REVISION QUESTIONS and TPH QUESTIONS FOR LEVEL FOUR (4) SEMISTER TWO.

1. Outline eight (8) recommended design features of a compounding section unit.

2. Mention seven (7) recommended references/ compendia used in compounding of

extemporaneous products

3. List three (3) types of balances used in weighing solid ingredients in compounding

4. Describe ten (10) rules/rules/steps for using dispensing balance during weighing of solid
ingredients

5. Explain six (6) rules/ procedures/steps for the use of pipette during measuring volume of
liquids

6. Explain five (5) rules/ procedures/steps for the use of measuring cylinders during measuring
volume of liquids

7. Mention four examples of ingredients that do require the use of metal spatula because they
stain.

8. Describe two (2) methods of clarification of liquid preparation

9. Enlist six (6) commonly used solvents

10. List three (3) solvents that cannot be filtered through filter paper

[Link] three (3) factors that determine the rate of sedimentation of a suspension according
to Stokes's law

[Link] four (4) differences between flocculated suspension from deflocculated suspensions

[Link] two (2) differences between diffusible solids from in diffusible solid with example in each

14. Mention five (5) examples of non-oral liquid preparations

[Link] five (5) examples of oral liquid preparations

16. Describe three (3) factors affecting the stability of emulsions

17. Give the meaning of the following terms
A. Mixing
B. Suspension
C. Clarification
D. Agitation
E. Comminution
F. Trituration
G. Levigation
H. Emulsion
18. Highlight five (5) causes of emulsion cracking
[Link] four (4) factors to increase the viscosity of an emulsion
20. Mention seven (7) information of the extemporaneous label
21. Describe four (4) general guidelines for the selection of containers for the package of
extemporaneous preparation made in small scale compounding
22. Mention five (5) criteria of a good label
23. List five (5) criteria of a good packaging container
24. Explain four categories of granules
25. Enumerate five (5) appropriate procedures for storage of weighing balances in compounding
laboratory.
26. List four solvents/diluents used in the reconstitution of oral powders/granulated powders
[Link] seven standard procedures of reconstituting granulated powders/ oral rehydrated
salts (ORS)
28. Explain five (5) general procedure of preparing methylated spirit
29. Explain eight (8) general procedure of preparing suspension
30. Explain five (5) general procedure of preparing specialized food/ powders
31. Explain seven (7) general procedure of preparing syrup
32. Outline three (3) types of specialized food products

33. Enumerate four (4) examples of solid in liquid preparations

34. Give four (4) importance of stock solution in pharmacy practice

35. How many millilitres of 15% (w / v) concentrated phenol should be used in preparing 300mls
of a solution, such that 15 mLs diluted to 1 litre yield 1:4,000(w/v) solution?

36. How many ml of 0.05% potassium permanganate solution must be added to 135ml potassium
permanganate solution 1.5% in order to prepare a 0.5% potassium permanganate solution?

[Link] 500 ml. of a 15% v/v solution are diluted to 1500 mL, what is the percent strength (v / v) of
the dilution?

38. How many milliliters of a 1:5000 w/v solution of the preservative lauralkonium chloride can
be made from 125 mL of a 0.2% w/v solution of the preservative?

39. How many milliliters of water should be added to 80 mL of a 20% w/v aqueous solution to
prepare a 3% w/v solution?

40. How many milliliters of 1 * 10% * w / v stock solution should be used in preparing I gallon o a
0.05% * w / v solution? (lgallon= 3785ml )
[Link] many milliliters of a 1% w/v stock solution of a certified red dye should be used in
preparing 4000 m of a mouthwash that is to contain 1:20,000 w/v o the certified red dye as a
coloring agent?

42. How much drug should be used in preparing 50 ml of a stock solution such that 5 ml. diluted
to 500 mL will yield a 1:1000 w/v solution?

[Link] many milliters of a I / 400 * (w / v) of stock solution should be used to make 4 liters of a
I / 2000 * (w / v) solution?

44. How many millilires of a 17% (w/v) concentrate of benzalkonium chloride should be used in
preparing 300ml of a stock solution such that 15ml diluted to litres will yield 1:5000 (w/v)
solution?

45. Calculate the actual amount of dextrose in 2000ml dextrose solution 35%
46, What is the % strength of an ointment which contains 1.5g benzoic acid in 30g
47. From the following formula, calculate the quantity of cach ingredient required to make 1000 g
of the ointment.

Coal tar. 5 parts

Zinc oxide. 10 parts

Hydrophilic ointment. 50 parts

47. From the following formula for 40 sertraline hydrochloride capsules, calculate the quantity of
each ingredient needed to prepare 250 such capsules.

Sertraline hydrochloride ..300 mg

Silica gel. 6g
Calcium citrate. 4g

48. From the following formula of Magnesium carbonate Mixture PCx.

Light magnesium carbonate. 5.0g

Sodium bicarbonate.. 8.0g
Peppermint emulsion, concentrated. 2.5ml
Chloroform water, double strength-strength 50 ml
Water for preparation. 100ml

Sig: 0.5g sodium bicarbonate bid 3/7

Calculate;
i. Factor
ii. Amount of each ingredient

iii. Total amount of diluent

iv. State the instruction to the patient

49. From the following formula for artificial tears, calculate the quantity of each ingredient
required to prepare a dozen 30-ml containers.

Polyvinyl alcohol........1.4 g
Povidone. 0.6 g
Chlorobutanol. 0.5 g
Sterile sodium chloride solution 0.9%.....ad 100 ml.

50. What is the percent of alcohol in a mixture containing 500 ml of terpin hydrate clixir 40% v/v
alcohol, 400 ml of theophylline glycinate elixir 21% v/v elixir and also certain amount of
theophylline to make 1000ml

51. You are instructed to make 2454g of 3% zinc oxide paste. You have in stock 10% and 1% zinc
oxide paste how much of each will you use?
52.20ml of a 50% (w/v) solution is to be diluted to produce a 5% (w/v), calculate the amount of
diluent required for this purpose.

53. How many grams of coal tar should be added to 420g of 6% coal tar ointment to prepare an
ointment containing 25% coal tar?

54. What is the percentage of zinc oxide in an ointment prepared by mixing 200 g of 10%
ointment, 50 g of 20% ointment, and 100 g of 5% ointment?

[Link] what proportion should 20% benzocaine ointment be mixed with an ointment base to
produce a 2.5% benzocaine ointment?

56.A hospital pharmacist wants to use three lots of zinc oxide ointment containing, respectively,
50%, 20%, and 5% of zinc oxide. In what proportion should they be mixed to prepare a 10% zinc
oxide ointment?

57.n what proportions may a manufacturing pharmacist mix 20%, 15%, 5%, and 3% zinc oxide
ointments to produce a 10% ointment?

58. From the following formula, calculate the quantities required to make 5 gallons of a
phenobarbital elixir.
Phenobarbital. 4 g
Orange Oil. 0.25ml
Certified Red color. q.s
Alcohol. 200ml
Propylene Glycol. 100ml
Sorbitol Solution. 600ml
Water, to make. 1000ml

59.A timed-release cold capsule contains the following ingredients. Calculate, in grams, the
amount of each ingredient required to manufacture 100,000 capsules.
Phenindamine. 24 mg
Chlorpheniramine Maleate. 4 mg
Phenylpropanolamine Hydrochloride 50 mg
60. Explain six importance/ reasons for compounding
61. Explain seven pre-historical background of pharmaceutical compounding