MBC 202
Nucleic Acid Chemistry
Prof. Oseni O. A.
01 Genome organization.
02 Nucleic acids (DNA and RNA), Structures of bases and sugars in
nucleic acids.
03 Nucleotides and nucleosides.
04 Structures (Primary, secondary, tertiary, and quaternary) of nucleic
acids.
05 Watson-Crick base pairing rules: A=T, G≡C.
06 H-bonds and stability.
07 Structures and types of RNAs.
08 Physical and Chemical Properties of nucleic acids.
09 Modified nucleotides and analogues.
10 Replication of nucleic acid and nucleic acid sequencing.
11 Human Genome Sequencing Project and Its Clinical Relevance.
200L MBBS – Medical Biochemistry – Second Block
MBC 204
Enzymes, Coenzymes and
Bioenergetics
Dr. Ogunmoyole T.
01 Introduction to enzymes.
02 Properties and functions, nature and properties of enzymes.
03 Kinetics of enzyme action, allosteric effects.
04 Enzyme assay in clinical medicine, immobilised enzymes, hybridoma
technology, and monoclonal antibodies in medicine and biological
research.
05 The role of electron transport chain and oxidative phosphorylation in the
generation of ATP, theories and models proposed for ATP generation.
200L MBBS – Medical Biochemistry – Second Block
MBC 206
Amino Acid Metabolism
Prof. Awoyinka O. A. / Mr Ayita E. D.
01 Introduction to the metabolism of amino acid.
02 Transamination, oxidative deamination, decarboxylation.
03 The urea cycle and its biochemical importance.
04 Biosynthesis and degradation of amino acids.
05 Inborn errors of metabolism of some amino acids, phenylketonuria,
tyrosinosis, alkaptonuria, albinism, cystinuria.
200L MBBS – Medical Biochemistry – Second Block
MBC 208
Carbohydrate Metabolism
Dr. (Mrs) Oladele F. C.
01 Glycolysis (Embden-Meyerhof pathway), aerobic and anaerobic
phases.
02 Control mechanisms and substrate level phosphorylation.
03 The kerb’s cycle/citric acid cycle.
04 Metabolism of galactose and fructose, the uronic acid pathway,
gluconeogenesis, glycogenesis and glycogenolysis.
05 The HMP shunt and its biochemical importance.
200L MBBS – Medical Biochemistry – Second Block
MBC 212
Lipid Metabolism
Mr Ayita E. D.
01 Biosynthesis of fatty acids, triacylglycerol and phospholipids.
02 Fatty acid oxidation, Ketogenesis and its clinical relevance.
03 Cholesterol metabolism, Arachidonate metabolism (prostaglandins,
prostacyclins, thromboxanes, leukotrienes), phospholipids, and
glycolipid metabolism and their clinical relevance.
04 Disorders of lipid metabolism.
200L MBBS – Medical Biochemistry – Second Block