Unit-8 Infection Control
Unit-8 Infection Control
INFECTION
Nature of infection
Chain of Infection
Types of infection
Methods of transmission
Introduction:
The word "infection" is different from "disease," although the two terms
sometimes are confused. Disease is a general word that describes any abnormality of the
human body or something that interferes with the normal, healthy functioning of the body.
Infection results only if the pathogens invade the host. multiply and alert normal
tissue function.
If the infectious disease is transmitted from one person to another it is called
contagious or communicable disease
CHAIN OF INFECTION
A parasite is an organism that lives in a host and obtains its nourishment from it. The
capability of organisms to produce infectious process depends on many factors such as:
b. Reservoir / Source
The reservoir must have certain characteristics such as availability of food, water and
oxygen to grow. Some organisms live in the absence of O, (anaerobic).
Insects, birds, and other animals are common reservoirs of infection.
The culex mosquito carries the filarial parasite Food, water, milk, and feces also can
be reservoirs.
Before an infection can establish itself in a host, the micro-organisms must have the
reservoir, if the reservoir is within a human. The micro-organisms have a number of exits,
depending on the site of reservoir.
d. Methods of Transmission:
Transmission Transmission
Indirect
Transmission
Vector Borne
Airborne Transmission
Transmission
Direct Transmission:
Indirect Transmission:
Vehicle-borne transmission:
Vector-borne transmission:
Air Borne-transmission:
Air borne transmission occurs when droplet nuclei (residue of evaporated droplets
that may remain in the air for long periods of time) emitted by an infected host (eg.
One with tuberculosis) or dust particles containing the infectious agent (eg.
Clostridium spores from the soil) are transmitted by air currents to a suitable portal of
entry, usually the respiratory tract of another person.
e. Portal of Entry to the Susceptible Host:
Before a person can become infected, micro-organism must enter the body. The skin
is the barrier to infectious agents however any break in the skin can readily serve as a
portal of entry Micro-organisms can enter the body through the same routes they use
to leave the body such as respiratory tract, urinary tract etc
f. Susceptible Host:
TYPES OF INFECTION
Various types of infection are mentioned below
I. Primary infection: results directly from a specific pathogen e.g. Streptococcal throat
infection
Secondary infection: results indirectly due to another pathogen e.g. AIDS
Super infection: secondary infection that occurs during antibiotic therapy for a primary
infection
II. Acute infection: for a short duration but severe
III. Endogenous infection: type of infection that originates from within the body
Exogenous infection: type of infection that originates from outside the body
Latent infection: persisting in tissues for long periods in most of which there are no
symptoms
In this case, the pathogen is distributed throughout the body, rather than being
concentrated in one area. Bacterial toxin is the major reason that leads to systemic infection
Prodromal stage
Illness stage
Convalescence stage
Stage Description
Incubation period Interval between entrance of pathogen into the body and appearance of
first symptoms e.g. incubation period of Chicken pox is 2 to 3 weeks
and that of Covid-19 is 4days to14 days
Prodromal Stage Interval from the onset of non-specific signs and symptoms (malaise,
low grade fever, Fatigue) to more specific symptoms. Micro-organism
grows and multiplies and patient is more capable of spreading disease
to others.
Illness Stage Period when the patient manifests signs and symptoms specific to the
type of infection E.g. Chicken pox manifested by vesicles.
Age:
Nutritional Status:
A reduction in the intake of protein and other nutrients such as carbohydrates. fats and
vitamins reduce body's defences against infection and it impairs wound healing
Stress:
The body responds to emotional or physical stress by the general adaptation syndrome
Adrenocorticotrophic hormone (ACTH) acts on adrenal gland to secrete a hormone
cortisone which acts to increase serum glucose levels and decrease anti-inflammatory
response.
If stress increases, increased cortisone levels result in decreased resistance to
infection
Disease process:
Patients with diseases of the immune system are at particular risk for infection e.g.
Leukaemia. AIDS, lymphoma, and Aplastic anaemia
Medical Therapy:
The immune system attacks foreign bodies to prevent infections from spreading. A
weak immune system causes increased susceptibility to disease.
Some drugs and medical therapies compromise immunity to infection e.g. immune
suppressant drugs Imuran.
The nurse assesses the patient's history to determine whether he takes medications at
home that increase susceptibility to infection
Broken skin or mucus membrane- Intact skin acts as a mechanical barrier to prevent
organisms from getting into the body tissues.
Traumatized tissues
Decreased ciliary action. Mucous membranes can filter microorganisms out before
they get into the body
Altered peristalsis
Obstructed urine outflow
Change in pH of Secretions.
Reduced haemoglobin level
Suppression of white blood corpuscles
It may be drug related or disease related WBC ingests microorganisms by
phagocytosis and thereby reduce infection
Thinner dermal and epidermal layers of skin decreases sweat and skin elasticity (in
older adults)
Circulatory or heart disorders like congestive heart disease, calcified heart valves in
lower extremities.
Dehydration, loss of saliva production
Loss of ability to secrete Hydrochloric Acid in the stomach. HCI destroys organisms
in the stomach
Increased colonization of oropharynx, decreased macrophages function, decreased
cough reflex
The micro-organisms are present everywhere from bacteria to viruses to fungi. Most
of them are perfectly harmless, but there are some that can harm the body. And it's because of
these pathogenic organisms our bodies have a sophisticated set of defence systems both
inside and outside.
The first line of defence includes physical and chemical barriers that are always ready
and prepared to defend the body from infection. These include skin, tears, mucus,
cilia, Hydrochloric Acid in the stomach, urine flow and white blood cells called
Neutrophils.
Pathogenic micro-organisms must cross this first line of defence. If this defence is
broken, the second line of defence within the body is activated
Skin
Cilia
The cilia (very fine hairs) lining the respiratory tract move mucus and trapped
particles away from the lungs. Particles may be bacteria or material such as dust or
smoke.
Urine flow
The urine flow flushes out pathogens from the bladder area.
Commensal microbes are essential to human health. These bacteria are present on the
skin, in the mouth and in the gut and they stop other harmful bacteria from taking
over.
Commensal microbes stimulate the gastrointestinal epithelium to produce
antimicrobial peptides (AMPs) that act as a first line of defence against invading
pathogenic bacteria.
Neutrophils
These are white blood cells that can find, kill and ingest pathogens seeking an
entrance into the body (phagocytosis).
Immune system
The immune system is a defence system comprising of many biological structures and
processes within an organism that protects against diseases.
To function properly, an immune system must detect pathogens. Acquired immunity
creates immunological memory after an initial exposure to a specific pathogen.
It leads to an enhanced response to same pathogen on subsequent exposure.
This process of acquired immunity is the basis for vaccination.
Autoimmunity
results from a hyperactive immune system attacking normal tissues as if they were
foreign organisms
Pollution
Parasites Fungi
IMMUNE
SYSTEM
Viruses Taxins
Bacteria
Localized infections are most common in areas of skin break down, such as surgical
and traumatic wounds. pressure ulcers and mouth lesions. Infections may also develop
locally in cavities beneath skin e.g. Abscess
Isolation Practices:
NOSOCOMIAL INFECTION
Nosocomial Infections are those infections acquired in the hospital after admission;
other than the health problems he had on admission. Patients in health care settings are at
increased risk for acquiring infections. A hospital is one of the most likely places for
acquiring infection because it harbours a high population of virulent strains of micro-
organisms that may be resistant to antibiotics. Unfortunately, many nosocomial infections are
transmitted by health care workers. Now the term Health Care Associated Infections is being
used for nosocomial infections
Types:
Latrogenic Exogenous Endogenous
infections infections infections
Exogenous infection: arises from micro-organisms external to the individual that do not exist
as normal flora eg. Salmonella, Clostridium Tetani
Endogenous infection: can occur when part of patient's normal flora become altered and an
over growth results.
Urinary
system
Surgical
Blood common or
stream sites traumatic
wounds
Respiratory
Tract
Urinary tract
Following unsterile techniques for urinary catheterization
Improper specimen collection techniques.
Open drainage system
Obstruction in urine drainage
Urine from drainage tube being allowed to re-enter in to the bladder
Repeated catheter irrigations
Improper hand hygiene.
Respiratory Tract:
Blood Stream:
Contamination of 1.V fluids
Addition of connecting tube to IV system.
Improper care of needle insertion site.
Contaminated needles or catheters.
Failure to change IV access site when inflammation first appears.
Improper technique during administration of multiple blood products.
Prevention
Nosocomial infections can be prevented if all members of health care team take
special care/precautions
It includes:
Meticulous hand washing before and after attending each patient
Follow strict aseptic techniques while doing invasive procedures
Follow medical and surgical
Proper sterilization of instruments and disinfection of limen, utensils, floor etc.
Proper waste management-collection and disposal
Follow universal precautions while handling blood and blood products
Avoid recapping of needles
Proper handling, cleansing of linen contaminated with blood, secretions, urine and
excreta.
Isolate patients with conditions which spread through air provide separate room
Avoid sharing of instruments
Safe food and water supply as many diseases spread through food and water
Practice cohorting i.e. In case the space is inadequate, the patients with same type of
conditions can be put together in a room.
Limit visitors in hospitals especially for postoperative and immune compromised
patients.
Avoid overcrowding of patients. Beds should be at least 1-2 meters apart.
Provide single room especially for patients with communicable diseases.
Take precautions to prevent airborne diseases such as covering mouth and nose while
coughing. sneezing, laughing etc.
Patient should be worn mask while transferring or contracting with others.,
ASEPSIS
INTRODUCTION
Asepsis is the state of being free from disease-causing micro-organisms such as
pathogenic bacteria, viruses, pathogenic fungi, and parasites. The term often refers to those
practices used to promote or induce asepsis in an operative field of surgery or medicine to
prevent infection.
Concept of asepsis:
The nurse's efforts to minimize the onset and spread of infection are based on the
principles of aseptic technique.
Aseptic technique is an effort to keep the patient free from exposure to infection-
causing pathogens. In medical settings, care providers use a number of procedures to
create and maintain asepsis for patient safety.
Definition:
Aseptic technique is the effort taken to keep the patient as free from hospital micro-
organisms as possible (Crow 1989).
Medical Surgical
asepsis asepsis
Medical or Clean Asepsis reduces the number of organisms and prevents their spread by
following certain principles and procedures to prevent infection and control its spread.
Medical Asepsis
Basic medical aseptic techniques are focused on breaking the chain to prevent spread
of infection
During daily routine care, the nurse uses basic medical aseptic techniques to break the
infection chain. Examples of medical asepsis are changing patient's bed linen daily,
hand washing, barrier techniques and routine environmental cleaning.
Follow isolation technique as required.
Patients with high susceptibility to infection require special precautions to prevent
exposure to pathogens.
In medical asepsis, an area or object is considered contaminated only if it is suspected
of containing pathogen (e.g. used bedpan, the floor and a wet piece of gauze).
Hand washing
Utilizing gloves, gown and mask as indicated
Cleaning/disinfection of equipment
Handling linens in ways that prevent germs from spreading
Surgical asepsis
Surgical asepsis refers to the highest level of aseptic technique and requires that all areas be
kept as free as possible of micro-organisms
Barrier Nursing:
The nursing technique by which a patient with an infectious disease is prevented from
infecting other people is called barrier nursing. Hand hygiene is the simplest, most effective
measure for infection control.
HAND HYGIENE
Hand Washing
Hand washing also known as hand hygiene, is the act of cleaning one's hands with
soap (or equivalent materials) and water to remove viruses/ bacteria/germs/microorganisms,
dirt, grease, or other harmful and unwanted substances from the hands.
It refers to the practices used to prevent and control the spread of pathogenic
organisms. It protects the patient and his environment from the transmission of disease
producing organisms (prevention of cross infection). The infection can be transferred reduces
the number of bacteria.
After contacting patients, direct or indirect contact with blood and body fluids.
Before eating food, after visiting the toilets, touching patients and before going from
one patient to another
Equipment/Articles:
Surgical Asepsis:
Surgical hand washing refers to the procedure performed for the maximum
elimination of bacteria from the hands and to decrease and suppress the growth of skin
microbes in case of glove tear.
1. Apply solution:
Apply approximately 5ml of appropriate solution from the dispenser, using one
downward stroke. Work the solution into the hands, encompassing all areas of the hands and
arms up to just below the elbows.
Place the right palm over the back of the left hand and vice versa, interlacing fingers.
3. Palm to palm:
4. Rubbing fingers:
Rotate and rub backwards and forwards with clasped fingers of the right hand into the
left palm and vice versa.
5. Rubbing thumbs:
Rotationally rub the right thumb clasped in the left hand and vice versa.
6. Fingertips on palms:
Continue with a rotating action down opposing arms, working to just below the
elbows.
Rinse hands under running water, moving from the clean to dirty area. Turn off the tap
using elbows if necessary. Open a gown pack onto a squared-off surface and take a hand
towel. Dry hands first by placing the opposite hand behind the towel and blotting the skin,
then using a corkscrew motion to dry from hand to elbow. Discard the towel and repeat with a
second towel for the other hand and forearm
Steps
1. Open the glove pack. With the left hand, grab the right glove by the folded back cuff
2. Slip your right hand into the glove while keeping the fingers and glove pointed downwards
[Link] the second glove with the gloved hand by sliding the finger tips under the cuff of the
second glove
4. Slide the ungloved hand into the glove. Wiggle the fingers into the correct holes until the
gloves fit comfortably.
All personal protective equipment should be safely designed and constructed, and
should be maintained in a clean and reliable fashion. It should fit comfortably, encouraging
worker use. If the personal protective equipment does not fit properly, it can make the
difference between being safely covered or dangerously exposed Employers are required to
ensure its proper use by training the workers
Due to the Covid 19 pandemic the use of PPE became worldwide and known to the
general public
OSHA issues workplace health and safety regulations regarding PPE, employers
must:
Provide appropriate PPE for employees
Ensure that PPE is disposed or reusable PPE is cleaned, laundered, repaired and
stored after use
OSHA also specifies circumstances for which PPE is indicated eg. Covid pandemic
CDC recommends when, what and how to use PPE
During delivery a splash of amniotic fluid can be expected likewise during surgery
spray of blood /discharges may occur.
Durability and appropriateness for the task
Goggles
Gown or face
shield
Mask or
Gloves
respirator
Gown first
Mask or respirator
Goggles or face shield
Gloves
PPE use in healthcare settings: How to Safely Don, Use, and Remove PPE:
Don before contact with the patient, generally before entering the room
Use carefully don't spread contamination
Remove and discard carefully, either at the doorway or immediately outside patient
room; remove respirator outside room
Immediately perform hand hygiene.
GOWN
MASK
Wearing Mask
Hold mask by top two strings. Tie those two strings at the top and back of the head
with ties above the ears
Tie two lower ties snugly around the neck with the mask well under the chin.
Ensure that the mask covers the mouth and the nose adequately
If glasses are worn, fit the upper edge of the mask under the glasses
Avoid unnecessary talking and, if possible, sneezing or coughing
While removing a mask with strings, first untie the lower strings of the mask.
Discard a disposable mask in the waste container.
Particulate Respirator
Position goggles over eyes and secure to the head using the car pieces or headband
Position face shield over face and secure on brow with headband
Adjust to fit comfortably.
GLOVES
Don Gloves:
Goggles
Gloves or Face
Shield
Gown Mask or
respirator
Gloves
Goggles or Face Shield
Gown
Mask or respirator
Removal of gloves:
Unfasten ties
Peel gown away from neck and shoulder
Turn contaminated outside toward the inside
Fold or roll into a bundle
Discard
Removing a mask:
Hand hygiene:
-If hands become visibly contaminated during PPE removal, wash hands before continuing to
remove PPE
o Wash hands with soap and water or use an alcohol-based hand rub
-PPE is available to protect you from exposure to infectious agents in the healthcare
workplace
-Know what type of PPE is necessary for the duties you perform and use it correctly.
STANDARD PRECAUTIONS
Standard infection control precautions (SICPs) are the minimum infection prevention
practices that apply to all patient care, regardless of whether infection is known to he present
of not. This helps to prevent the spread of infection and ensure the safety of patients,
healthcare workers and visitors
Standard Precautions are used for all patient care. They're based on a risk assessment
and make use of common-sense practices and personal protective equipment use that protect
healthcare providers from infection and prevent the spread of infection from patient to
patient.
Standard precautions are meant to reduce the risk of transmission of blood borne and
other pathogens from both recognized and unrecognized sources. They are the basic level of
infection control precautions which are to be used, as a minimum, in the care of all patients
Contact Precautions
Airborne Precautions
Droplet Precautions
Respiratory hygiene cough etiquette
Safe injection practices
Blood isolation
Enteric isolation
Contact Precautions:
Clean, non-sterile gloves are usually adequate for routine care of the patients
Use gloves before providing care to patient
Change gloves after contact with infective material.
After providing care, remove gloves and wash hands
Follow proper use of protective gown in case of direct contact with patient with
communicable diseases. Observe hand hygiene
Limit the movement or transport of the patient from the room
Make sure that any infected or colonized areas are covered
Ensure that patient care items, bedside
Inte, to Infection Control in Clinical Setting (Asepsis)
frequently touched surfaces receive cleaning at least two times daily. Keep toilet items
separate for each patient.
Airborne Precautions:
Droplet Precautions:
Teach patients and visitors to cover their mouth/nose while coughing and sneezing
Follow proper disposal of used materials after coughing and sneezing
Use surgical masks for patients having cough
Provide alcohol-based hand-rubbing dispensers and supplies for hand hygiene and
educate patients and staff in their use
Encourage hand hygiene after coughing or sneezing.
Separate persons with cough and infectious diseases at least 3 feet away from others
to Infection Control in Clinical Setting (Asepsis)
Instruct patients and care providers not to touch eyes, nose, or mouth.
Health care workers should use standard precautions with all patients.
Blood Isolation
Enteric Isolation
This is indicated when the organisms causing the disease are transmitted through
feces e.g. Typhoid fever is transmitted through feco- oral route and salmonella organisms are
present in the feces of patients. Practice thorough hand washing. Use gown and gloves while
caring for the patient.
It refers to the precautions taken to prevent the spread of infection from the health
care providers or from the attendants to the patients, e.g. immunocompromised patients are
liable to get infection from health providers or patient's care givers unless precautions are
taken. They should wear gloves, mask and gown to protect the patient.
The waste produced in the course of health care activities carmes a higher potential
for infection and injury than any type of waste.
Therefore, safe and reliable method for its handling is essential, inappropriate
methods in handling of health cars waste may have serious public health problems and
significant impact on health
Definition
Sharps Sharp waste e.g. Needles, infusion sets, scalpels, knives, blades,
broken glass
Pharmaceutical waste Waste containing pharmaceutical waste e.g. expired medicines that are
no longer needed, items that are contaminated by or containing
pharmaceuticals (bottles, boxes)
Genotoxic waste Waste substances with genotoxic properties e.g. Cytotoxic drugs often
used in cancer therapy (genotoxic chemicals)
Chemical waste Waste containing chemical substance e.g. Laboratory reagents, film
developer disinfectants that are expired or no longer needed solvents
Radioactive waste Radioactive waste substance e.g. unused liquids from radio therapy or
laboratory research, contaminated glass, waste packages, absorbent
papers urine, excreta from patient treated with sealed sources
Infectious waste Laboratory cultures
Waste from isolation wards
Tissues (Swabs)
Materials or equipment that have been in contact with the infected
patient’s excreta
Health care waste generation differs froth country to country. Within the country the
waste generation depends on the numerous factory such as established waste management
methods, type of health care establishment, hospitals, proportion of reusable items employed
in health care etc.
80% are of general health-care waste, which can be managed by the normal domestic
and urban waste management system.
15% are pathological and infectious waste.
1% of sharp waste
3% is of chemical and pharmacological waste
Less than 1% special waste, such as radioactive or cytotoxic waste, pressurized
containers, broken thermometers.
Paper 15%
Plastic 10%
Rags 15%
Metal (sharps) 1%
Glass 4.0%
Many of the chemicals and pharmaceuticals used in health care settings are toxic,
genotoxic, corrosive, flammable, reactive, explosive or shock sensitive.
Although present in small quantity they may cause intoxication either by acute or
chronic exposure and injuries including burns.
The severity of the hazards for health care personnel depends on the extent and
duration of exposure by inhalation of dust or aerosols, or by absorption through the
skin.
The type of disease caused by radioactive waste is determined by the type and extent
of exposure.
It can range from headache, dizziness and vomiting to much more serious problems.
It as genotoxic, it may also affect the genes.
5. Public Sensitivity:
Apart from health hazards, the general public is very sensitive to visual impact of health care
waste particularly anatomical
CAUTION:
Among all health care workers nurses spend more time and longer time in the
hospitals. Because of more exposure to hospital waste, they are at risk for infection like HIV
and Hepatitis
Chemical Land
disinfection disposal
1. Incineration:
Incineration is a high temperature, dry oxidation process that reduces organic and
combustible waste to inorganic and incombustible matter which results in very
significant reduction of wastes volume and weight.
The process is usually selected to treat waste that cannot be recycled, reused or
disposed of in a land fill site.
Incineration requires no pre-treatment.
Type of Incinerators:
Incinerators can range from very basic combustion unit that operate at much lower
temperature to extremely high temperature operating plants.
The use of a land fill has to be regarded as an acceptable disposal route. There are two
types of land disposal-open dumps and sanitary landfills.
The health care waste should not be dumped on or around the open dumps. The risk
with this is the animals coming into contact with infectious pathogens.
Sanitary landfills: Sanitary landfills are a method of waste disposal where the waste is
buried either underground or in large piles. This method of waste disposal is controlled and
monitored very closely. A landfill, also called sanitary landfill, is a land disposal site for
waste, which is designed to protect from environmental pollution and health risks. It is not
the same as an open dump.
Chemicals are added to wastes to kill or inactivate the pathogens it contains. This
treatment usually results in disinfection rather than sterilization.
Screw-feed technology:
This technology is based on non-burn and dry thermal disinfection process in which
the waste is shredded and heated on rotatory or rotating anchor.
The waste is reduced to 80% in volume 20-35% in weight. It is suitable for infectious
waste and sharps.
VI. Inertization:
The process of inertization involves mixing waste with cement and other substance
before disposal in order to minimize the risk of toxic substance contained in the waste
migrating into surface water or into ground water."
National legislation is the basis for improving health care waste disposal practices in
any country.
Bio Medical waste management in India (Management and Handling) Rules 1998,
prescribed by ministry of environment and forests, Government of India came into
force on 28th July 1998. This rule applies to those who generate, collect, receive,
store, dispose, treat or handle the biomedical waste in any manner. Wastes are
differentiated into 10 categories (see below) colour code is assigned for the
segregation of wastes.
According to National guidelines for waste management 2016, there are only four
categories of wastes and four colour codes. These new guidelines may be followed in the
country in the near future.
2. Red: Waste items that can be recycled are collected in these bags. Examples are soiled
wastes that could be recycled and used, bottles, tubing, catheters, syringes without needles
etc.
3. White: (puncture proof)- e.g. Metal sharps such as needles, scalpels, blades etc
4. Blue: Nonmetal glass wastes (e.g. ampoules) are collected in these bags.
SAFETY MEASURES
To prevent the transmission of disease from patient to patient, from patient to nurses,
health care workers or and vice versa.
To prevent injury to nurses while handling the waste
To prevent general exposure to the harmful toxic effects of the cytotoxic and
genotoxic chemical biomedical waste as much as possible.
Measures of protection:
Cap/Scarf
Shield (for working in a radiation prone zone)
Goggles/plain glass
Mask
Apron/gowns (or full sleeve shirt)
Gloves
Gumboots.
(ii) General Protective measures:
All nurses and other hospital employees must be vaccinated against Hepatitis B.
Take extreme care while handling needles and other sharps, since most sharp injuries
occur between the points of use and disposal.
Sharps should not be left casually on counter tops, food trays, beds, etc.
Clipping, bending or breaking the glass and needles with hands must not be practiced
as this can cause accidental injuries.
Sharps should be segregated at the site of generation and there after placed in
puncture proof containers.
All disposable items must be dipped in hydrochloride solution for at least half an hour
to ensure that they are disinfected.
Use protective devises while taking care of patients with infections.
In operation theatre, goggles/glasses must be worn
Use bowls to transfer sharp instruments from doctor to nurse or vice versa.
(a) Special precaution is needed if injury occurs with sharps infected with HIV or hepatitis B
cases.
Remove the soiled clothes and wash the part thoroughly with the plenty of water.
Apply non-irritant antiseptic cream on the part.
In case of spillage in eyes, wash it with water, avoid rubbing.
Consult the physician.
Post exposure prophylaxis with anti-retroviral combination of 2-3 drugs is advisable to nurses
or care workers within two hours of exposure. Follow the post exposure guidelines of NACO.