DRUG INDEX
General Data
Patient number:
Name:
Age/sex:
Date of admission:
Date of discharge:
Attending physician:
Admitting diagnosis:
GENERIC/
BRAND NAME
Co Amoxiclav
DOSAGE
1.2 g tiv q 8
MODE OF ACTION
INDICATIONS
CONTRAINDICATIONS
ADVERSE EFFECTS
Amoxicillin is a semisynthetic penicillin
(beta-lactam antibiotic) that inhibits one
or more enzymes (often referred to as
penicillin-binding proteins, PBPs) in the
biosynthetic pathway of bacterial
peptidoglycan, which is an integral
structural component of the bacterial
cell wall. Inhibition of peptidoglycan
synthesis leads to weakening of the cell
wall, which is usually followed by cell
lysis and death.
Amoxicillin is susceptible to
degradation by beta-lactamases
produced by resistant bacteria and
therefore the spectrum of activity of
amoxicillin alone does not include
organisms which produce these
enzymes.
Clavulanic acid is a beta-lactam
structurally related to penicillins. It
inactivates some beta-lactamase
enzymes thereby preventing
inactivation of amoxicillin. Clavulanic
acid alone does not exert a clinically
useful antibacterial effect.
Co-amoxiclav is indicated
for the treatment of the
following infections in
adults and children
Acute bacterial sinusitis
(adequately diagnosed)
Acute otitis media
Acute exacerbations of
chronic bronchitis
(adequately diagnosed)
Community acquired
pneumonia
Cystitis
Pyelonephritis
Skin and soft tissue
infections in particular
cellulitis, animal bites,
severe dental abscess with
spreading cellulitis.
Bone and joint infections,
in particular osteomyelitis.
Consideration should be
given to official guidance
Hypersensitivity to the
active substances, to
any of the penicillins or
to any of the excipients.
History of a severe
immediate
hypersensitivity reaction
(e.g. anaphylaxis) to
another beta-lactam
agent (e.g. a
cephalosporin,
carbapenem or
monobactam).
History of
jaundice/hepatic
impairment due to
amoxicillin/clavulanic
acid.
The most commonly
reported adverse drug
reactions (ADRs) are
diarrhoea, nausea and
vomiting.
Moxifloxacin HCl
1 drop every
2 hours on
the right eye
Inhibits DNA gyrase and
topoisomerase IV. This results in
inhibition of DNA replication and
translation and DNA repair,
recombination and transposition,
which causes bacterial cell death.
Prednisolone
1 drop every
3 hours on
the right eye
Decreases inflammation by
suppression of PMNs and reversal
of increased capillary permeability
Dexpanthenol
gel
1 drop into
conjunctival
sac 3-5
times/day
and before
retiring
Omeprazole
40 mg cap, 1
cap 30 mins
before
breakfast
on the appropriate use of
antibacterial agents.
Antibiotic/ Quinolone
Hypersensitivity to
moxifloxacin or to other
quinolones
Transient ocular
discomfort, burning &
stinging. Ocular pain,
pruritus & hyperemia.
Headache, keratitis,
pharyngitis
&subconjunctival
hemorrhage.
Steroid responsive
inflammation of the
palpebral and bulbar,
cornea and anterior
segment
Acute, untreated
purulent ocular
infections. Acute
superficial herpes
simplex, varicella and
most other viral
diseases of the cornea
and conjunctiva
Increase intraocular
pressure with optic
nerve damage and
visual field defects.
Posterior sub capsular
cataract formation
secondary ocular
infection from fungi or
viruses
Relieving dry skin, preventing and
treating sore nipples during breastfeeding, and promoting healing of
burns and poorly-healing wounds.
Corneal erosions;
supportive and post
treatment of all types of
keratitis; scald burns;
dystrophic corneal
diseases; prevention and
treatment of corneal
damage in wearers of
contact lenses
do not use with contact
lenses. May cause
transient blurring of
vision and caution when
driving or operating
machines
Occasionally, symptoms
of intolerance
Proton pump inhibitors act by
irreversibly blocking
the hydrogen/potassium adenosine
triphosphatase enzyme system (the
+ +
H /K ATPase, or, more commonly,
the gastric proton pump) of the
gastric parietal cells
Hypersensitivity to
omeprazole
This may be due to its
longer availability and,
hence, clinical
experience. Common
adverse effects
include: headache, nau
sea, diarrhea, abdomina
l pain, fatigue,
and dizziness
Dyspepsia
Peptic ulcer disease
Gastroesophageal
reflux disease (GERD
or GORD)
Laryngopharyngeal
reflux
Barrett's esophagus
Eosinophilic
esophagitis
Stress gastritis preven
tion
Gastrinomas and
Clerk-in-Charge
other conditions that
cause hypersecretion
of acid
Zollinger-Ellison
syndrome (often 2-3x
the regular dose is
required as compared
to the other
indications)