Module 3 (Exchange and Transport) Revision Notes

How do Microorganisms Obtain Nutrients & Remove Waste?

 by exchange via their surface

 nutrients (e.g. glucose, oxygen) move in by diffusion via their surface
 waste (e.g. carbon dioxide) move out by diffusion via their surface

Why are Microorganisms able to perform exchange via their surface?

 have a large surface area to volume ratio

 have a short diffusion distance
 have low demand

Why can't Animals/Plants perform exchange via their surface?

 have a small surface area to volume ratio

 multicellular (large diffusion distance and high demand)
 impermeable surface (prevent pathogens entering and reduce water loss)
 therefore, require specialised Exchange & Transport systems
 exchange system = increases rate of diffusion of nutrients in and wastes out
 transport system = deliver nutrients and remove waste from all cells

Why do Fish have Specialised Gas Exchange Systems?

 multicellular organism so has a small surface area to volume ratio, large diffusion
distance, high demand & body surface impermeable
 therefore, cannot perform gas exchange (O2 in/CO2 out) via their surface, they
require a specialised gas exchange system called Gills

Structure of Gills in Fish?

 many gill filaments and gill lamellae = large surface area

 gill lamellae have a thin wall (short diffusion distance) and are permeable
 ventilation brings in pure water (high oxygen, low carbon dioxide) and circulation
brings in deoxygenated blood (low oxygen, high carbon dioxide), the water and blood
pass over in opposite directions (countercurrent flow), which maintains concentration
gradient all the way along the gill lamellae

Why do Insects have Specialised Gas Exchange Systems?

 multicellular organism so has a small surface area to volume ratio, large diffusion
distance, high demand & body surface made of exoskeleton (impermeable barrier
to reduce water loss)
 therefore, cannot perform gas exchange (O2 in/CO2 out) via their surface, they
require a specialised gas exchange system called Tracheal System

Structure of Tracheal System in Insects?

  starts with openings on body surface called Spiracles
 spiracles contain valves, open = gas exchange, closed = prevent water loss
 spiracles connect to Trachea
 trachea connect to Tracheoles
 tracheoles connect directly to Respiring Cells (delivering oxygen, removing
carbon dioxide)

How does Gas Exchange occur in Tracheal System of Insects?

 at rest = down a concentration gradient, oxygen moves in & carbon dioxide moves
out by simple diffusion
 when active = by ventilation, air inhaled for mass flow of O 2 in & air exhaled for
mass flow of CO2 out

Function of Lungs? site of gas exchange in mammals

(oxygen into blood – used in cells for respiration,
carbon dioxide out of the blood – toxic waste product of respiration)

What is Lungs made up of? Trachea, Bronchi, Bronchioles, Alveoli (+ capillaries)

Function of trachea, bronchi, bronchioles? transport of air and filter air, (bronchioles also
controls amount of air
reaching alveoli)

Structure of trachea/bronchi?

 wall made of c-shaped cartilage

 cartilage is strong so trachea/bronchi do not collapse
 cartilage is c-shaped to give flexibility
 lining made of goblet cells and ciliated epithelial cells
 goblet cells make mucus, which traps pathogens/particles
 ciliated epithelial cells have cilia, which pushes mucus up and out of lungs

Structure of bronchioles?

 wall made of smooth muscle

 smooth muscle contracts, lumen narrows, bronchiole constricts
 (occurs when surrounded by noxious gases – reduces amount reaching alveoli)
 lining made of goblet cells and ciliated epithelial cells

Adaptation of alveoli?

 millions of tiny alveoli that are folded (large surface area)

 thin wall/one cell thick/squamous epithelial cells (short diffusion distance)
 elastic tissue in wall (stretches when breathing in to increase surface area, recoils
when breathing out to push the air out)
 ventilation maintains concentration gradient (high oxygen, low carbon dioxide)
Adaptation of capillaries?
  millions of tiny capillaries (large surface area)
 thin wall/one cell thick/squamous epithelial cells (short diffusion distance)
 narrow lumen (increases diffusion time, decreases diffusion distance)
 circulation maintains concentration gradient (low oxygen, high carbon dioxide)

How O2 moves from the alveoli to the capillaries? by simple diffusion passing thru the
alveolar epithelium and
capillary epithelium

How CO2 moves from capillaries to the alveoli? by simple diffusion passing thru the
capillary epithelium and alveoli
epithelium

Describe the process of Breathing/Ventilation?

 Breathing In/Inhalation = external intercostal muscles contract (rib cage moves up

and out) & diaphragm contracts (flattens), therefore increase in volume in chest
and decrease in pressure, so air moves in
 Breathing Out/Exhalation = external intercostal muscle relax (rib cage moves
down and in) & diaphragm relaxes (back to dome shape), therefore decrease in
volume in chest and increase in pressure, so air pushed out (aided by elastic recoil
in the alveoli)

Formula for Pulmonary Ventilation?

 PV = tidal volume x ventilation rate

 tidal volume = volume of air breathed in/out in one breath
 ventilation rate = number of breaths per minute
 Pulmonary Ventilation = volume of air breathed in/out per minute

Function of Intestines? site of exchange of digested nutrients in mammals

What is Digestion?

 Breakdown of Large Insoluble Molecules into Small Soluble Molecules (so they
can move into the blood and then into the body cells)
 Starch/Glycogen (Carbohydrates) into Glucose by Amylase (Salivary in mouth,
Pancreatic in small intestine) and Maltase/Lactase/Sucrase (on lining of small
intestine)
 Proteins into Amino Acids by Endopeptidase/Exopeptidase/Dipeptidase
(Endopeptidase in stomach, Exopeptidase in small intestine, Dipeptidase on lining
of small intestine)
 Lipids into Monoglyceride and 2 Fatty Acids by Lipase (in small intestine)

What do Intestine Absorb?

 Small Intestine absorbs small soluble nutrients (glucose, amino acids,

monoglyceride and fatty acid, vitamins and minerals)
 Large Intestine absorbs water
Why do Humans/Mammals require a Specialised Transport System?

 multicellular organisms therefore have large diffusion distances and high demand
 need a transport system to deliver nutrients and remove waste from all cells
 transport system in humans/mammals called Circulatory System
 Circulatory System made of heart, blood vessels, blood
(heart pumps blood, blood vessels carry blood, blood carries nutrients/waste)

Why is the transport system in mammals called a double circulatory system?

the heart pumps twice, the blood goes through the heart twice – generates enough
pressure to supply
all body cells

Why is the transport system in mammals called a closed circulatory system?

blood is transported in blood vessels – helps to maintain pressure and redirect blood
flow

Layout of Circulatory System?

 heart pumps blood which is carried in arteries which flow into arterioles which
flow into capillaries which then are carried in venules then veins back to the heart
 Artery to Arterioles to Capillaries to Venules to Veins
 Artery/Arterioles carry blood away from the heart
(arterioles are small arteries)
 Capillaries are the site of exchange (nutrients out, waste in)
 Veins/Venules return blood back to the heart
(venules are small veins)

Heart?

 job is to pump blood around the body (delivers nutrients to cells and remove
waste)
 made of 4 muscular chambers (2 atria, 2 ventricles)
 atria pumps blood to ventricles, ventricles pump blood out of heart (R to lungs, L
to body)
 ventricles thicker then atria (has to pump blood further)
 left ventricle has a thicker muscular wall then right ventricle, therefore has
stronger contractions, so can generate higher pressure and pump the blood further
around the body

Blood vessels of the heart?

 artery takes blood away from the heart, vein returns blood to the heart
 Vena Cava supplies R atrium (with deoxygenated blood from body)
  Pulmonary Vein supplies L atrium (with oxygenated blood from lungs)
 R ventricle supplies Pulmonary Artery (deoxygenated blood to lungs)
 L ventricle supplies Aorta (oxygenated blood to body)

Job of valves in heart?

 Ensure one way flow of blood, no backflow

 (blood flows from atria to ventricles to arteries)
 2 sets of valves: Atrio-ventricular Valve & Semi-lunar Valve
 AV valve = between atria and ventricles
 SL valve = between ventricles and arteries

When are AV valves open or closed? Open = pressure in atria greater then pressure in
ventricles, Closed = pressure in ventricles greater then
pressure in atria

When are SL valves open or closed? Open = pressure in ventricles greater then pressure in
arteries, Closed = pressure in arteries greater then pressure in ventricles

Describe the processes of the cardiac cycle?

 Filling Stage = atria relaxed, ventricles relaxed, AV valve open, SL valve closed
 Atria Contracts = the SAN located in the R atrium initiates the heart beat and
sends the impulse across both atria making them contract, this pushes all the
remaining blood into the ventricles so it becomes full
 Ventricles Contract = the AVN picks up the impulse, delays it (stops the atria and
ventricles contracting at the same time, so the atria empties and the ventricles
fill), sends the impulse down the septum in the Bundle of His, then at the apex the
impulse goes up both walls of the ventricles in the purkine fibres, so the ventricles
contract from the base upwards, pushing the blood up thru the arteries, when the
ventricles start to contract the AV valve closes then the SL valve opens and blood
leaves the heart
 Ventricles Relax = the SL valve closes then the AV valve opens and filling starts
again

What causes the Heart Sounds?

 when the valves close

 1st = AV closes
 2nd = SL closes

Formula for Cardiac Output?

 CO = Stroke Volume x Heart Rate

 stroke volume = volume of blood pumped out of the heart in one beat
 heart rate = number of beats per minuted
  Cardiac Output = volume of blood pumped out of the heart in one minute

Coronary Heart Disease and Myocardial Infarction?

 high blood pressure damages lining of coronary artery

 fatty deposits/cholesterol builds up beneath the lining, in the wall = Atheroma
 the atheroma breaks thru the lining forming a Atheromatous Plaque on the lining, in
the lumen
 this causes turbulent blood flow
 a blood clot (thrombus) forms
 this block the coronary artery
 therefore less blood flow to the heart muscle
 less glucose and oxygen delivered
 the heart muscle cannot respire
 so it dies (myocardial infarction)

Risk Factors of CHD?

 Age, gender, ethnicity

 Saturated fats (increases LDL, LDL deposits cholesterol in the arteries to form
atheroma)
 Salts (increases blood pressure – lowers water potential of the blood so it holds the
water)
 Smoking (nicotine = increase HR and makes platelets more sticky – blood clot,
carbon monoxide = permanently blocks haemoglobin)
 Obesity and Lack of Exercise

Atheroma & Aneurysm? atheroma weakens wall of artery, blood builds up in the wall, the
wall swells then bursts = aneurysm

Role of Arteries/Arterioles?

 generally carry oxygenated blood away from the heart

 for example, Coronary Artery to heart muscle
Hepatic Artery to liver
Renal Artery to kidneys
 exception = Pulmonary Artery carries deoxygenated blood to lungs

Role of Veins/Venules?

 generally carry deoxygenated blood back to the heart

 for example, Coronary Vein from heart muscle
Hepatic Vein from liver
Renal Vein from kidneys
 exception 1 = Pulmonary Vein carries oxygenated blood back to the heart
 exception 2 = Hepatic Portal Vein carries deoxygenated blood from digestive
system to
liver (for filtering)
Function of Arteries/Arterioles?

carry blood away from the heart so should be able to withstand high blood pressures
& maintain high blood pressures

Structure of Arteries/Arterioles?

 narrow lumen = maintains pressure

 lining made of squamous epithelial cells = smooth lining to reduce friction
 thick wall = withstand pressure
 elastic tissue in wall,
ventricles contract – elastic tissue stretches to withstand pressure
ventricles relax – elastic tissue recoils to maintain pressure and smooth out
flow
 smooth muscle in wall (particularly in arterioles),
smooth muscle contracts – lumen narrows and arteriole constricts
smooth muscle relaxes – lumen widens and arteriole dilates
 collagen in wall
prevents artery from tearing

Function of Veins/Venules? return blood back to the heart, the blood is under low pressure

Structure of Veins/Venules?

 wide lumen = ease of blood flow

 lining made of squamous epithelial cells = smooth lining to reduce friction
 thin wall = vein can be squashed by skeletal muscle pushing blood back to the heart
 valves in lumen = prevents backflow of blood

Function of Capillaries?

 site of exchange
 3 locations,
With Alveoli, takes in O2 and removes CO2
With Microvilli, takes in glucose/amino acids/monoglyceride and fatty
acids/vitamins/minerals
With All Cells, deliver nutrients and remove waste

Adaptation of Capillaries?

 many small capillaries = large surface area

 thin wall, one cell thick, squamous epithelial cells = short diffusion distance
 pores between cells = allows fluid to move in and out
 narrow lumen = increase diffusion time and decrease diffusion distance

Content of Blood?

 main component = Plasma (fluid)

 plasma carries,
  Cells = red blood cells, white blood cells, platelets
 Solutes = nutrients, waste, protein

How does exchange occur between Capillaries & All Cells?

 by mass flow
 fluid moves out of the blood in the capillaries carrying the nutrients
 fluid moves back into blood in the capillaries carrying the waste
 (fluid in the blood called plasma, fluid surrounding cells called tissue fluid, fluid
in lymph system called lymph)

How is tissue fluid formed and returned to circulatory system?

 at the start of the capillary (arterial end) there is a build up hydrostatic pressure
 this pushes fluid out of the capillary via the pores
 the fluid carries the nutrients with it
 the fluid surrounds the cells, this is called tissue fluid
 at the finish of the capillary (venous end) the fluid moves back in by osmosis
 the capillary has low water potential due to the presence of proteins (too large to move
out of capillaries)
 any excess tissue fluid is picked up by the lymph system and deposited in the vena
cava

Why does high blood pressure cause accumulation of tissue fluid?

increases hydrostatic pressure, so more tissue fluid is formed – not as much can be
returned to the circulatory system

Why does diet low in protein cause accumulation of tissue fluid?

the water potential in the capillary is not as low as normal, so not as much fluid can
move back into the capillary by osmosis

Blood Pressure changes along the Circulatory System?

Arteries = - highest pressure (connects directly with heart/ventricles)

- pressure fluctuates (increases when ventricles contract which
causes the elastic tissue to stretch, decreases when
ventricles relax which causes the elastic tissue to recoil)
- overall decrease in pressure due to friction

Arterioles = large decrease in pressure due to increase in total cross-

sectional area (ensures pressure is not to high to damage
capillaries)

Capillaries = pressure here is called hydrostatic pressure (decreases due to a

loss in
fluid)

Venules/Veins = blood under low pressure

Job of Red Blood Cells?

 found in humans/mammals (animals)

 carries haemoglobin
 haemoglobin carries oxygen

Structure of Haemoglobin?

 globular protein (soluble & specific 3d shape)

 quaternary structure made of 4 polypeptide chains (2α, 2β)
 each chain carries a haem group
 each haem group carries Fe2+
 each Fe2+ carries an O2
 therefore, each haemoglobin carries 4 lots of O2

Job of Haemoglobin? load oxygen in the lungs and deliver it to the respiring tissues

What is Affinity?

the level of attraction haemoglobin has to oxygen

(high affinity = strong attraction, low affinity = weak attraction)

Role of haemoglobin in oxygen transport?

 haemoglobin has High Affinity in the lungs – due to high partial pressure of
oxygen and low partial pressure of carbon dioxide, so haemoglobin
loads/associates oxygen in the lungs and becomes saturated (full)
 the haemoglobin is transported in the blood in the red blood cell
 at the respiring tissues, haemoglobin has Low Affinity – due to low partial
pressure of oxygen and high partial pressure of carbon dioxide, so oxygen is
unloaded/dissociated/delivered and haemoglobin becomes unsaturated

Relationship between O2 Partial Pressure & Affinity/Saturation of Haemoglobin?

 positive correlation
 as O2 partial pressure increases, affinity/saturation of haemoglobin increases
 the correlation is not linear but is curved (produces a s-shaped, sigmoid curve
called Oxygen Dissociation Curve)
 middle portion of ODC has a steep gradient so when respiring tissues change from
resting to active and partial pressure of O2 falls, there is a large drop in affinity, so
more O2 would be delivered to the respiring tissues

Relationship between CO2 Partial Pressure & Affinity/Saturation of Haemoglobin?

 negative correlation
 as CO2 partial pressure increases, affinity/saturation of haemoglobin decreases
 this occurs at the site of respiring tissues = the carbon dioxide lowers the pH of
 the blood, makes the haemoglobin change shape, so oxygen is released, lowering
affinity. this shifts the ODC to the right, called the bohr shift. benefit = more
oxygen delivered to respiring cells

How does a Fetus receive oxygen? from mother's blood, oxygen dissociates from mother's
haemoglobin and associates with fetal haemoglobin in the placenta – fetal haemoglobin has a
higher affinity compared to mother's haemoglobin

Benefit of fetal haemoglobin having high affinity? fetal haemoglobin's ODC will be to the
left, it has high affinity – so the oxygen will dissociate from the mother's haemoglobin and
associate with the fetal haemoglobin at the low partial pressures of oxygen in the placenta, so
it has enough oxygen for its needs

Why do adults not keep with fetal haemoglobin? the high affinity will mean less oxygen
will be unloaded at the respiring tissues

Affinity of Organisms in a Low Oxygen Environment?

has a high affinity, curve to the left, therefore it can readily associate oxygen at the
low oxygen partial pressures

Affinity of Active Organisms?

has a low affinity, curve to the right, therefore more oxygen can be unloaded to meet
the cell's demand for more respiration

Affinity of Small Organisms?

have a large surface area to volume ratio, lose a lot of heat, needs to respire to
generate heat, therefore has a low affinity, curve to the right, so unloads enough oxygen for
the cells demand of more respiration

What are the Exchange & Transport Systems in Plants?

 exchange systems = leaf and root

 leaf to absorb light and CO2 for photosynthesis
 roots to absorb water and minerals
 transport systems = xylem and phloem
 xylem transports water and minerals
 phloem transports glucose/sugars
 xylem transports in one direction from roots to leaves, phloem transports in both
directions

Job of the Roots?

 absorb water and minerals

 absorbs water by osmosis
 absorbs minerals by active transport
 plants need water for photosynthesis, cytoplasm hydration, turgidity of cells
 plants need magnesium, nitrate, phosphate (magnesium to make chlorophyll,
 nitrate to make amino acids, phosphate to make phospholipids/ATP/DNA)

Function of the Xylem? transport water and minerals from roots, up the plant, to the leaves

Structure of the xylem?

 long continuous hollow tube (no resistance to water flow)

 narrow lumen
 wall made out of lignin
 lignin: strong, waterproof, adhesive
 wall contains pits/pores (water and minerals can leave)

How does water move up the xylem?

 loss of water at the leaves (transpiration)

 water moves from the top of the xylem into the leaf by osmosis (transpirational pull)
 this applies TENSION to the column of water in the xylem
 the column of water moves up as one as the water particles stick together,
COHESION
 this is is the cohesion-tension theory
 it is supported by capillary action, adhesion and root pressure
 (capillary action = water automatically moves up narrow lumen of xylem)
 (adhesion = water particles stick to lignin in wall of xylem)
 (root pressure = water absorbed at the roots pushes the column of water up slightly by
hydrostatic
pressure)

Why does the diameter of a tree decrease during the day?

 more light and higher temperature

 increase rate of transpiration
 increase transpirational pull
 water pulled up xylem by cohesion-tension
 because the water particles stick to the wall of the xylem (adhesion)
 the walls of the xylem are pulled inwards

Structure of Leaves?

 upper layer called Upper Epidermis

 waxy cuticle on upper epidermis (barrier to reduce water loss)
 beneath the upper epidermis are Palisade Cells
 palisade cells are were photosynthesis takes places
 beneath palisade cells are Spongy Mesophyll Cells
 are loosely packed leaving air spaces to allow ease of gas exchange
 lower layer called Lower Epidermis

Adaptation of palisade cells for photosynthesis?

  located near top of leaf, closer to light
 large size, large surface area for light
 thin cell wall, short diffusion distance for carbon dioxide
 contains many chloroplasts, site of photosynthesis
 large vacuole, pushes chloroplast to the edge of the cell closer to light

Structure of chloroplast?

 organelle for photosynthesis

 has double membrane
 contains discs called thylakoids
 thylakoids contain chlorophyll
 stack of thylakoids called granum
 thylakoids surrounded by a fluid called stroma

How does Exchange occur in Leaves?

 lower epidermis of leaf contains pairs of cells called Guard Cells

 when turgid, guard cells form an opening called Stomata
 gas exchange occurs via the stomata
 In Day, plant photosynthesises and respires, CO2 moves in for photosysnthesis and
O2 moves out (some is used in respiration)
 At Night, plant only respires, O2 moves in for respiration and CO2 moves out

What is Transpiration? loss of water vapour from the leaf via the stomata

How does Transpiration occur?

 moist lining of spongy mesophyll cells evaporate forming water vapour

 water vapour builds up in air spaces
 if water vapour concentration is high enough & stomata is open, water vapour
diffuses out

Factors that increase rate of transpiration?

 light = more light, more stomata open, increase surface area for transpiration
 temperature = more temperature, more evaporation (increase water vapour
concentration) & more kinetic energy
 wind = more wind, maintains concentration gradient
 humidity = less humidity, less water vapour in the surrounding air, increase in water
vapour
concentration gradient

What is a Potometer? apparatus used to measure rate of transpiration

Principle of potometer?
  as transpiration occurs from the leaves, the plant will pull up more water from the
potometer by cohesion-tension causing the bubble to move towards the plant
 the more water lost by transpiration, the more water taken up, the further the
bubble moves

Measuring Rate of Transpiration?

 rate of transpiration = volume of transpiration divided by time

 for volume of transpiration, distance bubble moved x cross-sectional area of tube
(πr2)

How to set up a potometer?

 choose healthy leaf and shoot

 cut shoot underwater and connect to potometer underwater (prevents air bubbles
entering/blocking
xylem)
 ensure potometer is air tight and water tight

What does a potometer actually measure?

measures rate of water uptake as a result of water loss from plant

(water loss can be due to: transpiration, photosynthesis, making cells turgid, loss from

potometer)

What is a Xerophyte? a plant adapted to reduce water loss (reduce transpiration)

Adaptations of Xerophyte?

 spiky, needle like leaves = reduced surface area

 thick waxy cuticle = waterproof, impermeable barrier
 densely packed spongy mesophyll = less air spaces, less water vapour build up
 sunken stomata/hairy leaves/rolled up leaves = traps moist layer of air,
reduces concentration gradient

Function of Phloem? transport organic material (e.g. Sucrose) up and down a plant

Structure of phloem? made of 2 parts (Sieve Tube with Companion Cells alongside)

How does phloem transport organic material like sucrose?

 by principle of Mass Flow (mass flow of water carries the sucrose)

 Sucrose loaded into Phloem at Source
 Hydrogen Ions (H+) actively transported from companion cells into source
 therefore, H+ diffuses back into companion cells from source
 as they do, they pull in sucrose with them by co-transport
 sucrose then diffuses into sieve tube
 this lowers the water potential of sieve tube so water follows by osmosis
 this water will carry the sucrose by hydrostatic pressure (mass flow)
  Sucrose unloaded from Phloem at Sink
 sucrose moves out of phloem/sieve tube into sink by diffusion
 water follows by osmosis

Enzymes of Carbohydrate Digestion?

 Starch/Glycogen (Salivary Amylase in Mouth, Pancreatic Amylase in Small

Intestine) into Maltose
 Maltose (Maltase on lining of Small Intestine) into Glucose
 Lactose (Lactase on lining of Small Intestine) into Glucose and Galactose
 Sucrose (Sucrase on lining of Small Intestine) into Glucose and Fructose

Enzymes of Protein Digestion?

 Endopeptidase (in stomach), hydrolyses peptide bonds in middle of polypeptide

chain into many smaller chains
 Exopeptidase (in small intestine), hydrolyses peptide bonds at end of chains to
leave dipeptides
 Deipeptidase (on lining of small intestine), hydrolyse dipeptides into amino acids

Enzymes of Lipid Digestion?

- Lipase in Small Intestine leaves Monoglyceride and 2 Fatty Acids

Adaptations of SI for Absorption?

 folded to form Villus (large surface area)

 cells lining SI have Microvilli (large surface area)
 wall of SI is thin (short diffusion distance)
 rich blood supply (maintains concentration gradient)
 cells lining SI have transport proteins, enzymes (maltase, lactase, sucrase,
didpeptidase) and many mitochondria

Absorption of Glucose and Amino Acids in SI?

 sodium ions are actively transported from the cells lining the SI into the blood
 lowers the sodium ion concentration in the cell
 therefore sodium ions move from the lumen of the SI into the cell
 this pulls in glucose and amino acids via a cotransport protein
 therefore glucose and amino acids builds up in the cell and moves into the blood
by diffusion

Absorption of Monoglyceride and Fatty Acids?

 Lipids initially emulsified by Bile into Micelles (smaller droplets)

 Micelles digested by Lipase into Monoglyceride and 2 Fatty Acids
 Monoglyceride and Fatty Acids absorbed by Cells lining SI by simple diffusion
 Form a Chylomicron (lipid + cholesterol + lipoprotein)
  Enters Lymph as Lacteal, then enters Blood

What is Lactose Intolerance

 Person does not make Lactase Enzyme

 Lactose remains Undigested
 Leads to Diarrhoea and Flatulence
 Undigested Lactose in Lumen of Intestine lowers it's water potential, so water
enters the lumen by osmosis leading to water faeces (Diarrhoea)
 Undigested Lactose brokendown by micro-organisms in Large Intestine, giving
off gas (Flatulence)