714X Technical Data Overview
714X Technical Data Overview
Trimethylaminohydroxybicycloheptane Chloride.
B. COMMERCIAL NAME
C. COMMERCIAL PRESENTATION
714X is manufactured by the private laboratory Centre expérimental de recherches biologiques de l’Estrie Inc.
(C.E.R.B.E. inc.). The product is exclusively distributed by CERBE Distribution Inc. and its authorized agents.
1. 714X developed for perinodular injections (basic 2. 714X developed for inhalation through the respi-
treatment) ratory tract (secondary treatment, if necessary).
This product is available in 6.5 ml vials. Two vials are The secondary treatment of 714X is performed with
required to complete 21 consecutive days of treatment the use of a medical device known as a nebulizer.
referred to as one cycle. This basic treatment is directly This treatment is added to reach the smaller seg-
administered into the large lymphatic circulation (See ment of the lymph system known as the small lym-
Section J). phatic circulation (See Section J).
CH3 CH3
+
C O C NH3
H2C C H2C C O
C C
H H
Camphre
CH3 CH3
NH C NH2
C
H2C C H2C C OH
C C
H H
NaCl
CH3
+
C NH2 Cl
H2C C
H3C C CH3
H2C CH2
C
H
Content :
714X contains nitrogen as its primary ingredient, cam-
phor as its vehicle, mineral salts and 18 trace elements. The results described below were obtained through
a gas chromatography and a mass spectrometry.
The chemical analysis was performed by an inde-
pendent laboratory asked to identify the ingredients
of an unidentified product.
No precipitation is obtained when 714X is combined with trifluoroacetic acid, indicating an absence of proteins.
After concentrating the sample twice under a nitrogen flow, one microliter of the liquid was injected under con-
trolled conditions.
2.2 Results
• Peak number 1 (evaluated after 10 minutes 18 seconds) has been identified by its mass spectrum and shows
the main characteristics of CAMPHOR or trimethyl (1.7.7) bicyclo (2.2.1) heptanone-2 (C10H160, m.w. =
152).
• Peaks number 2 and 3 which are not well separated, coelute after 15 minutes and 16 minutes 28 seconds
respectively.
• Peak number 2 corresponds to an HCl molecule. Its mass spectrum could not be identified. The base peak at
m/e 46 is characteristic of a nitrous compound (NO2+) and is often accompanied as is the case here with a
fragment (NO+) at m/e 30.
The gas chromatography (Intersmat 120 DFL) with a 12 m long OV1 column at a temperature of 70 oC reveals a
camphor level of 0.09 mg/ml.
The nitrogen derivative molecule in 714X was found to be chemically close to camphoroxime but not identical to
it.
Comparing U.V. spectra of camphoroxime with those of the compounds of 714X shows a small discrepancy of
the maximum absorption, indicating that the two products are slightly different.
This test was carried out by plasma emission spectrometry and shows the following results in parts per million :
Aluminum < 0.5 ppm Calcium 0.5 ppm Magnesium 6.5 ppm
Antimony < 1.0 ppm Chromium < 0.1 ppm Mercury < 1.0 ppm
Arsenic < 1.0 ppm Cobalt < 1.0 ppm Molybdenum < 1.0 ppm
Barium 0.7 ppm Copper 0.01 ppm Nickel < 0.1 ppm
Bore < 0.05 ppm Iron < 0.1 ppm Phosphorus < 5.0 ppm
Cadmium < 0.05 ppm Lead < 1.0 ppm Zinc 2.0 ppm
2.6 pH determination
pH=7
a. The absence of proteins and immunoglobulins shows that 714X is not an immune serum prepared
after injection to animals. 714X is not a vaccine.
b. The presence of sodium chloride at a level of 8.2 g/liter shows that it is an isotonic solution having a
pH=7 (physiological solution). This solution complies with norms for injectable solutions of the phar-
maceutical industry.
c. The gas chromatography coupled with the mass spectrometry reveals the presence of camphor or
trimethyl-(1.7.7) bicyclo (2.2.1.) heptanone-2 that we have quantified. Its concentration is 0.09 mg/
ml (90 ppm). A nitrogenated compound and hydrochloric acid were also detected.
d. The test using the camphoroxime that was synthesized shows that this molecule does not exist as
such in the sample of 714X analyzed. The nitrogenated compound could not be clearly identified with
the testing done.
e. Eighteen metals have been measured. They are all at trace levels, of the order of ppm (parts per
million) and are without biological significance, except magnesium, whose level of 6.5 ppm is still with
no therapeutic significance. (This is the opinion of the laboratory. However, the manufacturer
claims that the trace levels identified do have a biological significance.)
Summary :
Recently, two complementary tests were conducted on 714X using mass spectrometry analysis (ion selective).
These tests were performed by two independent laboratories : one in Boston [March 1999] and the other in
Toronto [September 2000].
Both have confirmed the presence of nitrogenated compounds in the 714X product.
Structural analyses of molecular components contained in 714X and its inactive, negative control, revealed the pres-
ence of two camphor derived, nitrogen containing compounds, MW 169.15 and MW 151.25, unique to 714X.
CONCLUSION
Based on the foregoing data, Sponsor suggests that 714X may contain at least one component which acts as a
chemokine agonist in vitro, possessing the established agonist characteristics of :
• Being capable of binding to a receptor to initiate activity;
• Possessing affinity; and
• Possessing intrinsic activity.
The results clearly demonstrate that 714X is a strong activator of monocytes/macrophages and induces the secretion
of proinflammatory cytokines including TNF-α, IL-1β, IL-6 and IL-8 . Monocytes/macrophages play a key role in
host immune defense. Macrophages represent a major recognition system for foreign cells including tumor cells, and
a major source for a wide variety of secretory cytokines with immunomodulatory and antitumor activities, including
proinflammatory cytokines TNF-α, IL-1β, IL-6 and IL-8. These data provide scientific evidence supporting that
714X is an immune modulator.
714X is thought to elevate the immune response and have some role in killing tumor cells. The results appear to sup-
port this theory by suggesting that induction of proinflammatory cytokines may represent at least one of the mecha-
nisms responsible for in vivo anti-tumor activity of 714X.
• 714X is not designed to destroy diseased cells. the venous blood (that is the blood which brings waste
matter to the heart) at the junction of the sub-clavicle
• 714X is a product created to improve health by veins and the internal jugular veins in the neck area.
revitalizing the immune system and is not The lymphatic system is comprised of the lymph, the
designed to directly act on disease related lymphatic vessels in which the lymph flows and many
symptoms. structures and organs which contain lymphatic tissue
and bone marrow where lymphocytes are produced.
• 714X supports natural defenses (including the
immune system) when introduced into the The lymphatic system fills several roles :
lymphatic circulation.
1. It drains interstitial fluids. The lymphatic vessels
The particular method of administration of the pro- drain any excess interstitial fluids located between
duct makes it unique. the cells. This liquid once collected in the lymphatic
vessels is called the lymph.
A brief overview of the physiology of the lymph sys-
tem is necessary given 714X’s method of adminis- 2. It carries away the digestive fats. The lymphatic
tration : vessels transport the various fats and liposoluble
vitamins absorbed by the digestive tube.
Most of the constituting elements of blood plasma flow
freely through the capillary walls to form the interstitial 3. It protects the organism against foreign bodies.
fluid. Blood capillaries lose more fluid through filtra- The lymphatic tissue triggers immune responses.
tion than they recover through reabsorption. The excess These responses are specific to bacteria, viruses or
fluid filtered through the blood system (approximately 3 immature cells. The lymphocytes (a type of white
liters per day) penetrates the lymphatic capillaries blood cell that creates antibodies) with the help of
where it creates the lymph. macrophages, detect foreign bodies, microbes, viru-
ses and immature cells such as cancerous cells.
The resulting lymph then flows in parallel to the large
blood circulation. The lymph is then discharged into
Canals which discharge into the Vessels which discharge into two Lymphatic vessels
venous blood located in the heart collector tubes : the thoracic canal
region by way of sub clavical arter- and the right lymphatic canal
The lymph is a liquid flowing in the lymphatic vessels and is in constant renewal.
From an anatomical point of view, nature has provided Diagram 1 : A double lymphatic circulation
the body with a double lymphatic circulation. These
two circulations, which do not communicate with each
other, act in a closed circuit. Never touching each
other, they nonetheless both discharge into the blood
stream (See adjoining diagram). The small lymphatic
circulation :
The large lymphatic circulation drains 75 % of the for ultrasonic
nebulizer use
body, being the lower left and right sides of the body as
well as the upper left side of the body.
714X acts directly on the lymph to restore its immune nisms include the skin, the mucous membranes, the
activity. anti-microbial chemical reactions, phagocytosis by
neutrophiles, inflammation and fever mechanisms.
By its direct action on the lymph and its arrival into the
blood stream (once mixed with the lymph), 714X nor- 2. An increase in the specific immune responses
malizes the biological functions related to homeostasis. principally assured by lymphocytes (B and T) and
It is a product which harmonizes the biochemical reac- macrophages which acting together detect cells and
tions involved in normal cellular development, in tissue foreign bodies, germs and cancerous cells flowing
repair and in the body’s specific and non-specific de- through the body. These immune responses are
fense mechanisms. triggered to establish contact with foreign sub-
stances, destroy them and then eliminate them so
714X’s therapeutic effects can be summarized in two that they will not impede the normal metabolic
ways : functions of the body’s organs. 714X thus allows a
weakened organism the opportunity to regain its
1. An increase in the body’s natural defense defense mechanisms and therefore enhance the
mechanisms, that is, the non-specific immune de- process of cellular repair.
fense mechanisms that act upon foreign bodies such
as bacteria and viruses. Natural defense mecha-
• Vitamin B12 coating around immature cells and thus delay their
It is recommended not to simultaneously use 714X identification and elimination by the immune sys-
and vitamin B12 supplements. tem.
Vitamin B12 accelerates cellular division (espe- • All antiangiogenic products / treatments
cially blood cells) without distinguishing healthy It is not recommended to use 714X simultaneously
cells from immature cells. There is nothing to be with antiangiogenic products (products aiming at
gained by stimulating cell division in an already killing cancerous cells by shrinking blood vessels).
hyperactive organism. This restriction does not
affect vitamin B12’s properties in a normal context. All antiangiogenic products/treatments seek to as-
phyxiate a tumoral mass by stopping its vascularisa-
For those persons having had a partial or total tion process. This is a valid approach if one consid-
removal of the small intestine who wish to take ers cancer as a localized problem.
714X, the above exception concerning vitamin
B12 does not apply as this vitamin is essential for However, if one considers cancer as a generalized
such persons’ survival. disease which localizes itself in a vulnerable area of
the body, it becomes useless to act locally if the
• Vitamin E defense mechanisms are not supported. In this ap-
It is not recommended to use 714X and vitamin E proach, the tumor is only confirmation of a more
supplements simultaneously. profound problem.
It is a recognized fact that vitamin E protects cellu- All antiangiogenic products/treatments are incom-
lar membranes against free radicals. This antioxi- patible with 714X as 714X requires a good blood
dant property of vitamin E is important in the pre- circulation so that the body may eliminate tumoral
vention of cancer, but once cancer has taken hold of masses.
the organism, this vitamin could create a protective
714X is not toxic and does not destroy diseased cells. It Manufacturer’s recommendation
only supports the body’s natural defense mechanisms
and its immune system. It can be used with most con- If surgery is to occur and the patient’s life is not in any
ventional treatments whether they be surgery, radiation immediate danger, it is recommended that a full 21 con-
therapy or chemotherapy (except for the ones with secutive day course of 714X be done prior to surgery.
antiangiogenic properties). It does not hinder their re- This procedure can only assist the organism by promot-
spective modes of action nor does it modify their effec- ing a strong local and systemic immune response.
tiveness. 714X combined with conventional therapies
can only benefit the patient as it promotes the elimina- For those cancer patients requiring surgery, the above
tion of metabolic waste matter (meaning toxins) pro- recommendation becomes even more important as it
duced by the above mentioned conventional treatments. reduces the risks of spreading cancer to a new site
It can also reduce the intensity of certain side effects (metastasis), given that surgery can assist the migration
associated with conventional therapies such as nausea, of cancerous cells via the lymphatic system.
loss of appetite, etc. as it helps the body to cleanse itself
by favoring the circulation of the lymph and by assist-
ing in cellular repair by bringing nitrogen to the organ-
ism.
VOLUME TO BE USED
714X may be used for preventive purposes. In such Subsequent
Day First cycle
cases, one to three consecutive cycles of perinodular cycles
injections are recommended.
Day 1 0.1 ml 0.5 ml
It is pointless to increase daily doses in the hope of 5. Children weighing less than 30 kg (66 pounds) will
speeding up the healing process. The recommended receive one half of the daily dose prescribed for
dosages have been clinically determined and remain adults but will also complete full twenty-one day
those having afforded the best results. cycles.
2. From day five of the cycle to day twenty-one, the The nebulizer treatment is a secondary treatment which
daily dose will be 0.5 ml. begins only during the second injection cycle. A 12
hour interval is required between the injections and the
3. Each twenty-one day cycle must be followed by inhalations by way of the nebulizer. Some people pre-
two days with no injections being performed to al- fer injecting in the morning while others prefer the eve-
low the organism to rest. ning. This depends on each person’s tolerance and rou-
tine. From a biological standpoint, there is no differ-
4. The second and all subsequent cycles will consist of ence. It remains a strictly personal choice.
0.5 ml injections from day one to day twenty-one
inclusively.
1. Perinodular injection
The basic 714X treatment, which targets the large lym- navel
phatic circulation, is the perinodular injection. Whether
714X is used in a preventive mode or to restore some
imbalance which has occurred, the perinodular injection
remains the treatment of choice.
Injection site
m
The perinodular injection is to be performed in the right
5c
groin area unless the right inguinal nodes have been Pubic bone
surgically removed. This area insures the best possible Pulse of the right
femoral artery
draining of the lymph.
Crural fold of the
The injection is performed between 3 and 5 cm (1 to 2 right groin area
inches) above the pulse of the right femoral artery lo-
cated in the crural fold, on an imaginary line drawn be- The perinodular injection must be done :
tween the femoral artery and the navel.
1. Each day for 21 days.
2. After cooling down the injection site.
3. With the recommended professional material (inclu-
ding injectable 714X product).
4. According to a tried and tested methodology.
2. Inhalation by nebulizer
M. CONCLUSION
714X is a health product conceived and manufactured nitrogen (brought to the system by the camphor mole-
to support the body’s natural defenses. The method cule) and a variety of trace elements.
chosen to achieve this objective is the liquifying of the
lymph. Once liquefied, the lymph can resume its nor- 714X is non-toxic. It produces no harmful side effects.
mal draining functions as well as its other immunologi- It may be used in a preventive mode. It is recom-
cal properties. mended for those people suffering from some sort of
immune deficiency or degenerative disease confirmed
714X is easily absorbed by the body : it sustains life by by a medical diagnosis.
bringing to the organism fundamental elements such as