Uka Tarsadia University

Maliba Pharmacy College

[Link].
PH5009 Pharmacology - II

Semester - V

EFFECTIVE FROM JULY-2021

Syllabus version: 1.0
 Uka Tarsadia University
SEMESTER-V
PH5009 Pharmacology - II
Theory credits: 3 Theory contact hours per week: 3
Practical credits: 3 Practical contact hours per week: 3

Objective of the Course:

To impart the fundamentals of pharmacology and various drugs acting on the different
systems with emphasis on their therapeutic use.
Outcome:
Upon completion of the course, the student shall be able to
CO1 Describe t h e g e n e r a l p h a r m a c o l o g y c o m p r i s i n g o f v a r i o u s r o u t e s
of drug administration together with pharmacokinetics and pharmacodynamics,
combined effects of drugs including drug tolerance.
CO2 Describe the neuro-humoral transmission in autonomic nervous system and
pharmacology aspects of drugs acting on parasympathetic and sympathetic
nervous system.
CO3 Explain the pharmacological aspects of agents used as neuromuscular blockers
and local anaesthetics.
CO4 Explain the pharmacological aspects of drugs acting on renal and cardiovascular
system.
CO5 Define the term autacoids and the therapeutic use of autacoids in various
disease and disorder
CO6 Explain the pharmacological aspects of drugs acting on blood and blood forming
agents.

Sr. No. Theory Topic Hours

Unit – I
1 Pharmacology of drugs acting on cardio vascular system 10
a. Introduction to hemodynamic and electrophysiology of heart.
b. Drugs used in congestive heart failure
c. Anti-hypertensive drugs.
d. Anti-anginal drugs.
e. Anti-arrhythmic drugs.
f. Anti-hyperlipidemic drugs.
Unit – II
2 A. Pharmacology of drugs acting on cardio vascular system 6
a. Drug used in the therapy of shock.
b. Hematinics, coagulants and anticoagulants.
c. Fibrinolytics and anti-platelet drugs
d. Plasma volume expanders
 Uka Tarsadia University
B. Pharmacology of drugs acting on urinary system
a. Diuretics
b. Anti-diuretics.
Unit – III
3 Bioassay 6
a. Principles and applications of bioassay.
b. Types of bioassay
c. Bioassay of insulin, oxytocin, vasopressin, ACTH,
d-tubocurarine, digitalis, histamine and 5-HT
Unit – IV
4 Autocoids and related drugs 9
a. Introduction to autacoids and classification
b. Histamine, 5-HT and their antagonists.
c. Prostaglandins, Thromboxanes and Leukotrienes.
d. Angiotensin, Bradykinin and Substance P.
e. Non-steroidal anti-inflammatory agents
f. Anti-gout drugs
g. Antirheumatic drugs
Unit – V
5 Pharmacology of drugs acting on endocrine system 9
a. Basic concepts in endocrine pharmacology.
b. Anterior Pituitary hormones- analogues and their inhibitors.
c. Thyroid hormones- analogues and their inhibitors.
d. Hormones regulating plasma calcium level- Parathormone,
Calcitonin and
Vitamin-D.
e. Insulin, Oral Hypoglycemic agents and glucagon.
Unit – VI
6 Pharmacology of drugs acting on endocrine system 5
a. Androgens and Anabolic steroids.
b. Estrogens, progesterone and oral contraceptives.
c. Drugs acting on the uterus.
d. ACTH and corticosteroids.

[Link]. Practical details Hours

1) Introduction to in-vitro pharmacology and physiological salt 45
solutions.
2) Effect of drugs on isolated frog heart.
3) Effect of drugs on blood pressure and heart rate of dog.
4) Study of diuretic activity of drugs using rats/mice.
 Uka Tarsadia University
5) DRC of acetylcholine using frog rectus abdominis muscle.
6) Effect of physostigmine and atropine on DRC of
acetylcholine using frog rectus abdominis muscle and rat
ileum respectively.
7) Bioassay of histamine using guinea pig ileum by matching
method.
8) Bioassay of oxytocin using rat uterine horn by interpolation
method.
9) Bioassay of serotonin using rat fundus strip by three point
bioassay.
10) Bioassay of acetylcholine using rat ileum/colon by four point
bioassay.
11) Determination of PA2 value of prazosin using rat
anococcygeus muscle (by Schilds plot method).
12) Determination of PD2 value using guinea pig ileum.
13) Effect of spasmogens and spasmolytics using rabbit jejunum.
14) Anti-inflammatory activity of drugs using carrageenan
induced paw-edema model.
15) Analgesic activity of drug using central and peripheral
methods
Text Books:
1) Sharma H. L., Sharma K. K., Principles of Pharmacology, Paras medical publisher
2) Tripathi K.D., Essentials of Medical Pharmacology, , JAYPEE Brothers Medical
Publishers (P) Ltd, New Delhi.
3) Goyal R.K. et al: Practical in Pharmacology, 12th edition, 2017, B.S. Shah Prakashan,
Ahmedabad.
Reference books:
1) Rang H. P., Dale M. M., Ritter J. M., Flower R. J., Rang and Dale’s Pharmacology,
Churchil Livingstone Elsevier
2) Katzung B. G., Masters S. B., Trevor A. J., Basic and clinical pharmacology, Tata Mc
Graw-Hill.
3) Marry Anne K. K., Lloyd Yee Y., Brian K. A., Robbin L.C., Joseph G. B., Wayne A.
K., Bradley R.W., Applied Therapeutics, The Clinical use of Drugs, The Point
Lippincott Williams & Wilkins.
4) 5. Mycek M.J, Gelnet S.B and Perper M.M. Lippincott’s Illustrated Reviews-
Pharmacology.
5) Laurence L. Brunton, John S Lazo, Keith L. Parker. Goodman & Gilman's The
Pharmacological Basis of Therapeutics: McGraw-Hill, medical publishing division.
6) Satoskar, R.S. and Bhandarkar, S.D. Pharmacology and Pharmacotherapeutics, (single
volume), Popular, Dubai.
7) Craig, C.R. and Stitzel, R.E. Modern Pharmacology, Latest Edition, Little Brown and
Company.
 Uka Tarsadia University
Books Recommended (Practicals)
1) Kulkarni S.K. Handbook of experimental pharmacology, 3rd edition, 1999, Vallabh
Prakashan, New Delhi.
2) Ghosh, M.N. fundamentals of experimental pharmacology, 1954, Scientific Book
agency, Kolkata.

Course objectives and Course outcomes mapping:

 To develop a comprehensive understanding of various drugs and used in various disease
in several system specific: CO1, CO2, CO3, CO4, CO5, CO6
 To acquire adequate knowledge & necessary skills related to the evaluation of drugs on
preclinical based practical: CO1, CO2, CO3, CO4, CO5, CO6

Course units and Course outcome mapping:

CO1 CO2 CO3 CO4 CO5 CO6

Pharmacology of drugs acting on cardio vascular √
system
Pharmacology of drugs acting on CVS & urinary √
system
Bioassay √
Autocoids and related drugs √
Pharmacology of drugs acting on endocrine √
system
Pharmacology of drugs acting on endocrine √
system

Programme Outcomes

 PO 1: Knowledge: Demonstrate knowledge of basic skills and techniques in in

pharmaceutical industry, hospitals, community and institutes or any other profession
they would like to pursue.
 PO 2: Core Competence: Students will be competent in the domain of
Pharmaceutics, Pharmaceutical Chemistry, Pharmacology and Pharmacognosy as per
the requirement of Industrial, Community and Hospital Pharmacy.
 PO 3: Breadth: Trained students will have practical efficiency in pharmacodynamics,
pharmacokinetics, drug synthesis and analysis and formulation & development of
dosage forms so that they are able to extend this knowledge to create new herbal &
synthetic pharmaceutical products for the benefit of life.
 PO 4: Preparation: Students will be prepared to excel in postgraduate programmes
and also to succeed in pharmaceutical industry or any other chosen profession
through innovative teaching methodologies that stimulate students to self-learning
and further their knowledge.
 Uka Tarsadia University
 PO 5: Professionalism: Display legal, moral, ethical attitudes and consistent
behaviors with the standards of the profession.
 PO 6: Evaluation: The ability to evaluate important aspects of the matter they have
studied, pharmaceutical technology, they have learned and pros and cons of the
ethical outlook they adhere to in the field of Pharmaceutical Sciences.

Programme Outcomes and Course Outcomes mapping:

Programme Course out comes

Out come
CO1 CO2 CO3 CO4 CO5 CO6
PO1 √ √ √ √ √ √
PO2 √ √ √ √ √ √
PO3 √ √ √ √ √ √
PO4 √ √ √ √ √ √
PO5 - - - - - -
PO6 √ √ √ √ √ √
Uka Tarsadia University

[Link].
PH5016: Pharmaceutical Biotechnology
Semester - V

EFFECTIVE FROM JULY-2024

 Uka Tarsadia University
SEMESTER-V
PH5016 Pharmaceutical Biotechnology

Theory credits: 4 Theory Contact Hours Per week: 3+1

Objective of the Course:
 To impart knowledge to students with the basic fundamentals of biotechnology and
their application in pharmacy.
 To acquire adequate knowledge of various fermentation techniques, genetic
engineering, hybridoma techniques, and immobilization of enzymes.

Outcomes: Upon completion of the course, the student shall be able to comprehend
CO1 Fundamentals of biotechnology, enzyme biotechnology and protein engineering
CO2 Concepts in genetic engineering and recombinant DNA technology
CO3 Hybridoma technology, immunology and vaccines
CO4 Microbial genetics and immune blotting techniques
CO5 Application of fermentation technology in pharmacy
CO6 Production of enzymes and blood products

Sr. No. Topic Hours

Unit – I
1 Brief introduction to biotechnology with reference to pharmaceutical 8
sciences. Enzyme biotechnology: Methods of enzyme immobilization
and applications. Biosensors: Working and applications of biosensors
in pharmaceutical industries. Brief
introduction to protein engineering. Use of microbes in industry.
Unit – II
2 Study of cloning vectors, restriction endonucleases and DNA ligase. 7
Recombinant DNA technology. Application of genetic engineering in
medicine. Application of rDNA technology and genetic engineering in
the production of: i) Interferon ii) Vaccines: Hepatitis-B iii)
Hormones: Insulin.
Unit – III
3 Hybridoma technology: Production, purification and applications. 8
Types of immunity: Humoral immunity, cellular immunity.
Structure of immunoglobulin’s. Structure and function of MHC.
Hypersensitivity reactions, immune stimulation and immune
suppressions. General method of the preparation of bacterial
vaccines, toxoids, viral vaccine, antitoxins, serum-immune blood
derivatives and other products relative to immunity. Storage
conditions and stability of official vaccines.
 Uka Tarsadia University
Unit – IV
4 Immune blotting techniques: ELISA, Western blotting, Southern 7
blotting. Genetic organization of eukaryotes and prokaryotes.
Microbial genetics including transformation, transduction,
conjugation, plasmids and transposons. Introduction to microbial
biotransformation and applications. Mutation: Types of
mutation/mutants.
Unit – V
5 Fermentation methods and general requirements, study of media, 8
equipment’s, sterilization methods, aeration process, stirring. Large
scale production fermenter design and its various controls. Study of
the production of - penicillins, citric acid, Vitamin B12, glutamic acid,
griseofulvin.
Unit – VI
6 Blood products: Collection, processing and storage of whole human 7
blood, dried human plasma, and plasma substitute. Production of
enzymes: General consideration: Amylase, catalase, peroxidase,
lipase, protease, penicillinase. Basic principles of genetic
engineering. Brief introduction to PCR.

Text Books:
1. Pharmaceutical Biotechnology, S. P. Vyas & V. K. Dixit, CBS Publishers & Distributors,
New Delhi, 2008.
2. Microbiology, Michael J. Pelczar, 5th Edition, Tata McGraw-Hill, New York, 1993.
3. Tutorial Pharmacy, Cooper & Gunn, 6th edition, CBS Publishers & Distributors, Delhi,
2005.
Reference books:
1. B. R. Glick and J. J. Pasternak: Molecular Biotechnology: Principles and Applications
of Recombinant DNA: ASM Press Washington D.C.
2. R. A. Goldshy et. al., Kuby Immunology.
3. J. W. Goding: Monoclonal Antibodies.
4. J. M. Walker and E. B. Gingold: Molecular Biology and Biotechnology by Royal Society
of Chemistry.
5. Zaborsky: Immobilized Enzymes, CRC Press, Degraland, Ohio.
6. S. B. Primrose: Molecular Biotechnology (Second Edition) Blackwell Scientific
Publication.
7. Stanbury F. P., Whitakar A., and Hall J. S., Principles of fermentation technology, 2nd
edition, Aditya books Ltd., New Delhi.
 Uka Tarsadia University
Course objectives and Course outcomes mapping:
• To impart knowledge to students with the basic fundamentals of biotechnology and their
application in pharmacy: CO1, CO2, CO3, CO4, CO5, CO6.
• To acquire adequate knowledge of various fermentation techniques, genetic engineering,
hybridoma techniques, and immobilization of enzymes: CO1, CO2, CO3, CO4, CO5, CO6.
Course units and Course outcome mapping:

CO1 CO2 CO3 CO4 CO5 CO6

Fundamentals of biotechnology, enzyme
√
biotechnology and protein engineering
Concepts in genetic engineering and recombinant
√
DNA technology
Hybridoma technology, immunology and vaccines √
Microbial genetics and immune blotting techniques √
Application of fermentation technology in pharmacy √
Production of enzymes and blood products √

Programme Outcomes

 PO 1: Knowledge: Demonstrate knowledge of basic skills and techniques in in

pharmaceutical industry, hospitals, community and institutes or any other profession
they would like to pursue.
 PO 2: Core Competence: Students will be competent in the domain of Pharmaceutics,
Pharmaceutical Chemistry, Pharmacology and Pharmacognosy as per the requirement
of Industrial, Community and Hospital Pharmacy.
 PO 3: Breadth: Trained students will have practical efficiency in pharmacodynamics,
pharmacokinetics, drug synthesis and analysis and formulation & development of
dosage forms so that they are able to extend this knowledge to create new herbal &
synthetic pharmaceutical products for the benefit of life.
 PO 4: Preparation: Students will be prepared to excel in postgraduate programmes
and also to succeed in pharmaceutical industry or any other chosen profession
through innovative teaching methodologies that stimulate students to self-learning
and further their knowledge.
 PO 5: Professionalism: Display legal, moral, ethical attitudes and consistent
behaviours with the standards of the profession.
 PO 6: Evaluation: The ability to evaluate important aspects of the matter they have
studied, pharmaceutical technology, they have learned and pros and cons of the
ethical outlook they adhere to in the field of Pharmaceutical Sciences.
 Uka Tarsadia University
Programme Outcomes and Course Outcomes mapping:

Programme Course outcomes

Out come
CO1 CO2 CO3 CO4 CO5 CO6
PO1 √ √ √ √ √ √
PO2 √ √ √ √ √ √
PO3 √ √ √ √ √ √
PO4 √ √ √ √ √ √
PO5 √ √ √ √ √ √
PO6 √ √ √ √ √ √
Uka Tarsadia University

[Link].
PH5019 HERBAL DRUG TECHNOLOGY

Semester - V
EFFECTIVE FROM JULY-2024
 Uka Tarsadia University
SEMESTER-V

PH5019 HERBAL DRUG TECHNOLOGY

Theory credits: 4 Theory contact hours per week: 3+1
Practical credits: 2 Practical contact hours per week: 4

Objective of the Course:

This subject gives the student the knowledge of basic understanding of herbal drug
industry, the quality of raw material, guidelines for quality of herbal drugs, herbal
cosmetics,
Natural sweeteners, nutraceutical etc. The subject also emphasizes on Good
Manufacturing
Practices (GMP), patenting and regulatory issues of herbal drugs.
Student Learning Outcomes/Objectives:
Upon completion of this course the student should be able to:
1. Understand raw material as source of herbal drugs from cultivation to herbal drug
product
2. Know the WHO and ICH guidelines for evaluation of herbal drugs
3. Know the herbal cosmetics, natural sweeteners, nutraceuticals
4. Appreciate patenting of herbal drugs, GMP .

Sr.
Theory Topic Hours
No.
Unit – I
1 Herbs as raw materials 11
Definition of herb, herbal medicine, herbal medicinal product, herbal
drug preparation
Source of Herbs
Selection, identification and authentication of herbal materials
Processing of herbal raw material
Biodynamic Agriculture
Good agricultural practices in cultivation of medicinal plants including
Organic farming.
Pest and Pest management in medicinal plants:
Biopesticides/Bioinsecticides.
Indian Systems of Medicine
a) Basic principles involved in Ayurveda, Siddha, Unani and
Homeopathy
b) Preparation and standardization of Ayurvedic formulations viz Aristas
and Asawas, Ghutika,Churna, Lehya and Bhasma
 Uka Tarsadia University
Unit – II
2 Nutraceuticals 7
General aspects, Market, growth, scope and types of products
available in the market. Health benefits and role of Nutraceuticals in
ailments like Diabetes, CVS diseases, Cancer, Irritable bowel syndrome
and various Gastro intestinal diseases.
Study of following herbs as health food: Alfaalfa, Chicory, Ginger,
Fenugreek, Garlic, Honey, Amla, Ginseng, Ashwagandha, Spirulina
Herbal-Drug and Herb-Food Interactions: General introduction to
interaction and classification. Study of following drugs and their possible
side effects and interactions: Hypercium, kava-kava, Ginkobiloba,
Ginseng, Garlic, Pepper & Ephedra.
Unit – III
3 Evaluation of Drugs: WHO & ICH guidelines for the assessment of 5
herbal drugs, Stability testing of herbal drugs.
Regulatory Issues - Regulations in India (ASU DTAB, ASU DCC),
Regulation of manufacture of ASU drugs - Schedule Z of Drugs &
Cosmetics Act for ASU drugs.
Unit – IV
4 Herbal Cosmetics 10
Sources and description of raw materials of herbal origin used via,
fixed oils, waxes, gums colours, perfumes, protective agents, bleaching
agents, antioxidants in products such as skin care, hair care and oral
hygiene products.
Herbal excipients:
Herbal Excipients – Significance of substances of natural origin as
excipients – colorants,
sweeteners, binders, diluents, viscosity builders, disintegrants, flavors
& perfumes.
Herbal formulations :
Conventional herbal formulations like syrups, mixtures and tablets and
Novel dosage forms
like phytosomes
Unit – V
5 Patenting and Regulatory requirements of natural products: 5
a) Definition of the terms: Patent, IPR, Farmers right, Breeder’s right,
Bioprospecting and Biopiracy
b) Patenting aspects of Traditional Knowledge and Natural Products.
Case study of Curcuma & Neem.
 Uka Tarsadia University
Unit - VI
6 General Introduction to Herbal Industry 07
Herbal drugs industry: Present scope and future prospects.
A brief account of plant based industries and institutions involved in
work on medicinal and aromatic plants in India.
Schedule T – Good Manufacturing Practice of Indian systems of
medicine
Components of GMP (Schedule – T) and its objectives Infrastructural
requirements, working space, storage area, machinery and
equipments, standard operating procedures, health and hygiene,
documentation and records.

Practical details Hours

1. To perform preliminary phytochemical screening of crude drugs. 45
2. Determination of the alcohol content of Asava and Arista
3. Evaluation of excipients of natural origin
4. Incorporation of prepared and standardized extract in cosmetic
formulations like creams, lotions and shampoos and their
evaluation.
5. Incorporation of prepared and standardized extract in formulations
like syrups, mixtures and tablets and their evaluation as per
Pharmacopoeial requirements.
6. Monograph analysis of herbal drugs from recent Pharmacopoeias
7. Determination of Aldehyde content
8. Determination of Phenol content
9. Determination of total alkaloids
Recommended Books: (Latest Editions)
1. Textbook of Pharmacognosy by Trease & Evans.
2. Textbook of Pharmacognosy by Tyler, Brady & Robber.
3. Pharmacognosy by Kokate, Purohit and Gokhale
4. Essential of Pharmacognosy by [Link]
5. Pharmacognosy & Phytochemistry by [Link]
6. Pharmacopoeal standards for Ayurvedic Formulation (Council of Research in
Indian Medicine & Homeopathy)
7. Mukherjee, P.W. Quality Control of Herbal Drugs: An Approach to Evaluation of
Botanicals. Business Horizons Publishers, New Delhi, India, 2002.
Uka Tarsadia University

[Link].
PH5018 Medicinal Chemistry - I

Semester - V

EFFECTIVE FROM JULY-2024

 Uka Tarsadia University
SEMESTER-V
PH5018: Medicinal Chemistry - I
Theory credits: 4 Theory contact hours per week: 3+1
Objective of the Course:
This subject is designed to impart fundamental knowledge on the structure emphasizes
on structure activity relationships, chemistry and therapeutic value of drugs.

Student Learning Outcomes:

Upon completion of the course the student shall be able to
CO1: To understand the physicochemical properties and metabolism of drugs with respect
to their biological activity.
CO2: Understanding adrenergic and antiadrenergic drugs along with its mechanism, SAR,
adverse effect and therapeutic uses.
CO3: Study in detail cholinergic and anticholinergic drug.
CO4: Study drugs acting on central nervous system such as anesthesia, sedatives and
hypnotics
CO5: Study in detail antipsychotic and antidepressant drugs
CO6: Study narcotic, antipyretic and anti-inflammatory agents.

Instructional Methods and Pedagogy:

Faculty members shall explain in a class room using black board and multimedia projector
through PowerPoint presentation.
Sr. No. Theory Topic Hours
Unit – I
1 Introduction to Medicinal Chemistry: History and development 8
of medicinal chemistry
2 Physicochemical properties in relation to biological action
Ionization, Solubility, Partition Coefficient, Hydrogen bonding,
Protein binding, Chelation, Bioisosterism, Optical and Geometrical
isomerism.
3 Drug metabolism
Drug metabolism principles- Phase I and Phase II. Factors affecting
drug metabolism including stereo chemical aspects.
Study of the development of the following classes of drugs,
classification, mechanism of action, uses of drugs mentioned in
the course, Structure activity relationship of selective class of
drugs as specified in the course and synthesis of drugs
superscripted by (*)
Unit – II
Drugs acting on Autonomic Nervous System 7
4 Adrenergic Agonists:
Biosynthesis and catabolism of catecholamine. Adrenergic
receptors (Alpha & Beta) and their [Link] of
Sympathomimetic agents, Direct acting: Nor-epinephrine,
 Uka Tarsadia University
Epinephrine, Phenylephrine*, Dopamine, Methyldopa, Clonidine,
Dobutamine, Isoproterenol, Terbutaline, Salbutamol*, Bitolterol,
Naphazoline, Oxymetazoline and Xylometazoline. Indirect acting
agents: Hydroxyamphetamine, Pseudoephedrine,
Propylhexedrine. Agents with mixed mechanism: Ephedrine,
Metaraminol.
5 Adrenergic Antagonists:
Alpha adrenergic blockers: Tolazoline*, Phentolamine,
Phenoxybenzamine, Prazosin, Dihydroergotamine, Methysergide.
Beta adrenergic blockers: SAR of beta blockers, Propranolol*,
Metibranolol, Atenolol, Betazolol, Bisoprolol, Esmolol,
Metoprolol, Labetolol, Carvedilol
Unit – III
Drugs acting on Autonomic Nervous System 7
6 Cholinergic neurotransmitters: Biosynthesis and catabolism of
acetylcholine. Cholinergic receptors (Muscarinic & Nicotinic) and
their distribution. SAR of Parasympathomimetic agents. Direct
acting agents: Acetylcholine, Carbachol*, Bethanechol,
Methacholine, Pilocarpine. Indirect acting/ Cholinesterase
inhibitors (Reversible & Irreversible): Physostigmine,
Neostigmine*, Pyridostigmine, Edrophonium chloride, Tacrine
hydrochloride, Ambenonium chloride, Isofluorphate,
Echothiophate iodide, Parathione, Malathion. Cholinesterase
reactivator: Pralidoxime chloride.
Cholinergic Blocking agents: SAR of cholinolytic agents
Solanaceous alkaloids and analogues: Atropine sulphate,
7 Hyoscyamine sulphate, Scopolamine hydrobromide, Homatropine
hydrobromide, Ipratropium bromide*. Synthetic cholinergic
blocking agents: Tropicamide, Cyclopentolate
hydrochloride, Clidinium bromide, Dicyclomine hydrochloride*,
Glycopyrrolate, Methantheline bromide, Propantheline bromide,
Benztropine mesylate, Orphenadrine citrate, Biperidine
hydrochloride, Procyclidine hydrochloride*, Tridihexethyl
chloride, Isopropamide iodide, Ethopropazine hydrochloride.
Unit – IV
Drugs acting on Central Nervous System 7
8 General anesthetics:
Inhalation anesthetics: Halothane*, Methoxyflurane, Enflurane,
Sevoflurane, Isoflurane, Desflurane. Ultra short acting
barbitutrates: Methohexital sodium*, Thiamylal sodium,
Thiopental sodium. Dissociative anesthetics: Ketamine
9 hydrochloride.*
Sedatives and Hypnotics:
Barbiturtes: SAR of barbiturates, Barbital*, Phenobarbital,
Mephobarbital, Amobarbital, Butabarbital, Pentobarbital,
Secobarbital, Amides & imides: Glutethmide. Alcohol & their
 Uka Tarsadia University
10 carbamate derivatives: Meprobomate, Ethchlorvynol. Aldehyde &
their derivatives: Triclofos sodium, Paraldehyde.
Anticonvulsants: SAR of Anticonvulsants, mechanism of
anticonvulsant action. Barbiturates: Phenobarbitone,
Methabarbital. Hydantoins: Phenytoin*, Mephenytoin, Ethotoin
Oxazolidine diones: Trimethadione, Paramethadione
Succinimides: Phensuximide, Methsuximide, Ethosuximide* Urea
and
monoacylureas: Phenacemide, Carbamazepine* Benzodiazepines:
Clonazepam Miscellaneous: Primidone, Valproic acid ,
Gabapentin, Felbamate
Unit – V
Drugs acting on Central Nervous System 8
11 Anxiolytics:
Benzodiazepines: SAR of Benzodiazepines, Chlordiazepoxide,
Diazepam*, Oxazepam, Chlorazepate, Lorazepam, Alprazolam,
Zolpidem
Antipsychotics:
12 Phenothiazeines: SAR of Phenothiazeines - Promazine
hydrochloride, Chlorpromazine hydrochloride*, Triflupromazine,
Thioridazine hydrochloride, Piperacetazine hydrochloride,
Prochlorperazine maleate, Trifluoperazine hydrochloride. Ring
Analogues of Phenothiazeines: Chlorprothixene, Thiothixene,
Loxapine succinate, Clozapine. Fluro buterophenones:
Haloperidol, Droperidol, Risperidone. Beta amino ketones:
Molindone hydrochloride. Benzamides: Sulpieride.
13 Antidepressants:
Tricyclic antidepressants, Monoamine Oxidase inhibitors
Unit - VI
Drugs acting on Central Nervous System 8
14 Narcotic and non-narcotic analgesics: SAR of Morphine
analogues, Morphine sulphate, Codeine, Meperidine
hydrochloride, Anilerdine hydrochloride, Diphenoxylate
hydrochloride, Loperamide hydrochloride, Fentanyl citrate*,
Methadone hydrochloride*, Propoxyphene hydrochloride,
15 Pentazocine, Levorphanol tartarate.
Narcotic antagonists: Nalorphine hydrochloride, Levallorphan
16 tartarate, Naloxone hydrochloride.
antipyretic & Anti-inflammatory agents: Sodium salicylate,
Aspirin, Mefenamic acid*, Meclofenamate, Indomethacin,
Sulindac, Tolmetin, Zomepriac, Diclofenac, Ketorolac, Ibuprofen*,
Naproxen, Piroxicam, Phenacetin, Acetaminophen, Antipyrine,
Phenylbutazone.
 Uka Tarsadia University
Text Books:
1) Wilson and Gisvold’s – Textbook of Organic, Medicinal and Pharmaceutical
Chemistry
2) Foye’s Principles of Medicinal Chemistry
Reference books:
1) Burger’s Medicinal Chemistry – Volume I to VI
2) Andrejus Korolkovas – Essentials of Medicinal Chemistry
3) Comprehensive Medicinal Chemistry – Volume I to VIII
4) Kadam, Mahadik and Bothara – Principles of Medicinal Chemistry Volume I & II
5) Ashutosh Kar – Medicinal Chemistry
6) Lednicer’s – Organic Synthesis – Volume I to VI
7) An Introduction to the Chemistry of Heterocyclic Compounds, by Acheson RN,
Interscience Publishers New York.
8) Computer Aided Drug Design, by Pops and Perruns, Academic Press, NY
9) R K Bansal – Heterocyclic Chemistry
10) Heterocyclic Chemistry by Joule and Mill, 4/Ed., Blackwell Publishing Oxford.
Books Recommended (Practicals)
1) Vogel’s Text Book of Practical Organic Chemistry- Brian Furniss, Antony Hannaford,
Peter Smith, Austrin (Eds), 5th edition, ELBS Publication, Singapore, 1997.
2) Practical Organic Chemistry by Mann FC & Saunders BC, The English Language Book
Society and Longman Group Limited, London.
3) Exploring QSAR Vol; I Fundamentals and Applications in Chemistry and Biology by C
Hansh and A Leo Vol. II: hydrophobic, Electronic and Steric Constants by C Hansh, A
Leo and D Hockman ACS Book Catalog
4) Computer Software Application in Chemistry by Jurs PC, John Wiley & Sons, New
York.

Course objectives and course outcomes mapping

To impart knowledge to students with Classification, structure activity relationship, synthesis
of drugs. CO1, CO2, CO3, CO4, CO5, CO6
Course units and Course outcome mapping:
CO1 CO2 CO3 CO4 CO5 CO6
Physicochemical properties of drugs, metabolism √
Adrenergic drugs √
Cholinergic drugs √
CNS depressants √
Psychoactive drugs √
Narcotic drugs and NSAIDs √

Program outcomes:
PO1: Knowledge: Demonstrate knowledge of basic skills and techniques in pharmaceutical
industry, hospitals, community and institutes or any other profession they would like to
pursue
 Uka Tarsadia University
PO2: Core Competence: Students will be competent in the domain of Pharmaceutics,
Pharmaceutical Chemistry, Pharmacology and Pharmacognosy as per the requirement of
Industrial, Community and Hospital Pharmacy
PO3 Breadth: Trained students will have practical efficiency in pharmacodynamics,
pharmacokinetics, drug synthesis and analysis and formulation & development of dosage
forms so that they are able to extend this knowledge to create new herbal & synthetic
pharmaceutical products for the benefit of life.
PO4: Preparation: Students will be prepared to excel in postgraduate programmes and also
to succeed in pharmaceutical industry or any other chosen profession through innovative
teaching methodologies that stimulate students to self-learning and further their knowledge.
PO5: Professionalism: Display legal, moral, ethical attitudes and consistent behaviours with
the standards of the profession.
PO6: Evaluation: The ability to evaluate important aspects of the matter they have studied,
pharmaceutical technology
Uka Tarsadia University

[Link].
PH5020 Biopharmaceutics and Pharmacokinetics

Semester - V

EFFECTIVE FROM JULY-2024

 Uka Tarsadia University
Semester V
PH5020: Biopharmaceutics and Pharmacokinetics
Theory credits: 4 Theory contact hours per week: 3+1
Practical Credits: 2 Practical contact hours per week: 4
Objective of the Course:
This subject is designed to impart knowledge and skills of Biopharmaceutics and
Pharmacokinetics and their applications in pharmaceutical development, design of dose
and dosage regimen and in solving the problems raised therein.

Student Learning Outcomes/Objectives:

Upon completion of the course student shall be able to:
CO1. Understand the basic concepts in biopharmaceutics and their significance
CO2. Understand the basic concepts in pharmacokinetics and their significance
CO3. Understand the basic concepts of one compartment modelling and use data to
describe the kinetics of drug absorption, distribution, metabolism, excretion, elimination.
CO4. Understand he basic concepts of multi compartment modelling and to calculate
loading and maintenance dose.
CO5. Understand the basic concepts of non-linear pharmacokinetics
CO6. Understand the concepts of bioavailability and bioequivalence of drug products and
their significance.

Instructional Methods and Pedagogy:

Faculty members shall teach the content in a class room using black board and multimedia
projector.
Unit - I
Sr.
Topic Hours
No.
1 Introduction to Biopharmaceutics: 09
Absorption; mechanisms of drug absorption through GIT, factors
influencing drug absorption though GIT, absorption of drug from
Non per oral extra-vascular routes, Distribution Tissue permeability
of drugs, binding of drugs, apparent, volume of drug distribution,
plasma and tissue protein binding of drugs, factors affecting
protein-drug binding. Kinetics of protein binding, Clinical
significance of protein binding of drugs
Unit - II
2 Elimination: 06
Drug metabolism and basic understanding metabolic pathways,
renal excretion of drugs, factors affecting renal excretion of drugs,
renal clearance, Non renal routes of drug excretion of drugs
Pharmacokinetics:
 Uka Tarsadia University
Definition and introduction to Pharmacokinetics, Compartment
models, Non compartment models, physiological models
Unit – III
3 Compartment modelling: 08
One compartment open model. (a). Intravenous Injection (Bolus)
(b). Intravenous infusion and (c). Extra vascular administrations.
Estimation of pharmacokinetic parameters - KE, t1/2, Vd, AUC, Ka, Clt
and CLR; definitions, methods of eliminations, understanding of
their significance and applications
Unit – IV
4 Multi-compartment models: 07
Two compartment open model. IV bolus, Kinetics of multiple
dosing, steady state drug levels, calculation of loading and
maintenance doses and their significance in clinical settings.
Unit – V
5 Nonlinear Pharmacokinetics: 06
a. Introduction, b. Factors causing Non-linearity. c. Michaelis-
Menton method of estimating parameters, Explanation with
example of drugs.
Unit – VI
6 Bioavailability and Bioequivalence: 09
Definition and Objectives of bioavailability, absolute and relative
bioavailability, measurement of bioavailability, in-vitro drug
dissolution models, in-vitro-in-vivo correlations, bioequivalence
studies, methods to enhance the dissolution rates and
bioavailability of poorly soluble drugs.
Sr. No. PH5020 Biopharmaceutics and Pharmacokinetics (Practical) 2 Credits
4hrs/week
1 To prepare the calibration curve of given drugs in different media.
2 To determine solubility of given drugs in various solvents/ media.
3 To compare the dissolution rate profile of marketed formulations
(bioequivalence).
4 To study the effect of protein binding on diffusion rate profile of
given drug.
5 To study the effect of incubation time on diffusion of protein-bound
drug.
6 To formulate solid dispersion of given drug by fusion method for
improvement in dissolution rate of the drug.
7 To calculate the absorption rate by residual method.
 Uka Tarsadia University
8 To calculate the absorption rate constant by Wagner Nelson
method.
9 To calculate the elimination rate by urinary excretion method.
10 To calculate the elimination rate by sigma minus method.
11 To calculate absolute and relative bioavailability of given dosage
form.
12 To calculate the various pharmacokinetic parameters for oral
route/I.V route.

Reference books:
1. Biopharmaceutics and Clinical Pharmacokinetics by, Milo Gibaldi.
2. Biopharmaceutics and Pharmacokinetics; By Robert F Notari
3. Applied biopharmaceutics and pharmacokinetics, Leon Shargel and Andrew B.C. YU
4th edition, Prentice-Hall Inernational edition. USA
4. Bio pharmaceutics and Pharmacokinetics-A Treatise, By D. M. Brahmankar and Sunil
B. Jaiswal, Vallabh Prakashan, Pitampura, Delhi
5. Pharmacokinetics: By Milo Glbaldi Donald, R. Mercel Dekker Inc.
6. Hand Book of Clinical Pharmacokinetics, By Milo Gibaldi and Laurie Prescott by ADIS
Health Science Press.
7. Biopharmaceutics; By Swarbrick
8. Clinical Pharmacokinetics, Concepts and Applications: By Malcolm Rowland and
Thomas, N. Tozer, Lea and Febrger, Philadelphia, 1995.
9. Dissolution, Bioavailability and Bioequivalence, By Abdou H.M, Mack, Publishing
Company, Pennsylvania 1989.
10. Biopharmaceutics and Clinical Pharmacokinetics-An introduction 4th edition
Revised and expanded by Rebort F Notari Marcel Dekker Inn, New York and Basel,
1987.
11. Remington’s Pharmaceutical Sciences, By Mack Publishing Company, Pennsylvnia

Course objectives and Course outcomes mapping:

 To impart basic knowledge and skills in pharmacokinetics and biopharmaceutics:
CO1, CO2, CO4
 To apply basics of pharmacokinetics in pharmaceutical development and
dosageform design: CO2, CO3, CO4

Course units and Course outcome mapping:

CO1 CO2 CO3 CO4
Unit I √ √
Unit II √ √ √
Unit III √ √ √
Unit IV √ √ √
Unit V √ √ √
Unit VI √
 Uka Tarsadia University

Programme Outcomes

 PO 1: Knowledge: Demonstrate knowledge of basic skills and

techniques in in pharmaceutical industry, hospitals, community and
institutes or any other professionthey would like to pursue.
 PO 2: Core Competence: Students will be competent in the domain of
Pharmaceutics, Pharmaceutical Chemistry, Pharmacology and
Pharmacognosy as per the requirement of Industrial, Community and
Hospital Pharmacy.
 PO 3: Breadth: Trained students will have practical efficiency in
pharmacodynamics, pharmacokinetics, drug synthesis and analysis and
formulation & development of dosage forms so that they are able to
extend this knowledge to create new herbal & synthetic pharmaceutical
products for the benefit of life.
 PO 4: Preparation: Students will be prepared to excel in postgraduate
programmes and also to succeed in pharmaceutical industry or any
other chosen profession through innovative teaching methodologies
that stimulate students to self-learning and further their knowledge.
 PO 5: Professionalism: Display legal, moral, ethical attitudes and
consistent behaviours with the standards of the profession.
 PO 6: Evaluation: The ability to evaluate important aspects of the
matter they have studied, pharmaceutical technology, they have
learned and pros and cons of the ethical outlook they adhere to in the
field of Pharmaceutical Sciences.

Programme Outcomes and Course Outcomes mapping:

Programme Course outcomes

outcomes
CO1 CO2 CO3 CO4
PO1 √ √ √ √
PO2 √ √ √ √
PO3 √ √ √ √
PO4 √ √ √ √
PO5
PO6 √ √ √ √
Uka Tarsadia University

[Link]
Semester - V
UE5004:
COMPUTER APPLICATION IN PHARMACY

EFFECTIVE FROM JULY-2024

 Uka Tarsadia University

Semester V
UE5004 Computer Application In Pharmacy
Theory credits: 4 Theory contact hours per week: 3+1
Practical Credits: 2 Practical contact hours per week: 4

Objective:
 This subject deals with the introduction about different types of number system,
information system, web technology, Database technology, Database
Management system, computer application in clinical studies and use of databases
in bioinformatics and different data analysis tools in preclinical development.

Course Outcomes
CO1 Know the difference types of number system and different types of
information system and software.
CO2 Know the various types of web technology and programming
languages.
CO3 Know the various types of database technology and applications of
databases in pharmacy.
CO4 Know the various computer application of pharmacy.
CO5 Know the detail about bioinformatics and different drug database of
bioinformatics.
CO6 Know about different data analysis tools and preclinical development.

Sr. No. Topic Hours

Unit – I
1 Number System 05
Binary number system, Decimal number system, Octal number
system, Hexadecimal number systems, conversion decimal to
binary, binary to decimal, octal to binary etc, binary addition,
binary subtraction – One’s complement ,Two’s complement
method, binary multiplication, binary division.

Concept of Information Systems and Software

Information gathering, requirement and feasibility analysis,
data flow diagrams, process specifications, input/output
design, process life cycle, planning and managing the project.
Unit – II
2 Web technologies 05
Introduction to HTML, XML, CSS and Programming languages,
introduction to web servers and Server Products.
Unit – III
 Uka Tarsadia University
3 Database technologies 05
Introduction to databases, MYSQL, Open Office: Base,
Pharmacy Drug database.
Unit – IV
4 Application of computers in Pharmacy 05
Drug information storage and retrieval, Pharmacokinetics,
Mathematical model in Drug design, Hospital and Clinical
Pharmacy, Electronic Prescribing and discharge (EP) systems,
barcode medicine identification and automated dispensing of
drugs, mobile technology and adherence monitoring.
Diagnostic System, Lab-diagnostic System, Patient Monitoring
System, Pharma Information System.
Unit – V
5 Bioinformatics 05
Introduction, Objective of Bioinformatics, Bioinformatics
Databases, Concept of Bioinformatics, Impact of
Bioinformatics in Vaccine Discovery
Unit – VI
6 Computers as data analysis in Preclinical development 05
Chromatographic Data Analysis (CDS), Laboratory Information
Management System (LIMS) and Text Information
Management System (TIMS).

Practical Detail
Sr. No. UE5004 Computer Application In Pharmacy(Practical)
1 Design a questionnaire using a word processing package (Open
Office: Writer) to gather information about a particular disease
2 Create a HTML web page to show personal information
3 Retrieve the information of a drug and its adverse effects using
online tools
4 Creating mailing labels Using Label Wizard , generating label in
Open Office: Writer
5 Create a database in Open Office: Base to store the patient
information with the required fields Using Open Office: Base
6 Design a form in Open Office: Base to view, add, delete and modify
the patient record in the database
7 Generating report and printing the report from patient database
8 Creating invoice table using – Open Office: Base
9 Drug information storage and retrieval using Open Office: Base
10 Creating and working with queries in Open Office: Base
11 Exporting Tables, Queries, Forms and Reports to web pages
12 Exporting Tables, Queries, Forms and Reports to XML pages
 Uka Tarsadia University

Reference books:
1) Computer Application in Pharmacy – William [Link] –Lea and Febiger, 600 South
Washington Square, USA, (215) 922-1330.
2) Computer Application in Pharmaceutical Research and Development –Sean Ekins –
Wiley-Interscience, A John Willey and Sons, INC., Publication, USA.
3) Bioinformatics (Concept, Skills and Applications) – [Link]-CBS Publishers and
Distributors, 4596/1- A, 11 Darya Gani, New Delhi – 110 002(INDIA).
4) Jean Hollis Weber. – Taming Apache Open Office, Getting Started – Friends of
OpenDocument, Inc.
5) James Steinberg. – Open Office Basic: An Introduction.

Course objectives and Course outcomes mapping:

 To Familiar student with different types of number system, information system : CO1
 To performed operations on Web technology, Database technology: CO2, CO3
 To use computer applications in clinical studies and bioinformatics and data analysis :
CO4, CO5, CO6

Course units and Course outcome mapping:

CO1 CO2 CO3 CO4 CO5 CO6

Outline of number system and information √

system

Web technology and Programming language √ √

Database technology and application of √ √ √

database in Pharmacy

Computer application √ √ √ √

Bioinformatics and drug database √ √ √

Data analysis and preclinical development √ √

 Uka Tarsadia University
Program Outcomes:
PO1: Knowledge: Demonstrate knowledge of basic skills and techniques in
pharmaceutical industry, hospitals, community and institutes or any other
profession they would like to pursue.
PO2: Core Competence: Students will be competent in the domain of Pharmaceutics,
Pharmaceutical Chemistry, Pharmacology and Pharmacognosyas per the
requirement of Industrial, Community and Hospital Pharmacy.
PO3: Breadth: Trained students will have practical efficiency in pharmacodynamics,
pharmacokinetics, drug synthesis and analysis and formulation & development of
dosage forms so that they are able to extend this knowledge to create new herbal
& synthetic pharmaceutical products for the benefit of life.
PO4: Preparation: Students will be prepared to excel in postgraduate programs and also
to succeed in pharmaceutical industry or any other chosen profession through
innovative teaching methodologies that stimulate students to self-learning and
further their knowledge.
PO5: Professionalism: Display legal, moral, ethical attitudes and consistent behaviors
with the standards of the profession.
PO6: Evaluation: The ability to evaluate important aspects of the matter they have
studied, pharmaceutical technology, they have learned and pros and cons of the
ethical outlooks they adhere to in the field of pharmaceutical sciences.

Program Outcomes and Course Outcomes mapping:

Program Outcomes/ CO1 CO2 CO3 CO4 CO5 CO6

Course outcomes

PO1 √ √ √ √ √ √

PO2 √ √ √

PO3 √ √ √

PO4 √

PO5 √

PO6 √ √ √