DMPA (Depot Medroxyprogesterone Acetate)
Introduction
DMPA (Depot Medroxyprogesterone Acetate) is a long-acting progesterone injection used
for contraception and for the treatment of abnormal or heavy uterine bleeding.
Dose and Schedule
• 150 mg intramuscular injection
• Given once every 3 months (12 weeks)
Mechanism of Action
• Suppresses ovulation
• Thins the endometrium, reducing menstrual bleeding
• Thickens cervical mucus to prevent pregnancy
Uses
• Contraception (Family planning)
• Dysfunctional/Abnormal Uterine Bleeding
• Endometriosis (in selected cases)
Advantages
• Highly effective method of contraception
• Reduces heavy menstrual bleeding
• May stop periods after prolonged use
• No need for daily medication
Side Effects
• Irregular spotting in initial months
• Amenorrhea (absence of periods)
• Weight gain
• Delayed return of fertility (6–12 months)
• Mild reduction in bone density with long-term use
Conclusion
DMPA is a safe and effective long-acting progesterone injection given every three months
for contraception and control of heavy menstrual bleeding.