G.B.

TECHNICAL UNIVERSITY,
LUCKNOW

Syllabus

3rd Year (V & VI Semester)

[Link]. BIOMEDICAL ENGINEERING

[1]
 U.P. TECHNICAL UNIVERSITY, LUCKNOW
Study and Evaluation Scheme
[Link]. Electronics Engineering, [Link]. Electronics & Communication Engg.,
[Link]. Electronics & Tele Communication Engg.
(Also for [Link]. Biomedical Engineering)
[Effective from the session 2009-10]
YEAR 2nd, SEMESTER-III
Evaluation Scheme

Credit
S. SUBJECT PERIODS SESSIONAL
Course Code Subject
No. EXAM. ESE
Total
L T P CT TA Total
THEORY SUBJECTS
1. EHU-301/ Industrial Psychology/ 2 0 0 15 10 25 50 75 2
EHU-302 Industrial Sociology
2. EAS-301/ EOE-Mathematics III/ Science 3 1 0 30 20 50 100 150 4
031-EOE-038 based open Elective**
3. EEC-301 Fundamentals of 3 1 0 30 20 50 100 150 4
Electronics Devices
4. EEC-302 Digital Electronics 3 1 0 30 20 50 100 150 4
5. EEC-303 Electromagnetic Field 3 1 0 30 20 50 100 150 4
Theory
6. EEC-304 Fundamentals of Network 3 1 0 30 20 50 100 150 4
Analysis & Synthesis
7. EHU-111 *Human Values & 2 2 0 15 10 25 50 75 -
Professional Ethics
PRACTICAL/DESIGN/DRAWING
8 EEC-351 Electronics Engineering 0 0 2 -- 20 20 30 50 1
Lab I
9. EEC-352 Digital Electronics Lab-I 0 0 2 -- 20 20 30 50 1
10. EEC-353 PCB & Electronics 0 0 2 -- 10 10 15 25 1
Workshop
11. GP 301 General Proficiency - - - - - 50 - 50 1
Total 17 5 6 165 160 375 625 1000 26
* Human Values & Professional Ethics will be offered as compulsory Audit Course for which passing
marks are 40% in theory & 50% in aggregate. Students will be required to audit it within the period of their
study. There will not be carry over facility for this course and a failure student will be required to repeat this
course.
** Science based open Elective
EOE031/EOE041 Introduction to soft computing (Neural network, Fuzzy logic and Genetic algorithm)
EOE032/EOE042 Nano-sciences
EOE033/EOE043 Laser systems and applications
EOE034/EOE044 Space sciences
EOE035/EOE045 Polymer science and technology
EOE036/EOE046 Nuclear science
EOE037/EOE047 Material science
EOE038/EOE048 DISCRETE mathematics

[2]
 U.P. TECHNICAL UNIVERSITY, LUCKNOW
Study and Evaluation Scheme
[Link]. Electronics Engineering, [Link]. Electronics & Communication Engg.,
[Link]. Electronics & Tele Communication Engg.
(Also for [Link]. Biomedical Engineering)
[Effective from the session 2009-10]

YEAR 2nd , SEMESTER-IV

Evaluation Scheme

Credit
S. Course SUBJECT PERIODS
SESSIONAL EXAM. Subject
No. Code
L T P CT TA Total ESE Total
THEORY SUBJECTS
1. EHU-402/ Industrial 2 0 0 15 10 25 50 75 2
EHU-401 Sociology/Industrial
Psychology
2. EOE-041- Science based open 3 1 0 30 20 50 100 150 4
EOE-048/ Elective**/
EAS-401 Mathematics III
3. EEC-401 Electronic circuits 3 1 0 30 20 50 100 150 4
4. EEC-402 Computer 3 1 0 30 20 50 100 150 4
Architecture &
Organization
5. EEC-403 Electronic 3 1 0 30 20 50 100 150 4
Instrumentation and
Measurements
6. EEC-404 Signals and Systems 3 1 0 30 20 50 100 150 4
7. EHU-111 *Human Values & 2 2 0 15 10 25 50 75 -
Professional Ethics
PRACTICAL/DESIGN/DRAWING
8. EEC-451 Electronics 0 0 2 -- 20 20 30 50 1
Engineering lab II
9 EEC-452 Digital Electronics 0 0 2 -- 20 20 30 50 1
Lab II
10 EEC-453 Measurement lab 0 0 2 -- 10 10 15 25 1
11. GP 401 General Proficiency - - - - - 50 - 50 1
Total 17 5 6 165 160 375 625 1000 26
**Science based open Elective
EOE031/EOE041 Introduction to soft computing (Neural network, Fuzzy logic and Genetic algorithm)
EOE032/EOE042 Nano-sciences
EOE033/EOE043 Laser systems and applications
EOE034/EOE044 Space sciences
EOE035/EOE045 Polymer science and technology
EOE036/EOE046 Nuclear science
EOE037/EOE047 Material science
EOE038/EOE048 DISCRETE mathematics

[3]
SYLLABUS & EVALUATION SCHEME FOR BIO-MEDICAL ENGINEERING (B. Tech
Course)
[Effective from the session 2010-11]
Year III, Semester V

S. Course Subject Periods Evaluation Scheme

Credit
No. Code
L T P Sessional ESE TOTAL
CT TA TOTAL
THEORY
1 EHU-501 Engineering & 3 1 0 30 20 50 100 150 3
Managerial
Economics
2 EIC-501 Control System-I 3 1 0 30 20 50 100 150 4
3 EBM-501 Bio- 3 1 0 30 20 50 100 150 4
Instrumentation
4 EEC-501 Integrated Circuit 3 1 0 30 20 50 100 150 4

5 EBM-502 Micro-Processor & 3 0 0 15 10 25 50 75 3

its Applications

6 EBM-503 Human Anatomy 3 0 0 15 10 25 50 75 3

& Physiology
PRACTICAL /TRAINING/PROJECTS
7 EBM-551 Bio- 0 0 2 10 10 20 30 50 1
Instrumentation
Lab
8 EBM-552 Linear Integrated 0 0 2 10 10 20 30 50 1
Circuit Lab
9 EBM-553 Microprocessor 0 0 2 10 10 20 30 50 1
Lab
10 EIC-551 Control System 0 0 2 10 10 20 30 50 1
Lab
11 GP-501 General - - - - - 50 - 50 1
Proficiency
TOTAL 1000 26

[4]
SYLLABUS & EVALUATION SCHEME FOR BIO-MEDICAL ENGINEERING ([Link]
Course)
(Effective from the session 2010-11)
Year III, Semester VI

S. Course Subject Periods Evaluation Scheme

Credi
No. Code L T P Sessional ESE TOTAL
CT TA TOTAL
THEORY
1 Departmental 3 1 0 15 10 25 50 75 3
Elective- I

2 EBM-601 Physiological Control 3 1 0 30 20 50 100 150 4

System & Simulation
Modeling
3 EBM-602 Microcontroller & Bio- 3 1 0 30 20 50 100 150 4
Medical Applications
4 EBM-603 Bio- Medical Signal 3 1 0 30 20 50 100 150 4
Processing
5 EHU-601 Industrial 3 0 0 30 20 50 100 150 3
Management
6 EBM-604 Bio-Material 3 0 0 15 10 25 50 75 3
PRACTICAL /TRAINING/PROJECTS
7 EBM-651 PCSM Lab 0 0 2 10 10 20 30 50 1
8 EBM-652 Microcontroller & its 0 0 2 10 10 20 30 50 1
Application Lab
9 EBM-653 Bio- Medical Signal 0 0 2 10 10 20 30 50 1
Processing Lab
10 EBM-654 Seminar 0 0 2 10 10 20 30 50 1
11 GP-601 General Proficiency - - 50 - 50 1
TOTAL 1000 26
Departmental Elective-I
EBM 011 : Laser & Fibre Optics & Its Medical Applications.
EBM 012 :Rehabilitation Engineering.
EBM 013 : Bio-Mechanics
EEC 013 : Advance Semiconductor Devices

[5]
Unit SEMESTER – V Text Propos
Book/ ed
EIC 501 CONTROL SYSTEM I Chapter number
of
Lecture
s
I Basic Components of a control system, Feedback and its effect, 1.1 to 1.3
types of feedback control systems.
Block diagrams and signal flow graphs, 3.1 to 3.2 8
Modeling of Physical systems: electrical networks, mechanical 4.1 to 4.6
systems elements, equations of mechanical systems, sensors and
encoders in control systems, DC motors in control systems.
II State-Variable Analysis: Vector matrix representation of state 5.1 to 5.6
equation, state transition matrix, state-transition equation,
relationship between state equations and high-order differential 8
equations, relationship between state equations and transfer
functions.
III Time domain Analysis of Control Systems: Time response of 7.1 to 7.6
continuous data systems, typical test signals for the time response
of control systems, the unit step response and time-domain 8
specifications, Steady-State error, time response of a first order
system, transient response of a prototype second order system
IV Stability of Linear Control Systems: Bounded-input bounded- 6.1 to 6.5
output stability- continuous data systems, zero-input and
8
asymptotic stability of continuous data systems, methods of
determining stability, Routh Hurwitz criterion.
V Frequency Domain Analysis: Mr (resonant peak) and r (resonant 9.1to
frequency) and bandwidth of the prototype Second order system, 9.11
effects of adding a zero to the forward path, effects of adding a
10
pole to the forward path, Nyquist stability criterion, relative
stability: gain margin and phase margin, stability analysis with the
Bode plot
Text Book: B.C. Kuo & Farid Golnaraghi, “Automatic Control Systems”, 8th Edition, John Wiley
India, 2008.
Reference Books:
1. William A. Wolovich, “Automatic Control Systems”, Oxford University Press, 2010.
2. Joseph J. Distefano III, Allen R. Stubberud, Ivan J. Williams, “Control Systems” Schaums
Outlines Series, 3rd Edition, Tata McGraw Hill, Special Indian Edition 2010.
3. I. J. Nagrath & M. Gopal, “Control System Engineering”, New Age International Publishers

SEMESTER – V
BIO-INSTRUMENTATION

EBM-501
L T P: 3 1 0

Unit 1.
Oximeters: Oximetry, Ear Oximeter, Pulse Oximeter, Skin Reflectance Oximeters,
Intravascular Oximeter.

Blood Flow meters: Electromagnetic Blood flow meters, Types of electromagnetic

Blood Flow meters, Ultrasonic Blood Flow meters, NMR Blood Flow meter and Laser
[6]
Doppler Blood Flow meter.

Unit 2.
Cardiac Output Measurement: Indicator dilution Method, Dye dilution Method,
Thermal dilution Techniques, Measurement of Continuous Cardiac Output Derived
from the Aortic Pressure Waveform, Impedance Technique, Ultrasound method.

Unit 3
Pulmonary function Analyzer: Pulmonary function Measurement, Spirometery,
Pneumo tachometers, Measurement of volume, Pulmonary function Analyzer,
Respiratory Gas Analyzers.

Blood Cell Counters: Types of Blood cells, Methods of Cell Counting, Coulter
Counters, Automatic Recognition and Differential Counting of Cells.

Unit 4
Clinical Laboratory Instruments: Medical Diagnosis with chemical tests,
Spectrophotometer, Spectrophotometer Type instruments, Colorimeters,
Spectrophotometers, Automated Biochemical Analysis Systems, Clinical Flame
photometers, Selective ion Electrodes Based Electrolytes Analyzer.

Unit 5
Audiometers and Hearing Aids: Mechanism of Hearing, Measurement of sound,
Basic Audiometer, Pure Tone Audiometer, Speech Audiometer, Audiometer System
Bekesy, Evoked Response Audiometery System, Calibration of Audiometers,
Hearing Aids.
Unit 6

Patient Safety: Electric Shock Hazards, Leakage Currents, and Safety Codes for
Electro Medical Equipments, Electrical Safety Analyzer, and Testing of Biomedical
Equipment.

TEXT
1. Handbook of Biomedical Instrumentation. By: R. S. Khandpur. Pub: Tata McGraw -
Hill, New Delhi.
2. Biomedical Electronics and Instrumentation. By: S. K. Venkata Ram. Pub: Galgotia
Publication Pvt. Ltd., New Delhi.
3. Medical Instrumentation. Application and Design. By: John Webster. Pub: John Wiley
and Sons. Inc., New York.
4. Biomedical Instrumentation and Measurements. By: Leslie Cromwell, Fred J.
Weibell. Pub: Erich A. Pfeiffer.

[7]
 (Revised) 310
EEC 501 INTEGRATED CIRCUITS
Unit Topic Chapter/ Proposed
Section number of
From Text [1] Lectures
I Analog Integrated circuit Design: an overview: Current Mirrors using 5.6, 6.4, 6.5
BJT and MOSFETs, Simple current Mirror, Base current
compensated current Mirror, Wilson and Improved Wilson Current
Mirrors, Widlar Current source and Cascode current Mirror

The 741 IC Op-Amp: Bias circuit, short circuit protection circuitry, the 10.1-10.6
8
input stage, the second stage, the output stage, and device
parameters; DC Analysis of 741: Small Signal Analysis of input
stage, the second stage, the output stage; Gain, Frequency
Response of 741; a Simplified Model, Slew Rate, Relationship
Between ft and SR

II Linear Applications of IC op-amps: An Overview of Op-Amp (ideal 2.2-2.7

and non ideal) based Circuits V-I and I-V converters, generalized
Impedance converter, simulation of inductors
8
Filters: First and second order LP, HP, BP BS and All pass active 11.4, 11.7,
filters, KHN, Tow-Thomas and State Variable Biquad filters; 12.1, 12.2
Sinusoidal oscillators
III Digital Integrated Circuit Design-An Overview: CMOS Logic Gate 13.2-13.3
Circuits: Basic Structure CMOS realization of Inverters, AND, OR,
NAND and NOR Gates
8
Latches and Flip flops: The Latch, The SR Flip-flop, CMOS
Implementation of SR Flip-flops, A Simpler CMOS Implementation of 13.7
the Clocked SR Flip-flop, D Flip-flop Circuits.

IV Non-Linear applications of IC Op-amps: Log–Anti Log Amplifiers, 12.1, 12.4,

Precision Rectifiers, Peak Detectors, Simple and Hold Circuits, 12.5 12.9
Analog Multipliers and their applications. Op-amp as a comparator,
Zero crossing detector, Schmitt Trigger, Astable multivibrator, 8
Monostable multivibrator, Generation of Triangular Waveforms

V D/A and A/D converters 10.9-10.11 8

Integrated Circuit Timer: The 555 Circuit, Implementing a

Monostable Multivibrator Using the 555 IC, Astable Multivibrator 12.7
Using the 555 IC.

Phase locked loops (PLL): Ex-OR Gates and multipliers as phase 6.5 of Ref [2]
detectors, Block Diagram of IC PLL, Working of PLL and
Applications of PLL.

Text Book:
[1] Sedra and Smith, “Microelectronic Circuits”, 4th Edition, Oxford University Press.
Reference Books:
[2] Michael Jacob, `Applications and Design with Analog Integrated Circuits’, PHI, 2nd Edn, 2006

[8]
[3] Jacob Milliman and Arvin Grabel, “Microelectronics”, 2nd Edition, TMH, 2008.

[9]
 SEMESTER - V
MICROPROCESSOR & ITS APPLICATIONS
EBM-502
L T P: 3 0 0

UNIT1.
THE 8085 PROCESSOR:
Introduction to microprocessor, 8085 microprocessor: Architecture, instruction set.

UNIT2.
THE 8086 MICROPROCESSOR :
Architecture, block diagram of 8086, memory segmentation and physical address
computations, program relocation, addressing modes, Pin Diagram and description of
various signals instruction formats, Instruction Set , Assembler instruction format,
Directives and Operators

UNIT3
INTERFACING DEVICE:
The 8255 PPI chip: DMA CONTROLLER (8237),

UNIT4
INTERRUPT AND TIMER:
8259 Programmable interrupt controller, Programmable interval timer chips(8253/8254).

TEXT BOOKS:
[Link] Architecture, Programming & Applications with 8085: Ramesh S
Gaonkar; Wiley Eastern Ltd.
2. The Intel Microprocessors 8086- Pentium processor: Brey; PHI
REFERENCE BOOKS:
1. Microprocessors and interfacing: Hall; TMH
2. The 8088 & 8086 Microprocessors-Programming, interfacing, Hardware & Applications
: Triebel & Singh; PHI
3. Microcomputer systems: the 8086/8088 Family: architecture, Programming & Design:
Yu-Chang Liu & Glenn A Gibson; PHI.
4. Advanced Microprocessors and Interfacing: Badri Ram; TMH

[10]
 SEMESTER – V
HUMAN ANATOMY & PHYSIOLOGY

EBM-503
L T P: 3 1 0
ANATOMY:
Unit 1.
Structure & functions of cell. Polarization & depolarization of cell, Basic tissues &
functions in brief.

Unit 2
Outline of structures of the following systems:
Cardiovascular system, Respiratory system, Alimentary system, Central Nervous system,
Muscular System, Endocrine system Sense organs: Eye, Ear, Integument system (skin
study)

PHYSIOLOGY:
Unit 3
Cardiovascular system,: Heart, conductive tissue of heart, cardiac cycle, heart valves,
systemic & pulmonary circulation, Transmission of cardiac impulse, blood pressure.
Respiratory system: respiration external (ventilation), Exchange in gases in the alveoli,
Artificial respiration, Spiro meter (Forced expiration volumes), peak flow meter.
Alimentary system: all organs of the digestive system, other secretions & main
functions.

Unit 4
Blood: composition of blood-blood cells & their functions. Cell counting, hemoglobin
Excretory system: Structure of Nephron, formation of urine & function of kidneys,
urinary bladder, urethra, internal/external sphincters.
Nervous system: different parts, their functions, Reflex action & reflex arc. Function of
sympathetic nervous system. Nervous conduction & action potentials.

TEXT
1. Anatomy and physiology in health and illness by : Ross and Wilson (ELBS pub)
2. Human Physiology by A. Vander, J. Sherman and D. Luciante.
3. Basic Human theory By Charles E Tobin Mc Graw Hill.
4. Human Physiology by A. Vander, J. Sherman and D. Luciano Mc Graw Hill.
5 Basic Human Theory by Charles E Tobin Mc Graw Hill.

[11]
 SEMESTER – V

BIO-INSTRUMENTATION LAB

EBM-551 L T P: 0 0 2

LIST OF EXPERIEMENTS

1. Study of pulmonary function analyzer using spirogram.

2. To study finger tip oximeter.
3. Designing of instrumentation amplifier.
4. Designing of notch filter.
5. To study voltage regulator IC 7805, 7809, 7812 series.
6. To determine Bradycardia and Tachycardia using ECG Training Kit.
7. To determine heart rate using ECG simulator Kit.
8. Circuitry explanation for patient leakage current.
9. To determine balancing condition for thermistor using wheat stone bridge.
10. Study of pressure changes using strain gauge.

Important: Four Experiments should be added in above as per the

requirement of the relevant subject.

SEMESTER – V

LINEAR INTEGRATED LAB

EBM-552 L T P: 0 0 2

1. Measurement of Op-amp Parameters. (Open Loop Gain, Input offset Voltage, CMRR,
Slew rate)
2. Determination of Frequency response of Op-Amp.
3. Precision Rectifier
4. Instrumentation Amplifier.
5. Open Loop operation of Op-amp -Comparators - Schmitt Trigger.
6. Astable & Monostable Operation Using 555.
7. IC Voltage Regulator.
8. Voltage Controlled Oscillator.
9. Phase Locked Loop.
10. Frequency Multiplier
11. A/D Converters & D/A Converters.
12. Second Order Active Filter- High Pass & Low Pass Realization

Important: Two Experiments should be added in above as per the

requirement of the relevant subject.
[12]
 SEMESTER – V

MICROPROCESSOR LAB

EBM-553 L T P: 0 0 2

LIST OF EXPERIMENTS:

[Link] of 8085 Microprocessor kit.

2. Write a program using 8085 and verify for :

a. Addition of two 8-bit numbers.
b. Addition of two 8-bit numbers (with carry).

3. Write a program using 8085 and verify for :

a. 8-bit subtraction (display borrow)
b. 16-bit subtraction (display borrow)

4. Write a program using 8085 for multiplication of two 8- bit numbers by repeated
addition or by bit rotation method.

5. Write a program using 8085 for division of two 8- bit numbers by repeated subtraction
method and test for typical data.

6. Study of 8086 microprocessor kit.

7. Write a program using 8086 for finding the square root of a given number and verify.

8. Write a program using 8086 for copying 12 bytes of data from source to destination
and

9. Write a program using 8086 and verify for:

a. Finding the largest number from an array.
b. Finding the smallest number from an array.

10. Write a program using 8086 for arranging an array of numbers in descending order.

11. Write a program using 8086 for arranging an array of numbers in ascending order
and verify.

12. Write a program for finding square of a number using look-up table and verify. .

14. Write a program to control the operation of stepper motor using 8085/8086
Microprocessor and 8255 PPI.

[13]
 EIC 551 CONTROL SYSTEM LAB
LTP : 002
1. DC SPEED CONTROL SYSTEM
(a) To study D.C. speed control system on open loop and close loop.
(b) To study of Transient performance, another time signal is added at the input of control
Circuit.
(c) To study how eddy current breaking is being disturbance rejected by close and open
loop.
2. DC MOTOR POSITION CONTROL
(a) To study of potentiometer displacement constant on D.C. motor position control.
(b) To study of D. C. position control through continuous command.
(c) To study of D.C. position control through step command.
(d) To study of D.C. position control through Dynamic response.
3. AC MOTOR POSITION CONTROL
(a) To study of A.C. motor position control through continuous command.
(b) To study of error detector on A.C. motor position control through step command.
(c) To study of A.C. position control through dynamic response.
4. MAGNETIC AMPLIFIER
(a) To study Input / Output characteristic of a magnetic amplifier in mode (i) Saturable
Reactor, (ii) Self Saturable Reactor.
5. SYNCHRO TRANSMITTER / RECEIVER
(a) To study of Synchro Transmitter in term of Position v/s Phase and voltage magnitude
with respect to Rotor Voltage Magnitude/Phase.
(b) To study of remote position indication system using Synchro-transmitter/receiver.
6. PID CONTROLLER
(a) To observe open loop performance of building block and calibration of PID Controls.
(b) To study P, PI and PID controller with type 0 system with delay.
(c) To study P, PI and PID controller with type 1 system.
7. LEAD LAG COMPENSATOR
(a) To study the open loop response on compensator.
(b) Close loop transient response.
8. LINEAR SYSTEM SIMULATOR
(a) Open loop response
(i) Error detector with gain, (ii) Time constant, (iii) Integrator
(b) Close loop system
(I) First order system (II) Second order system (III) Third order system
9. Introduction to MATLAB (Control System Toolbox), Implement at least any two
experiment in MATLAB.
a. Different Toolboxes in MATLAB, Introduction to Control Systems Toolbox.
b. Determine transpose, inverse values of given matrix.
c. Plot the pole-zero configuration in s-plane for the given transfer function.
d. Determine the transfer function for given closed loop system in block diagram
representation.
e. Plot unit step response of given transfer function and find peak overshoot, peak
time.
f. Plot unit step response and to find rise time and delay time.
g. Plot locus of given transfer function, locate closed loop poles for different values
of k.
h. Plot root locus of given transfer function and to find out S, Wd, Wn at given root &
to discuss stability.
i. Plot bode plot of given transfer function.
j. Plot bode plot of given transfer function and find gain and phase margins
k. Plot Nyquist plot for given transfer function and to compare their relative stability
l. Plot the Nyquist plot for given transfer function and to discuss closed loop
stability, gain and phase margin.
[14]
 SEMESTER – VI

PHYSIOLOGY CONTROL SYSTEM AND SIMULATION MODELLING

EBM-601
L T P: 3 1 0
Unit 1.
Introduction to state variable analysis of control systems: -Introduction to state variable
concept, definition of state variables, matrix representation of state equation, state
transition equation, properties of transition matrix, relationship between state equations
and higher order differential equations, state equation and transfer function,
characteristics equation, Eigen values & Eigen vectors.

Unit 2.
Transformation to phase variables canonical forms of state variables, controllability
canonical form, observability canonical form Jordan canonical form, controllability of
linear system, observability of linear system relationship among controllability,
observability and transfer function.

Unit 3.
Introduction to biological control system: Introduction, Dynamic systems and their
control, modeling and block diagrams, the pupil control systems(Human Eye), general
structure of control systems, the dynamic response characteristics of the pupil control
system, open & close loop systems instability, automatic aperture control.

Unit 4.
Mathematical modeling of the system: Thermo regulation, Thermoregulation of cold
bloodedness & warm bloodedness, the anatomy of thermo regulation, lumping & partial
differential equations, heat transfer examples, mathematical model of the controlled
process of the body.

Unit 5.
Modeling the body as compartments, behavior in simple compartmental system,
pharmacokinetic model, multi compartmental system. distribution and accessibility of
body water & tissue compartments, basis for zero order & first order chemical kinetic
behavior in the biological system.

Unit 6.
Biological receptors: -Introduction, receptor characteristics, transfer function models of
receptors, receptor and perceived intensity. Respiratory model & systems,
Neuromuscular model, Cardiovascular control system.

TEXT
1. Automatic control systems: By Benjamin C Kuo.
2. Control system Engineering: By I. J . Nagarath. & M. Gopal.
3. Bio- Medical Engineering Principles By: David. 0. Cooney , Michel Deckker INC
4. Biological control systems: John H Milsum Mc Graw Hill 1966.
5. The Application Of Control Theory Of A Physiological System by Howard T Milhorn
Sounders Publication

[15]
 SEMESTER – VI

MICROCONTROLLER AND BIO-MEDICAL APPLICATION

EBM-602
L T P: 3 1 0

Unit 1.
Introduction: 8051, Comparison with microprocessor, pin diagram explanation,
internal diagram 8051.

Unit 2.
Instruction Set: Addressing mode, data transfer instruction, logical, arithmetic
instruction, bit instruction, branching instruction.

Unit 3.
Timers: Control Word, mode of timers, simple programming, generation of square
wave.
Serial Interface: Introduction, Control Word, mode of serial interface, simple
Programming.

Unit 4.
Interrupts: Introduction, Control word Simple Programming, generation of
waveforms using interrupt, serial interface using interrupt.

Unit 5.
Applications: Interfacing of memory, intelligent LCD, 8255, ADC, DAC, LED display.

Text Books
1. Micro controllers & its applications by B.S. Chhabra, Dhanpat Rai Pub. Co., India
2. 8051m C, Scott Mackenizie, PHI, Englewood Cliffs, New Jersey.
3. Myke Predko,’Programnming & Customizing the 8051 Microcontroller,’ Tata McGraw-
Hill Pub. Co. Ltd., New Delhi.
Reference Books:
1. 8051 m C Architecture Programming & Applications, K.J. Ayata: Penram
International Publishers, India.
2. S.K. Venkata Ram,’Advanced Microprocessor & Microcontrollers,’Luxmi Pub. Pvt.
Ltd., New Delhi

SEMESTER – VI

BIO-MEDICAL SIGNAL PROCESSING

EBM-603
L T P: 3 1 0

Unit 1.
Introduction, Characteristics of Bio - Signals, Types of Signals, Measurement,
Transformation. and reduction, computation of signal parameters that are diagnostically
significant, stationary and non - stationary bio - signals, Application areas of Bio -Signals
analysis - EEG, ECG, Phonocardiogram, Spiro Gram, Evoked Signals.
[16]
Unit 2.
Z transform introduction, definition, convergence. Inverse Z transforms, Analysis of
discrete
time systems using Z transforms. Solutions of differential equations. Transfer functions
and
stability.

Unit 3.
Fourier transform for continuous signals. Energy spectrum, Properties (without proof),
Gibbs
phenomena, Auto and cross correlation. Discrete Fourier transforms. Properties (without
proof), Inverse DFT. FFT, Decimation in time and decimation in frequency.

Unit 4.
Digital filter design, introduction, Realization of Digital system, canonical form, direct
form &
Cascade Realization of IIR & FIR Filters. Design of IIR & FIR Filters, Low pass, High
Pass,
Band Pass Filters using windows – Kaiser Windows.

Unit 5.
Data reduction Techniques, Power spectrum analysis, Sampling Theorem, aliasing
Nyquist
criteria, ADC’s and DAC’s.

Unit 6.
Digital signals and systems: Classification of systems causal, time varying, time invariant,
lumped. Introduction to digital signals systems. Convolution, Auto-correlation and cross
correlation , Use of Mat lab signal processing toolbox on various real bio - medical
signals.

TEXT
1. Digital signal processing, Proakis (PHI)
2. Signal Analysis By R. P. Singh , Second edition Tata McGraw – Hill
3. Engineering Electronics By Mauro R Prentice – Hall
4. Malmivuo, J. and Plonsey, R. Bioelectromagnetism: Principles and Applications
of Bioelectric and Biomagnetic Fields, Oxford University Press, New York, 1995.
5. D C Reddy, McGraw Hill, Biomedical Signal Processing.

References
1. Biomedical signal processing: Metin Akay (academic press)
2. Biomedical signal processing: Tompkins (academic press)
3. Theory and application of digital signal processing: Rabiner and Gold (EEE
pub)

[17]
 SEMESTER – VI
BIO-MATERIALS
EBM-604 L T P: 3 0 0

Unit-1
Introduction: Definition of biomaterials, requirements & classification of biomaterials,
Comparison of properties of some common biomaterials. Effects of physiological fluid on
the properties of biomaterials. Biological responses (extra and intra-vascular system).
Surface properties of materials, physical properties of materials, mechanical properties.

Metallic implant materials: Stainless steel, Co-based alloys, Ti and Ti-based alloys.
Importance of stress-corrosion cracking. Host tissue reaction with bio metal, corrosion
behavior and the importance of passive films for tissue adhesion. Hard tissue
replacement implant: Orthopedic implants, Dental implants. Soft tissue replacement
implants: Percutaneous and skin implants, Vascular implants, Heart valve implants-Tailor
made composite in medium.

Unit-2
Polymeric implant materials: Polyolefin’s, polyamides, acrylic polymers, fluorocarbon
polymers, silicon rubbers, acetyls. (Classification according to thermo sets,
thermoplastics and elastomers).Viscoelastic behavior: creep-recovery, stress-relaxation,
strain rate sensitivity. Importance of molecular structure, hydrophilic and hydrophobic
surface properties, migration of additives (processing aids), aging and environmental
stress cracking. Physiochemical characteristics of biopolymers. Biodegradable polymers
for medical purposes, Biopolymers in controlled release systems. Synthetic polymeric
membranes and their biological applications.

Unit-3
Ceramic implant materials: Definition of bio ceramics. Common types of bio
ceramics: Aluminum oxides, Glass ceramics, Carbons. Bio resorbable and bioactive
ceramics. Importance of wear resistance and low fracture toughness. Host tissue
reactions: importance of interfacial tissue reaction (e.g. ceramic/bone tissue reaction).
Composite implant materials: Mechanics of improvement of properties by
incorporating different elements. Composite theory of fiber reinforcement (short and
long fibers, fibers pull out). Polymers filled with osteogenic fillers (e.g. hydroxyapatite).
Host tissue reactions.

Unit-4
Biocompatibility & Toxicological screening of biomaterials: Definition of
biocompatibility, blood compatibility and tissue compatibility. Toxicity tests: acute and
chronic toxicity studies (in situimplantation, tissue culture, haemolysis, thrombogenic
potential test, systemic toxicity, intracutaneous irritation test), sensitization,
carcinogenicity, mutagenicity and special tests.

TEXT
1. Biomaterials Science: An Introduction to Materials in Medicine, By Buddy D. Ratner,
et. al. Academic Press, San Diego, 1996.
2. Sujata V. Bhat, Biomaterials, Narosa Publishing House, 2002.
3. J B Park, Biomaterials - Science and Engineering, Plenum Press, 1984.

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 SEMESTER – VI
PHYSIOLOGY CONTROL SYSTEM AND SIMULATION MODELLING
(PCSM) LAB

EBM-651 L T P: 0 0 2

LIST OF EXPERIMENTS

1. To Study the Cardiovascular system.

2. Simulation of Cardiovascular system by using MATLAB/SIMULINK.
3. To Study the Heart Model and simulate it using MATLAB/SIMULINK.
4. To Study the Eye Movement System, its mathematical mode.
5. To study linear muscle model.
6. To study model of respiratory mechanics.
7. Implement the simulink model for Lung Mechanics.
8. Implement the glucose insulin regulation model by MATLAB tools.
9. To study the circulatory model by MATLAB.
10. Implement the simulink model for neuromuscular transient response

Important: Four Experiments should be added in above as per the

requirement of the relevant subject.

SEMESTER – VI
MICROCONTROLLER AND ITS APPLICATION LAB

EBM-652 L T P: 0 0 2

LIST OF EXPERIMENTS

1. Study of 8051 Microcontroller, Architecture & command.

2. Write an ALP for the Addition & Subtraction of 8 bit no’s.
3. Write an ALP for multiplication of Two 8 bit no’s.
4. Write an ALP for Division of Two 8 bit no’s.
5. Write an ALP to find smallest & largest no in a given array.
6. Write an ALP to generate 10 KHz frequency using interrupt.
7. Write an ALP to interface intelligent LCD display with m C.
8. Write an ALP for m C & HLL for PC (VB/C++/VC++) to demonstrate/implement serial
Interfacing.
9. Write an ALP to interface LED display.
10. Write an ALP to interface one m C with other using serial/parallel communication.
11. Write an ALP to switch ON alarm when m C receive interrupt

Important: Three Experiments should be added in above as per the

requirement of the relevant subject.

[19]
 SEMESTER – VI

BIO-MEDICAL SIGNAL PROCESSING LAB

EBM-653 L T P: 0 0 2

LIST OF EXPERIMENTS

1. Realization of signal-continuous & discrete by using MATLAB.

2. Write a MATLAB program to perform convolution of two signals.
3. Write a short program to perform
(a) DFT
(b) Inverse DFT
(c) FFT
By using MATLAB.

4. By using toolbox(MATLAB) simulate

(a) FIR Filter
(b) IIR Filter
5. Data acquisition of EEG & ECG signals by using DSP kit.
[Link] removal from EEG & ECG signals
7. Power spectrum analysis of EEG signals.

Important: Five Experiments should be added in above as per the requirement

of the relevant subject.

SEMESTER – VI
LASER & FIBER OPTICS AND ITS MEDICAL APPLICATION

EBM-011 L T P: 3 1 0

Elective-I

Unit1.
Introduction to fiber optics: Basic fiber link, applications, principles of light:
Introduction, EM spectrum, internal & external reflections, Snell' slaw, optical
fiber
numerical aperture, Fresnel reflection.

Unit2.
Optic fiber & its properties: Introduction, Basic fiber construction, propagation of
light, modes of operation, refractive index profile, types of fibers, dispersion, data
rate and bandwidth, attenuation, losses. Connectors, Splices & Couplers:
Introduction, splices: mechanical, fusion, protection of splice, connectors: SMA,

[20]
STC, bionic etc, coupling: passive, Stan, TEE types. Optical sources & Photo
Detectors: Introduction: creation of photons, LED, ILD, photo detectors:
introduction, PIN photodiode, avalanche photodiode, photodiode parameters,
detector noise, speed of response, SNR.

Unit 3. Modulation scheme for fiber optics transmission: Introduction, digital

modulation, analog modulation schemes, multiplexing.

Unit 4.
Laser Systems: Introduction, types of lasers: Solid state lasers, Gas lasers, Dye
lasers, Lasers used in medical practice: Ruby laser, CO2 laser, Nd-Y AG laser and
related solid state laser. Laser -Tissue Interaction: Terminology : spectral band
designations, energy & power, irradiant & radiant exposure, fluency, thermal
diffi1sion fibers & contact tips, Types of laser-tissue interactions
Unit 5. Laser Application in Medical Therapy: Introduction, application in general
surgery, dermatology, ophthalmology, cardiovascular & chest surgery, dentistry,
neuro surgery, otolaryngology & head and neck surgery, tumor surgery,
gynecologic laser.

TEXT
1. Therapeutic Lasers -Theory and practice by G. David Baxter, Churchill
Livingstonepublications.
2. Medical Lasers and their safe use by David H Shiney, Stephen and L. Trokel,
Springer-Verlag publications.
3. Elements of fiber optics by S. L. Wymer, Regents-Prentice Hall publications.
4. Biomedical Electronics & Instrumentation by S. K. Venkata Ram, Galgotia
publications.
REFERENCE
1. Laser and optical fibers in medicine by Katzer and Abraham, Academic press
publications
2. An Introduction to optical fibers by A. M. Cherin, McGraw Hill publications.

SEMESTER – VI

REHABILITATION ENGINEERING

EBM-012 L T P: 3 1 0

Elective-II

Unit 1.
Introduction to Rehabilitation Engineering
Principles and Application involved in the study of Rehabilitation Engineering.

Unit 2.
Rehabilitation Engineering – Science and Technology
Concepts in Motor rehabilitation and Communication disorders.
[21]
Unit 3.
Prosthetics and Orthotics in Rehabilitation Engineering
Introduction, Fundamentals and applications of externally powered and controlled
orthotics and prosthetics.

Unit 4.
Sensory Augmentation and Substitution
Visual Systems – Retinal Implants, Auditory system- Cochlear Implants, Tactual
System.

Unit 5.
Future development of Rehabilitation Science – Neural Prosthesis

Text book / Reference Books

1. The Biomedical Engineering Handbook ; Joseph D Bronzino ; 3rd Ed.; CRC
Press(2006)
2. Handbook of Biomedical Engineering (Handbooks in Science and
Technology);Jacob Kline ; Academic Press (1988)

SEMESTER – VI
BIO-MECHANICS L T P: 3 1 0
EBM-013

Unit 1. Scalar And Vector Quantities:

Different operations on vectors, forces and Moments.

Unit 2.
System of Forces in 2D and 3D; Equilibrium equation, Applications with examples on
Human Body.

Unit 3
Work Energy Equation, Application to Bio-Medical System.

Unit 4.
Stress Strain Diagram, Stress in Bending ,Torsion and Compound Loading, Stress
Shielding of Bone.

Unit 5.
Mechanical Properties of Human Bone and Soft Tissues, Cortical and Cancellous
Bone,Viscoelasticity,Elastic Model of Bone.

TEXT
[Link] Nihat,Margrate Nordine,”Fundamental of Bio- Mechanics”. Springer Publication.
[Link] G. L.,[Link] “ A priemer of Bio Mechanics”. Springer Publication.
3. Gardiner M .Dena ,” The Principle of Exercise Therapy”. CBS Publicer.c. Orthotics

[22]
 EEC 013 ADVANCE SEMICONDUCTOR DEVICES 310
Unit Topic Chapter/ Proposed
Section number
of
Lectures
I Review of Fundamentals of Semiconductors:
Semiconductor Materials and their properties 3.1 to 3.8
Carrier Transport in Semiconductors 4.1 to 4.9 10
Excess Carriers in Semiconductor 5.1 to 5.7

II Junctions and Interfaces:

Description of p-n junction, Action, The Abrupt 6.1 to 6.4
Junction, Example of an Abrupt Junction, The linearly
graded Junction. 7.1 to 7.5
The Ideal Diode Model, Real Diodes, Temperature 8
Dependence of I-V Characteristics, High Level 8.1,8.3,8.5,8.7
Injection Effects, Example of Diodes.
Description of Breakdown Mechanism, Zener and
Avalanche Breakdown in p-n Junction
III Majority Carrier Diodes:
The Tunnel Diode, The Backward Diode, The 10.1 to 10.5
6
Schottkey Barrier Diode, Ohmic Contacts
Heterojunctions.
IV Microwave Diodes:
The Varactor Diode, The p-i-n Diode, The IMPATT 11.1 to 11.6
Diode, TRAPATT Diode, The BARITT Diode,
Transferred Electron Devices 8
Optoelectronic Devices: 12.1 to 12.4
The Solar Cell, Photo detectors, Light Emitting Diodes,
Semiconductor Lasers.
V Metal Semiconductor Field Effect Transistors:
Basic Types of MESFETs, Models for I-V 15.4 to 15.7
Characteristics of Short –Channel MESFETs, High
Frequency Performance, MESFETs Structures.
8
MOS Transistors and Charge Coupled Devices:
Basic Structures and the Operating Principle, I-V 16.4 to 16.9
Characteristics, Short-Channel Effects, MOSFET
Structures, Charge Coupled Devices.
Text Book: M.S. Tyagi, “Introduction To Semiconductor Materials And Devices”, John Willy-
India Pvt. Ltd.
Reference Books:
1. S. M. Sze, “Physics of Semiconductor Devices”, 2nd Edition, John Willy-India Pvt. Ltd.
2. B. G. Streetman and S. Banerjee, “Solid state electronics devices”, 5th Edition, PHI.

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