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Biochemistry Topicwise QuestionBank

This document is a comprehensive question bank for First MBBS Biochemistry, compiled by Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, and Dr. Akhlaq Hasan, covering topics from past university papers from 2019 to 2025. It includes various types of questions such as short notes, clinical cases, and long essay questions across multiple subjects including cell biology, enzymes, metabolism of carbohydrates, lipids, proteins, vitamins, and more. The aim is to facilitate topic-by-topic revision for students in the Department of Biochemistry.
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0% found this document useful (0 votes)
8 views10 pages

Biochemistry Topicwise QuestionBank

This document is a comprehensive question bank for First MBBS Biochemistry, compiled by Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, and Dr. Akhlaq Hasan, covering topics from past university papers from 2019 to 2025. It includes various types of questions such as short notes, clinical cases, and long essay questions across multiple subjects including cell biology, enzymes, metabolism of carbohydrates, lipids, proteins, vitamins, and more. The aim is to facilitate topic-by-topic revision for students in the Department of Biochemistry.
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

Prepared By: Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, Dr.

Akhlaq Hasan

First MBBS — BIOCHEMISTRY


Topic-wise Question Bank from Past University Papers
RUHS / GMC Banswara • Papers 2019 – 2025 (Main & Supplementary)
Compiled for topic-by-topic revision • Department of Biochemistry

PAPER I

1. Cell, Subcellular Organelles & General Chemistry


SHORT NOTES / EXPLAIN BRIEFLY
– Second messenger / secondary messenger [S19 P1, J19 P1]
– Denaturation of protein [S19 P1]
– Biologically active nucleotides & peptides [N23 P2, S19 P1]
CLINICAL CASE / APPLIED
– Lysosomal storage disorders — Tay-Sachs (hexosaminidase A), Niemann-Pick (sphingomyelinase);
Hurler/Hunter/Morquio/Scheie corneal-clouding themes (MCQ) [A24 P1, A25 P1]

2. Enzymes
SHORT NOTES / EXPLAIN BRIEFLY
– Therapeutic uses of enzymes [A24 P1]
– Isoenzymes [N23 P1, F21 P1]
– Isoenzymes in clinical diagnosis [J21 P1]
– Transaminases [F21 P1]
– Enzymes of diagnostic significance [A25 P1]
– Cardiac enzymes [J19 P1]
– Clinical importance of competitive enzyme inhibition [M22 P1]
– Diagnostic significance of various liver enzymes [J19 P2]
EXPLAIN WHY (REASONING QUESTIONS)
– A number of enzymes are secreted as zymogens [A25 P1]
– Hyaluronidase is called the spreading factor [M22 P1]
– Fluoride acts as an inhibitor of glycolysis / blood for sugar is collected in a fluoride vial [J21 P1, M22 P1]
– Methotrexate acts as a competitive inhibitor [J21 P1]
CLINICAL CASE / APPLIED
– Competitive inhibition of enzymes — mechanism, effect on kinetics, two examples [S19 P1, J19 P1]

3. Chemistry & Metabolism of Carbohydrates (incl. Diabetes Mellitus)


LONG ESSAY QUESTIONS (SECTION B / STRUCTURED ESSAY)
– Hormonal regulation of blood glucose levels; metabolic derangements in diabetes mellitus; note on
HbA1c and clinical significance [J21 P1]
– Mechanism of blood sugar regulation — add a note on diabetes mellitus [S19 P1]

Prepared By: Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, Dr. Akhlaq Hasan
Prepared By: Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, Dr. Akhlaq Hasan

SHORT NOTES / EXPLAIN BRIEFLY


– Significance of NADPH [M22 P1]
– Reverse cholesterol transport / effect of hyperglycemia on sorbitol pathway [J21 P1]
– Complications of diabetes mellitus [M22 P1]
– Biochemical basis of diabetic cataract [A24 P1]
– Difference between glycemic index and glycemic load [N23 P2]
– Enlist substrates of gluconeogenesis [F21 P1]
– Cori's cycle [M22 P1]
– Glucose transporters (GLUT family) [J19 P1]
– Glycogen [S19 P1]
– Von Gierke's disease [J19 P1]
– Fate of pyruvate [J19 P1]
– Laboratory diagnosis of diabetes mellitus [F21 P1]
EXPLAIN WHY (REASONING QUESTIONS)
– For estimation of blood sugar, blood is collected in a fluoride bulb/vial [M22 P1]
– HbA1c is a good indicator of sugar control in T2DM [F21 P1]
– Why does Von Gierke disease cause gouty arthritis / hyperuricemia in Von Gierke's disease [A24 P2, F21 P1]
– Glucose uptake in intestine & kidney is called secondary active transport [N23 P1]
DIFFERENTIATE BETWEEN
– G-6-PD & G-6-Phosphatase [N23 P1]
CLINICAL CASE / APPLIED
– Principles of communication with a diabetic patient about diet and exercise (applied/AETCOM) [A24 P1]
– Hormonal control of glycogen metabolism (schematic) [A24 P1]

4. Chemistry & Metabolism of Lipids


LONG ESSAY QUESTIONS (SECTION B / STRUCTURED ESSAY)
– Beta-oxidation of a long-chain saturated fatty acid (palmitic acid, 16C) and energy yield [M22 P1, S19 P1]
– Define lipoproteins with examples; metabolism of HDL cholesterol and its role in health and disease [F21
P1]
– Atherosclerosis [S19 P1]
SHORT NOTES / EXPLAIN BRIEFLY
– Ketogenesis and ketolysis / ketogenesis and its regulation [M22 P1, J21 P1]
– Ketosis [F21 P1, S19 P1]
– Metabolism and regulation of ketone bodies — diabetic ketoacidosis [J19 P1]
– Fatty liver — definition and causes [M22 P1]
– Fatty liver and lipotropic factors [J21 P1, N23 P1, A24 P1]
– Fate of acetyl CoA [A25 P1]
– Functions of cholesterol [S19 P1]
– Chylomicrons [J19 P1]
– Essential fatty acids [J19 P1]
– Mucopolysaccharides [S19 P1]

Prepared By: Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, Dr. Akhlaq Hasan
Prepared By: Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, Dr. Akhlaq Hasan

– Prostaglandins — functions / therapeutic uses [A24 P1, S19 P1]


EXPLAIN WHY (REASONING QUESTIONS)
– Lipoprotein(a) is known as 'little rascal' [A24 P1]
– Dipalmitoyl lecithin structure differs from other phospholipids [A24 P1]
– Essential fatty acids help prevent fatty liver [F21 P1]
– Deficiency of lipoprotein lipase results in hypertriglyceridemia [M22 P1]
– Marine fish oil is protective against myocardial infarction [A25 P1]
– Pancreatic insufficiency patients are advised medium/short-chain fatty acids [N23 P1]
– Vegetarian diet helps control cholesterol [F21 P2]
CLINICAL CASE / APPLIED
– Lung surfactant / dipalmitoyl lecithin and respiratory distress syndrome [M22 P1]

5. Chemistry & Metabolism of Proteins / Amino Acids (incl. Plasma Proteins & PEM)
LONG ESSAY QUESTIONS (SECTION B / STRUCTURED ESSAY)
– Fate of amino-acid nitrogen; acquired hyperammonemias and biochemical basis of coma [A24 P1]
– Toxicity of ammonia and its detoxification process [S19 P1]
– Essay on the biochemical basis of protein-energy malnutrition [M22 P1]
SHORT NOTES / EXPLAIN BRIEFLY
– Methionine metabolism [N23 P1]
– Products of glycine metabolism [J19 P1]
– Phenylketonuria [M22 P1, F21 P1, S19 P1]
– Maple syrup urine disease [F21 P1]
– Disorders associated with tyrosine metabolism [A25 P1]
– Balanced diet [N23 P2]
– Biogenic amines / biologically important peptides & functions [F21 P1, S19 P1]
– Kwashiorkor's disease [S19 P1]
EXPLAIN WHY (REASONING QUESTIONS)
– Pulses + cereals become equivalent to first-class protein [N23 P2]
– Arginine becomes semi-essential [N23 P1]
– Hypoalbuminemia causes oedema / oedema in Kwashiorkor [A25 P1, M22 P2]
– Eating maize causes pellagra-like symptoms / tryptophan deficiency causes pellagra [F21 P1, A24 P1]
DIFFERENTIATE BETWEEN
– Marasmus and Kwashiorkor [A24 P2]
CLINICAL CASE / APPLIED
– PEM — define; marasmus; differences from kwashiorkor; cause of emaciated appearance; prevention
[A24 P2]
– Phenylketonuria / albinism — diagnosis, deficient enzyme, inheritance, management [F21 P1, N23 P1]
– Alkaptonuria & ochronosis — biochemical basis [J21 P1, J22 P2]

Prepared By: Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, Dr. Akhlaq Hasan
Prepared By: Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, Dr. Akhlaq Hasan

6. Vitamins
LONG ESSAY QUESTIONS (SECTION B / STRUCTURED ESSAY)
– Define & classify vitamins; chemistry & functions of Vitamin D; coenzyme functions of Vit B9 & folic acid
with deficiency [A25 P1]
– Source, daily requirement, function & deficiency of Vitamin C [S19 P1]
– Dietary sources, biochemical role and deficiency disorders of Vitamin D [J19 P1]
SHORT NOTES / EXPLAIN BRIEFLY
– Vitamins as coenzymes [J21 P1]
– Functions of Vitamin C [F21 P1]
– Antioxidant vitamins [F21 P1]
– Reactions catalyzed by PLP (pyridoxal phosphate) [J19 P1]
– Wald's visual cycle [A24 P1]
– Beri-Beri [J19 P1]
– Pellagra [M22 P1]
EXPLAIN WHY (REASONING QUESTIONS)
– Neonates are prone to Vitamin K deficiency / single IM dose of Vit K to newborns [F21 P1, M22 P1]
– Vitamin B12 deficiency leads to folate trap [N23 P1]
– Vitamin C is involved in post-translational modification of collagen [M22 P2]
DIFFERENTIATE BETWEEN
– Thiamine & Thymine [A24 P1]
– Carnitine & Carotene [A24 P1]
CLINICAL CASE / APPLIED
– Wernicke-Korsakoff syndrome (thiamine deficiency) — fill/MCQ [A24 P1]

7. Bioenergetics & Biological Oxidation


LONG ESSAY QUESTIONS (SECTION B / STRUCTURED ESSAY)
– Amphibolic role of TCA cycle / outline steps, regulation and energetics of the TCA cycle [J19 P1, S19 P1]
SHORT NOTES / EXPLAIN BRIEFLY
– Electron transport chain [J21 P1]
– Uncouplers and inhibitors of the electron transport chain [A24 P1, M22 P2, S19 P1, J19 P1]
– Chemiosmotic theory / hypothesis [F21 P1, A25 P1]
– Significance of NADPH / NADH vs NADPH roles [M22 P1, A24 P1]
EXPLAIN WHY (REASONING QUESTIONS)
– TCA cycle is anabolic / amphibolic [A24 P1]
– Cyanide inhibits the electron transport chain (complex IV) [J22 P1]
– Rotenone is a classical competitive inhibitor of Complex I (MCQ) [A25 P1]

Prepared By: Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, Dr. Akhlaq Hasan
Prepared By: Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, Dr. Akhlaq Hasan

8. Acid–Base Balance, Water–Electrolyte Balance & ABG


LONG ESSAY QUESTIONS (SECTION B / STRUCTURED ESSAY)
– Respiratory and renal regulation of pH; note on pH derangement in diabetes [N23 P1]
– Role of the renal system in blood pH regulation [M22 P1, J19 P2]
SHORT NOTES / EXPLAIN BRIEFLY
– Metabolic acidosis [J21 P1, J19 P2]
– Anion gap [F21 P1]
– Protein buffer system [J19 P2]
– Dehydration — etiology & biochemical changes [N23 P1, O20 P2, J19 P2]
– Metabolic adaptations in starvation [J21 P1]
EXPLAIN WHY (REASONING QUESTIONS)
– Blood buffers act quickly but not permanently [M22 P1]
– Hyperventilation is a compensatory response to metabolic acidosis [M22 P2]
DIFFERENTIATE BETWEEN
– Metabolic acidosis and respiratory acidosis [A24 P1]
– Hypokalemia and Hyperkalemia [A24 P1]

9. Mineral Metabolism
SHORT NOTES / EXPLAIN BRIEFLY
– Regulation of blood calcium level [M22 P1]
– Functions of calcium [F21 P1, S19 P1]
– Disorders of iron metabolism [J21 P1]
– Calcitriol [F21 P1]
– Wilson's disease [M22 P1]
EXPLAIN WHY (REASONING QUESTIONS)
– Iron metabolism is called one-way metabolism [M22 P1]
– Vitamin C is given in iron-deficiency anaemia (role in iron metabolism) [M22 P1]
CLINICAL CASE / APPLIED
– Iron-deficiency anaemia — sources & RDA of iron, causes, role of Vit C, biochemical role of iron with two
iron-containing enzymes [M22 P1]
– Keshan's disease (selenium) / acrodermatitis enteropathica (zinc) — MCQ [A25 P1, J21 P1]

10. Heme & Porphyrin Metabolism, Hemoglobin & Bilirubin/Jaundice


LONG ESSAY QUESTIONS (SECTION B / STRUCTURED ESSAY)
– Jaundice — types and biochemical basis [S19 P1]
SHORT NOTES / EXPLAIN BRIEFLY
– Regulation of heme synthesis [J21 P1]
– Degradation of heme [A25 P1]

Prepared By: Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, Dr. Akhlaq Hasan
Prepared By: Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, Dr. Akhlaq Hasan

– Erythropoietic porphyrias [J21 P1]


– Abnormal haemoglobin / haemoglobinopathies [S19 P1]
– Rapoport–Luebering cycle [A24 P1]
EXPLAIN WHY (REASONING QUESTIONS)
– Rapoport-Luebering cycle is important to deliver O2 at tissue level [A24 P1]
– Blue fluorescent light is useful in neonatal jaundice [M22 P2]
– Urobilinogen absent from urine in obstructive jaundice / clay stool [N23 P2, M22 P2]
– Direct bilirubin is increased in obstructive jaundice [F21 P1]
DIFFERENTIATE BETWEEN
– Haemoglobin & Myoglobin [N23 P1, M22 P1]
– Pre-hepatic and post-hepatic jaundice [N23 P1]
CLINICAL CASE / APPLIED
– Obstructive jaundice — type, biochemical basis, normal ranges, tests for bile salts/pigments, enzyme
markers [J22 P2, J21 P2]
– Neonatal jaundice — diagnosis, precursors/types of bilirubin, enzyme defect, treatment [F21 P2]
– Haemolytic jaundice in G6PD deficiency / chloroquine — type, cause of haemolysis, reaction, role of
pathway [A24 P1]

11. Metabolism of Alcohol & Integration of Metabolism


SHORT NOTES / EXPLAIN BRIEFLY
– Alcohol metabolism [M22 P1]
– Metabolic adaptations in starvation [J21 P1]
EXPLAIN WHY (REASONING QUESTIONS)
– Chronic alcoholics can develop ketoacidosis on abrupt alcohol consumption [A25 P1]
– Disulfiram inhibits aldehyde dehydrogenase (MCQ) [A25 P1]
CLINICAL CASE / APPLIED
– Main energy source of brain in prolonged starvation (ketone bodies) — MCQ/integration [J21 P1]

12. Free Radicals & Antioxidants


SHORT NOTES / EXPLAIN BRIEFLY
– Endogenous antioxidants [A24 P1]
– Antioxidant enzymes / enzymatic antioxidant system [N23 P2, J21 P2, J22 P2]
– Antioxidants: definition and classification [J22 P2]
– Reactive oxygen species and its formation [M22 P2]
EXPLAIN WHY (REASONING QUESTIONS)
– Serum malondialdehyde acts as a marker of oxidative stress [N23 P2]
– Glutathione acts as a biologically active peptide [J21 P1]

Prepared By: Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, Dr. Akhlaq Hasan
Prepared By: Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, Dr. Akhlaq Hasan

PAPER II

13. Chemistry & Metabolism of Nucleotides


SHORT NOTES / EXPLAIN BRIEFLY
– Salvage pathway of purine synthesis [J21 P1, J19 P1]
– Catabolism of purine and its disorders / outline purine catabolism [F21 P1, J22 P2]
– Orotic aciduria [N23 P1, J19 P2]
– Lesch-Nyhan syndrome [F21 P1]
– Gout [J19 P2]
– Biologically active nucleotides [N23 P1]
EXPLAIN WHY (REASONING QUESTIONS)
– Dietary purines are non-essential [A24 P2]
– Hyperuricemia is associated with Von-Gierke's disease [F21 P1]
CLINICAL CASE / APPLIED
– Gout — normal serum uric acid, primary vs secondary gout, biochemical basis, treatment, why restrict
non-veg diet & alcohol [J22 P2, J19 P1]
– Orotic aciduria / urea-cycle defect — elevated glutamine & uracil, brain involvement, treatment [N23 P1]

14. Molecular Biology — Replication, Repair, Transcription, Translation, Gene Regulation


LONG ESSAY QUESTIONS (SECTION B / STRUCTURED ESSAY)
– Transcription in detail; post-transcriptional modifications; inhibitors of transcription [M22 P2, J22 P2]
– Translation in prokaryotes with inhibitors; note on post-translational modifications [A24 P2, F21 P2]
– Mechanism of translation in eukaryotes; protein targeting and related diseases [J22 P2]
– Types of RNA and their role; note on post-transcriptional modifications [J19 P2]
– Damage and repair of DNA; disorders of defective repair [S19 P2]
– DNA replicase system / regulation of gene expression in eukaryotes [S19 P2]
SHORT NOTES / EXPLAIN BRIEFLY
– DNA polymerases in eukaryotes and their functions [N23 P2]
– Okazaki fragments/segments [N23 P2]
– Post-transcriptional modifications / processing of hnRNA [A24 P2, M22 P2]
– Structure of tRNA and its function [A24 P2, S19 P2]
– Lac operon / concept [N23 P2, M22 P2, F21 P2, J19 P2]
– Salient features / degeneracy of the genetic code [J22 P2, S19 P2]
– Diseases related to defective repair of DNA damage [J22 P2]
– Wobble hypothesis — importance [J22 P2]
– DNA supercoiling / mitochondrial DNA [J22 P2]
– Inhibitors of translation [S19 P2]
EXPLAIN WHY (REASONING QUESTIONS)
– DNA is much more stable than RNA [A24 P2]
– Puromycin inhibits protein synthesis [N23 P2]

Prepared By: Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, Dr. Akhlaq Hasan
Prepared By: Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, Dr. Akhlaq Hasan

– Telomerase is implicated in ageing and cancers [A24 P2]


– Genetic code is degenerate [F21 P2]
– UV radiation can cause Xeroderma Pigmentosum (defective NER) [M22 P2]
– DNA ligase is essential in lagging-strand synthesis [M22 P2]

15. Recombinant DNA Technology & Biotechnology


SHORT NOTES / EXPLAIN BRIEFLY
– Applications of PCR / mechanism and applications [M22 P2, F21 P2, J22 P2]
– Restriction endonucleases [N23 P2]
– Restriction fragment length polymorphism (RFLP) [N23 P2, M22 P2]
– Blotting techniques (Southern/Northern/Western) and applications of each [A24 P2, N23 P2]
– DNA probes [M22 P2]
– Vectors / gene library / bacterial artificial chromosomes [M22 P2, N23 P2]
– Application of recombinant DNA technology [J22 P2]
– Human Genome Project [F21 P2]
– Hybridoma technology [N23 P2]
– ELISA / applications of ELISA [N23 P2, M22 P2, J19 P2]
EXPLAIN WHY (REASONING QUESTIONS)
– Restriction endonucleases are called molecular scissors [F21 P2]
– Western blotting is more specific for HIV antibody detection (MCQ) [O25 P2]

16. Immunology
SHORT NOTES / EXPLAIN BRIEFLY
– Classification / structure of immunoglobulins [M22 P2, F21 P2]
– Primary and secondary immune response [A24 P2, N23 P2]
– MHC / major histocompatibility complex [F21 P2]
– Severe combined immunodeficiency disorder (SCID) [A24 P1]
– Multiple myeloma / Bence Jones proteins [S19 P2, A24 P2]
EXPLAIN WHY (REASONING QUESTIONS)
– Immunity is both a boon and evil [F21 P2]
– Bence Jones proteins are a diagnostic/monitoring marker [A24 P2]
– IgA is found in tears / predominant in colostrum (MCQ) [N23 P2, O25 P2]

17. Biochemistry of Cancer — Oncogenes & Tumor Markers


SHORT NOTES / EXPLAIN BRIEFLY
– Oncogenes / name four tumour markers with clinical relevance [A24 P2, M22 P2, S19 P2]
– Tumor markers [N23 P2, F21 P2]
– Tumor suppressor genes [J22 P2]
– Activation of proto-oncogene to oncogene [S19 P2]

Prepared By: Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, Dr. Akhlaq Hasan
Prepared By: Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, Dr. Akhlaq Hasan

EXPLAIN WHY (REASONING QUESTIONS)


– p53 functions as a tumour suppressor / 'guardian of the genome' [N23 P2]
– Malignant cells develop resistance to long-term methotrexate [N23 P2]
– Folate antimetabolites / methotrexate used to treat neoplastic disease [M22 P2, F21 P2]
– CA-125 elevated in ovarian cancer; AFP in hepatoma (MCQ) [F21 P2, O25 P2]

18. Clinical Biochemistry — Organ Function Tests


LONG ESSAY QUESTIONS (SECTION B / STRUCTURED ESSAY)
– Diagnostic significance of various liver enzymes / clinical interpretation of enzyme markers of liver injury
[J19 P2, J22 P2]

SHORT NOTES / EXPLAIN BRIEFLY


– Tests to assess biosynthetic function of liver / liver function tests [A24 P2]
– Laboratory tests for adrenal hypo- and hyper-function [A24 P2]
– Thyroid function tests [S19 P2]
– Pancreatic function tests [O20 P2]
– Creatinine clearance test and significance / clearance test [J22 P2, F21 P2]
– Renal function tests / BMR [J19 P2, F21 P2]
– Applications of electrophoresis [A24 P2]
EXPLAIN WHY (REASONING QUESTIONS)
– Serum creatinine is more sensitive than urea for renal function [F21 P2]
– Amylase/lipase most specific for acute pancreatitis; ALP elevated in cholestasis (MCQ) [A25 P2]
CLINICAL CASE / APPLIED
– Primary hypothyroidism — signs/symptoms, causes, normal Free T3/T4/TSH ranges [N23 P2]
– TSH is elevated in primary hypothyroidism [M22 P2]

19. Xenobiotics, Detoxification & Environmental Biochemistry


SHORT NOTES / EXPLAIN BRIEFLY
– Conjugation reactions / Phase II detoxification (define; four Phase-2 reactions) [A24 P2, S19 P2, M22 P2]
– Cytochrome P450 / P450-mediated biotransformation [M22 P2, F21 P2, S19 P2]
– Mercury poisoning [N23 P1]
– Conjugation of xenobiotics [J22 P2]
EXPLAIN WHY (REASONING QUESTIONS)
– Uronic acid pathway is important for detoxification of drugs [N23 P1]

20. Human Genetics & Molecular Disease


SHORT NOTES / EXPLAIN BRIEFLY
– Mutation / mutations [N23 P2, M22 P2, J22 P2, F21 P2, S19 P2]
– Human genome project [F21 P2]

Prepared By: Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, Dr. Akhlaq Hasan
Prepared By: Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, Dr. Akhlaq Hasan

EXPLAIN WHY (REASONING QUESTIONS)


– Sickle-cell anaemia is a classic example of missense (point) mutation [N23 P2]
– Xeroderma pigmentosum, Down syndrome (FISH), HER2 in breast cancer — clinical MCQ themes [A25 P2,
O25]

CLINICAL CASE / APPLIED


– Prenatal diagnosis / FISH for chromosome 21 (Down syndrome) [M22 P2, A25 P2]

21. Nutrition
SHORT NOTES / EXPLAIN BRIEFLY
– Balanced diet [N23 P2]
– Specific dynamic action (SDA) of proteins [F21 P2, O25 P2]
EXPLAIN WHY (REASONING QUESTIONS)
– We need dietary fibre (roles in health) [A24 P2]

22. Hormone Action & Signal Transduction


SHORT NOTES / EXPLAIN BRIEFLY
– Second messenger systems [S19 P1, J19 P1]
– Hormonal control of glycogen metabolism [A24 P1]
CLINICAL CASE / APPLIED
– Primary hypothyroidism / thyroid case (see Clinical Biochemistry) [N23 P2]

AETCOM (Attitude, Ethics & Communication)


RECURRING THEMES
– Professional qualities and role of a physician; responsibilities toward society and community
– Commitment to lifelong learning as a pathway for professional growth
– Principles of communication with a diabetic patient about diet and exercise [A24 P1]
– Role of the physician in the healthcare system

Prepared By: Dr. Vireandra Kumar Charpota, Dr. Naresh Solanki, Dr. Akhlaq Hasan

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