Mutations Test Name _______________ Per.
_______
In each of the following DNA sequences, you will use the mRNA that you will translate as well as amino acids
you transcribe to identify the mutation as well as the types that occur by circling to the TWO that apply.
Original DNA Sequence: C A C A C C T T G G C G A C G A C T
mRNA Sequence:
Amino Acid Sequence:
Mutated DNA Sequence #1: C A C A T C T T G G C G A C G A C T
(Circle the change)
mRNA sequence:
amino acid sequence:
Type of mutations (circle all that apply): Insertion Deletion Substitution
Frameshift Missense Silent Nonsense
Mutated DNA Sequence #2: C A C G A C C T T G G C G A C G A C T
(Circle the change)
What’s the mRNA sequence?
What will be the amino acid sequence?
Type of mutations (circle all that apply): Insertion Deletion Substitution
Frameshift Missense Silent Nonsense
Mutated DNA Sequence #3: C A C A C C T T A G C G A C G A C T
(Circle the change)
What’s the mRNA sequence?
What will be the amino acid sequence?
Type of mutations (circle all that apply): Insertion Deletion Substitution
Frameshift Missense Silent Nonsense
Mutated DNA Sequence #4: C A C A C C T T G G C G A C T A C T
(Circle the change)
What’s the mRNA sequence?
What will be the amino acid sequence?
Type of mutations (circle all that apply): Insertion Deletion Substitution
Frameshift Missense Silent Nonsense
Mutated DNA Sequence #5: C A C A C C T T G G G A C G A C T
(circle the change)
What’s mRNA sequence?
What will be the amino acid sequence?
Type of mutations (circle all that apply): Insertion Deletion Substitution
Frameshift Missense Silent Nonsense
Match the following pictures with the name belonging to the type of
chromosomal mutation it represents.
1. ________ Deletion 2. ________ Insertion/Duplication
3. ________ Inversion 4. ________ Translocation
Match each term with its description
5. ________ Exchange of one base for another
6. ________ Reverses the order of the parts of a chromosome
7. ________ Affects the entire DNA sequence of the chromosome
8. ________ Mutation that only changes a single amino acid in the sequence
9. ________ Involves the change of only one single nucleotide
10. ________ Production of extra copies of a part of a chromosome or a base
11. ________ Mutation that doesn’t change in the amino acid which the codon will produce
12. ________ Involves one part of a chromosome breaking off and attaching to another chromosome
13. ________ Involves the loss of a part of a chromosome or a base
14. ________ Mutation that changes the amino acid to a premature STOP
15. ________ Substance that changes the chemical nature of DNA
A. Insertion B. Point Mutation C. Translocation D. Mutagen E. Frameshift mutation
F. Deletion G. Inversion H. Substitution I. Silent J. Nonsense K. Missense
Use the same set of options above for the following questions:
16. _________________ List all of the mutations that are point mutations
17. _________________ List all of the mutations that are chromosomal mutations
18. ________Which is the only mutation listed that involves two chromosomes