Module-1 Slide Notes
Module-1 Slide Notes
Contents
Introduction to Biological • Overview and importance of biology in engineering,
Sciences • Origin of Life,
• Cell Theory and Structure
Module I
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Biotechnology
Genetic Engineering: Engineers manipulate genetic material to create
new crops or medicinal products, showcasing the intersection of
biology and technology.
Synthetic Biology: This emerging field combines biology and
engineering to design and construct new biological parts, devices, and
systems for practical applications.
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Agricultural Engineering:
Crop Improvement: Biology helps in developing genetically modified
organisms (GMOs) for enhanced yield and resistance to pests.
Soil and Water Management: Understanding biological systems
contributes to better agricultural practices, optimizing resource use
while minimizing environmental impact.
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Characteristic of Life
Life – Definition and Regulation
• Homeostasis
– Regulation of the internal environment to maintain a constant state; for example, electrolyte
concentration or sweating to reduce temperature • The oxford dictionary defines life as “the condition that distinguishes
• Organization animals and plants from inorganic matter, including the capacity for
– Being structurally composed of one or more cells growth, reproduction, functional activity, and continual change preceding
• Metabolism death”.
– Maintain energy and regulate life through Catabolism and Anabolism
• Any contiguous living system is called an “organism”.
• Growth
– Maintenance of a higher rate of anabolism than catabolism • Organisms undergo metabolism, maintain homeostasis, possess a
• Adaptation capacity to grow, respond to stimuli, reproduce and, through natural
– The ability to change over time in response to the environment selection, adapt to their environment in successive generations. More
• Response to stimuli (Irritability) complex living organisms can communicate through various means.
– A response is often expressed by motion (Chemotaxis, phototaxis in plants) and reaction of body
against any stimuls (+ve and –ve).
• These complex processes, called physiological functions, have underlying
• Reproduction physical and chemical bases, as well as signalling and control mechanisms
– The ability to produce new individual organisms, either asexually from a single parent organism, or that are essential to maintaining life.
sexually from two parent organisms
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1. Theory of Special Creation • A Mythology based theories which believes that all forms
of life created by god. It has no scientific basis. It is religion
2. Theory of Spontaneous Generation based concept.
– As per Hindu mythology, Lord Brahma, has created earth and
3. Theory of Catastrophism all life forms.
– According to the Christian and Islamic belief, God created
4. Cosmozoic Theory (Theory of Panspermia) this universe, plants, animals and human beings in about six
natural days.
5. Theory of Chemical Evolution – The Sikh mythology says that all forms of life including
human beings came into being with a single word of God.
• Special creation theory believes that the things have not
undergone any significant change since their creation
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Cells
Contents • All living organisms, unicellular or multicellular, are made
up of cells. The cell is the simplest unit of matter that is
alive and is called as structural and functional unit of life.
• Overview and importance of biology in engineering • Each cell is amazing world in itself. It takes in nutrients,
• Origin of Life convert these nutrients into energy, carry out specialized
functions, and they grow with time and self-propagate
• Cell Theory and Structure by reproduction for survival.
• Each cell differentiates into specific cell type for playing
specific role in the life of organism. Means, specific
organs for specific function. For eg, Cardiac, Hepatic,
Nerve, Myeloma etc.
• About 300 different types of cell have been identified so
far.
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Cell History
• In 1665, the first cell was discovered and named by
Robert Hooke while observing dead cork samples
with a crude lens.
• Anton Von Leeuwenhoek in 1674 first saw and
described a live cell in algae Spirogyra. Also called
Father of Microbiology.
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Cell Size
Prokaryotic
• Cells differ greatly in size, shape and activities.
• Human eyes have a resolution of about 100 µm. But, most of the and
biological structures are smaller than the unaided human eye can see.
• Mycoplasma, the smallest cell, is only 0.3 µm (micrometer) in length
Eukaryotic Cells
while bacteria could be 3 to 5 µm.
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Bacterial cell
Prokaryotic Cells • A typical bacterial cell is composed of Cell wall, Plasma membrane, Nucleoid, Ribosomes, Pilli, Flagella, storage
granules and a Capsule. Not all structures are present in all prokaryotic cells; it may vary from one species to
other.
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Bacterial cell • Capsule (or slime layer) Bacterial cell • Cell Wall
– A thick polysaccharide layer outside the cell wall. – Made up of murein (not cellulose), which is a
– Not present in all bacteria. Found only in some glycoprotein (also called peptidoglycan).
Capsule (or slime layer) gram +ve bacteria, if a capsule is present, then Cell Wall – There are two kinds of cell wall, which can be
flagella are not. Cell or Plasma membrane distinguished by Gram staining.
Flagella (singular flagellum) – Used for sticking cells together, as a food reserve, • Gram +ve bacteria have a thick cell wall, stain purple,
as protection against desiccation and chemicals Cytoplasm may have spores and are sensitive to penicillin and
lysosomes (an antibacterial enzyme found in tears and
Pilli and Fimbriae and as protection against phagocytosis. saliva)
• Flagella (singular flagellum) • Gram –ve bacteria have a thin cell wall with an outer
lipid layer, have no spores and stain pink – these are
– A thin and long filamentous extension or
thought to be more highly evolved.
whip-like protrusion that aids in cellular
locomotion • Plasma membrane or cell membrane
– It is extended from the cell wall and used for the – Boundary (“wall”) between the cell and the
environment. Allows nutrients/ regulates
motility of bacteria.
movement in and out of the cell. (“Selectively
– Bacterial flagellum is composed of three parts – Permeable”).
filament, hook and basal body. – Made of phospholipids and proteins like eukaryotic
• Pilli and Fimbriae membranes.
– Hair-like structures on the surface of the cell that • Cytoplasm
attach to other bacterial cells. Shorter pili called – Cytoplasm is a jelly-like substance that is sometimes
fimbriae help bacteria attach to surfaces. described as "the cell-matrix".
– Contains all the enzymes needed for all the
metabolic reactions, since there are no organelles
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• Plasma membrane
• Plasmodesmata
• Vacuole
• Microtubules
• Chloroplasts
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Nucleus No clear membrane bound nucleus present Clean membrane bound nucleus present
Organelles No membrane bound organelles Membrane bound organelles presents such as ER,
present like ER, Golgi complex, mitochondria Golgi bodies, mitochondria etc.
etc.
DNA DNA is circular, without proteins DNA is linear and associated with proteins to form
chromatin
Ribosomes Ribosomes are small ( 70S type) Ribosomes are large ( 80S type)
Motility Motility by rigid rotating flagellum Motility by flexible waving cilia or flagella
(made up of flagillin) (made up of tubulin )
Cell division Cell division is by binary fission Cell division by mitotic or meiosis
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