The Health Stack Guide
The Health Stack Guide
GUIDE
2
TABLE OF CONTENTS
Introduction…………………………………………3 ............
1. Anxiety……… ……………………………….….4 ............
2. Heart health ……………………………………...5
3. Performance enhancement ………………………7 ............
4. PCOS……………………………………………..9
5. Sleep management………………………………10............
6. Brain health and Focus………………………….11 ............
7. Fat burner………………………………………..12 ...........
8. Diabetes and blood glucose…………...……...…13
9. Gut health……………………………………….14
10. Skin health and acne.………………………......16
11. Common cold….……………………………....17
12. Osteoarthritis….…………………………….....19
13. Hunger suppression …………………….……..20
14. Testosterone boosters…………………….…....21
15. Reference……………………………………...23
INTRODUCTION
This guide dives into a wide range of health disorders and objectives, both
common and uncommon, as well as the most recent findings from research on
non-medical interventions such as dietary supplements. We will only support
those supplements which have moderate to strong quality available human
evidence (TIER 1, TIER 2A and in some cases TIER 2B and TIER 3) in this “
THE HEALTH STACK” as many substances are currently at preliminary
stage in terms of data and can be useless, You can find more than 100+
supplements on “ THE ULTIMATE GUIDE” We encourage only evidence-
based products which are tested on humans.
SUPPLEMENT TIER
TIER 2A Multiple trials from different research groups and labs support
efficacy with meaningful effects but further quality trials are
needed in different populations with different methodology.
Note: supplements generally begin with Tier 3 and move up or down over time as
evidence available.
3
ANXIETY
SUBSTANCE MECHANISM AND EFFECTS DOSAGE TIER
Vitamin B- People who are vitamin b1, b2, b3, b5, b6, b12 deficient, RDA (click TIER 1
complex they can develop mood disorder, consuming enough here to
vitamin- B complex and help and prevent in neurological know the
and psychiatric conditions [1, 2]. dosage)
Ashwagandha is famous for its stress-relieving and
Ashwagandha 600- TIER 1
anxiolytic properties. cortisol levels appear to decrease.
Ashwagandha also improves sleep time and quality in 1000mg/day
those with and without insomnia, according to
accumulating research [3-6] .
Vitamin and Vitamin and minerals deficiency such as Vitamin E, D Based on TIER A
minerals and magnesium, zinc, iron may cause anxiety and other RDA. (click
disorders [16-21]. here)
Reduces stress and anxiety, L-theanine can pass the
L-theanine 100- Tier 2B
blood-brain barrier and influence brain activity by
increasing alpha-wave activity, which is associated with a 400mg/day
more relaxed state. This could explain its stress- and
anxiety-reducing benefits [22].
4
HEART HEALTH
SUBSTANCE MECHANISM AND EFFECTS DOSAGE TIER
Different fibers have different mechanisms of action,
Psyllium husk 15 grams per TIER 1
including slower gastric emptying, increased satiety,
suppression of hepatic cholesterol production, and day (Thrice
increased fecal cholesterol and bile salt excretion. The gel- daily dosing
forming properties of soluble fiber may improve lipid of 5 g)
profiles (reduces LDL-c) and glucose balance, especially
helpful for those who do not consume enough fiber [23].
Fish oil Fish oil provides EPA and DHA, which elevated the 2- TIER 1
(omega 3’s) omega index, resulting in lower cardiovascular risk. It’s 4grams/day
always worth mentioning, people should consume fish oils
with lower TOTOX value (less oxidized)[24, 25].
Fermented red yeast rice, usually taken as a supplement,
Red yeast rice 600mg twice TIER 2B
helps lower cholesterol. Monacolins, a class of naturally
occurring statins, are present in different daily.
concentrations[26, 27].
5
Berberine Berberine could improve blood lipids in metabolic disease 900- TIER
patients, according to limited research. Most berberine trials 2000mg/day 2B
on the above outcomes are weak methodologically [31].
Beta-glucans Beta-glucans in grains are the most studied and have 3grams/day TIER
benefits similar to other soluble dietary fiber. Beta-glucans 2A
from oats or barley may lower LDL and total cholesterol in
dyslipidemia patients [32].
6
PERFORMANCE ENHANCEMENT
SUBSTANCE MECHANISM AND EFFECTS DOSAGE TIER
Creatine The main benefit of creatine is resistance workout 3-5gram/day TIER1
strength and power it increases your stores of
phosphocreatine. This is a form of stored energy in the
cells. It helps your body produce more of a high energy
molecule called adenosine triphosphate (ATP). Creatine
has been extensively studied for this purpose, and its
effects as a supplement are noticeable in older adults
and the general population. Creatine and resistance
exercise may somewhat increase lean mass. Creatine
can reduce body fat and improve anaerobic workout
performance, strength, and power output in trained
athletes. Much research has examined the effects of
creatine on anaerobic running ability, with inconsistent
results but a slight improvement [33-36].
Sodium Sodium Bicarbonate (baking soda) buffers body acidity 0.2- TIER
bicarbonate and improves performance in elite and novice athletes.
Health advantages and digestive side effects may occur, 0.5grams/kg/day 2A
but it can be dose dependent [37, 39] .
7
Beetroot Beetroot mostly produces nitrate, which can be turned 6.4-12.8mg/kg TIER
extracts into nitric oxide. Nitric oxide lowers blood pressure by
dilatation of blood vessels. Nitric oxide vasodilation 2B
(nitrates)
enhances muscle blood flow and oxygen and nutrient
delivery, enhancing exercise performance. Nitric oxide
also improves muscle contraction and energy
efficiency[37].
8
PCOS
SUBSTANCE MECHANISM AND EFFECTS DOSAGE TIER
There are other supplements as well which can help in pcos (Omega-3 fatty acids
(like fish oil), alpha-lipoic acid, berberine, and N-Acetylcysteine) but we have very
limited trials, more quality trials are needed. So, we currently don’t know how they
are effective and cannot recommend these supplements for PCOS either.
9
SLEEP MANAGEMENT
SUBSTANCE MECHANISM AND EFFECTS DOSAGE TIER
Omega 3’s Studies aren’t strong enough, but regular fish oil 2-4g/day TIER 3
consumption was associated with lower risk of incident
11
all cause dementia [56, 57].
Vitamins and We always promote adequate vitamin and mineral AS PER TIER 2B
minerals intake, we have mixed studies but reasonable enough to RDA (click
consuming every essential vitamin and mineral. In here)
every 6-8 months, performing blood tests and check for
vitamin and mineral status is must.
α-GPC enhanced cognition, behavior, and function in 1,200 mg
Alpha-GPC TIER 2B
cerebrovascular damage patients when used alone or in daily, divided
conjunction with donepezil [58, 59]. into three
doses of 400
mg.
FAT BURNER
12
DIABETES AND BLOOD GLUCOSE
MANAGEMENT
SUBSTANCE MECHANISM AND EFFECTS DOSAGE TIER
Berberine supplementation activates energy-regulating
Berberine 1-2g/day TIER 2B
enzymes. Most importantly, berberine stimulates
AMPK, PKC, and SIRT 1, which helps to reduce blood
glucose levels and HBA1C [61].
13
GUT HEALTH
SUBSTANCE MECHANISM AND EFFECTS DOSAGE TIER
Pre and Probiotics Prebiotics are the food for bacteria’s, which Billion CFU’s TIER 2A
consist of fibers and Probiotics are the “good” per tablet
bacteria’s have also proven beneficial in IBS
patients by slowing down the transit time of the
colon, reducing the average number of bowel
movements per day, improving stool consistency,
overall symptoms, and above all, the quality of
life in these patients [68] .
Psyllium husk It traps water in the intestine increasing stool taken at every TIER 2A
water, easing defecation and positively affects meal if desired.
gut microbiome [74, 75].
14
Magnesium glycinate Supporting gut health, relieving anxiety, 350-420mg per TIER 2B
improving sleep quality, increasing energy levels, day.
and reducing inflammation[76].
Melatonin It has analgesic effects, regulates gastrointestinal 2-5mg per day TIER 2B
tract motility, and may influence abdominal
distention. Melatonin is a neuroendocrine hormone
that regulates sleep and circadian rhythm, and is
also produced in the gastrointestinal tract, where it
influences gut motility[77].
15
SKIN HEALTH AND ACNE
SUBSTANCE MECHANISM AND EFFECTS DOSAGE TIER
Oral collagen supplements improve skin elasticity,
Collagen 10-15g/day TIER 2A
hydration, dermal collagen density and reduce skin
wrinkles. Collagen supplementation is usually
considered safe, with no recorded adverse consequences
[78, 79].
Hyrulonic acid As we age, we reduce our HA levels in our body, we N/A TIER 2A
(HA) need to restore it via supplement which can reduce
wrinkles and get more hydrated[80].
protein, certain micronutrients (e.g., cysteine, lysine,
Protein, AS PER TIER 2A
iron, vitamin A, vitamin C, B vitamins, zinc, selenium),
Vitamin and and essential fatty acids such as omega-6 and omega-3 RDA
minerals polyunsaturated fatty acids—are crucial because they
play a role in repair and functionality[81].
sunscreen Delays and even reverse skin-aging process and protects N/A TIER 2A
us from UV rays. SPF 50+ is recommended[84].
Salicylic acid acts by softening keratin, a protein found 0.2-0.5%
Salicylic acid TIER 2B
in the skin structure. This helps to loosen dry, scaly skin
and makes it easier to remove. When salicylic acid is
taken in conjunction with other medications, it removes
the top layer of skin, allowing the other medications to
penetrate more effectively.
16
In acne, topical salicylic acid slows cell shedding inside
the follicles, avoiding blockage. Salicylic acid is also
effective at breaking out blackheads and whiteheads.
(DERMnet)
Excessive Some supplements like iodine, whey protein, vitamin AS PER TIER 2B
intake of b6 and b12 were shown to worsen acne symptoms or RDA
nutrients lead to breakouts. ( but only in some cases)[85]
TIPS- we should focus our overall diet, reduce stress, maintain a good hygiene and
smoking cigarettes, vape, hookah and substances or habits which are similar to this
should be avoided.
COMMON COLD
SUBSTANCE MECHANISM AND EFFECTS DOSAGE TIER
Vitamin C functions as a cofactor for a variety of
Vitamin c 200- TIER 2A
enzymes, most notably those involved in collagen
formation, and as an antioxidant. It is an essential 2000mg/day
vitamin that humans cannot produce, thus it must be
obtained through food sources. When people get a cold,
they commonly take vitamin C supplements. According
to several studies, vitamin C may be useful in lowering
the length of a cold, but it does not appear to lessen the
frequency of colds in a population [86].
17
killer cells and γε-T cells in their blood (2- and 8-fold
higher, respectively). This was linked to a much lower
risk of getting sick and a lesser decrease in symptoms
[91].
Heated and We have no convincing data but can be used for 5-10mins TIER 4
humidified air temporary relaxation in some cases
18
OSTEOARTHRITIS
SUBSTANCE MECHANISM AND EFFECTS DOSAGE TIER
Seventy people with knee OA and ultrasound-
Curcumin 1000mg/day TIER 2B
confirmed effusion synovitis took part in a study. At 12
weeks, those who took Curcuma longa 1000 mg daily
felt less pain than those who took a placebo. Its worth
mentioning, it should be taken with piperine to enhance
the bioavailablity [92].
19
HUNGER SUPPRESION
SUBSTANCE MECHANISM AND EFFECTS DOSAGE TIER
5-HTP is the building block for serotonin, a chemical
5-HTP 750- TIER 2B
that controls mood, sleep, and hunger, among other
things. 5-HTP can raise the amount of serotonin in the 900mg/day
brain, which may help people who are depressed and
make them lose their hunger [96].
20
TESTOSTERONE BOOSTERS
In a recent, systematic review which studied over 28 different testosterone boosters
found that, most of them doesn’t boost or increase testosterone.
Only HMB, betaine, ashwagandha, tongkat-ali, shilajit and a blend Punica
granatum fruit rind and Theobroma cacao seed extracts (Tesnor™) May able to
increase testosterone but most of the studies were either industry funded, poor-
quality, non-tested in healthy adults and not availability of multiple studies.
Therefore, there is no natural ingredient or substance that can raise testosterone
levels in healthy adults which can provide better hypertrophy and masculinity at
this time that has been evaluated in a reliable manner.
21
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26
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