Page 1/7
Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 19.09.2023 Version number 1 Revision: 19.09.2023
SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1 Product identifier
Trade name: HFC-32
Article number: HFC32
EC number:
200-839-4
1.2 Relevant identified uses of the substance or mixture and uses advised against:
No further relevant information available.
1.3 Details of the supplier of the safety data sheet
Manufacturer/Supplier:
DAIKIN INDUSTRIES, LTD. CHEMICALS DIVISION:
OSAKA UMEDA TWIN TOWERS SOUTH, 1-13-1 Umeda, Kita-ku, Osaka-shi, Osaka, 530-0001, Japan
Phone:+81-6-6147-9702 Fax:+81-6-6147-9807
Further information obtainable from: [Link]
1.4 Emergency telephone number:
Japan: +81-6-6349-7521
China: +86-532-8388-9090, +86-21-34151689
South Korea: +82-2-568-1722
Americas: CHEMTREC +1-800-424-9300 (Outside US/Canada: +1-703-527-3887)
Europe: +49-211-179 225-0
* SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Flam. Category: 1B, Hazard statement code: H221 Flammable gas (GHS version 7)
Flam. Category: 1, Hazard statement code: H220 Extremely flammable gas (GHS Version 6)
Press. Gas (Liq.) H280 Contains gas under pressure; may explode if heated.
2.2 Label elements
Labelling according to Regulation (EC) No 1272/2008:
The substance is classified and labelled according to the CLP regulation.
Signal word: Danger
Precautionary statements:
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P377 Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P381 In case of leakage, eliminate all ignition sources.
P410+P403 Protect from sunlight. Store in a well-ventilated place.
SECTION 3: Composition/information on ingredients
Information on ingredients:
CAS: 75-10-5 Difluoromethane 100%
Flam. Gas 1B, H221（GHS Version 7) Flam. Gas 1, H220（GHS Version 6)Press. Gas
(Liq.), H280 Identification number(s) EC number: 200-839-4
SECTION 4: First aid measures
4.1 Description of first aid measures
General information: Seek immediate medical advice.
After inhalation:
Take affected persons into fresh air. Keep at rest.
At high levels, cardiac arrhythmia may occur.
(Contd. on page 2)
57.0
Page 2/7
Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 19.09.2023 Version number 1 Revision: 19.09.2023
Trade name: HFC-32
(Contd. of page 1)
After skin contact:
Immediately wash with water and soap and rinse thoroughly.
In cases of frost bites, rinse with plenty of water. Do not remove clothing.
After eye contact: Rinse opened eye for several minutes under running water.
Information for doctor:
Catecholamines such as adrenaline, and other compounds having similar effects, should be reserved for emergencies
and then used only with special caution.
4.2 Most important symptoms and effects, both acute and chronic:
Frost bites
High concentrations cause asphyxiation. May cause an abnormal heart rhythm and prove suddenly fatal.
4.3 Indication of any immediate medical attention and special treatment needed:
No further relevant information available.
SECTION 5: Firefighting measures
5.1 Extinguishing media
Suitable extinguishing agents:
CO2, powder or water spray. Fight larger fires with water spray or alcohol resistant foam.
For safety reasons unsuitable extinguishing agents: Water with full jet
5.2 Special hazards arising from the substance or mixture:
Formation of toxic gases is possible during heating or in case of fire.
Hydrogen fluoride (HF)
5.3 Advice for firefighters:
Protective equipment: Wear fully protective suit.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures:
Stay on the windward side.
Wear protective equipment. Keep unprotected persons away.
6.2 Environmental precautions: Do not allow to enter sewers/surface or ground water.
6.3 Methods and material for containment and cleaning up: Ensure adequate ventilation.
6.4 Reference to other sections: See Section 8 for information on personal protection equipment.
SECTION 7: Handling and storage
7.1 Precautions for safe handling:
Waste air is to be released into the atmosphere only via suitable separators.
Open and handle receptacle with care.
Information about fire - and explosion protection:
Keep ignition sources away - Do not smoke.
Protect against electrostatic charges.
7.2 Conditions for safe storage, including any incompatibilities:
Storage
Requirements to be met by storerooms and receptacles:
Store only in unopened original receptacles.
Store in a cool and dry location.
Information about storage in one common storage facility: Not required.
Further information about storage conditions:
Keep container tightly sealed.
Store in cool, dry conditions in well sealed receptacle.
Protect from heat and direct sunlight.
Maximum storage temperature: 40
7.3 Specific end use(s): No further relevant information available.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters No further information available.
(Contd. on page 3)
57.0
Page 3/7
Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 19.09.2023 Version number 1 Revision: 19.09.2023
Trade name: HFC-32
(Contd. of page 2)
Ingredients with limit values that require monitoring at the workplace:
CAS: 75-10-5 Difluoromethane
WEEL (USA) 1000 ppm
DNELs:
Inhalative
DNEL - general population 750 mg/m³ (long-term exposure) (systemic effects)
DNEL - worker 7035 mg/m³ (long-term exposure) (systemic effects)
PNECs:
PNEC
0.142 mg/l (freshwater) (aqua)
0.534 mg/kg dw (freshwater) (sediment)
1.42 mg/l (intermittent release) (aqua)
Additional information: The lists valid during the making were used as basis.
8.2 Exposure controls
Appropriate engineering controls No further data; see section 7.
Individual protection measures, such as personal protective equipment
General protective and hygienic measures:
Wash hands before breaks and at the end of work.
Do not eat or drink while working.
Keep away from tobacco products.
Respiratory protection:
Wear respirator for organic gases, where leakage may occur.
Use suitable respiratory protective device in case of insufficient ventilation.
Use respiratory protective device with organic gas cartridge.
Hand protection
The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.
Protective gloves
To avoid skin problems reduce the wearing of gloves to the required minimum.
Material of gloves:
Strong material gloves
The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and
varies from manufacturer to manufacturer. As the product is a preparation of several substances, the resistance of
the glove material can not be calculated in advance and has therefore to be checked prior to the application.
Leather
Penetration time of glove material
The exact break trough time has to be found out by the manufacturer of the protective gloves and has to be observed.
Eye/face protection
Safety glasses
Body protection: Protective work clothing
* SECTION 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties
General Information
Physical state Liquefied gas
Colour: Colourless
Odour: Odourless
Odour threshold: Not determined.
Melting point/freezing point: -136 °C
Boiling point or initial boiling point and boiling range -51.7 °C
(Contd. on page 4)
57.0
Page 4/7
Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 19.09.2023 Version number 1 Revision: 19.09.2023
Trade name: HFC-32
(Contd. of page 3)
Flammability Flammable
Lower and upper explosion limit
Lower explosive limit: 13.8 Vol %
13.8 Vol% (High Pressure Gas Safety Act: Japan)
Upper explosive limit: 29.9 Vol %
29.9 Vol% (High Pressure Gas Safety Act: Japan)
Flash point: Not applicable.
Auto-ignition temperature: 530 °C (1018hPa)
Decomposition temperature: No further information available.
pH Not determined.
Viscosity:
Kinematic viscosity Not determined.
Dynamic: Not determined.
Solubility
water: No further information available.
1680 mg / l (25 atmospheric pressure)
Partition coefficient n-octanol/water (log value) 0.21 log POW
Vapour pressure at 25 °C: 1.69 MPa
Density and/or relative density
Density at 25 °C: 0.961 g/cm³ (Saturated liquid)
Relative density Not determined.
Vapour density Not determined.
Particle characteristics No further information available.
9.2 Other information:
Form: Liquefied gas
Ignition temperature: Not determined.
Explosive properties: Not determined.
Evaporation rate Not applicable.
Information with regard to physical hazard classes
Explosives Not applicable
Flammable gases Flammable gas.
Aerosols Not applicable
Oxidising gases Not applicable
Gases under pressure Contains gas under pressure; may explode if heated.
Flammable liquids Not applicable
Flammable solids Not applicable
Self-reactive substances and mixtures Not applicable
Pyrophoric liquids Not applicable
Pyrophoric solids Not applicable
Self-heating substances and mixtures Not applicable
Substances and mixtures, which emit flammable gases
in contact with water Not applicable
Oxidising liquids Not applicable
Oxidising solids Not applicable
Organic peroxides Not applicable
Corrosive to metals Not applicable
Desensitised explosives Not applicable
SECTION 10: Stability and reactivity
10.1 Reactivity No further relevant information available.
10.2 Chemical stability
Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.
10.3 Possibility of hazardous reactions: Reacts with alkali and metals.
10.4 Conditions to avoid: No further relevant information available.
10.5 Incompatible materials: Alkali or alkaline earth metals - powdered Al, Zn, Mg, etc.
10.6 Hazardous decomposition products: Poisonous gases/vapours
(Contd. on page 5)
57.0
Page 5/7
Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 19.09.2023 Version number 1 Revision: 19.09.2023
Trade name: HFC-32
(Contd. of page 4)
* SECTION 11: Toxicological information
11.1 Information on hazard classes as defined in Regulation (EC) No 1272/2008
Acute toxicity Based on available data, the classification criteria are not met.
LD/LC50 values relevant for classification:
CAS: 75-10-5 Difluoromethane
Inhalative LC0/4h > 520000 ppm (Rat)
Skin corrosion/irritation:
CAS: 75-10-5 Difluoromethane
Inhalative Cardiac sensitive 350000 ppm (Dog)
Development 50000 ppm (Rat and rabbit)
Serious eye damage/irritation: No further information available.
after inhalation: No further information available.
Respiratory or skin sensitisation: No further information available.
Germ cell mutagenicity: Based on available data, the classification criteria are not met.
Carcinogenicity: Based on available data, the classification criteria are not met.
Reproductive toxicity: Based on available data, the classification criteria are not met.
STOT-single exposure: Based on available data, the classification criteria are not met.
STOT-repeated exposure: No further information available.
Aspiration hazard: Based on available data, the classification criteria are not met.
Other information (about experimental toxicology):
Chromosomal Aberration Study in vitro- Negative
Mouse Micronucleus Assay in Vivo - Negative
Additional toxicological information:
Repeated dose toxicity NOAEC (inhalation): 105000 mg/m³ (rat) (OECD 413)
CMR effects
Mutagenicity:
Ames test: negative (OECD 471)
In vitro mammalian chromosome aberration test: negative (OECD 473)
Mammalian erythrocyte micronucleus test: negative (OECD 474)
Toxicity for reproduction:
NOAEC (inhalation): 208000 mg/m³ (mouse) (OECD 478; read across)
Developmental toxicity:
NOAEC (inhalation): 105000 mg/m³ (rat)
11.2 Information on other hazards:
Endocrine disrupting properties:
The substance/mixture does not contain components considered to have endocrine disrupting properties according to
REACH Article 57(f) or Commission Delegated Regulation (EU) 2017/2100 or Commission Regulation (EU)
2018/605 at levels of 0.1% or higher.
* SECTION 12: Ecological information
12.1 Toxicity
Aquatic toxicity:
EC50/96 h 142 mg/l (algae) (QSAR)
LC50/48 h 652 mg/l (daphnia) (QSAR)
LC50/96 h 1507 mg/l (fish) (QSAR)
12.2 Persistence and degradability:
Not easily biodegradable
5% after 28 days (OECD 301 D)
Behaviour in environmental systems
Components: Half-life in air: 1237 days
12.3 Bioaccumulative potential:
Due to the distribution coefficient n-octanol/water an accumulation in organisms is not expected.
(Contd. on page 6)
57.0
Page 6/7
Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 19.09.2023 Version number 1 Revision: 19.09.2023
Trade name: HFC-32
(Contd. of page 5)
Other information
Koc = 1.49 - 21-73 (QSAR)
log Koc = 0.17 - 1.34 (QSAR)
12.4 Mobility in soil: No further relevant information available.
12.5 Results of PBT and vPvB assessment
PBT: Not applicable.
vPvB: Not applicable.
12.6 Endocrine disrupting properties The product does not contain substances with endocrine disrupting properties.
12.7 Other adverse effects:
Additional ecological information:
General notes:
Ozone depletion potential(ODP) : 0
Global warming potential(GWP) : 675 / IPCC Fourth Assessment Report (AR4)
SECTION 13: Disposal considerations
13.1 Waste treatment methods
Recommendation:
Must be specially treated adhering to official regulations.
Incineration in an adequate incinerator is recommended.
Uncleaned packaging
Recommendation: Disposal must be made according to official regulations.
SECTION 14: Transport information
14.1 UN number or ID number
ADR, IMDG, IATA 3252
14.2 UN proper shipping name:
ADR: 3252 DIFLUOROMETHANE (REFRIGERANT GAS R 32)
IMDG, IATA DIFLUOROMETHANE (REFRIGERANT GAS R 32)
14.3 Transport hazard class(es):
ADR
Class: 2 Gases.
Label: 2.1
IMDG, IATA
Class: 2.1 Gases.
Label: 2.1
14.4 Packing group:
IMDG, IATA Not applicable
14.5 Environmental hazards:
Marine pollutant: No
14.6 Special precautions for user: Warning: Gases.
Hazard identification number (Kemler code): 23
14.7 Maritime transport in bulk according to IMO
instruments Not applicable.
Transport/Additional information: Avoid direct sunlight. Make sure of no damage, corrosion, leaks
on the receptacles.
Take necessary measures for preventing cargo shift.
(Contd. on page 7)
57.0
Page 7/7
Safety data sheet
according to 1907/2006/EC, Article 31
Printing date 19.09.2023 Version number 1 Revision: 19.09.2023
Trade name: HFC-32
(Contd. of page 6)
UN "Model Regulation": UN3252, DIFLUOROMETHANE (REFRIGERANT GAS R 32),
2.1
* SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
Labelling according to Regulation (EC) No 1272/2008
The substance is classified and labelled according to the CLP regulation.
Hazard pictograms
GHS02
Signal word Danger
Hazard statements
H221 Flammable gas.
H280 Contains gas under pressure; may explode if heated.
Precautionary statements
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P377 Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P381 In case of leakage, eliminate all ignition sources.
P410+P403 Protect from sunlight. Store in a well-ventilated place.
DIRECTIVE 2011/65/EU on the restriction of the use of certain hazardous substances in electrical and electronic
equipment – Annex II
Other regulations, limitations and prohibitive regulations:
High Pressure Gas Safety Act (Japan) : inert gas
ISO817 : Classification A2L (lower flammability)
15.2 Chemical safety assessment: A Chemical Safety Assessment has not been carried out.
SECTION 16: Other information
The product is for the industrial use only. We do not guarantee the safety in case the product is used for the other
purposes. When using the product for health-care application or food/feed application, consult us in advance.
This information is based on our present knowledge. However, this shall not constitute a guarantee for any specific
product features and shall not establish a legally valid contractual relationship.
Department issuing SDS: EHS Department
Contact: [Link]
Abbreviations and acronyms:
RID: Règlement international concernant le transport des marchandises dangereuses par chemin de fer (Regulations Concerning the
International Transport of Dangerous Goods by Rail)
ICAO: International Civil Aviation Organisation
ADR: Accord relatif au transport international des marchandises dangereuses par route (European Agreement Concerning the International
Carriage of Dangerous Goods by Road)
IMDG: International Maritime Code for Dangerous Goods
IATA: International Air Transport Association
GHS: Globally Harmonised System of Classification and Labelling of Chemicals
EINECS: European Inventory of Existing Commercial Chemical Substances
DNEL: Derived No-Effect Level (REACH)
PNEC: Predicted No-Effect Concentration (REACH)
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
PBT: Persistent, Bioaccumulative and Toxic
vPvB: very Persistent and very Bioaccumulative
Flam. Gas 1B: Flammable gases – Category 1B
Press. Gas (Liq.): Gases under pressure – Liquefied gas
* Data compared to the previous version altered.
57.0