Scribd
Upload
5 views3 pages

NaPAP Complete Interview Notes

The document outlines the production process of Sodium Para Amino Phenol (NaPAP) through three main stages: hydrolysis, hydrogenation, and crystallization. Key raw materials and chemical reactions are detailed, along with operating conditions, safety measures, and the importance of pH control. Additionally, it includes safety protocols and answers to common questions regarding the process.

Uploaded by

nikptl09
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
5 views3 pages

NaPAP Complete Interview Notes

The document outlines the production process of Sodium Para Amino Phenol (NaPAP) through three main stages: hydrolysis, hydrogenation, and crystallization. Key raw materials and chemical reactions are detailed, along with operating conditions, safety measures, and the importance of pH control. Additionally, it includes safety protocols and answers to common questions regarding the process.

Uploaded by

nikptl09
Copyright
© All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

NaPAP (Sodium Salt of Para Amino Phenol) -

Complete Interview Notes

STAGE-1: HYDROLYSIS SECTION

Raw Materials: Para Nitro Chloro Benzene (PNCB), Caustic Lye (NaOH), Water

Reaction: Nucleophilic Aromatic Substitution

Chemical Reaction: PNCB + NaOH → NaPNP + NaCl

Operating Conditions: 158–164°C, High Pressure, Continuous Agitation

Objective: Replace Cl group with OH group to form Sodium Para Nitro Phenoxide

Key Control: Temperature control, Pressure safety, Proper agitation

STAGE-2: HYDROGENATION SECTION

Raw Materials: NaPNP, Hydrogen Gas, Nickel Catalyst

Reaction: Reduction of Nitro (-NO2) to Amino (-NH2)

Chemical Reaction: NaPNP + 3H2 → NaPAP

Operating Conditions: 90–110°C, 3–6 kg/cm² Hydrogen Pressure

Safety: Hydrogen leak test, Explosion prevention, Catalyst handling

STAGE-3: NEUTRALIZATION & CRYSTALLIZATION

Chemicals Used: HCl, EDTA, CAT-1

Purpose: pH adjustment and crystal formation

pH Maintain: 6.5 – 7.0

Cooling required for proper crystallization

EDTA removes metal impurities

FINAL STEP: Cooling & Transfer to Stage-II

Product cooled and sent for filtration/drying

Used further in Paracetamol manufacturing


IMPORTANT SAFETY POINTS

PPE mandatory, Pressure Relief Valve check, Caustic handling care, HCl handling precautions

VIVA QUESTIONS & ANSWERS

Q1: Why hydrolysis is done?

Ans: To replace chlorine group with hydroxyl group.

Q2: What happens in hydrogenation?

Ans: Nitro group converts into amino group using hydrogen gas.

Q3: Why EDTA is used?

Ans: To remove metal impurities.

Q4: Why pH 6.5–7 maintained?

Ans: For product stability and proper crystallization.

FLOW DIAGRAM EXPLANATION SCRIPT (Interview Speaking Format)

First, PNCB, NaOH and water are charged into hydrolysis reactor.

Temperature maintained at 158–164°C to form NaPNP.

Then mass transferred to hydrogenation reactor.

Hydrogen gas introduced with catalyst at 90–110°C.

Nitro group reduced to amino group forming NaPAP.

Then mass sent to crystallizer.

HCl added for neutralization, pH maintained 6.5–7.

Cooling done to form crystals.

Final product transferred to next stage.

P&ID; LEVEL EXPLANATION

Hydrolysis Reactor equipped with Steam Jacket, Temperature Indicator (TI), Pressure Gauge (PG),
Safety Relief Valve (SRV).
Hydrogenation Reactor has Hydrogen inlet with Pressure Control Valve (PCV), Rupture Disc,
Agitator.

Crystallizer equipped with Cooling Jacket, pH meter, Sampling valve.

Transfer pumps used between stages.

All sections connected with proper isolation valves and safety systems.

You might also like