Digestion from Mouth to Small Intestine
Mouth
Mechanical digestion begins with chewing. Saliva lubricates food and forms a bolus. Salivary
amylase begins carbohydrate digestion while lingual lipase starts lipid digestion.
Enzyme Source Function Process/ActivationEquation
Salivary amylase Salivary glands Starts starch digestion
Acts in neutral pHStarch
on starch
--(Salivary amylase)→ Maltose +
Lingual lipase Tongue glands Begins fat digestion
More active after reaching
Triglycerides
stomach
--(Lingual lipase)→ Diglyc
Stomach
Food is churned into chyme. Hydrochloric acid denatures proteins and converts pepsinogen into
active pepsin. Mucus protects the stomach lining.
Enzyme Source Function Process/ActivationEquation
Pepsin Chief cells (as pepsinogen)
Digests proteins Pepsinogen --(HCl)→
Proteins
Pepsin;
--(Pepsin)→
pepsin also
Polypeptides
activates more
Gastric lipase Chief cells Digests some fatsWorks in acidic stomach
Triglycerides --(Gastric lipase)→ Diglyc
Small Intestine
Bicarbonate neutralizes stomach acid. Bile emulsifies fats. Pancreatic enzymes and brush-border
enzymes complete digestion before nutrients are absorbed.
Enzyme Source Function Process/ActivationEquation
Trypsin Pancreas (trypsinogen)
Protein digestion Trypsinogen --(Enteropeptidase)→
Polypeptides --(Trypsin)→
Trypsin; trypsin
Smalleractiva
pept
Chymotrypsin Pancreas Protein digestion ChymotrypsinogenProteins/Peptides
activated by trypsin
--(Chymotrypsin)→ S
Pancreatic amylase
Pancreas Starch digestion Acts in alkaline pHStarch --(Pancreatic amylase)→ Maltos
Lipase Pancreas Fat digestion Bile emulsifies fat Triglycerides
before lipase --(Pancreatic
acts lipase)→ Mo
Maltase Brush border Maltose digestion Membrane enzyme
Maltose --(Maltase)→ Glucose
Sucrase Brush border Sucrose digestion Sucrose --(Sucrase)→ Glucose + Fruct
Lactase Brush border Lactose digestion Lactose --(Lactase)→ Glucose + Galac
Peptidases Brush border Complete protein digestion Peptides --(Peptidases)→ Amino acids