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Abstract

The document discusses the regenerative abilities of various animals, highlighting that while most cannot regenerate limbs, urodele amphibians like newts and salamanders can. It focuses on the epimorphic regeneration process in amphibian tadpoles, specifically the Indian tree frog, and the formation of the blastema that facilitates limb regeneration. The study investigates cell proliferation patterns through immunofluorescence activity of FGF1 and PCNA to understand the mechanisms behind this regenerative process.

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Neha gupta
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7 views1 page

Abstract

The document discusses the regenerative abilities of various animals, highlighting that while most cannot regenerate limbs, urodele amphibians like newts and salamanders can. It focuses on the epimorphic regeneration process in amphibian tadpoles, specifically the Indian tree frog, and the formation of the blastema that facilitates limb regeneration. The study investigates cell proliferation patterns through immunofluorescence activity of FGF1 and PCNA to understand the mechanisms behind this regenerative process.

Uploaded by

Neha gupta
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd

ABSTRACT

Animals such as mammals, birds, and lizards cannot restore lost limbs but instead merely

undergo a process of wound healing. In contrast, urodele amphibians such as newts and

salamanders can regenerate their amputated limbs, while anuran amphibians are intermediate

between urodele amphibians and other vertebrates in terms of their regenerative capacity.

Epimorphic regeneration in amphibian tadpoles occurs through the establishment of a

balanced growth state in which a blastema gives rise to all the mesenchymal cells, whereas

definite areas of the epidermis proliferate leading to its extension, thus, allowing the

enlargement of the whole structure. This type of regeneration involves specific mechanisms

that coordinate and regulate cell proliferation. To understand how the blastema is formed and

how this growth situation is set up, we investigated cell proliferation patterns in different

regenerating stages of the tadpoles of Indian tree frog, Polypedates maculates by studying

their immunofluorescence activity of FGF1 and PCNA.

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