Chapter 12
Chapter 12
Electrical Nerve
Stimulation 12
LEARNING OBJECTIVES
On completion of the chapter, the student will be able to:
• Describe transcutaneous electrical nerve stimulation (TENS).
• Explain the mechanism of action of TENS.
• Describe different types of TENS modes.
• Understand the clinical uses of TENS.
• Describe the contraindications and precautions of TENS.
• Explain electrode placement.
• Understand the application procedure.
CHAPTER OUTLINE
• Mechanism of Action • Contraindications and Precautions
• Parameters • Electrode Placement
• TENS Modes • Application Procedure
• Clinical Uses
KEY TERMS
Acupuncture TENS: It is the low frequency and high amplitude TENS.
Brief intense mode TENS: It is the high amplitude and high frequency TENS.
Conventional TENS: It is the high frequency and low amplitude TENS.
Hyperstimulation mode: It is the electroacupuncture TENS. It uses high amplitude that produces noxious cutaneous
stimulation which is sharp and burning in character, without resultant muscle contraction.
Modulated mode: Modulated mode allows one of the parameters of the TENS such as pulse duration, or amplitude, or
frequency to change automatically by a given percentage from an initial set level.
Opioid activation: It is the activation of descending inhibitory pathway through release of endogenous opioids.
Pain gate theory: As the name suggests, there is a gate in the spinal cord through which pain- carrying nociceptor fibers
pass to the brain. The use of TENS results in stimulation of pain inhibitor fibers which also enter at the gate in the spinal
cord. It is believed that these pain inhibitors stop the transmission of the pain carrying fibers at the gate. Therefore, the
mechanism is known as pain gate theory.
Phantom limb pain: Phantom limb pain is the sensation experienced by the individuals after the amputation. There is a
feeling of intact leg, though the part is amputated.
Pulse burst mode: It consists of both the high setting (high amplitude) and low setting (low amplitude).
TENS: Transcutaneous Electrical Nerve Stimulation is the low frequency current used clinically by a variety of health care
professionals for reducing pain.
Electrotherapy: Principles and Practice
INTRODUCTION
Unit IV ▶ Therapeutic Currents
Transcutaneous Electrical Nerve Stimulation (TENS) is a noninvasive analgesic technique that is used to
relieve nociceptive, neuropathic and musculoskeletal pain.1 TENS is the use of electric current produced by
a device to stimulate the nerves for therapeutic purposes. TENS, by definition, covers the complete range
of transcutaneously applied currents used for nerve excitation, although the term is often used with a more
restrictive intent, namely to describe the kind of pulses produced by portable stimulators used to treat pain.2 In
the clinical context, it is most commonly assumed to refer to the use of electrical stimulation with the specific
intention of providing symptomatic pain relief.
Over 77% of pain specialists use transcutaneous electrical nerve stimulation (TENS) to manage chronic
pain, and over half of chronic pain patients who have been given TENS report that they find it beneficial and
wish to continue using it.3 Transcutaneous electrical nerve stimulation (TENS) is used clinically by a variety
of health care professionals for reducing pain.4 Long before the invention of the TENS unit – thousands of
years earlier, the ancient Egyptians discovered that the shock produced by the electric eels provided relief
from pain. Hieroglyphs dating as far back as 2500 BC show an electric fish, or eel, being used as a form of
treatment. The first recorded use of electricity for pain relief appeared in compositions Medicae, written in
46 AD by Scribonis Largus, a Roman physician. A live torpedo fish (also called the electric ray) was used for
the treatment of gout and headache, its electrical discharge being used to shock the affected body part into
numbness.5
MECHANISM OF ACTION
The use of conventional (high-frequency) TENS was originally based on the gate control theory of pain,7
which suggested that counter stimulation of the nervous system could modify the perception of pain. Later
studies suggested that with low-frequency, high- amplitude (“acupuncture-like”) stimulation, TENS could
also raise endorphin levels in the spinal fluid.8
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Chapter 12 ▶ Transcutaneous Electrical Nerve Stimulation
cord acted as a gate to modulate sensory input.10 This theory has been credited with rekindling interest
in electrical control of pain and inspiring research with important scientific and clinical ramifications.11
The essence of this theory is that small diameter myelinated A-delta neurons and small diameter, unmyelinated
C fiber, also known as pain carrying nociceptives, project to the spinal cord where they synapse directly or via
interneurons with the transmission cells (T cells) in the dorsal horn of the gray matter. The T cells relay the
small diameter pain carrying sensation to the higher centers (Fig. 12.2).
Large diameter myelinated A beta and alpha fibers (mechanoceptors), also known as pain inhibiting
fibers, arise from the peripheral part and terminate on T cells through substantia gelatinosa of the spinal cord.
The stimulation of the mechanoceptors large diameter fibers (A beta and alpha) inhibit the nociceptors at the
T cells and prevent transmission to the higher centers. The inhibitory input caused by activation of the large
diameter, mechanosensitive afferent is said to close the gate to nociceptor transmission. This is also known as
“Pain Gate Control Theory”.19
Opioid Activation
Another mechanism proposed is activation of descending inhibitory pathway through release of endogenous
opioids.9 The areas involved in descending inhibition include nucleus raphe magnus in rostral ventral medulla
(RVM) and the periaqueductal gray (PAG). The PAG sends projections to the RVM, which in turn sends
projections to the spinal dorsal horn. The stimulation of PAG or the RVM produces inhibition of dorsal
horn nucleus including spinothalamic tract cells. Specific and different opioid receptors are activated through
release of endogenous opioids by different frequencies of TENS.
Must Know
Application of low frequency TENS causes activation of δ-opioid receptors and high frequency TENS activates μ-opioid
receptors. These opioid receptors in turn activate the PAG-RVM pathway.
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Electrotherapy: Principles and Practice
PARAMETERS
Unit IV ▶ Therapeutic Currents
Must Know
Clinical trials suggest that adequate output, Judicious selection of various parameters such as waveform,
particularly intensity, is critical to obtaining frequency, pulse width, amplitude and frequency modulation
can play a great role in effective management of pain.
pain relief with TENS.10 Most of TENS
• Waveform: Rectangular monophasic or biphasic
units produce an electric output having one • Pulse duration: Up to 500 microseconds
characteristic waveform, usually of symmetric • Frequency: Between 01 and 200 Hz
or balanced asymmetric biphasic type with • Intensity: Up to 100 mA/as per the tolerance of the patient
zero net current to minimize skin irritation.11
Amplitude
The TENS units have amplitude control switch ranging from 1 mA to 100 mA. Intensity from 1 mA to 100
mA is sufficient because the primary target is the stimulation of sensory nerves, which can easily depolarize
the sensory nerves. The intensity of amplitude depends on the condition and severity of pain. The use of
high-intensity (9– to 12–mA) stimulation was significantly more effective in decreasing the postoperative
analgesic requirements than a low intensity (4–5 mA) of stimulation when used as an adjunct to PCA (patient
controlled analgesia).12 Furthermore, intermittent electrical stimulation for short intervals (30 min) has been
found to be more effective than prolonged or continuous stimulation.13
Frequency
The selection of frequency for TENS is one of the important parameters which may alter the results if selected
wrongly. The frequency may range from 1 Hz to 200 Hz. The frequency is one of the criteria for classification
of the TENS. High-frequency TENS reduces primary hyperalgesia to heat and mechanical stimuli for up to
1 day after treatment. In contrast, low-frequency TENS is ineffective in reducing primary hyperalgesia.14,15
Hansson P et al. reported that the use of high-frequency stimulation produced greater analgesic effects.16 They
reported comparable analgesic effects at both low and high frequencies of stimulation; however, the patients
“preferred” high-frequency stimulation. It has also been reported that low-frequency stimulation requires a
higher intensity to produce pain relief equivalent to high-frequency stimulation.17
Pulse Width
Pulse width is actually the length of time for which the current acts on the nerve. It ranges from 40 microseconds
to 500 microseconds. A microsecond is a millionth of a second and such short duration pulses are used to
achieve analgesic effects as the target is the sensory nerve which tends to have relatively low thresholds. Long
duration impulses are not required in order to force a sensory nerve to depolarize, therefore, stimulation for
less than a millisecond is sufficient. The 200 microsecond pulse duration in clinical practice is commonly
used by the clinicians; however, pulse width can be modified accordingly.
Waveform
Presently, the waveform used in the physiotherapy practice in TENS is biphasic which has positive and
negative phases. The biphasic nature of the pulse means that there is usually no net DC component (often
described by the manufacturers as ‘zero net DC’), thereby minimizing any skin reactions due to the buildup
of electrolytes under the electrodes (Fig. 12.3).
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Chapter 12 ▶ Transcutaneous Electrical Nerve Stimulation
The waveforms can be modified into square, triangular, rectangular and sine waves.
Modulation
The pulses of different frequency, intensity and pulse duration are modulated in such a way that leads to less
irregular pulses. This modulation helps in minimizing the effects of accommodation which often occur with
electrical stimulation of nerve and muscles.
Duration
Transcutaneous electrical nerve stimulation currents are used for a longer period of time. Many authors
suggest that analgesic effect of the TENS does not remain for a longer period of time.
TENS MODES
Five types of TENS modes have been discussed with regularity in the literature.18 The classification of
transcutaneous electrical stimulation is based on the frequency and amplitude.
Conventional
Conventional TENS is also known as high TENS as it is characterized by high frequency and low amplitude
(Fig. 12.4). Conventional mode has the frequency range from 10 Hz to 100 Hz and the amplitude that
produces comfortable cutaneous stimulation without muscle contraction.19 The studies have shown that the
frequencies approximately 60 Hz are optimal for relieving pain.20 On the other hand, frequencies above 80
to 200 Hz may worsen pain of some patients.21 A short pulse duration ranging from 50 to 100 microseconds
favors preferential stimulation of large diameter myelinated afferent neurons.22
Must Know
The conventional TENS stimulates selectively large diameter A beta fibers, without stimulating the pain nociceptor
A delta and C fibers. The A beta fibers block the pain carrying A delta and C fibers to reach the higher centers at the
spinal cord. This mode of TENS elicits segmental analgesia.
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Electrotherapy: Principles and Practice
Unit IV ▶ Therapeutic Currents
Figure 12.4: Conventional TENS with high frequency and low amplitude
Practical Tip
To prevent accommodation, the current must be periodically increased in order to maintain adequate perception of
electrical paresthesia. This mode is mostly used by the clinicians.
Acupuncture-Like TENS
Acupuncture mode of TENS is also known as strong low-rate mode TENS. It is a high amplitude and low
frequency TENS. This mode of TENS has a frequency below 10 Hz. However, the most commonly used
is 1 to 4 Hz with pulse duration rangeing from 100 to 300 microseconds. The amplitude is usually higher
(above 30 mA) than the conventional TENS to produce visibly strong and rhythmical muscle contraction.
Acupuncture-like TENS selectively stimulates the A delta and C fibers that releases endogenous opioid-like
substances at cord level. Substances like enkephalins and beta endorphins block the transmission of pain
stimuli and elicit extrasegmental analgesia. This type of TENS is effective in chronic and deep situated pain.
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Chapter 12 ▶ Transcutaneous Electrical Nerve Stimulation
Modulated Mode
Hyperstimulation Mode
This type of TENS is also known as noninvasive electroacupuncture TENS. It is the only mode that regularly
utilizes either direct or monophasic pulsed currents. Hyperstimulation mode uses high amplitude that
produces very noxious cutaneous stimulation which is sharp and burning in character, without resultant
muscle contraction. This type of TENS is applied through a small probe type electrode, with a tip that may
be only 1 to 3 mm in diameter. The pulse duration required for such type of TENS is very long, i.e., 500 msec
and the frequency can exceed 100 Hz with amplitude not exceeding 50 mA. Table 12.1 shows different modes
of TENS.
A B
Figures 12.6A to C: Modulated mode TENS in which the parameters of TENS are modulated. A. Intensity,
B. Pulse duration, C. Frequency
Contd…
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Electrotherapy: Principles and Practice
Unit IV ▶ Therapeutic Currents
CLINICAL USES
The primary use of TENS has been recognized as the symptomatic relief in the management of chronic
intractable pain and as an adjunctive treatment in the management of post-surgical and post-traumatic acute
pain23,11.
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Chapter 12 ▶ Transcutaneous Electrical Nerve Stimulation
Practical Tip
Postsurgical Pain
TENS undoubtedly has a role in the management of postoperative pain although its effect is not as strong as
that of epidural analgesia with local anesthetics. TENS, however, is easy to administer, has less side effects, and
can be applied by the patients themselves.
High frequency TENS given for 15 min to 20 min can decrease postsurgical pain perception by 50% at rest
and by 11% during movement. High frequency TENS increases muscle contraction ability by 30%, compared
with the initial contraction before treatment26.
Practical Tip
The use of acupuncture-like TENS with adequate treatment, pulse frequency of 1-8 Hz to produce strong, definite,
subnoxious, maximal tolerable contraction can reduce the consumption of analgesics after surgery. The electrodes
can be placed over the incision area27.
Neuropathic Pain
The use of TENS shows significant reduction in pain and hypersensitivity of the hand32. Nearly half of those
suffering from a spinal cord injury (SCI) are at risk of developing neuropathic pain. Providing relief from spinal
cord injury related neuropathic pain is often difficult.33 The conservative management for the patients with
spinal cord injury and pain include non-pharmacological conservative treatment such as physical therapy,
relaxation, and acupuncture; these are preferred over opioids.34 This preference might be associated with the
severity of the side effects experienced, the limited pain relief provided by pharmacological treatment, or
both. Treatment with transcutaneous electrical nerve stimulation (TENS) is rarely associated with negative
side effects and has been reported to be effective in patients with peripheral neuropathic pain,35 e.g., patients
with diabetic neuropathy36 and patients with pain of differing origin27.
Dysmenorrhea
Dysmenorrhea is a very common complaint that refers to painful menstrual cramps in the uterus. Stimulation
of the cutaneous sensory nerves directly over the area through the transcutaneous electrical nerve stimulation
(TENS) relieves pain. It is thought to alter the body’s ability to receive and perceive pain signals rather than by
having a direct effect on the uterine contractions. The studies found that high-frequency TENS may help in
relieving the pain pertaining to dysmenorrhea.38
Labor Pain
The Low-voltage currents emitted by transcutaneous electrical nerve stimulation are being used for pain relief
in labor. TENS application reduces the duration of the first stage of labor and the amount of analgesic drug
administered. Use of TENS in pregnancy does not affect the childbirth process consequences, the maternal
outcomes and the fetal outcomes. There are no adverse effects on mother or newborns. The application of
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Electrotherapy: Principles and Practice
both high and low frequency TENS has been found effective in reducing labor pain39. These TENS increase
Unit IV ▶ Therapeutic Currents
Hemorrhage
The contraction of muscles during application of high or burst TENS increases the blood circulation in the
local area that may lead to further increase in the size of hematoma. Therefore, electrodes should not be
placed over areas where there has been recent hemorrhage as the currents may cause further hemorrhage.
Thrombosis
The application of TENS is absolutely contraindicated on the calf muscles and other potential area of
thrombosis especially with postsurgical patients because of the potential for embolism.
Pregnancy
There are many studies which state that the use of TENS during labor and delivery29 is beneficial and reduces
the duration of the first stage of labor and the amount of analgesic drug administered. However; TENS
should not be administered over the abdomen or pelvis during pregnancy because the effects of TENS on
fetal development are still unknown and currents could inadvertently cause uterine contractions and induce
premature labor30.
Carotid Sinus
Application of TENS over the carotid sinus may reflexively induce slowing of the heart rate, fall in blood
pressure, or fainting, hence, should be recognized to be hazardous.
Epilepsy
TENS is not absolutely contraindicated for the patients with epilepsy. However, the clinicians should be
cautious while applying TENS to patients with epilepsy and should not apply electrodes on the neck or head.
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Chapter 12 ▶ Transcutaneous Electrical Nerve Stimulation
Undiagnosed Pain
ELECTRODE PLACEMENT
Different sizes and shapes of electrodes are available in the market. There are reusable, disposable, nonsterile
and presterilized electrodes, out of which reusable nonsterile electrodes are more often used in the clinics. The
electrodes are usually made up of carbonized and siliconized carbon rubber. These are the reusable nonsterile
electrodes which can be used for a long period of time, however; cuts and irregular surfaces should be checked
prior to application of the electrodes, and use of these electrodes for more than six months is not advisable.
There are four basic options for placement of electrodes as listed below. The first three are when using two
electrodes or one channel. The last option makes use of two channels or four electrodes.
i. The first option is the placement of electrode directly over the painful areas or proximal to the site of
pain.
ii. Second option is the placement of electrodes just outside the proximal and distal margins of the painful
region in a manner that ‘brackets’ this area. For example, if the site of pain is in the vertebral column, the
electrodes should be placed on either side of the column.
iii. The third option of placement of electrodes is basically for the radicular or referred pain. One electrode
is placed over the painful area (proximal part), while other electrode is placed over the distal area related
to the spinal nerve root of the referred pain.
iv. The fourth option of electrode placement is criss-cross or modified in which four electrodes of two
channels are used. For example, painful knee joint. Two electrodes of one channel can be placed directly
over the painful site and other two electrodes can be placed adjacent to the painful area.
Nerve
The electrodes over the course of peripheral nerve, especially where located superficially, can also be placed.
The stimulation of proximal part of the nerve is preferred over the distal, if two electrodes are used.
Trigger Points
Trigger point is a painful area on compression with some referred pain. The electrodes can be placed relative
to a trigger point. One electrode can be placed directly over the trigger point and other electrode is placed
over its relative area of referred pain.
Motor Point
Motor point is the area of a muscle where nerve enters into the muscle, it is usually situated in the proximal
one third of the muscle. Such points would seem well suited to afford input to the central nervous system,
permit efficient stimulation of muscle contractions.18
The electrodes are secured on the body or extremities with the help of surgical tape, or a variety of paper
or foam adhesive patches. The Velcro straps and bandages may also be used to secure the electrodes firmly on
the treatment area.
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Electrotherapy: Principles and Practice
Both the high and low frequency transcutaneous electrical nerve stimulator can be used for phantom pain.
High-frequency TENS
Electrodes are placed at the site of pain, over nerve bundles proximal to the site of pain (Fig. 12.7A). Electrodes
can also be placed on each paravertebral region in the same segment as the pain (Fig. 12.7B).
Low-frequency TENS
Both the electrodes are placed on the contralateral limb at the mirror site to the phantom limb pain in the
same myotome as the pain (Fig. 12.7C).
A B C
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Chapter 12 ▶ Transcutaneous Electrical Nerve Stimulation
13
Electrotherapy: Principles and Practice
Unit IV ▶ Therapeutic Currents
Figure 12.11: Placement of Electrodes for Knee Joint Figure 12.12: Placement of Electrodes for Left Shoulder
APPLICATION PROCEDURE
• The patient is screened for contraindication to the TENS.
• Skin should be thoroughly checked for cut and abrasions.
• The electrodes should not be used for a long period of time.
• The area of treatment is inspected after the treatment for skin allergy to the electrode or gels.
• The electrodes are placed as mentioned earlier.
• After securing electrodes firmly on the treatment area, the patient is made aware of the sensation of current
he or she is going to experience.
• The intensity of current is increased gradually till a desired muscle contraction or sensation is achieved.
Summary
• Transcutaneous electrical nerve stimulation is a noninvasive analgesic technique of delivery of electrical current
through the skin to cause depolarization of the sensory, motor, and nociceptive nerve for modulating the pain.
• The mechanism of action of TENS is to stimulate the large diameter myelinated A beta and alpha fibers, also
known as pain inhibiting fibers, which arise from the peripheral part and terminate at T cells.
• The stimulation of pain inhibiting fibers blocks the pain carrying nociceptors at the T cells and prevents transmission
to the higher centers.
• TENS uses rectangular monophasic or biphasic waveforms, with pulse duration up to 200 microseconds, and
frequency between 01 to 300 Hz.
• TENS can be delivered using conventional, acupuncture-like, bursts and brief intense modes.
• The electrodes of the TENS are placed directly over the tender areas, trigger points or acupuncture points, and on
the dermatomes of the nerves.
• TENS is used for providing relief from phantom and stump pain, postsurgical pain, neuropathic pain and
dysmenorrhea. However, it should not be applied directly over the pacemaker or the heart in case of any cardiac
disorder, hemorrhagic area and thrombotic area.
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Chapter 12 ▶ Transcutaneous Electrical Nerve Stimulation
References
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Electrotherapy: Principles and Practice
22. Howson DC, Peripheral neural excitability: Implication for transcutaneous electrical nerve stimulation. Phys
Unit IV ▶ Therapeutic Currents
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Chapter 12 ▶ Transcutaneous Electrical Nerve Stimulation
Short Notes
a. Gate theory
b. Opioid activation
c. Parameters of TENS
d. Conventional TENS
e. Acupuncture-like TENS
f. Brief Intense mode TENS
g. Pulse Burst mode TENS
h. Modulated mode of TENS
i. Hyperstimulation mode of TENS
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Electrotherapy: Principles and Practice
Unit IV ▶ Therapeutic Currents
18