ICD-10-CM E-SERIES ADVANCED CLINICAL QUESTION BANK

(E00–E89 ONLY)

1. Patient with Type 2 diabetes mellitus presenting with diabetic proliferative retinopathy and traction retinal
detachment of the right eye, also exhibiting Stage 3 chronic kidney disease -

2. A 42-year-old male with Type 1 diabetes mellitus presenting with ketoacidosis without coma, also
documented with diabetic autonomic neuropathy causing gastroparesis -

3. Patient diagnosed with drug-induced diabetes mellitus due to long-term corticosteroid use, presenting with
diabetic peripheral angiopathy without gangrene -

4. A 35-year-old female with Graves' disease (toxic diffuse goiter) presenting with thyrotoxic crisis (storm) and
exophthalmos -

5. Patient with secondary hyperparathyroidism of renal origin, presenting with hypercalcemia and muscle
weakness, secondary to end-stage renal disease -

6. A 50-year-old male diagnosed with Cushing's syndrome due to bilateral adrenal hyperplasia, presenting with
moon facies and central obesity -

7. Patient with panhypopituitarism following surgical resection of a pituitary tumor, requiring multiple
hormone replacements for ACTH and TSH deficiencies -

8. A 65-year-old female with Type 2 diabetes mellitus and Charcot's arthropathy of the left foot, also
documented with symptomatic hypoglycemia without coma -

9. Patient with primary hyperaldosteronism (Conn's syndrome) caused by a left adrenal adenoma, presenting
with refractory hypertension and hypokalemia -

10. A 28-year-old with Type 1 diabetes mellitus presenting with severe nonproliferative retinopathy and
macular edema in both eyes -

11. Patient diagnosed with severe protein-calorie malnutrition presenting with significant muscle wasting and
edema, documented as marasmic kwashiorkor -

12. A 19-year-old with cystic fibrosis-related diabetes mellitus, presenting with poor glycemic control and
diabetic mononeuropathy of the right lower limb -

13. Patient with hypothyroidism due to Hashimoto's thyroiditis, presenting with elevated TPO antibodies and
symptomatic bradycardia -

14. A 55-year-old with morbid obesity and a BMI of 45.2, also diagnosed with metabolic syndrome and non-
alcoholic steatohepatitis (NASH) -

15. Patient presenting with acute hypernatremia and dehydration due to central diabetes insipidus following a
head injury -

16. A 60-year-old male with Type 2 diabetes mellitus and diabetic chronic kidney disease Stage 4, currently
presenting with an infected skin ulcer of the right heel -

17. Patient with Addison's disease (primary adrenocortical insufficiency) presenting with hyponatremia and
hyperkalemia -
18. A 44-year-old with hyperprolactinemia due to a prolactin-secreting pituitary microadenoma, presenting
with galactorrhea and amenorrhea -

19. Patient diagnosed with subacute thyroiditis (de Quervain's) following a viral upper respiratory infection,
presenting with a painful, enlarged thyroid -

20. A 33-year-old with Type 1 diabetes mellitus presenting with a hypoglycemic coma and history of frequent
brittle diabetes -

21. Patient with secondary hyperaldosteronism due to renovascular hypertension, presenting with metabolic
alkalosis -

22. A 70-year-old female with Type 2 diabetes mellitus and diabetic polyneuropathy, also presenting with a
diabetic cataract in the left eye -

23. Patient diagnosed with severe hypermagnesemia secondary to excessive antacid intake in the setting of
renal insufficiency -

24. A 45-year-old with vitamin D deficiency osteomalacia and symptomatic hypocalcemia -

25. Patient with Type 2 diabetes mellitus presenting with hyperosmolar hyperglycemic state (HHS) without
coma -

26. A 58-year-old male with syndrome of inappropriate antidiuretic hormone secretion (SIADH) resulting in
profound euvolemic hyponatremia -

27. Patient with iatrogenic Cushing's syndrome resulting from chronic steroid therapy for rheumatoid arthritis
-

28. A 25-year-old female with polycystic ovary syndrome (PCOS) presenting with hirsutism, infertility, and
insulin resistance -

29. Patient diagnosed with hereditary hemochromatosis, presenting with bronze skin pigmentation and
laboratory evidence of iron overload -

30. A 52-year-old with Type 2 diabetes mellitus and diabetic periodontal disease, presenting with
hyperglycemia and poor dental hygiene -

31. Patient with vitamin B12 deficiency due to dietary inadequacy, presenting with megaloblastic anemia and
glossitis -

32. A 41-year-old with toxic multinodular goiter presenting with atrial fibrillation and hyperthyroid symptoms
-

33. Patient with Type 1 diabetes mellitus and diabetic amyotrophy, presenting with proximal muscle weakness
and pain in the pelvic girdle -

34. A 39-year-old male with acromegaly due to GH-secreting pituitary adenoma, presenting with increased
hand size and sleep apnea -

35. Patient diagnosed with hypoparathyroidism following thyroid surgery, presenting with Tetany and positive
Chvostek's sign -

36. A 66-year-old with Type 2 diabetes mellitus and diabetic foot ulcer involving the skin and subcutaneous
tissue of the left midfoot -
 37. Patient with metabolic acidosis and hyperkalemia secondary to Type 4 renal tubular acidosis -

38. A 47-year-old female with primary biliary cirrhosis presenting with vitamin A deficiency and night
blindness -

39. Patient with Type 1 diabetes mellitus and diabetic nephropathy with Kimmelstiel-Wilson nodules,
confirmed by renal biopsy -

40. A 30-year-old male with Klinefelter's syndrome (47,XXY) presenting with primary hypogonadism and
gynecomastia -

41. Patient with Type 2 diabetes mellitus and diabetic myonecrosis involving the skeletal muscle of the right
thigh -

42. A 56-year-old with postprocedural hypothyroidism following a total thyroidectomy for malignancy -

43. Patient diagnosed with Wernicke's encephalopathy due to chronic thiamine deficiency -

44. A 48-year-old with primary hyperoxaluria causing recurrent nephrolithiasis and systemic oxalosis -

45. Patient with Type 2 diabetes mellitus presenting with a localized fungal infection (Candidiasis) secondary
to poor glycemic control -

46. A 22-year-old with phenylketonuria (PKU) presenting with intellectual disability and musty body odor due
to poor dietary compliance -

47. Patient with Type 1 diabetes mellitus and diabetic gastroparesis, presenting with chronic nausea and
postprandial fullness -

48. A 63-year-old female with hypercalcemia of malignancy secondary to hyperparathyroidism-related protein

49. Patient with Type 2 diabetes mellitus presenting with diabetic autonomic neuropathy causing orthostatic
hypotension -

50. A 54-year-old male with scurvy due to chronic vitamin C deficiency, presenting with petechiae and
bleeding gums -

ANSWER KEY
1. E11.3511, E11.22 2. E10.10, E10.43 3. E09.51 4. E05.01

5. E21.1 6. E24.8 7. E23.0 8. E11.610, E11.649

9. E26.01 10. E10.3413 11. E42 12. E08.41

13. E06.3 14. E66.01, E88.81 15. E23.2, E87.0 16. E11.22, E11.621

17. E27.1, E87.1, E87.5 18. E22.1 19. E06.1 20. E10.641

21. E26.1, E87.3 22. E11.42, E11.36 23. E83.42 24. E55.0, E83.51

25. E11.00 26. E22.2 27. E24.2 28. E28.2

29. E83.110 30. E11.630, E11.65 31. E53.8 32. E05.20

33. E10.44 34. E22.0 35. E89.2 36. E11.621

41. E11.69 42. E89.0 43. E51.2 44. E72.53

45. E11.622, E11.65 46. E70.0 47. E10.43 48. E21.3, E83.52

49. E11.41 50. E54