SAFETY DATA SHEET
In compliance with EC Regulations No.: 1907/2006, 830/2015 and 1272/2008 (CLP).
Date last modified: 12 December 2017 - Version 4.0
1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND OF THE COMPANY
1.1 Product Identifier
Product Name: REFRIGERANT R404A
Product Code #: 330225
1.2 Relevant identified uses of the substance or mixture and uses advised against
Relevant identified uses: Refrigerant.
Industrial and professional uses only. Perform risk assessment prior to use.
Uses advised against: This product is not recommended for any industrial, professional or consumer
use other than the Intended Uses above and the instructions written in this Safety Data Sheet.
1.3 Details of the supplier of the safety data sheet
Company/undertaking identification
Supplier/Manufacturer:
Marichem Marigases Hellas SA
Sfaktirias 64,
185 45 Piraeus,
Greece
Tel. No.: ++30 210 4148800
Fax No.: ++30 210 4133985
[Link]
e-mail: mail@[Link]
1.4 Emergency telephone number
Tel. No.: ++30 210 4148800 (including working hours)
Emergency Information:
Inside U.S. and Canada: (800)-424-9300 (CHEMTREC)
Outside U.S. and Canada: 1-703-527-3887 (CHEMTREC)
National Emergency Centre (Greece): ++30 210 7793777
2. HAZARDS IDENTIFICATION
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2.1. Classification of the substance or mixture
Hazard Class and Category Code Regulation EC 1272/2008 (CLP/GHS)
Physical hazards
Gases under pressure, Liquefied gas.
H280: Contains gas under pressure; may explode if heated.
Not a hazardous substance or mixture according to EC-directives 67/548/EEC or 1999/45/EC.
2.2. Label elements
Labelling Regulation EC 1272/2008 (CLP)
Hazard pictograms:
GHS04
Signal word: Warning
Hazard Statements
H280 - Contains gas under pressure; may explode if heated.
Special labelling of certain substances and mixtures
Kyoto: Contains fluorinated greenhouse gas covered by the Kyoto Protocol., HFC-134a, HFC-125,
HFC-143a.
Precautionary statements
Storage
P410 + P403 Protect from sunlight. Store in a well-ventilated place.
2.3. Other hazards
This mixture contains no substance considered to be persistent, bioaccumulating and toxic (PBT).
This mixture contains no substance considered to be very persistent and very bioaccumulating
(vPvB).
Vapours are heavier than air and can cause suffocation by reducing oxygen available for breathing.
Rapid evaporation of the liquid may cause frostbite.
Misuse or intentional inhalation abuse may cause death without warning symptoms, due to cardiac
effects.
May cause cardiac arrhythmia.
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Mixture/substance classification and labelling according to Directive 67/548/EEC, European
Dangerous Preparations Directive (1999/45/EC), European Regulation 648/2004 and their
amendments.
Not classified as hazardous to users. No special information required according to EC directives.
3. COMPOSITION / INFORMATION ON INGREDIENTS
3.1 Chemical Composition:
Ingredients CAS Number Concentration (%) Hazard Code(s)*
1,1,1-Trifluoroethane 420–46–2 52% H220; H280.
(HFC 143a)
Pentafluoroethane 354–33–6 44% H280.
(HFC 125)
1,1,1,2-
Tetrafluoroethane (HFC 811–97–2 4% H280.
134a)
*
See section 16 for the full text of the Hazard Code(s) declared above.
Occupational Exposure Limits, if available, are listed in section 8.
4. FIRST AID MEASURES
4.1. Description of first aid measures
General advice
If unconscious place in recovery position and seek medical advice.
Never give anything by mouth to an unconscious person.
If breathing is irregular or stopped, administer artificial respiration.
First aider needs to protect himself.
If symptoms persist, call a physician.
Inhalation
Move to fresh air. Keep patient warm and at rest.
Remove from exposure, lie down.
Artificial respiration and/or oxygen may be necessary. Call a physician.
Skin contact
Flush area with lukewarm water. Do not use hot water. If frostbite has occurred, call a physician.
Take off contaminated clothing and shoes immediately.
Eye contact
Hold eyelids apart and flush eyes with plenty of water for at least 15 minutes.
Get medical attention.
Ingestion
Is not considered a potential route of exposure.
4.2. Most important symptoms and effects, both acute and delayed
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Symptoms
Misuse or intentional inhalation abuse may cause death without warning symptoms, due to cardiac
effects.
Other symptoms potentially related to misuse or inhalation abuse are:, Anaesthetic effects, Light-
headedness, dizziness, confusion, incoordination, drowsiness, or unconsciousness, irregular heartbeat
with a strange sensation in the chest, heart thumping, apprehension, feeling of fainting, dizziness or
weakness.
Skin contact may provoke the following symptoms:
Frostbite, Irritation, Discomfort, Itching, Redness, Swelling of tissue
Eye contact may provoke the following symptoms:
Frostbite, Irritation, Tearing, redness, or discomfort.
4.3. Indication of any immediate medical attention and special treatment needed
Treatment: Do not give adrenaline or similar drugs.
5. FIRE FIGHTING MEASURES
5.1. Extinguishing media
Suitable extinguishing media: Use extinguishing measures that are appropriate to local circumstances
and the surrounding environment.
Use water spray, alcohol-resistant foam, dry chemical or Carbon Dioxide.
5.2. Special hazards arising from the substance or mixture
Specific hazards during fire-fighting:
Exposure to fire may cause containers to rupture/explode. Non flammable.
Pressure build-up.
Fire or intense heat may cause violent rupture of packages.
Hazardous thermal decomposition products:
Fluorinated compounds
Hydrogen fluoride
Carbon oxides
Exposure to decomposition products may be a hazard to health.
5.3. Advice for fire-fighters
Special protective equipment for fire-fighters
In the event of fire, wear self-contained breathing apparatus. Use personal protective equipment.
Wear neoprene gloves during cleaning up work after a fire.
Further information: Cool containers/tanks with water spray
6. ACCIDENTAL RELEASE MEASURES
6.1. Personal precautions, protective equipment and emergency procedures
Personal precautions:
Evacuate personnel to safe areas. Ventilate area, especially low or enclosed places where heavy
vapours might collect. Refer to protective measures listed in sections 7 and 8.
6.2. Environmental precautions
Environmental precautions: Should not be released into the environment.
It must be used in accordance with local and national regulations.
Prevent from entering sewers, basements and workpits, or any place where its accumulation can be
dangerous. Try to stop release.
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6.3. Methods and materials for containment and cleaning up
Methods for cleaning up: Evaporates.
6.4. Reference to other sections
For disposal instructions see section 13.
7. HANDLING AND STORAGE
7.1. Precautions for safe handling
Advice on safe handling
Avoid breathing vapours or mist. Avoid contact with skin, eyes and clothing. Provide sufficient air
exchange and/or exhaust in work rooms. For personal protection see section 8.
Vapours are heavier than air and may spread along floors.
Advice on protection against fire and explosion
The product is not flammable in air under ambient conditions of temperature and pressure. When
pressurised with air or oxygen, the mixture may become flammable. Certain mixtures of HCFCs or
HFCs with chlorine may become flammable or reactive under certain conditions.
7.2. Conditions for safe storage, including any incompatibilities
Requirements for storage areas and containers
Do not drag, slide or roll cylinders. Never attempt to lift cylinder by its cap. Use a check valve or
trap in the discharge line to prevent hazardous back flow into the cylinder. Keep at temperature not
exceeding 52°C. Keep containers tightly closed in a dry, cool and well-ventilated place. Protect from
contamination. Protect cylinders from damage. Keep away from direct sunlight. Store only in
approved containers.
Advice on common storage
No materials to be especially mentioned. For further information see Section 10 of the safety data
sheet.
Storage period: > 10 years.
Storage temperature: < 52 °C.
7.3. Specific end use(s)
No data available.
8. EXPOSURE CONTROLS / PERSONAL PROTECTION
8.1. Control parameters
If sub-section is empty then no values are applicable.
Components with workplace control parameters
1,1,1,2-Tetrafluoroethane (CAS-No. 811-97-2)
Type/Form of exposure Control Update Regulatory basis Remarks
parameters
Time Weighted Average 4,240 mg/m3 2007 UK. EH40 Workplace
(TWA): 1,000 ppm Exposure Limits (WELs)
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Derived No Effect Level (DNEL)
1,1,1-Trifluoroethane
Type of Application (Use): Workers
Exposure routes: Inhalation
Health Effect: Chronic effects, Systemic toxicity
Value: 38800 mg/m3
Type of Application (Use): Consumers
Exposure routes: Inhalation
Health Effect: Chronic effects, Systemic toxicity
Value: 10700 mg/m3
Pentafluoroethane
Type of Application (Use): Workers
Exposure routes: Inhalation
Health Effect: Chronic effects, Systemic toxicity
Value: 16444 mg/m3
Type of Application (Use): Consumers
Exposure routes: Inhalation
Health Effect: Chronic effects, Systemic toxicity
Value: 1753 mg/m3
1,1,1,2-Tetrafluoroethane
Type of Application (Use): Workers
Exposure routes: Inhalation
Health Effect: Chronic effects, Systemic toxicity
Value: 13936 mg/m3
Type of Application (Use): Consumers
Exposure routes: Inhalation
Health Effect: Chronic effects, Systemic toxicity
Value: 2476 mg/m3
Predicted No Effect Concentration (PNEC)
1,1,1-Trifluoroethane
Value: 350 mg/l
Compartment: Fresh water
Pentafluoroethane
Value: 0.1 mg/l
Compartment: Fresh water
Value: 1 mg/l
Compartment: Water
Remarks: Intermittent use/release.
Value: 0.6 mg/kg
Compartment: Fresh water sediment.
1,1,1,2-Tetrafluoroethane
Value: 0.1 mg/l
Compartment: Fresh water
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Value: 0.01 mg/l
Compartment: Marine water
Value: 1 mg/l
Compartment: Water
Remarks: Intermittent use/release.
Value: 0.75 mg/kg dry weight (d.w.)
Compartment: Fresh water sediment.
Value: 73 mg/l
Compartment: Water
Remarks: Sewage treatment plants
8.2 Exposure Controls
Engineering measures
Ensure adequate ventilation, especially in confined areas. Local exhaust should be used when large
amounts are released.
Eye protection
Wear safety glasses or coverall chemical splash goggles. Eye protection complying with EN 166. or
ANSI Z87.1 Additionally wear a face shield where the possibility exists for face contact due to
splashing, spraying or airborne contact with this material.
Hand protection
Material: Leather gloves
The suitability for a specific workplace should be discussed with the producers of the protective
gloves.
Material: Low temperature resistant gloves
Protective gloves complying with EN 374. or US OSHA guidelines
The choice of an appropriate glove does not only depend on its material but also on other quality
features and is different from one producer to the other. Please observe the instructions regarding
permeability and breakthrough time which are provided by the supplier of the gloves. Also take into
consideration the specific local conditions under which the product is used, such as the danger of
cuts, abrasion, and the contact time.
Skin and body protection
Wear suitable protective equipment.
Wear as appropriate: impervious clothing
Protective measures
Self-contained breathing apparatus (SCBA) is required if a large release occurs.
The type of protective equipment must be selected according to the concentration and amount of the
substance at the specific workplace.
Hygiene measures
Handle in accordance with good industrial hygiene and safety practice.
Respiratory protection
For rescue and maintenance work in storage tanks use self-contained breathing apparatus. Vapours
are heavier than air and can cause suffocation by reducing oxygen available for breathing.
Respiratory protection complying with EN 137.
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9. PHYSICAL AND CHEMICAL PROPERTIES
9.1. Information on basic physical and chemical properties
Form: Liquified gas
Color: Colorless
Odor: Slight, ethereal odor
Boiling Point Range: -47.2 0C to –46.4 0C (boiling range)
Vapour Pressure: 8270 at 20 oC
Solubility in Water: insoluble
Solubility (Other): soluble in alcohol, esters, chlorinated solvents,
Density (g / ml): 1,06 at 20 oC
Vapour Density: 3,42 at bubble point temperature
9.2. Other information
No data available.
10. STABILITY AND REACTIVITY
10.1. Reactivity
Decomposes on heating.
10.2. Chemical stability
Τhe product is chemically stable.
10.3. Possibility of hazardous reactions
Stable under recommended storage conditions.
10.4. Conditions to avoid
The product is not flammable in air under ambient conditions of temperature and pressure. When
pressurised with air or oxygen, the mixture may become flammable. Certain mixtures of HCFCs or
HFCs with chlorine may become flammable or reactive under certain conditions. Avoid open flames
and high temperatures. Pressurized container: Do not pierce or burn, even after use. Keep at
temperature not exceeding 52°C.
10.5. Incompatible materials
Alkali metals
Alkaline earth metals
Powdered metals
Powdered metal salts
10.6. Hazardous decomposition products
Hazardous thermal decomposition products may include:
Hydrogen fluoride
Carbon oxides
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Fluorocarbons
Carbonyl fluoride
11. TOXICOLOGICAL INFORMATION
11.1. Information on toxicological effects
Acute inhalation toxicity
1,1,1-Trifluoroethane
LC50 / 4 h Rat :> 591000 ppm
Method: OECD Test Guideline 403
No Observed Adverse Effect Concentration / Dog :250000 ppm
Cardiac sensitization
Low Observed Adverse Effect Concentration (LOAEC) / Dog :300000 ppm
Cardiac sensitization
Pentafluoroethane
LC50 / 4 h Rat :> 800000 ppm
Method: OECD Test Guideline 403
No Observed Adverse Effect Concentration / Dog :75000 ppm
Cardiac sensitization.
Low Observed Adverse Effect Concentration (LOAEC) / Dog :100000 ppm
Cardiac sensitization.
1,1,1,2-Tetrafluoroethane
LC50 / 4 h Rat :> 567000 ppm
No Observed Adverse Effect Concentration / Dog :40000 ppm
Cardiac sensitization.
Low Observed Adverse Effect Concentration (LOAEC) / Dog :80000 ppm
Cardiac sensitization.
Skin irritation
1,1,1,2-Tetrafluoroethane
Rabbit
Classification: Not classified as irritant
Result: No skin irritation
Eye irritation
1,1,1,2-Tetrafluoroethane
Rabbit
Classification: Not classified as irritant
Result: No eye irritation
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Sensitisation
1,1,1-Trifluoroethane
Human
Classification: Does not cause respiratory sensitisation.
Result: Does not cause respiratory sensitisation.
Pentafluoroethane
Human
Classification: Does not cause respiratory sensitisation.
Result: Does not cause respiratory sensitisation.
1,1,1,2-Tetrafluoroethane
Guinea pig
Classification: Does not cause skin sensitisation.
Result: Does not cause skin sensitisation.
Rat
Classification: Does not cause respiratory sensitisation.
Result: Does not cause respiratory sensitisation.
Repeated dose toxicity
1,1,1-Trifluoroethane
Inhalation Rat
Method: OECD Test Guideline 413
No toxicologically significant effects were found.
Pentafluoroethane
Inhalation Rat
No toxicologically significant effects were found.
1,1,1,2-Tetrafluoroethane
Inhalation Rat
No toxicologically significant effects were found.
Mutagenicity assessment
1,1,1-Trifluoroethane
Animal testing did not show any mutagenic effects. Tests on bacterial or mammalian cell cultures
did not show mutagenic effects.
Pentafluoroethane
Animal testing did not show any mutagenic effects. Evidence suggests this substance does not cause
genetic damage in cultured mammalian cells. Did not cause genetic damage in cultured bacterial
cells.
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1,1,1,2-Tetrafluoroethane
Animal testing did not show any mutagenic effects. Tests on bacterial or mammalian cell cultures
did not show mutagenic effects.
Carcinogenicity assessment
1,1,1-Trifluoroethane
Not classifiable as a human carcinogen. Animal testing did not show any carcinogenic effects.
Pentafluoroethane
Not classifiable as a human carcinogen. Overall weight of evidence indicates that the substance is
not carcinogenic.
1,1,1,2-Tetrafluoroethane
Not classifiable as a human carcinogen. Overall weight of evidence indicates that the substance is
not carcinogenic.
Toxicity to reproduction assessment
1,1,1-Trifluoroethane
No toxic to reproduction. No effects on or via lactation. Animal testing showed no reproductive
toxicity.
Pentafluoroethane
No toxic to reproduction. Animal testing showed no reproductive toxicity.
1,1,1,2-Tetrafluoroethane
No toxic to reproduction. No effects on or via lactation. Animal testing showed no reproductive
toxicity.
Assessment teratogenicity
1,1,1-Trifluoroethane
Animal testing showed no developmental toxicity.
Pentafluoroethane
Animal testing showed no developmental toxicity.
1,1,1,2-Tetrafluoroethane
Animal testing showed no developmental toxicity.
Further information
Avoid skin contact with leaking liquid (danger of frostbite).
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12. ECOLOGICAL INFORMATION
12.1. Toxicity
Toxicity to fish
1,1,1-Trifluoroethane
LC50 / 96 h / Oncorhynchus mykiss (rainbow trout): > 40 mg/l
Method: OECD Test Guideline 203
Pentafluoroethane
LC50 / 96 h / Oncorhynchus mykiss (rainbow trout): 450 mg/l
Information given is based on data obtained from similar substances.
1,1,1,2-Tetrafluoroethane
LC50 / 96 h / Oncorhynchus mykiss (rainbow trout): 450 mg/l
Toxicity to aquatic plants
1,1,1-Trifluoroethane
ErC50 / 96 h / Pseudokirchneriella subcapitata (green algae): > 44 mg/l
Method: OECD Test Guideline 201
Pentafluoroethane
ErC50 / 96 h / Algae: 142 mg/l
Information given is based on data obtained from similar substances.
NOEC / 72 h / Pseudokirchneriella subcapitata (green algae): 13.2 mg/l
Information given is based on data obtained from similar substances.
1,1,1,2-Tetrafluoroethane
ErC50 / 96 h / Algae: 142 mg/l
Information given is based on data obtained from similar substances.
NOEC / 72 h / Pseudokirchneriella subcapitata (green algae): 13.2 mg/l
Information given is based on data obtained from similar substances.
Toxicity to aquatic invertebrates
1,1,1-Trifluoroethane
EC50 / 48 h / Daphnia magna (Water flea): 300 mg/l
Method: OECD Test Guideline 202
Pentafluoroethane
EC50 / 48 h / Daphnia magna (Water flea): 980 mg/l
Information given is based on data obtained from similar substances.
1,1,1,2-Tetrafluoroethane
EC50 / 48 h / Daphnia magna (Water flea): 980 mg/l
12.2. Persistence and degradability
Biodegradability
1,1,1-Trifluoroethane
Not rapidly biodegradable.
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Pentafluoroethane
Not rapidly biodegradable.
1,1,1,2-Tetrafluoroethane
Not biodegradable.
12.3. Bioaccumulative potential
Bioaccumulation
1,1,1-Trifluoroethane
Information given is based on data obtained from similar substances.
12.4. Mobility in soil
No data available.
12.5. Results of PBT and vPvB assessment
PBT and vPvB assessment
This mixture contains no substance considered to be persistent, bioaccumulating and toxic (PBT). /
This mixture contains no substance considered to be very persistent and very bioaccumulating
(vPvB).
12.6. Other adverse effects
Ozone depletion potential: 0
Global warming potential (GWP): 3922
Additional ecological information
IPCC - AR4 (Fourth Assessment Report of the Intergovernmental Panel on Climate Change) - 2007
13. DISPOSAL CONSIDERATIONS
13.1. Waste treatment methods
Product: Can be used after re-conditioning. If re-conditioning is not practicable, dispose of in
compliance with local regulations.
Contaminated packaging: Empty pressure vessels should be returned to the supplier. If recycling is
not practicable, dispose of in compliance with local regulations.
14. TRANSPORT INFORMATION
14.1 Proper shipping name: REFRIGERANT GAS R 404A
14.2 LAND TRANSPORT
UN number: 3337
ADR class: 2.2
RID-class: 2.2
Packing group (Packing Instruction): P200
Labeling: 2.2 - Non-flammable gas
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14.3 SEA TRANSPORT
UN number: 3337
IMDG class: 2.2
IMDG packing group: Packing group (Packing Instruction): P200
Labeling: 2.2 - Non-flammable gas
EmS: F-C, S-V
14.4 AIR TRANSPORT
UN number: 3337
IATA/ICAO class: 2.2
Packing group: Packing group (Packing Instruction): P200
Labeling: 2.2 - Non-flammable gas
14.5 GENERAL
Gas cylinders must be equipped with valve protection caps during transportation.
14.6 GENERAL INFORMATION
Avoid transport on vehicles where the load space is not separated from the driver's compartment.
Ensure vehicle driver is aware of the potential hazards of the load and knows what to do in the event
of an accident or an emergency. Before transporting product containers ensure that they are firmly
secured. Ensure that the container valve is closed and not leaking. Ensure that the valve outlet cap
nut or plug (where provided) is correctly fitted. Ensure that the valve protection device (where
provided) is correctly fitted. Ensure adequate ventilation. Ensure compliance with applicable
regulations.
15. REGULATORY INFORMATION
15.1. Safety, health and environmental regulations/legislation specific for the substance or
mixture
Other regulations: Take note of Directive 98/24/EC on the protection of the health and safety of
workers from the risks related to chemical agents at work.
15.2. Chemical Safety Assessment
Chemical Safety Assessments have been carried out for these substances.
16. OTHER INFORMATION
16.1 Full text of Hazard Code(s) referred in Section 3.
H220: Extremely flammable gas.
H280: Contains gas under pressure; may explode if heated.
16.2 Abbreviations and acronyms
ADR: Accord européen sur le transport des marchandises dangereuses par Route (European
Agreement concerning the International Carriage of Dangerous Goods by Road).
RID: Règlement international concernant le transport des marchandises dangereuses par chemin de
fer (Regulations Concerning the International Transport of Dangerous Goods by Rail).
IMDG: International Maritime Code for Dangerous Goods.
IATA: International Air Transport Association.
ICAO: International Civil Aviation Organization.
bw: Body weight.
Carc.: Carcinogenicity.
CAS number: Chemical Abstracts Service number.
CLP: Classification Labelling Packaging Regulation.
CSA: Chemical Safety Assessment.
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CSR: Chemical Safety Report.
DNEL: Derived No Effect Level.
dw: Dry weight.
EC number: EINECS and ELINCS number.
EC: European Commission.
EC50: Half maximal effective concentration.
EINECS: European Inventory of Existing Commercial Chemical Substances.
ELINCS: European List of Notified Chemical Substances.
EmS: Emergency Schedule.
ERC: Environmental Release Category.
ES: Exposure scenario.
food: oral feed.
GHS: Globally Harmonized System of Classification and Labelling of Chemicals.
Irrit.: Irritation.
LC50: Lethal concentration, 50 %.
LD50: Median Lethal dose.
LOAEC: Lowest Observed Adverse Effect Concentration.
LOAEL: Lowest Observed Adverse Effect Level.
MK value: Maximum Concentration value.
NCO: An international corporation that provides customer service contracting.
NOAEC: No Observed Adverse Effect Concentration.
NOAEL: No Observed Adverse Effect Level.
NOEC: No Observed Effect Concentration.
OECD: Organisation for Economic Cooperation and Development.
PBT: Persistent, Bioaccumulative and Toxic.
PNEC: Predicted No Effect Concentration.
PROC: Process category.
REACH: The Registration, Evaluation, Authorisation and Restriction of Chemicals.
Resp.: Respiratory.
Sens.: Sensitization.
STEL value: Short Term Exposure Limit value.
STOT RE: Specific target organ toxicity — repeated exposure.
STOT SE: Specific target organ toxicity — single exposure.
STOT: Specific Target Organ Toxicity.
STP: Sewage Treatment Plant.
SU: Sector of use.
Tox.: Toxicity.
TWA value: Time Weighted Average value.
vPvB: Very Persistent and Very Bioaccumulative.
16.3 Notice to reader
All information, instructions and statements contained in this Material Safety Data Sheet are
compiled in accordance with European Directives, corresponding national legislation and on the
basis of information given by our suppliers.
The information disclosed in this Material Safety Data Sheet (which supersedes all previous
versions) is believed to be correct, at the date of issue, to the best of our current knowledge and
experience. It only relates to the specific product designated herein and it may not be valid when said
product is used in combination with any other products or in any processed form, unless specified in
the text. This document aims to provide the necessary health and safety information of the product
and is not to be considered a warranty or quality specification. It is the responsibility of the recipient
of this Material Safety Data Sheet to ensure that information given here is read and understood by all
who use, handle, dispose of or in any way come in contact with the product.
Also, it is the responsibility of the user to comply with local legislation relating to safety, health,
environment and waste management. Data and information provided concerning the product are
informative, exclusively presented to the customer.
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