Plot
Four years after the Lockwood Estate incident that followed the volcanic eruption of Isla Nublar,[b] once-extinct dinosaurs and
other prehistoric animals freely roam the Earth. Amid global efforts to control them, Biosyn Genetics establishes a dinosaur
preserve in Italy's Dolomites and conducts genomics research, ostensibly for pharmacological applications.
Claire Dearing, Zia Rodriguez, and Franklin Webb investigate illegal dinosaur breeding sites, also gathering proof of cases of
animal cruelty. Claire's partner, Owen Grady, helps relocate stray dinosaurs. At their remote cabin in the Sierra Nevada
mountains, Claire and Owen secretly raise 14-year-old Maisie Lockwood (Benjamin Lockwood's biogenetic granddaughter) and
protect her from groups seeking to exploit her unique genetic makeup.
When Blue, the Velociraptor Owen raised and trained, arrives at the cabin with an asexually-reproduced hatchling, Maisie
names it Beta. Increasingly frustrated living in seclusion, Maisie sneaks away to explore. Mercenaries searching for Maisie find
and kidnap her and capture Beta.
Meanwhile, swarms of giant locusts are decimating U.S. crops. Dr. Ellie Sattler observes that crops grown with Biosyn seeds
are left uneaten, raising suspicions that Biosyn created the insects. She takes a captured locust to her former romantic
partner, paleontologist Dr. Alan Grant and reveals she is now divorced from her husband Mark.[c] They determine the locust
was genetically engineered with Cretaceous-period and contemporary DNA.
Franklin, now with the CIA's dangerous-species division, believes Maisie may have been taken to Malta. Upon arrival there,
Claire and Owen infiltrate a dinosaur black market with Owen's former Jurassic World colleague Barry Sembène, who is
leading a French Intelligence raid. Carnivorous dinosaurs are unleashed during the foray, wreaking havoc. When Claire and
Owen learn that Maisie and Beta were transported to the Biosyn facility, sympathetic cargo pilot Kayla Watts agrees to fly
them there.
Chaotician Dr. Ian Malcolm now works for Biosyn. He sought Ellie's help to expose CEO Dr. Lewis Dodgson after
communications director Ramsay Cole warned him of Dodgson's illegal activities. Dodgson is exploiting dinosaurs and coerces
former InGen geneticist Dr. Henry Wu to modify the transgenic locust to let Biosyn corner the world's food supply. Wu
denounces the plan, warning it will cause an ecological collapse as the locusts spread unchecked.
Wu meets Maisie and explains that his former colleague, Dr. Charlotte Lockwood (Benjamin Lockwood's deceased daughter),
used her own DNA to replicate and give birth to the genetically identical Maisie. She also altered Maisie's DNA to prevent her
from inheriting the fatal disease which she had. Wu believes that Maisie and Beta's asexual conception and DNA are key to
creating a pathogen to halt the locust outbreak.
A Quetzalcoatlus attacks Kayla's plane in Biosyn's airspace, forcing Owen and Kayla to crash land while Claire is ejected. After
separate dinosaur encounters, the three regroup. Inside Biosyn, Ian and Ramsay covertly advise Ellie and Alan on where to
obtain a locust DNA sample. While searching for the lab, they encounter Maisie. Discovering the breach, Dodgson attempts to
incinerate the locusts to destroy evidence; some locusts escape through an air vent while ablaze, sparking a wildfire around
the preserve.
Alan, Ellie, and Maisie barely escape the facility before finding Ian. They meet Owen, Claire and Kayla, with Ramsay later
joining them. Dodgson flees with dinosaur embryos[d] via a hyperloop, but becomes trapped after Claire and Ellie reroute the
power and is then killed by a trio of Dilophosaurus. As the group works together, Owen, with Alan and Maisie's help, captures
Beta. They and Wu escape in a Biosyn helicopter amidst a fight between a Giganotosaurus and Isla Nublar's former resident
Tyrannosaurus,[e] the latter assisted by a Therizinosaurus.
Ellie and Alan rekindle their romantic relationship before testifying with Ian and Ramsay against Biosyn. Owen, Claire and
Maisie return home and reunite Beta and Blue. Wu releases a host locust carrying the pathogen, gradually eradicating the
swarms. Dinosaurs and humans adapt to a new co-existence, and the United Nations declares Biosyn Valley an international
dinosaur sanctuary.