______________________________
b. ______________________________
c. ______________________________
e. The primary bronchi divide into __________________________________
1. How many in the left lung? ____________________
2. How many in the right lung? ____________________
f. The secondary bronchi divide into _______________________________
g. The bronchi continue to branch giving rise to _______________________
h. Several more subdivisions finally become _________________________
i.

As the tubes divide the amount of cartilage and smooth muscle changes:
1. Primary bronchi have ______________________________________
2. Secondary bronchi have ____________________________________
3. Terminal bronchioles have __________________________________

j.

Diameter of the air passageways is changed by ____________________

___________________________________________________________

k. What happens to the air passageways in an asthma attack? ___________

___________________________________________________________
3. Respiratory Zone
a. Extends from the ____________________ to ______________________
called _______________ which are sites of ________________________
b. How many generations of branching are present? ___________________
c. The terminal bronchioles divide to form ___________________________
1. Have a few attached alveoli so have a limited ability _______________
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Community College of Southern Nevada

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Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

d. As respiratory bronchioles divide into smaller branches the number of

attached alveoli ____________________
e. The respiratory bronchioles finally form ____________________ ducts
1. The alveolar duct wall is little more than ________________________
2. The alveolar duct ends as ___________________________________
f. The tissue surrounding the alveoli contains ________________________
1. This allows the alveoli to:
a. Expand ______________________________
b. Recoil ______________________________
g. Structurally the walls of respiratory bronchioles consists of:
a. ____________________ and ____________________________ with
b. Bundles of ______________________________
c. Epithelium is a ________________________________________
h. Structurally the alveolar ducts and alveoli consist of __________________
________________________________________
i.

Debris in the respiratory zone is removed by _______________________

1. Where does the debris end up? ____________________________ or
________________________________________________________

j.

Alveolar walls are composed of two cell types:

1. Type I pneumocytes are _____________________________ that form
________________________________________
2. Type II pneumocytes are ________________________________ that
produce ____________________ which ________________________
3. Most gas exchange occurs through which cells? _________________

k. What is the respiratory membrane? ______________________________

l.

Why does the respiratory membrane need to be thin? ________________

___________________________________________________________

m. List the elements of the respiratory membrane:

1. ________________________________________________________
2. ________________________________________________________
3. ________________________________________________________
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Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

4. ________________________________________________________
5. ________________________________________________________
6. ________________________________________________________
F. Lungs
1. What is the shape of a lung? ______________________________________
2. What is the hilum? ______________________________________________
3. What is the root of the lung? _______________________________________
4. How many lobes does each lung have?
a. Right lung has ____________________
b. Left lung has ____________________
5. What separates the lobes of the lung? _______________________________
6. Internally each lobe is supplied by a ____________________ bronchus
7. The lobes are subdivided into _____________________________ which are
supplied by ______________________________
8. Bronchopulmonary segments are subdivided into ____________________
that are supplied by ______________________________
G. Thoracic Wall and Muscles of Respiration
1. The thoracic wall consists of the:
a. ______________________________
b. ______________________________
c. ______________________________
d. ______________________________
e. ______________________________
2. How is the thoracic cavity defined? _________________________________
______________________________________________________________
3. The associated muscles are responsible for __________________________
4. The muscles of inspiration include:
a. ______________________________
b. ______________________________
c. ______________________________
d. ______________________________
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Chapter 23: Respiratory System

5. Which muscle is responsible for two-thirds of the thoracic cavity volume

increase? ______________________________
6. Which muscles elevate the ribs to increase thoracic cavity volume?
______________________________________________________________
7. The muscles of expiration that compress the ribs and sternum include:
a. ______________________________
b. ______________________________
8. How is inward collapse of the thoracic cage prevented during inspiration?
______________________________________________________________
9. Describe the shape of the diaphragm: _______________________________
a. The base is attached to ________________________________________
b. What is the central tendon? ____________________________________
10. What happens to the diaphragm during normal quiet breathing? ___________
______________________________________________________________
11. When breathing deeper what happens to the diaphragm? ________________
______________________________________________________________
12. When the ribs are elevated the costal cartilage allows ___________________
______________________________________________________________
13. During quiet breathing expiration occurs when _______________________ &
____________________ relax and the ______________________________
cause a __________________________________________________
a. Contraction of the abdominal muscles ____________________________
H. Pleura
1. Each lung is contained inside a ____________________________________
2. What is the mediastinum? ________________________________________
3. What does the parietal pleura cover? ________________________________
______________________________________________________________
4. What does the visceral pleura cover? _______________________________
5. The pleural cavity is filled with _____________________________________
6. Functionally the pleural fluid:
a. Acts as a ______________________________
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Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

b. Helps hold __________________________________________________

I. Blood Supply
1. What is oxygenated blood? _______________________________________
2. What is deoxygenated blood? _____________________________________
3. The major blood flow route:
a. Brings deoxygenated blood from the heart through __________________
b. Flows through pulmonary capillaries where it is _____________________
c. Then flows back to the heart through _____________________________
4. The smaller blood flow route:
a. Brings oxygenated blood from the ______________________________
b. Passes through ____________________ to ____________________
where oxygen is released
c. The now deoxygenated blood from the proximal part of the bronchi returns
to the heart through __________ veins and the _____________________
d. The now deoxygenated blood from the distal part of the bronchi returns to
the heart through the ____________________ containing ____________
J. Lymphatic Supply
1. Where are the superficial lymphatic vessels located? ___________________
a. Functionally they drain lymph from _______________________________
___________________________________________________________
2. Where are the deep lymphatic vessels located? _______________________
a. Functionally they drain lymph from ______________________________
___________________________________________________________
3. The lymphatic vessels exit the lungs at the ____________________
III. Ventilation
A. Pressure Differences and Airflow
1. What is ventilation? _____________________________________________
2. Airflow into the lungs requires _____________________________________
3. Airflow out of the lungs requires ___________________________________

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Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

B. Pressure and Volume

1. The general gas law reveals that air pressure is _______________________
____________________ to ______________________________
a. As volume increases ______________________________
b. As volume decreases ______________________________
C. Airflow into and out of Alveoli
1. Barometric air pressure is defined to be equal to ____________________
2. What is alveolar pressure? ________________________________________
a. This pressure is usually expressed in terms of ______________________
3. During the process of ventilation:
a. At the End of Expiration:
1. No air is moving because ___________________________________
b. During Inspiration
1. Contraction of ______________________________
2. ____________________ thoracic volume
3. Results in ____________________ of the lungs and an
________________________________________
4. Causes a ____________________ in alveolar pressure
5. Air flows ____________________ because ____________________
is ________________________________________
c. End of Inspiration
1. Thorax and alveoli ______________________________
2. Alveolar pressure becomes __________________________________
3. No further movement of air because ___________________________
d. During Expiration
1. Diaphragm ______________________________
2. ____________________ thoracic volume
3. Thorax and lungs ____________________
4. Decreased thoracic volume results in _______________ alveolar
volume and ____________________ alveolar pressure

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Created by Martin E. Hicks,

Community College of Southern Nevada

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Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

5. Air flows ____________________ because _____________________

is __________________________________________________
6. As expiration ends:
a. ____________________ in thoracic volume stops
b. Alveoli ______________________________
D. Changing Alveolar Volume
1. Lung Recoil
a. What does lung recoil cause? ______________________________
b. Lung recoil is the result of:
1. Elastic __________________________________________________
2. Surface _________________________________________________
c. Surfactant composed of _______________________________________
d. How does surfactant reduce the tendency of the lungs to collapse?
___________________________________________________________
2. Pleural Pressure
a. Pleural pressure is the pressure in the ____________________________
b. Normally the alveoli are expanded because ________________________
c. When pleural pressure is lower than alveolar pressure _______________
________________________________________
d. This expansion is opposed by the tendency of the lungs to ____________
e. What happens if the pleural pressure is sufficiently low? ______________
___________________________________________________________
f. What happens if the pleural pressure is not low enough to overcome lung
recoil? ______________________________
3. Pressure Changes During Inspiration and Expiration
a. At the end of a normal expiration:
1. Pleural pressure is ______________________________
2. Alveolar pressure is ______________________________
b. During normal quiet inspiration:
1. Pleural pressure ____________________ to ____________________
2. Alveolar volume ____________________
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Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

3. Alveolar pressure ________________________________________

4. Air flows ______________________________
5. As air flows into the lungs, alveolar pressure ____________________
and _________________________________ at the end of inspiration
6. The tendency for the lungs to recoil increases as _________________
____________________ similar to ____________________________
c. During expiration:
1. Thoracic volume _____________________________
2. Pleural pressure ______________________________
3. Alveolar volume ______________________________
4. Alveolar pressure ________________________________________
5. Air flows ______________________________
6. As air flows out of the lungs, alveolar pressure ___________________
and __________________________________ at the end of expiration
IV. Measuring Lung Function
A. Compliance of the Lungs and the Thorax
1. What is compliance a measure of? _________________________________
______________________________________________________________
2. Compliance of the lungs and thorax is the ______________ by which they
____________ for each unit of ___________________in ________________
3. The greater the compliance _______________________________________
___________________________________________________________
4. A higher than normal compliance means the lungs will expand ____________
5. A lower than normal compliance means that __________________________
B. Pulmonary Volumes and Capacities
1. What is spirometry? _____________________________________________
2. What is a spirometer? ___________________________________________
3. List and describe the pulmonary volumes:
a. ___________________________________________________________
___________________________________________________________
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Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

b. ___________________________________________________________
___________________________________________________________
c. ___________________________________________________________
___________________________________________________________
d. ___________________________________________________________
___________________________________________________________
4. List and describe the pulmonary capacities:
a. ___________________________________________________________
___________________________________________________________
b. ___________________________________________________________
___________________________________________________________
c. ___________________________________________________________
___________________________________________________________
___________________________________________________________
d. ___________________________________________________________
___________________________________________________________
5. List factors that cause variations in pulmonary volumes and capacities:
______________________________________________________________
6. Do males or females have a larger vital capacity? ______________________
7. The vital capacity is usually highest at what age? ______________________
8. What is the forced expiratory vital capacity? __________________________
____________________________________________________________
C. Minute Ventilation and Alveolar Ventilation
1. Define minute ventilation: _________________________________________
______________________________________________________________
2. Minute ventilation is equal to ______________________________________
3. The anatomic dead space is the part of the respiratory system where gas
exchange ______________________________
4. What structures make up the anatomic dead space? __________________,
___________, ___________, ___________, ___________, & ___________
5. What is physiologic dead space? ___________________________________
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Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

6. Alveolar ventilation is the volume of air ______________________________

per ______________________________
V. Physical Principles of Gas Exchange
A. Partial Pressure
1. What is atmospheric pressure at sea level? ___________________________
2. What does Dalton's law say about pressures in a mixture of gases?
______________________________________________________________
______________________________________________________________
3. What is a partial pressure? ________________________________________
4. How do you calculate a partial pressure? _____________________________
______________________________________________________________
5. What is water vapor pressure? _____________________________________
B. Diffusion of Gases Through Liquids
1. The amount of gas that will dissolve in a liquid is determined by:
a. Partial ______________________________
b. Solubility ______________________________
1. This is described by ________________________________________
2. What is the solubility coeffiecient? __________________________________
3. The calculated partial pressure of a gas in a liquid is a measure of
______________________________
C. Diffusion of Gases Through the Respiratory Membrane
1. Respiratory Membrane Thickness
a. Increasing the thickness of the respiratory membrane ________________
________________________________________
b. How thick is the respiratory membrane normally? ___________________
c. What happens if the thickness increases two or three times? __________
___________________________________________________________
d. What is the most common cause of an increase in the thickness of the
respiratory membrane? ______________________________

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Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

e. List a few examples of conditions that can cause such fluid accumulation:
___________________________________________________________
2. Diffusion Coefficient
a. What is the diffusion coefficient? _________________________________
1. This takes into account:
a. Solubility ________________________________________
b. Size ________________________________________
b. Does oxygen or carbon dioxide diffuse more easily? _________________
c. Damage to the respiratory membrane interferes with the diffusion of
__________________ more than the diffusion of ___________________
d. Extensive oxygen therapy can result in large blood increases of ________
3. Surface Area
a. What is the normal surface area of the respiratory membrane of a healthy
adult? ______________________________
b. What diseases might decrease surface area? ______________________
c. Small decreases in surface area affect the ability to exchange gases
during ______________________________
d. The ability to exchange gases becomes a problem even under resting
conditions when the surface area is decreased by ___________________
e. List examples of how surface area for gas exchange can be reduced:
___________________________________________________________
4. Partial Pressure Difference
a. Define partial pressure difference: _______________________________
___________________________________________________________
___________________________________________________________
b. Net diffusion occurs from the ____________________ partial pressure to
____________________ partial pressure
c. Normally the partial pressure of oxygen (PO2) is higher in _____________
than the ______________________________
d. Normally the partial pressure of carbon dioxide (PCO2) is higher in
____________________ than the ______________________________
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Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

e. How can the partial pressure difference for oxygen and carbon dioxide be
raised? __________________________________________________
f. A lower than normal partial pressure difference is caused by:
___________________________________________________________
D. Relationship Between Ventilation and Pulmonary Capillary Blood Flow
1. Regular ventilation of the alveoli and normal blood flow through pulmonary
capillaries allows effective ____________________ between air and blood
2. During exercise effective gas exchange is maintained because:
a. Ventilation ____________________
b. Cardiac output ____________________
3. The normal relationship can be disrupted in two ways:
a. Cardiac output is ____________________ and therefore not enough
blood flows to the lungs to pick up the available oxygen
b. Ventilation is ______________________________ to provide enough
oxygen for the blood flowing through the pulmonary capillaries
4. What is shunted blood? ________________________________________
5. What is the anatomic shunt? ______________________________________
6. What is the physiologic shunt? _____________________________________
7. When a person is standing blood flow and ventilation in the lungs is effected
by ______________________________
8. When a person is standing most gas exchange occurs at ________________
9. There is decreased pressure at the ____________________ of the lungs
10. During exercise, cardiac output and ventilation ________________________
a. This __________________ pulmonary blood pressure throughout the lung
b. Blood flow _______________ most at the _________________________
c. Effectiveness of gas exchange increases __________________________
because of ________________________________________
11. If there is a low PO2 in one portion of the lung:
a. Causes arterioles to __________________________________ blood flow
b. This reroutes blood ___________________________________________
___________________________________________________________
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Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

c. This reduces the effect on gas exchange by rerouting the blood to

___________________________________________________________
VI. Oxygen and Carbon Dioxide Transport in the Blood
A. Oxygen Diffusion Gradients
1. The PO2 within the alveoli averages approximately ____________________
2. The PO2 of the blood as it flows into pulmonary capillaries is _____________
a. Therefore, oxygen diffuses from ______________ into ______________
3. Does the blood PO2 ever reach equilibrium with the alveoli PO2? ___________
4. Blood leaving the pulmonary capillaries has a PO2 of ____________________
but blood leaving the lungs in the pulmonary veins has a PO2 of ___________
a. What causes this decrease in PO2? ______________________________
___________________________________________________________
5. The PO2 of blood entering tissue capillaries is approximately _____________
6. The PO2 of the interstitial spaces is close to ____________________
7. The PO2 inside the cells is probably near ____________________
a. Therefore, oxygen diffuses from ______________ into _____________ &
from the ____________________ into ____________________
b. A constant diffusion gradient exists because _______________________
B. Carbon Dioxide Diffusion Gradients
1. Carbon dioxide is continually produced as a by-product of _______________
a. This establishes a diffusion gradient for carbon dioxide from the
______________________________ to the _______________________
1. The intracellular PCO2 is approximately ____________________
2. The interstitial fluid PCO2 is approximately ____________________
3. The blood entering the tissue capillaries has a PCO2 of _____________
a. Therefore, carbon dioxide diffuses from ______________________
to ______________________________
c. As the blood leaves the tissue capillaries it has a PCO2 of _____________
2. At the lungs:
a. The PCO2 of blood entering the pulmonary capillaries is _______________
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Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

b. The PCO2 of the alveoli is approximately ____________________

1. Therefore, carbon dioxide diffuses from ____________________ into
______________________________
c. The PCO2 of blood leaving the pulmonary capillaries has decreased to
____________________
C. Hemoglobin and Oxygen Transport
1. How much of the oxygen transported in blood is in combination with
hemoglobin? ____________________
2. The combination of oxygen with hemoglobin is ____________________
a. In the pulmonary capillaries ____________________________________
b. In the tissue capillaries ________________________________________
3. Effect of PO2
a. What is the oxygen-hemoglobin dissociation curve? _________________
___________________________________________________________
b. When is hemoglobin saturated with oxygen? _______________________
___________________________________________________________
c. At any PO2 above 80 mm Hg the hemoglobin is about ________ saturated
d. At the PO2 of 104 mm Hg the hemoglobin is ______________ saturated
e. In the skeletal muscle of a resting person:
1. The blood leaving the muscle has a PO2 of ____________________
a. At this PO2 the hemoglobin is approximately __________ saturated
1. Therefore the hemoglobin released ___________ of the oxygen
f. During vigorous exercise the blood PO2 can decline to __________
1. At this level approximately __________ of the hemoglobin is saturated
and ____________________ of the bound oxygen is released
g. When the oxygen needs of the tissue ____________________, blood PO2
________________ and ______________________________________
4. Effect of pH, PCO2, and Temperature
a. pH
1. As the pH of the blood declines ______________________________
_______________________________________________________
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Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

2. This occurs because decreased pH is caused by _________________

3. Hydrogen ions combine with _________________________________
& change ________________________________________________
a. This results in a decrease in the ability ______________________
4. As the pH of the blood increases ______________________________
________________________________________________________
5. The effect of pH on the oxygen-hemoglobin dissociation curve is called
______________________________
b. PCO2
1. An increase in PCO2 ____________________ the ability of hemoglobin
to bind oxygen because carbon dioxide effects __________
2. What is carbonic anhydrase? ________________________________
3. What is the chemical reaction carbonic anhydrase is involved in?
________________________________________________________
4. When carbon dioxide levels increase more ______________________
5. When carbon dioxide levels decline there is a decrease in __________
______________________________ and an increase in __________
6. As blood passes through tissue capillaries:
a. Carbon dioxide ______________________________
b. Blood carbon dioxide levels ____________________
c. Hemoglobin has ______________________________
d. Greater amount of ______________________________________
_____________________________________________________
7. As blood passes through the lungs:
a. Carbon dioxide __________________ & ____________________
b. Carbon dioxide levels in the pulmonary capillaries _____________
c. Affinity ________________________________________
c. Temperature
1. What effect does an increase in temperature have on the tendency of
hemoglobin to bind to oxygen? ____________________
2. Tissues with increased metabolism have higher temperature and
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Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

therefore ___________________ oxygen is released from hemoglobin

3. Less active tissues have a lower temperature and ________________
oxygen is released
d. During exercise what happens to the following in the tissues:
1. Carbon dioxide levels ____________________
2. Acidic substances _______________________ so the pH __________
3. Temperature ______________________________
a. These conditions cause how much of the oxygen to be released
from the hemoglobin? ____________________
1. This is due to the oxygen-hemoglobin curve shifting _________
e. In the lungs the hemoglobin becomes easily saturated because:
1. Carbon dioxide levels ____________________
2. Temperature ____________________
3. Lactic acid levels ____________________
5. Effect of BPG (2,3-biphosphoglycerate)
a. BPG is formed as red blood cells ________________________________
b. What does BPG do when it binds to hemoglobin? ___________________
c. When BPG levels increase _____________________________________
d. When BPG levels decrease ____________________________________
e. What happens to BPG levels at high altitudes? _____________________
f. What happens to BPG levels in stored blood? ______________________
1. Why does stored blood become unsuitable for transfusion? _________
________________________________________________________
6. Fetal Hemoglobin
a. Fetal blood is very efficient at picking up oxygen because:
1. Concentration of fetal hemoglobin is ___________________________
________________________________________________________
2. Fetal hemoglobin has an oxygen-hemoglobin dissociation curve that is
to the __________ of the maternal curve. This means that fetal
hemoglobin can ___________________________________________
3. BPG has ____________________ on fetal hemoglobin.
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Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

4. Of the double Bohr effect. Describe what happens in the double Bohr
effect: ___________________________________________________
________________________________________________________
________________________________________________________
D. Transport of Carbon Dioxide
1. Carbon dioxide is transported in the blood in three major ways:
a. 7% ________________________________________
b. 23% ________________________________________
c. 70% ________________________________________
2. Carbon dioxide binds in a reversible fashion to the ____________________
of the ______________________________
3. What is the Haldane effect? _______________________________________
______________________________________________________________
a. In the tissues ________________________________________________
b. In the lungs _________________________________________________
4. Chloride Shift
a. At the tissues:
1. Carbon dioxide diffuses into ______________________________
2. Some of the carbon dioxide binds to ________________________
3. Most of the carbon dioxide reacts with ____________________ to
form ______________________________
a. This reaction is catalyzed by the enzyme ____________________
4. The carbonic acid then dissociates into:
a. ______________________________
b. ______________________________
5. In the chloride shift carrier molecules move:
a. Bicarbonate ions ______________________________
b. Chloride ions ______________________________
1. This exchange maintains ______________________________
6. Hemoglobin binds to ______________________________
a. In this fashion hemoglobin functions as a ____________________
Page 21 of 28

Created by Martin E. Hicks,

Community College of Southern Nevada

th

Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

b. At the lungs:
1. Carbon dioxide ______________________________
2. Carbonic acid is converted to ______________________________
3. Bicarbonate ions join _________________ to form _______________
4. Bicarbonate ions _______ the red blood cell in exchange for ________
5. Hemoglobin releases ____________________
5. Carbon Dioxide and Blood pH
a. Blood pH refers to ____________________ not ____________________
b. Carbonic anhydrase is found on _________________________________
c. So in plasma carbon dioxide joins with ____________________ to form
______________________________ which dissociates to form
____________________ and ____________________
d. As carbon dioxide increases, hydrogen ions __________ & pH _________
e. The respiratory system regulates blood pH by ______________________
VII. Rhythmic Ventilation
A. Respiratory Areas in the Brainstem
1. The medullary respiratory center consists of:
a. Two _______________________________________________________
b. Two _______________________________________________________
1. Communication exists between _______________________________
2. Communication also exists between ___________________________
2. The dorsal respiratory groups are primarily responsible for _______________
______________________________
a. The input they receive allows ______________________________
3. The ventral respiratory group is a collection of neurons that are active during
____________________ & ____________________
a. The neurons of the ventral respiratory group primarily stimulate:
1. ______________________________
2. ______________________________
3. ______________________________
Page 22 of 28

Created by Martin E. Hicks,

Community College of Southern Nevada

th

Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

4. Functionally the pontine respiratory group has:

a. Some of the neurons ________________________________________
b. Some of the neurons ________________________________________
c. Some of the neurons ________________________________________
1. Appears to play a role in ____________________________________
B. Generation of Rhythmic Ventilation
1. Starting inspiration:
a. Neurons that promote inspiration are _____________________________
b. The medullary respiratory center constantly receives input related to:
1. Blood ____________________
2. Blood ____________________
3. Movements of ____________________ & ____________________
c. The medullary respiratory center can also receive input from:
1. Parts of brain concerned with ______________________________ &
____________________
d. Inspiration starts when the combined input from all sources causes the
production of ________________________________________________
2. Increasing inspiration:
a. What happens once inspiration begins? ___________________________
______________________________
b. What does this do to the stimulation of respiratory muscles? __________
___________________________________ lasts for ________________
3. Stopping inspiration:
a. Neurons in the medullary respiratory center that are responsible for
stopping inspiration:
1. Are _______________________ that stimulate the inspiratory muscles
2. Also receive input from:
a. Pontine ______________________________
b. Stretch ___________________________ & probably other sources
b. When these inhibitory neurons are activated, they inhibit ______________
___________________________________________________________
Page 23 of 28

Created by Martin E. Hicks,

Community College of Southern Nevada

th

Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

c. Relaxation of respiratory muscles results in ____________________ that

lasts ________________________________________
VIII. Modification of Ventilation
A. Cerebral and Limbic System Control
1. A person can consciously increase or decrease the rate and depth of
respiratory movements through the ____________________
2. Apnea is __________________________________________________
3. When a person holds their breath they eventually develop an urge to breathe:
a. This is associated with ________________________________________
b. Finally PCO2 is high enough that _________________________________
4. If a person is able to hold their breath until they pass out due to lack of
oxygen then ___________________________________________________
5. What causes the feeling of dizziness when a person hyperventilates?
______________________________________________________________
______________________________________________________________
______________________________________________________________
6. Emotions affect the respiratory system through the _______________ system
7. What kind of affects can strong emotions have on respiratory movements?
______________________________________________________________
B. Chemical Control of Ventilation
1. Chemoreceptors
a. What are chemoreceptors? _____________________________________
b. The chemoreceptors involved in respiration respond to changes in:
1. ______________________________ OR
2. ______________________________ or both
c. Where are the central chemoreceptors located? ____________________
___________________________________________________________
d. Where are the peripheral chemoreceptors located? __________________
___________________________________________________________

Page 24 of 28

Created by Martin E. Hicks,

Community College of Southern Nevada

th

Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

2. Effect of pH
a. Cerebrospinal fluid bathes the ______________________________
1. The cerebrospinal fluid pH is altered by changes in _______________
2. Therefore the __________________ is indirectly sensitive to blood pH
b. The carotid and aortic bodies are directly sensitive to ________________
______________________________
c. If blood pH decreases:
1. Respiratory center is ____________________
2. Results in ______________________________ &
3. ____________________ in blood pH back to normal
d. If blood pH increases:
1. Respiratory rate ____________________
2. Carbon dioxide levels ____________________
3. Causing blood pH to ______________________________
3. Effect of Carbon Dioxide
a. Blood carbon dioxide levels are a ______________________________
b. Even a small increase in carbon dioxide triggers ____________________
___________________________________________________________
c. What is hypercapnia? ________________________________________
d. What is hypocapnia? ________________________________________
e. Carbon dioxide exerts its effect on the chemosensitive area by
______________________________
f. If blood carbon dioxide levels increase:
1. Carbon dioxide diffuses _____________________________________
2. Carbon dioxide joins with water to form _________________________
which then dissociates into:
a. ______________________________
b. ______________________________
3. The increased concentration of ____________________________ pH
and stimulates the ______________________________ which then
stimulates the ______________________________
Page 25 of 28

Created by Martin E. Hicks,

Community College of Southern Nevada

th

Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

4. Resulting in ______________________________________________
5. This eliminates ____________________ from the body
g. The carotid and aortic bodies also respond to changes in carbon dioxide
because of __________________________________________________
h. Which is most important for regulating PCO2 and pH? ________________
i.

During intense exercise which responds fastest? ____________________

4. Effect of Oxygen
a. What is hypoxia? _____________________________________________
b. The effect of oxygen on the regulation of respiration is _______________
c. Arterial PO2 must decrease to approximately ____________________
to have a large stimulatory effect on respiratory movements
d. Why is a small change in PO2 not a problem? _______________________
___________________________________________________________
e. The carotid and aortic body chemoreceptors respond to decreased PO2 by
___________________________________________________________
C. Hering-Breuer Reflex
1. What does the Hering-Breuer reflex accomplish? ______________________
______________________________________________________________
2. The reflex depends on stretch receptors in the ________________________
3. Action potentials are initiated in the stretch receptors when ______________
________________________________________
4. The action potentials reach the medulla via the ____________________
5. The action potentials have an ____________________ on the respiratory
center and result in ______________________________
6. With expiration the stretch receptors are _____________________________
7. The decreased inhibitory effect on the respiratory center allows
________________________________________
IX. Respiratory Adaptations to Exercise
A. In response to training:
1. Vital capacity ______________________________
Page 26 of 28

Created by Martin E. Hicks,

Community College of Southern Nevada

th

Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

2. Residual volume ______________________________

3. At rest tidal volume ______________________________
4. At maximal exercise tidal volume ______________________________
5. At rest respiratory rate is ________________________________________
6. At maximal exercise respiratory rate is ______________________________
7. Minute ventilation at rest is ______________________________
8. Minute ventilation at maximal exercise is _____________________________
9. Blood flow through the lungs is __________ especially in the _____________
X. Effects of Aging on the Respiratory System
A. Vital capacity decreases with age because of a:
1. Decreased ability to ________________________________________ &
2. Decreased ability to ________________________________________
a. As a result maximum minute ventilation rates ____________________
3. The changes are related to:
a. Weakening ________________________________________
b. Decreased ________________________________________ caused by
________________________________________
B. Residual volume increases with age as the ____________________ and many
________________________________________ in diameter
1. This ____________________ the dead space
a. Which _________________ the amount of air available for gas exchange
C. Gas exchange across the respiratory membrane is reduced because:
1. Parts of the ______________________________ which decreases the
________________________________________
2. The remaining walls ____________________, which decreases
______________________________
D. Elderly are more susceptible to respiratory infections and bronchitis because:
1. Mucus ________________________________________
2. The mucus-cilia escalator is less able to move the mucus because:
a. The mucus ______________________________
Page 27 of 28

Created by Martin E. Hicks,

Community College of Southern Nevada

th

Seeley, Stephens, and Tate: Anatomy and Physiology, 6 ed.

Chapter 23: Respiratory System

b. The number ______________________________ & their rate of

________________________________________

Page 28 of 28

Created by Martin E. Hicks,

Community College of Southern Nevada